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2019-03-25 14:41:54, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002445               2960 bp    mRNA    linear   PRI 05-MAY-2013
DEFINITION  Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript
            variant SR-AII, mRNA.
ACCESSION   NM_002445
VERSION     NM_002445.3  GI:109148505
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Hendrickx,D.A., Koning,N., Schuurman,K.G., van Strien,M.E., van
            Eden,C.G., Hamann,J. and Huitinga,I.
  TITLE     Selective upregulation of scavenger receptors in and around
            demyelinating areas in multiple sclerosis
  JOURNAL   J. Neuropathol. Exp. Neurol. 72 (2), 106-118 (2013)
   PUBMED   23334594
  REMARK    GeneRIF: The results of this study found that SR-AI/II was highly
            expressed on the surface of foamy macrophages in MS lesions.
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Ben,J., Jin,G., Zhang,Y., Ma,B., Bai,H., Chen,J., Zhang,H.,
            Gong,Q., Zhou,X., Zhang,H., Qian,L., Zhu,X., Li,X., Yang,Q., Hu,Z.,
            Xu,Y., Shen,H. and Chen,Q.
  TITLE     Class A scavenger receptor deficiency exacerbates lung
            tumorigenesis by cultivating a procarcinogenic microenvironment in
            humans and mice
  JOURNAL   Am. J. Respir. Crit. Care Med. 186 (8), 763-772 (2012)
   PUBMED   22878280
  REMARK    GeneRIF: We identified in a Chinese population a functional
            polymorphism in SR-A linked to lung cancer risk. In vivo and in
            vitro studies demonstrated that SR-A may negatively modulate lung
            cancer growth and angiogenesis by regulating MMP9 production.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Lin,C.S., Lin,F.Y., Ho,L.J., Tsai,C.S., Cheng,S.M., Wu,W.L.,
            Huang,C.Y., Lian,C.H., Yang,S.P. and Lai,J.H.
  TITLE     PKCdelta signalling regulates SR-A and CD36 expression and foam
            cell formation
  JOURNAL   Cardiovasc. Res. 95 (3), 346-355 (2012)
   PUBMED   22687273
  REMARK    GeneRIF: Through regulating PI3K/Akt and ERK activity, PKCdelta
            affects SR-A and CD36 expression and foam cell formation.
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Piechota,M., Banaszewska,A., Dudziak,J., Slomczynski,M. and
            Plewa,R.
  TITLE     Highly upregulated expression of CD36 and MSR1 in circulating
            monocytes of patients with acute coronary syndromes
  JOURNAL   Protein J. 31 (6), 511-518 (2012)
   PUBMED   22763563
  REMARK    GeneRIF: In patients with symptoms of acute coronary syndrome the
            amount of CD36 and MSR1 mRNA in circulating monocytes, as well as
            the density of both receptors on the cells surface was
            significantly higher.
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Jozefowski,S.
  TITLE     [The role of the class A scavenger receptors, SR-A and MARCO, in
            the immune system. Part 2. Contribution to recognition and
            phagocytosis of pathogens as well as induction of immune response]
  JOURNAL   Postepy Hig Med Dosw (Online) 66, 120-131 (2012)
   PUBMED   22470186
  REMARK    GeneRIF: This review demonstrated that class A SR and MARCO are
            major pattern recognition receptors mediating opsonin-independent
            phagocytosis.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Ashkenas,J., Penman,M., Vasile,E., Acton,S., Freeman,M. and
            Krieger,M.
  TITLE     Structures and high and low affinity ligand binding properties of
            murine type I and type II macrophage scavenger receptors
  JOURNAL   J. Lipid Res. 34 (6), 983-1000 (1993)
   PUBMED   8394868
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Asaoka,H., Matsumoto,A., Itakura,H. and Kodama,T.
  TITLE     [Structural and function of the human macrophage scavenger
            receptor]
  JOURNAL   Nippon Rinsho 51 (6), 1677-1683 (1993)
   PUBMED   8391600
  REMARK    Review article
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Emi,M., Asaoka,H., Matsumoto,A., Itakura,H., Kurihara,Y., Wada,Y.,
            Kanamori,H., Yazaki,Y., Takahashi,E., Lepert,M. et al.
  TITLE     Structure, organization, and chromosomal mapping of the human
            macrophage scavenger receptor gene
  JOURNAL   J. Biol. Chem. 268 (3), 2120-2125 (1993)
   PUBMED   8093617
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Naito,M., Suzuki,H., Mori,T., Matsumoto,A., Kodama,T. and
            Takahashi,K.
  TITLE     Coexpression of type I and type II human macrophage scavenger
            receptors in macrophages of various organs and foam cells in
            atherosclerotic lesions
  JOURNAL   Am. J. Pathol. 141 (3), 591-599 (1992)
   PUBMED   1519666
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Matsumoto,A., Naito,M., Itakura,H., Ikemoto,S., Asaoka,H.,
            Hayakawa,I., Kanamori,H., Aburatani,H., Takaku,F., Suzuki,H. et al.
  TITLE     Human macrophage scavenger receptors: primary structure,
            expression, and localization in atherosclerotic lesions
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (23), 9133-9137 (1990)
   PUBMED   2251254
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA995755.1, D90188.1 and
            AC023396.4.
            On Jun 15, 2006 this sequence version replaced gi:20357509.
