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2024-04-20 02:16:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002526 4086 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens 5'-nucleotidase, ecto (CD73) (NT5E), transcript
variant 1, mRNA.
ACCESSION NM_002526
VERSION NM_002526.3 GI:325651882
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4086)
AUTHORS Ohta,M., Toyama,K., Gutterman,D.D., Campbell,W.B., Lemaitre,V.,
Teraoka,R. and Miura,H.
TITLE Ecto-5'-nucleotidase, CD73, is an endothelium-derived
hyperpolarizing factor synthase
JOURNAL Arterioscler. Thromb. Vasc. Biol. 33 (3), 629-636 (2013)
PUBMED 23288168
REMARK GeneRIF: Coronary vasodilation to adenine nucleotides is associated
with endothelial CD73-dependent production of extracellular
adenosine that acts as an endothelium-derived hyperpolarizing
factor.
REFERENCE 2 (bases 1 to 4086)
AUTHORS Knapp,K., Zebisch,M., Pippel,J., El-Tayeb,A., Muller,C.E. and
Strater,N.
TITLE Crystal structure of the human ecto-5'-nucleotidase (CD73):
insights into the regulation of purinergic signaling
JOURNAL Structure 20 (12), 2161-2173 (2012)
PUBMED 23142347
REMARK GeneRIF: Crystal structures of the dimeric human e5NT reveal an
extensive conformational switch between the open and closed forms
of the enzyme.
REFERENCE 3 (bases 1 to 4086)
AUTHORS Knapp,K.M., Zebisch,M. and Strater,N.
TITLE Crystallization and preliminary X-ray analysis of the open form of
human ecto-5'-nucleotidase (CD73)
JOURNAL Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68 (PT 12),
1545-1549 (2012)
PUBMED 23192044
REMARK GeneRIF: crystallization and preliminary X-ray crystallographic
analysis of an open structural conformation of human e5NT are
described.
REFERENCE 4 (bases 1 to 4086)
AUTHORS Nitschke,Y. and Rutsch,F.
TITLE Genetics in arterial calcification: lessons learned from rare
diseases
JOURNAL Trends Cardiovasc. Med. 22 (6), 145-149 (2012)
PUBMED 23122642
REMARK GeneRIF: Mutations in the underlying disease genes ENPP1, ABCC6,
NT5E, and SLC20A2, respectively, lead to arterial media
calcification.
Review article
REFERENCE 5 (bases 1 to 4086)
AUTHORS Hansen,K.R., Resta,R., Webb,C.F. and Thompson,L.F.
TITLE Isolation and characterization of the promoter of the human
5'-nucleotidase (CD73)-encoding gene
JOURNAL Gene 167 (1-2), 307-312 (1995)
PUBMED 8566797
REFERENCE 6 (bases 1 to 4086)
AUTHORS Klemens,M.R., Sherman,W.R., Holmberg,N.J., Ruedi,J.M., Low,M.G. and
Thompson,L.F.
TITLE Characterization of soluble vs membrane-bound human placental
5'-nucleotidase
JOURNAL Biochem. Biophys. Res. Commun. 172 (3), 1371-1377 (1990)
PUBMED 2173922
REFERENCE 7 (bases 1 to 4086)
AUTHORS Misumi,Y., Ogata,S., Ohkubo,K., Hirose,S. and Ikehara,Y.
TITLE Primary structure of human placental 5'-nucleotidase and
identification of the glycolipid anchor in the mature form
JOURNAL Eur. J. Biochem. 191 (3), 563-569 (1990)
PUBMED 2129526
REFERENCE 8 (bases 1 to 4086)
AUTHORS Thomson,L.F., Ruedi,J.M., Glass,A., Moldenhauer,G., Moller,P.,
Low,M.G., Klemens,M.R., Massaia,M. and Lucas,A.H.
TITLE Production and characterization of monoclonal antibodies to the
glycosyl phosphatidylinositol-anchored lymphocyte differentiation
antigen ecto-5'-nucleotidase (CD73)
JOURNAL Tissue Antigens 35 (1), 9-19 (1990)
PUBMED 2137649
REFERENCE 9 (bases 1 to 4086)
AUTHORS Boyle,J.M., Hey,Y., Guerts van Kessel,A. and Fox,M.
