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2020-10-24 06:41:34, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002470               6061 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens myosin, heavy chain 3, skeletal muscle, embryonic
            (MYH3), mRNA.
ACCESSION   NM_002470
VERSION     NM_002470.3  GI:345842434
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6061)
  AUTHORS   Kimber,E., Tajsharghi,H., Kroksmark,A.K., Oldfors,A. and
            Tulinius,M.
  TITLE     Distal arthrogryposis: clinical and genetic findings
  JOURNAL   Acta Paediatr. 101 (8), 877-887 (2012)
   PUBMED   22519952
  REMARK    GeneRIF: Molecular genetic investigations revealed pathogenic
            mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial
            cases of distal arthrogryposis.
REFERENCE   2  (bases 1 to 6061)
  AUTHORS   Rutland,C.S., Polo-Parada,L., Ehler,E., Alibhai,A., Thorpe,A.,
            Suren,S., Emes,R.D., Patel,B. and Loughna,S.
  TITLE     Knockdown of embryonic myosin heavy chain reveals an essential role
            in the morphology and function of the developing heart
  JOURNAL   Development 138 (18), 3955-3966 (2011)
   PUBMED   21862559
  REMARK    GeneRIF: eMYH plays a crucial role in important processes in the
            early developing heart and, hence, is a candidate causative gene
            for atrial septal defects and cardiomyopathy.
REFERENCE   3  (bases 1 to 6061)
  AUTHORS   Alvarado,D.M., Buchan,J.G., Gurnett,C.A. and Dobbs,M.B.
  TITLE     Exome sequencing identifies an MYH3 mutation in a family with
            distal arthrogryposis type 1
  JOURNAL   J Bone Joint Surg Am 93 (11), 1045-1050 (2011)
   PUBMED   21531865
  REMARK    GeneRIF: Identification of an MYH3 mutation in this family with
            distal arthrogryposis type 1 broadens the phenotype associated with
            MYH3 mutations to include distal arthrogryposis types 1, 2A
            (Freeman-Sheldon syndrome), and 2B (Sheldon-Hall syndrome).
REFERENCE   4  (bases 1 to 6061)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 6061)
  AUTHORS   Shyy,W., Wang,K., Sheffield,V.C. and Morcuende,J.A.
  TITLE     Evaluation of embryonic and perinatal myosin gene mutations and the
            etiology of congenital idiopathic clubfoot
  JOURNAL   J Pediatr Orthop 30 (3), 231-234 (2010)
   PUBMED   20357587
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6061)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   7  (bases 1 to 6061)
  AUTHORS   Bober,E., Buchberger-Seidl,A., Braun,T., Singh,S., Goedde,H.W. and
            Arnold,H.H.
  TITLE     Identification of three developmentally controlled isoforms of
            human myosin heavy chains
  JOURNAL   Eur. J. Biochem. 189 (1), 55-65 (1990)
   PUBMED   1691980
REFERENCE   8  (bases 1 to 6061)
  AUTHORS   Eller,M., Stedman,H.H., Sylvester,J.E., Fertels,S.H., Wu,Q.L.,
            Raychowdhury,M.K., Rubinstein,N.A., Kelly,A.M. and Sarkar,S.
  TITLE     Human embryonic myosin heavy chain cDNA. Interspecies sequence
            conservation of the myosin rod, chromosomal locus and isoform
            specific transcription of the gene
  JOURNAL   FEBS Lett. 256 (1-2), 21-28 (1989)
   PUBMED   2806546
REFERENCE   9  (bases 1 to 6061)
  AUTHORS   Karsch-Mizrachi,I., Travis,M., Blau,H. and Leinwand,L.A.
  TITLE     Expression and DNA sequence analysis of a human embryonic skeletal
            muscle myosin heavy chain gene
  JOURNAL   Nucleic Acids Res. 17 (15), 6167-6179 (1989)
   PUBMED   2771643
REFERENCE   10 (bases 1 to 6061)
  AUTHORS   Eller,M., Stedman,H.H., Sylvester,J.E., Fertels,S.H.,
            Rubinstein,N.A., Kelly,A.M. and Sarkar,S.
  TITLE     Nucleotide sequence of full length human embryonic myosin heavy
            chain cDNA
  JOURNAL   Nucleic Acids Res. 17 (9), 3591-3592 (1989)
   PUBMED   2726495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP233220.1, BQ956249.1,
            X13988.1, AC002347.3, BX500019.1, BY796597.2, BP232269.1,
            BP232093.1, AY517555.1, CD614924.1 and BP370003.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 9, 2011 this sequence version replaced gi:98986452.
            
            Summary: Myosin is a major contractile protein which converts
            chemical energy into mechanical energy through the hydrolysis of
            ATP. Myosin is a hexameric protein composed of a pair of myosin
            heavy chains (MYH) and two pairs of nonidentical light chains. This
            gene is a member of the MYH family and encodes a protein with an IQ
            domain and a myosin head-like domain. Mutations in this gene have
            been associated with two congenital contracture (arthrogryposis)
            syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X13988.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support ERS025081,
                                    ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               BP233220.1         1-449
            450-706             BQ956249.1         442-698
            707-1066            X13988.1           703-1062
            1067-1090           AC002347.3         98432-98455
            1091-1809           X13988.1           1087-1805
            1810-2103           BX500019.1         93-386
            2104-2238           X13988.1           2100-2234
            2239-2253           AC002347.3         103285-103299
            2254-2282           X13988.1           2250-2278
            2283-2377           AC002347.3         103727-103821
            2378-2619           X13988.1           2374-2615
            2620-3016           BY796597.2         89-485
            3017-3039           X13988.1           3013-3035
            3040-3136           BY796597.2         509-605
            3137-3225           X13988.1           3133-3221
            3226-3603           BP232269.1         168-545
            3604-3929           BP232093.1         256-581
            3930-4818           AY517555.1         846-1734
            4819-5046           CD614924.1         355-582
            5047-6030           AY517555.1         1963-2946
            6031-6061           BP370003.1         452-482
FEATURES             Location/Qualifiers
     source          1..6061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6061
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="myosin, heavy chain 3, skeletal muscle, embryonic"
                     /db_xref="GeneID:4621"
                     /db_xref="HGNC:7573"
                     /db_xref="MIM:160720"
     exon            1..21
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            22..80
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            81..292
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     CDS             89..5911
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="myosin, heavy polypeptide 3, skeletal muscle,
                     embryonic; myosin, skeletal, heavy chain, embryonic 1;
                     myosin heavy chain, fast skeletal muscle, embryonic"
                     /codon_start=1
                     /product="myosin-3"
                     /protein_id="NP_002461.2"
                     /db_xref="GI:98986453"
                     /db_xref="CCDS:CCDS11157.1"
                     /db_xref="GeneID:4621"
                     /db_xref="HGNC:7573"
                     /db_xref="MIM:160720"
                     /translation="
MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE
"
     misc_feature    191..316
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="Myosin N-terminal SH3-like domain; Region:
                     Myosin_N; pfam02736"
                     /db_xref="CDD:111612"
     misc_feature    329..2425
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="Myosin. Large ATPases; Region: MYSc; smart00242"
                     /db_xref="CDD:197599"
     misc_feature    332..2422
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="Myosin motor domain, type II myosins. Myosin II
                     mediates cortical contraction in cell motility, and is the