TITLE Assignment of ecto-5'-nucleotidase to human chromosome 6
JOURNAL Hum. Genet. 81 (1), 88-92 (1988)
PUBMED 2848759
REFERENCE 10 (bases 1 to 4086)
AUTHORS Stefanovic,V., Mandel,P. and Rosenberg,A.
TITLE Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells
JOURNAL J. Biol. Chem. 251 (13), 3900-3905 (1976)
PUBMED 819433
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA574510.1, X55740.1,
BC065937.1, AK075008.1 and BQ019358.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 10, 2011 this sequence version replaced gi:187131235.
Summary: The protein encoded by this gene is a plasma membrane
protein that catalyzes the conversion of extracellular nucleotides
to membrane-permeable nucleosides. The encoded protein is used as a
determinant of lymphocyte differentiation. Defects in this gene can
lead to the calcification of joints and arteries. Two transcript
variants encoding different isoforms have been found for this
gene.[provided by RefSeq, Mar 2011].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X55740.1, BC065937.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-507 DA574510.1 1-507
508-3069 X55740.1 1-2562
3070-3219 BC065937.1 2539-2688
3220-3834 X55740.1 2712-3326
3835-4059 AK075008.1 3160-3384
4060-4086 BQ019358.1 1-27 c
FEATURES Location/Qualifiers
source 1..4086
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q14-q21"
gene 1..4086
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="5'-nucleotidase, ecto (CD73)"
/db_xref="GeneID:4907"
/db_xref="HGNC:8021"
/db_xref="HPRD:00552"
/db_xref="MIM:129190"
exon 1..895
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 75
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:6919558"
variation 140
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:150152774"
variation 161
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:2295890"
variation 464
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:376344036"
variation 472
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:184283916"
variation 478
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:189229964"
misc_feature 485..487
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="upstream in-frame stop codon"
CDS 557..2281
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/EC_number="3.1.3.5"
/note="isoform 1 preproprotein is encoded by transcript
variant 1; Purine 5-Prime-Nucleotidase;
ecto-5'-nucleotidase; 5'-NT"
/codon_start=1
/product="5'-nucleotidase isoform 1 preproprotein"
/protein_id="NP_002517.1"
/db_xref="GI:4505467"
/db_xref="CCDS:CCDS5002.1"
/db_xref="GeneID:4907"
/db_xref="HGNC:8021"
/db_xref="HPRD:00552"
/db_xref="MIM:129190"
/translation="
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
"
sig_peptide 557..634
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 635..2278
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/product="5'-nucleotidase isoform 1 proprotein"
mat_peptide 635..2203
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/product="5'-nucleotidase isoform 1"
misc_feature 638..2152
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="5'-nucleotidase/2',3'-cyclic phosphodiesterase and
related esterases [Nucleotide transport and metabolism];
Region: UshA; COG0737"
/db_xref="CDD:31080"
misc_feature 641..1486
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="CD73 ecto-5'-nucleotidase and related proteins,
N-terminal metallophosphatase domain; Region: MPP_CD73_N;
cd07409"
/db_xref="CDD:163652"
misc_feature order(662..664,668..670,809..811,905..910,917..919,
1106..1108,1214..1216,1283..1285,1289..1291)
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="active site"
/db_xref="CDD:163652"
misc_feature order(662..664,668..670,809..811,905..907,1214..1216,
1283..1285,1289..1291)
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="metal binding site [ion binding]; metal-binding
site"
/db_xref="CDD:163652"
misc_feature 1592..2083
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/note="5'-nucleotidase, C-terminal domain; Region:
5_nucleotid_C; pfam02872"
/db_xref="CDD:202440"
misc_feature 2201..2203
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosyl phosphatidyl inositol (gpi) site; modified
site"
/citation=[7]
variation 557
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:202207703"
variation 598
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:368613430"
variation 620
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:372252780"
variation 632
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:201419844"
variation 658
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:142909102"
variation 664
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:368729244"
variation 685
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:371172793"
variation 697
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:369010777"
variation 714
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:374757389"
variation 723
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:369193143"
variation 740
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:200250022"
variation 778