                     motor in smooth and skeletal muscle. This catalytic (head)
                     domain has ATPase activity and belongs to the larger group
                     of P-loop NTPases. Myosins...; Region: MYSc_type_II;
                     cd01377"
                     /db_xref="CDD:30099"
     misc_feature    order(467..478,482..487,629..652)
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="ATP-binding site [chemical binding]; other site"
                     /db_xref="CDD:30099"
     misc_feature    809..826
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="switch I region; other site"
                     /db_xref="CDD:30099"
     misc_feature    1475..1498
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="switch II region; other site"
                     /db_xref="CDD:30099"
     misc_feature    order(1559..1594,1601..1630)
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="relay loop; other site"
                     /db_xref="CDD:30099"
     misc_feature    2054..2122
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11055.3);
                     Region: Actin-binding"
     misc_feature    2174..2218
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:30099"
     misc_feature    order(2213..2218,2225..2227,2243..2245,2252..2257,
                     2264..2266,2357..2359,2366..2368,2372..2377,2381..2389,
                     2399..2401,2408..2416)
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:30099"
     misc_feature    2360..2404
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11055.3);
                     Region: Actin-binding"
     misc_feature    3293..5869
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:144972"
     exon            293..436
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       415
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35589501"
     exon            437..593
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            594..621
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            622..730
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            731..823
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            824..887
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            888..986
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            987..1090
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            1091..1229
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            1230..1348
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       1241
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200891912"
     exon            1349..1498
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            1499..1669
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       1663
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34695778"
     exon            1670..1976
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            1977..2047
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            2048..2135
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            2136..2253
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       2239
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:876657"
     exon            2254..2377
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            2378..2514
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            2515..2770
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       2620
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2285469"
     exon            2771..3013
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       3004
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2285472"
     exon            3014..3190
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       3040
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2285474"
     variation       3096
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34088014"
     exon            3191..3336
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       3226
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2285475"
     exon            3337..3427
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            3428..3817
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       3436
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201626"