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:147423946"
variation 779
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:138139831"
variation 882
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:375481678"
exon 896..1118
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 898
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:35694460"
variation 935
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:147283805"
variation 943
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:148743555"
variation 956
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:200207416"
variation 1000
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:142302523"
variation 1013
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:200369370"
variation 1084
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:74858361"
variation 1098
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:199573247"
variation 1111
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:376172369"
exon 1119..1307
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1161
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:201534865"
variation 1218
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:373328681"
variation 1219
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:139237444"
variation 1238
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:144535109"
variation 1255
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:146630544"
variation 1258
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:141370047"
variation 1259
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:200664520"
variation 1271
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:200840390"
variation 1274
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:201657741"
variation 1294
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:143793168"
exon 1308..1505
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1331
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:376792488"
variation 1361
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:184831134"
variation 1388
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:41271617"
variation 1399
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:370583260"
variation 1432
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:149061664"
variation 1453
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:35478984"
variation 1454
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:148199616"
variation 1460
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="t"
/db_xref="dbSNP:368274173"
variation 1479
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:201782026"
variation 1480
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:141102470"
variation 1496
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:371640203"
exon 1506..1660
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1535
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:147019457"
variation 1567
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:374712948"
variation 1594
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:138198374"
variation 1597
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229522"
variation 1616
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:200648774"
variation 1629
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906620"
variation 1650
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:143679828"
exon 1661..1766
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1672
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:200094485"
variation 1682
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229523"
variation 1684
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:138566130"
variation 1692
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229524"
variation 1705
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:370951693"
variation 1706
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:375139069"
variation 1757
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:144719925"
variation 1758
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:139549986"
variation 1763
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:138876213"
exon 1767..1916
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1776
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:376406036"
variation 1777
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:146166792"
variation 1809
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:146054415"
variation 1815
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:370017735"
variation 1818
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="t"
/db_xref="dbSNP:72905321"
variation 1864
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:370536110"
variation 1878
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:377417331"
variation 1882
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:368679446"
variation 1883
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:373069568"
variation 1901
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:376616753"