     variation       3662
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2285477"
     exon            3818..3944
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            3945..4063
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       4026
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35230241"
     exon            4064..4260
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            4261..4444
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       4325
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34026068"
     exon            4445..4610
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            4611..4735
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            4736..5044
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       4819
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2285479"
     variation       4998
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34165480"
     exon            5045..5248
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            5249..5374
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     variation       5342
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34393601"
     exon            5375..5545
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            5546..5650
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            5651..5746
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            5747..5884
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     exon            5885..6038
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    6011..6016
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
     polyA_site      6038
                     /gene="MYH3"
                     /gene_synonym="HEMHC; MYHC-EMB; MYHSE1; SMHCE"
ORIGIN      
gtggctcgcttgtgggcggaggtctgggatctcctggctgttgctgtcttctgctctcatcctgcaggtgggactctcagctgacaccatgagtagtgacactgaaatggaagtgttcggcatagctgctcctttcctccggaagtcagaaaaggagaggatcgaggctcagaaccagccctttgatgccaagacgtattgcttcgtggtggactcaaaggaagaatatgccaaggggaaaatcaagagttctcaggatgggaaggtcactgtggaaactgaggacaacaggaccctggtggtcaaaccagaggatgtgtacgccatgaacccccccaagttcgacaggatcgaagacatggccatgctgacgcacctgaatgagccagccgtgctgtacaacctgaaggaccgttacacatcttggatgatctatacctactcaggcctcttctgtgtcactgtcaacccctacaagtggctgccggtgtacaaccccgaggtggtggaaggctaccgaggcaaaaagcgccaggaggccccaccccacatcttctccatctctgacaacgcctatcagttcatgctgactgatcgtgaaaaccagtccattctgatcaccggagaatccggggcaggaaagactgtgaacaccaaacgggtcatccagtactttgcaacaattgcagctactggggacctggccaagaagaaggactccaaaatgaaggggactctggaagatcaaatcatcagtgccaatcccctgctggaggcctttgggaacgccaagactgtgaggaatgacaactcctcccgttttggcaagttcatccgaatccattttggaaccactgggaagctggcctctgcagatattgaaacttatcttctggaaaaatcaagagtcactttccagctgaaggctgaaagaagctaccacatcttctaccagattctttctaacaagaagcctgagctcatagagctgctgcttattacgaccaacccttacgactacccgttcattagccagggggagatcctggtggccagcatagatgatgcagaggagctgctggctacagacagcgccattgacatcctgggcttcaccccagaagagaaatctgggctctacaagctgacgggagccgtgatgcactacgggaacatgaagttcaagcagaagcagcgagaggagcaggccgagccggatggcacagaagtggctgacaaaacagcctatctgatgggcctgaactcttcggacctcctaaaagctttgtgctttcctagagtgaaagttgggaatgagtacgttaccaaaggtcaaactgtggatcaggttcaccatgctgtgaatgctctttcaaaatcagtttatgaaaagttgttcttgtggatggtcactcgcattaaccagcaactggatacgaagcttccaagacaacacttcattggtgttttggacattgcaggctttgaaatctttgagtataacagcctggagcagctgtgcatcaacttcaccaatgagaaactgcaacagtttttcaaccaccacatgttcgtgctggagcaggaggagtacaagaaggaaggcatcgagtggacgttcattgacttcgggatggacctggctgcctgcatcgagctcatcgagaagcctatgggcatcttctccatcctggaagaggagtgcatgttccccaaggcaacagacacctccttcaagaacaagctgtatgaccagcatcttggaaagtccaacaacttccagaagcccaaggtggtcaaaggcagggccgaggctcacttctcactgatccactatgcgggcaccgtggactacagtgtctcaggttggctggagaagaacaaggaccctctgaacgagactgtggttgggctgtaccagaagtcttccaacaggctcctggcacacctctatgccacgtttgccacggcggatgctgacagtggaaagaagaaagttgccaagaagaagggttcttccttccaaactgtctctgcccttttcagggaaaacctgaacaagctgatgtcaaatttaagaactactcaccctcattttgtgcgttgtataattcccaatgaaaccaaaactccaggggctatggaacacagccttgttctgcaccagctgcggtgtaacggtgtcctggagggcatccgcatctgcaggaaagggttcccaaacaggattctctatggcgattttaaacaaagataccgagtgctgaatgccagtgcaatccctgagggacaattcattgacagcaagaaagcctgtgaaaagcttctggcatccattgatattgaccacactcagtacaaatttggacataccaaggtgttcttcaaggctggcttgctgggaaccctggaagagatgcgggatgaccgcctggccaaactaatcacccggacacaagctgtgtgcagagggttcctcatgcgtgtggaattccagaagatggtgcagaggagggagtccatcttctgcatccagtacaacattcgctcattcatgaacgtcaagcactggccctggatgaaactcttcttcaagatcaagcccctcctcaagagtgcagagactgagaaagagatggccaccatgaaggaagaattccagaaaaccaaagatgaactcgccaagtcggaggcaaaaaggaaggagctagaggaaaaactggtgactctggtccaagagaagaatgacctgcagctccaagtacaagctgaaagcgaaaatttgttggatgctgaggaaagatgcgatcagctgatcaaagccaaattccagctcgaggccaagatcaaggaggtgacagagagagctgaagatgaggaggagatcaatgctgagctgacggccaagaagaggaaactggaggatgaatgctcagagctcaagaaagacattgatgaccttgagttgaccctggccaaggttgagaaggagaagcatgccacagagaacaaggttaaaaaccttactgaggaactctctgggttagatgaaacaattgcaaagttaaccagagagaagaaggccctccaagaggcgcaccagcaggccttggatgacctccaagctgaagaagacaaagtcaattctttgaacaaaaccaagagcaaactggaacagcaagtggaagacctggaaagctccctagaacaagaaaagaagctccgagtagacctggaaaggaacaaaaggaaattggaaggagacttgaagcttgctcaagagtccatattagatctggagaatgacaagcaacagctggacgaaaggctcaagaagaaagattttgaatattgtcaacttcaaagcaaagtggaagatgagcagacactgggcctccagtttcagaagaaaatcaaagagttgcaggctcgaattgaggagctggaagaggagatagaggcggagagggccacccgcgcgaagacagagaaacagcgcagcgactatgcccgggagctggaggagctgagcgagcggctggaggaggcgggaggcgtcacctccacgcagatagagctcaacaagaagcgggaggcggagttcctgaagctgcgcagggacctggaggaggccacactgcagcacgaagccatggtggccgcgctgaggaagaagcatgcggatagtgtggccgagcttggggagcagattgacaacctgcagcgggtcaagcagaagctggagaaggagaagagcgagttcaagctggagatcgatgacctctccagcagcatggagagtgtgtcgaaatctaaggcaaatctggaaaaaatctgccgaaccctggaggatcagttaagtgaggccaggggcaagaatgaggaaattcagaggagcctgagcgagctgaccacacagaagtctcgtttgcagaccgaggctggtgagctgagtcgtcagctggaagaaaaagaaagcatagtatcccaactttccaggagcaagcaagcctttacccagcaaacagaagagctcaagaggcagctggaggaagagaacaaggccaagaacgccctggcgcacgccctgcagtcctcccgccacgactgtgacctgctgcgggaacagtatgaggaggagcaggaaggcaaagctgagctgcagagggcgctgtccaaggccaatagtgaggttgcccagtggagaaccaaatacgagacggacgccatccagcgcacagaagagctggaggaggccaagaaaaaacttgctcagcgccttcaagattccgaggaacaggttgaggcagtgaatgctaaatgtgcttcactggagaagaccaagcagaggctgcaaggagaggtggaggatctgatggttgatgttgaaagagccaattccttggccgccgctctggacaagaagcagaggaactttgacaaggtgttggcagagtggaagacaaagtgtgaggagagccaagcagagctggaggcatccctgaaggagtcccgctccttgagcactgagctcttcaaactgaaaaatgcctacgaggaagccttagatcaacttgaaactgtgaaacgggaaaataagaacttagagcaggagatagcagatctcacagaacaaattgctgaaaatggcaaaaccatccatgaactggagaaatcaagaaagcagattgagctggaaaaggctgatatccagctggctctcgaggaagcagaggctgctcttgagcatgaagaagccaagatcctccgaatccagcttgaattgacacaagtgaaatcagaaattgatagaaagatcgccgagaaggatgaagagatcgagcagctgaagaggaactaccagagaacagtggaaaccatgcagagcgccctggacgccgaggtgcggagcaggaatgaagccatccggctcaagaagaagatggagggggacctgaatgaaatcgagatccagctgagccacgccaaccgccaggcggcggagaccctcaaacacctcaggagtgtccagggacagctgaaggatacgcagctccacctggatgatgccctccggggccaggaggacctgaaggagcagctggcgattgtggagcgcagagccaacctgctgcaggccgaggtggaggagctgcgggctactctggagcagacggagagggcccggaaactggcggaacaggagctcctggactccaacgagagggtgcagctgctgcatacccagaacaccagcctcatccacaccaagaagaagctggagacagacctcatgcagctccagagtgaggtagaagatgccagcagggatgcaaggaacgctgaggagaaggccaagaaggccatcacggacgctgccatgatggcggaggagctgaagaaggagcaggacaccagcgcccaccttgagcggatgaagaagaacctggaacagacggtgaaggacctgcagcatcgtctagatgaggccgagcagctggcgctgaagggcgggaagaagcagatccagaaactggagaccaggatccgagagctggagtttgaacttgagggagagcagaagaagaacacagagtctgttaagggcctgaggaagtatgagcggagggtcaaggagctgacgtaccagagtgaagaggacaggaagaatgtgctgagattgcaggatctggtggataaactgcaagtgaaagtcaagtcctacaagaggcaggcggaggaggctgatgaacaagccaatgctcatctcaccaaattccgaaaggctcagcatgagctggaggaggccgaggaacgtgcggatatcgcagaatctcaagtcaacaagctccgcgctaagactcgagacttcacctccagcaggatggtggtccacgagagtgaagagtgagccagcccttctggagcaggacagaagatatgcaaaatgtatattttcttgattcctgaccattgatacttaatgtccatgtgactctttttcacatgcaataaactttgctttgtttcaatctgggaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4621 -> Molecular function: GO:0000146 [microfilament motor activity] evidence: NAS
            GeneID:4621 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
            GeneID:4621 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
            GeneID:4621 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:4621 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS
            GeneID:4621 -> Biological process: GO:0030048 [actin filament-based movement] evidence: NAS
            GeneID:4621 -> Biological process: GO:0030049 [muscle filament sliding] evidence: TAS
            GeneID:4621 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:4621 -> Cellular component: GO:0030016 [myofibril] evidence: IEA
            GeneID:4621 -> Cellular component: GO:0032982 [myosin filament] evidence: IEA

by @meso_cacase at DBCLS
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