variation 1912
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:140182435"
exon 1917..2117
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 1944
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:201008460"
variation 1964
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:142656691"
variation 2027
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:143859595"
variation 2034
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:151304292"
variation 2056
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:376526362"
variation 2059
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:139343924"
variation 2095
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:150989796"
variation 2098
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:145505137"
variation 2108
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:141170507"
exon 2118..4068
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/inference="alignment:Splign:1.39.8"
variation 2134
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:202181475"
variation 2144
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:34160251"
variation 2190
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:371449832"
variation 2205
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:368609058"
variation 2217
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:372698120"
variation 2328
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:193222810"
STS 2355..2464
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/standard_name="D6S1847"
/db_xref="UniSTS:38875"
variation 2511
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:183777053"
variation 2522
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:6913634"
variation 2708
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:74562712"
variation 2714
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:201230877"
variation 2720..2721
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace=""
/replace="a"
/db_xref="dbSNP:370566669"
variation 2721
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:371699211"
variation 2814
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:189184673"
variation 2892
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:137869371"
variation 2945
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="g"
/db_xref="dbSNP:192272181"
variation 3036
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:184664228"
variation 3162
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:149223779"
variation 3190
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:188358257"
variation 3204
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:112874886"
variation 3216..3220
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace=""
/replace="ttatt"
/db_xref="dbSNP:139107209"
variation 3220..3224
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace=""
/replace="tttat"
/db_xref="dbSNP:58177677"
STS 3227..3525
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/standard_name="WI-20546"
/db_xref="UniSTS:46296"
variation 3307
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:80260534"
variation 3329
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:375798700"
variation 3449
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="c"
/db_xref="dbSNP:143368737"
variation 3466
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="t"
/db_xref="dbSNP:148352610"
variation 3477
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:141542163"
variation 3516
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="t"
/db_xref="dbSNP:191717024"
variation 3572
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:370052880"
variation 3595
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="c"
/replace="t"
/db_xref="dbSNP:41271621"
STS 3649..3815
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/standard_name="STS-X55740"
/db_xref="UniSTS:73678"
variation 3882
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:6922"
variation 3892
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:150877880"
STS 3904..4026
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/standard_name="RH46710"
/db_xref="UniSTS:21108"
variation 3934
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="a"
/replace="g"
/db_xref="dbSNP:138351627"
variation 3950
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
/replace="g"
/replace="t"
/db_xref="dbSNP:142840005"
polyA_signal 4041..4046
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
polyA_site 4068
/gene="NT5E"
/gene_synonym="CD73; E5NT; eN; eNT; NT; NT5; NTE"
ORIGIN
actcctcctctctgcccctcagctcgctcatctttcttcccgccccctctcttttccttctttggttctttgaagtgatgagctagcgcaaccacaaaccatacattccttttgtagaaaaacccgtgcctcgaatgaggcgagactcagagaggacccaggcgcggggcggacccctccaattccttcctcgcgcccccgaaagagcggcgcaccagcagccgaactgccggcgcccaggctccctggtccggccgggatgcggccggtacccgctccccgccgggaacaacctctccactcttcctgcagggagctggtgccagccgacagccgcgccagggccgctccgggtaccagggtcggatcgggtgacgtcgcgaacttgcgcctggccgccaagccggcctccaggctgaagaaggacccgccccggccttgacccgggccccgcccctccagccggggcaccgagccccggccctagctgctcgcccctactcgccggcactcgcccggctcgcccgctttcgcacccagttcacgcgccacagctatgtgtccccgagccgcgcgggcgcccgcgacgctactcctcgccctgggcgcggtgctgtggcctgcggctggcgcctgggagcttacgattttgcacaccaacgacgtgcacagccggctggagcagaccagcgaggactccagcaagtgcgtcaacgccagccgctgcatgggtggcgtggctcggctcttcaccaaggttcagcagatccgccgcgccgaacccaacgtgctgctgctggacgccggcgaccagtaccagggcactatctggttcaccgtgtacaagggcgccgaggtggcgcacttcatgaacgccctgcgctacgatgccatggcactgggaaatcatgaatttgataatggtgtggaaggactgatcgagccactcctcaaagaggccaaatttccaattctgagtgcaaacattaaagcaaaggggccactagcatctcaaatatcaggactttatttgccatataaagttcttcctgttggtgatgaagttgtgggaatcgttggatacacttccaaagaaaccccttttctctcaaatccagggacaaatttagtgtttgaagatgaaatcactgcattacaacctgaagtagataagttaaaaactctaaatgtgaacaaaattattgcactgggacattcgggttttgaaatggataaactcatcgctcagaaagtgaggggtgtggacgtcgtggtgggaggacactccaacacatttctttacacaggcaatccaccttccaaagaggtgcctgctgggaagtacccattcatagtcacttctgatgatgggcggaaggttcctgtagtccaggcctatgcttttggcaaatacctaggctatctgaagatcgagtttgatgaaagaggaaacgtcatctcttcccatggaaatcccattcttctaaacagcagcattcctgaagatccaagcataaaagcagacattaacaaatggaggataaaattggataattattctacccaggaattagggaaaacaattgtctatctggatggctcctctcaatcatgccgctttagagaatgcaacatgggcaacctgatttgtgatgcaatgattaacaacaacctgagacacacggatgaaatgttctggaaccacgtatccatgtgcattttaaatggaggtggtatccggtcgcccattgatgaacgcaacaatggcacaattacctgggagaacctggctgctgtattgccctttggaggcacatttgacctagtccagttaaaaggttccaccctgaagaaggcctttgagcatagcgtgcaccgctacggccagtccactggagagttcctgcaggtgggcggaatccatgtggtgtatgatctttcccgaaaacctggagacagagtagtcaaattagatgttctttgcaccaagtgtcgagtgcccagttatgaccctctcaaaatggacgaggtatataaggtgatcctcccaaacttcctggccaatggtggagatgggttccagatgataaaagatgaattattaagacatgactctggtgaccaagatatcaacgtggtttctacatatatctccaaaatgaaagtaatttatccagcagttgaaggtcggatcaagttttccacaggaagtcactgccatggaagcttttctttaatatttctttcactttgggcagtgatctttgttttataccaatagccaaaaattctccttgcctttaatgtgtgaaactgcattttttcaagtgagattcaaatctgccttttaggacctggctttgtgacagcaaaaaccatctttacaggctcctagaagctgaaggttagagcattataaaatgaagagacagacatgattactcagggtcagcaacctagtgagttagaaaaaaaattaacatagggccctataaggagaaagccaactatgttaagtttacgtgtccaaattttaatgaaattttactaacaattttaaaccatatttttcttcttcatatccatttctaatccatcaaacagcttatgtttacataaaattttatcattcacaaggaagttttaagcacactgtctcatttgatatccacaacttatttttggtaggaaagagagatgtttttcccacctgtcagatgaaaaaactgaagctcaaaaagggttgacttgaccatacagctaatgctgacagatccaagacctagacctaggtcttttgaactcaagtccagcattctcaactatatcaagttactgttcagaatacttaatatctcctctcttcataattatcaatagccccaagctcatggatgacaaatctctgctttatttcttgtctctattttttcactttatagctcctgttataatagcaagtttaatggtataaacacaggataccatcctctcttgcaacacccatgtgcctttgatgagtcaggtagcaagctgtagtagataatgagaaaggccagaggctgcaaaagacagtcaaaggacacgagagaaaggaaggggaagaacaggactccaggactgttttatattatagaaaagcaagagctaaagagcatttacacatgttaaacagatacttgttaagcatagtgcctgacacacggcattagctgttattttatgagattccatcagctctgcctctgtcctctttcttctaacatgaaggtatcatgagaagagaaccttctaacataagctgtaattctaaacctgcacttgtccctctccagcaagaggctagcactgaattcattctactcatactacacacccagttatggaatgtccagagttctcgaagaaaataaatgactttaggaagaggtatacattttttaagtcgctctgcctccaaatctgaacagtcactgtaaatcattcttaagcccagatatgagaacttctgctggaaagtgggaccctctgagtgggtggtcagaaaatacccatgctgatgaaatgacctatgcccaaagaacaaatacttaacgtgggagtggaaccacatgagcctgctcagctctgcataagtaattcaagaaatgggaggcttcaccttaaaaacagtgtgcaaatggcagctagaggttttgataggaagtatgtttgtttcttagtgtttacaaatattaagtactcttgatacaaaatatacttttaaacttcataacctttttataaaagttgttgcagcaaaataatagcctcggttctatgcatatatggattagctataaaaaatgtcaataagattgtacaaggaaaattagagaaagtcacatttagggtttattttttacacttggccagtaaaatagggtaaatcctattagaattttttaaagaactttttttaagtttcctaaatctgtgtgtgtattgtgaagtggtataagaaatgactttgaaccactttgcaattgtagattcccaacaataaaattgaagataagctctttggtcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4907 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:4907 -> Molecular function: GO:0008253 [5'-nucleotidase activity] evidence: EXP
GeneID:4907 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:4907 -> Biological process: GO:0006144 [purine nucleobase metabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0006195 [purine nucleotide catabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0006196 [AMP catabolic process] evidence: IEA
GeneID:4907 -> Biological process: GO:0006206 [pyrimidine nucleobase metabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0006259 [DNA metabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0046086 [adenosine biosynthetic process] evidence: IEA
GeneID:4907 -> Biological process: GO:0046135 [pyrimidine nucleoside catabolic process] evidence: TAS
GeneID:4907 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: IEA
GeneID:4907 -> Biological process: GO:0055086 [nucleobase-containing small molecule metabolic process] evidence: TAS
GeneID:4907 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4907 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:4907 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4907 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:4907 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA
GeneID:4907 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002517 -> EC 3.1.3.5
by
@meso_cacase at
DBCLS
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