            
            Summary: This gene encodes the class A macrophage scavenger
            receptors, which include three different types (1, 2, 3) generated
            by alternative splicing of this gene. These receptors or isoforms
            are macrophage-specific trimeric integral membrane glycoproteins
            and have been implicated in many macrophage-associated
            physiological and pathological processes including atherosclerosis,
            Alzheimer's disease, and host defense. The isoforms type 1 and type
            2 are functional receptors and are able to mediate the endocytosis
            of modified low density lipoproteins (LDLs). The isoform type 3
            does not internalize modified LDL (acetyl-LDL) despite having the
            domain shown to mediate this function in the types 1 and 2
            isoforms. It has an altered intracellular processing and is trapped
            within the endoplasmic reticulum, making it unable to perform
            endocytosis. The isoform type 3 can inhibit the function of
            isoforms type 1 and type 2 when co-expressed, indicating a dominant
            negative effect and suggesting a mechanism for regulation of
            scavenger receptor activity in macrophages. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (SR-AII), also known as phSR2,
            uses two alternative exons and also lacks two downstream exons
            compared to variant SR-AI. These differences causes an alternate 3'
            end in the coding region, and has a distinct 3' UTR. It encodes
            isoform type 2 that is shorter and has a different C-terminus than
            isoform type 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90188.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               DA995755.1         2-133
            133-1352            D90188.1           1-1220
            1353-2960           AC023396.4         62754-64361
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..2960
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /note="macrophage scavenger receptor 1"
                     /db_xref="GeneID:4481"
                     /db_xref="HGNC:7376"
                     /db_xref="HPRD:01092"
                     /db_xref="MIM:153622"
     exon            1..194
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       28
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:72563174"
     variation       45
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:381178"
     variation       61
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:433235"
     variation       121
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41423547"
     variation       166
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306541"
     misc_feature    184..186
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /note="upstream in-frame stop codon"
     exon            195..301
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     CDS             199..1275
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /note="isoform type 2 is encoded by transcript variant
                     SR-AII; scavenger receptor class A, member 1; macrophage
                     scavenger receptor type III; macrophage acetylated LDL
                     receptor I and II; macrophage scavenger receptor types I
                     and II; scavenger receptor class A member 1"
                     /codon_start=1
                     /product="macrophage scavenger receptor types I and II
                     isoform type 2"
                     /protein_id="NP_002436.1"
                     /db_xref="GI:4505259"
                     /db_xref="CCDS:CCDS5997.1"
                     /db_xref="GeneID:4481"
                     /db_xref="HGNC:7376"
                     /db_xref="HPRD:01092"
                     /db_xref="MIM:153622"
                     /translation="
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLRPVQLTDHIRAGPS
"
     misc_feature    349..426
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21757.1);
                     transmembrane region"
     misc_feature    427..525
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21757.1);
                     Region: Spacer (Probable)"
     misc_feature    559..705
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /note="Macrophage scavenger receptor; Region: Macscav_rec;
                     pfam03523"
                     /db_xref="CDD:112346"
     misc_feature    1012..1200
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /note="Collagen triple helix repeat (20 copies); Region:
                     Collagen; pfam01391"
                     /db_xref="CDD:189968"
     variation       239
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372589091"
     variation       266
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35175081"
     exon            302..415
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       333
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35778274"
     variation       369
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35874867"
     exon            416..828
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       511
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306549"
     STS             622..723
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /standard_name="GDB:580807"
                     /db_xref="UniSTS:157850"
     variation       643
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72552388"
     exon            829..1015
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     STS             841..983
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /standard_name="PMC310830P19"
                     /db_xref="UniSTS:272764"
     variation       867
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35425627"
     variation       1004
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306543"
     exon            1016..1096
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       1021
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2229388"
     variation       1032
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34797070"
     variation       1079
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41440349"
     exon            1097..1177
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     exon            1178..1231
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       1212
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306540"
     exon            1232..2960
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /inference="alignment:Splign:1.39.8"
     variation       1900
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41488144"
     variation       2048
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2127568"
     variation       2116
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2170120"
     variation       2481..2496
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace=""
                     /replace="atatatatatatatatat"
                     /db_xref="dbSNP:71212606"
     variation       2607
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306552"
     variation       2678
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41488549"
     variation       2840
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1480143"
     polyA_site      2960
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
ORIGIN      
aaatttagattttgcaaacctgtgcattgatgagagtgctattgaaacacattaagaaagattttcaacgcaggaatgtgtcatttcctttcttcatgtaccagatgctgaaatactatgagataaagattttaggtttcaattgtaaagagagagaagtggataaatcagtgctgctttctttaggacgaaagaagtatggagcagtgggatcactttcacaatcaacaggaggacactgatagctgctccgaatctgtgaaatttgatgctcgctcaatgacagctttgcttcctccgaatcctaaaaacagcccttcccttcaagagaaactgaagtccttcaaagctgcactgattgccctttacctcctcgtgtttgcagttctcatccctctcattggaatagtggcagctcaactcctgaagtgggaaacgaagaattgctcagttagttcaactaatgcaaatgatataactcaaagtctcacgggaaaaggaaatgacagcgaagaggaaatgagatttcaagaagtctttatggaacacatgagcaacatggagaagagaatccagcatattttagacatggaagccaacctcatggacacagagcatttccaaaatttcagcatgacaactgatcaaagatttaatgacattcttctgcagctaagtaccttgttttcctcagtccagggacatgggaatgcaatagatgaaatctccaagtccttaataagtttgaataccacattgcttgatttgcagctcaacatagaaaatctgaatggcaaaatccaagagaataccttcaaacaacaagaggaaatcagtaaattagaggagcgtgtttacaatgtatcagcagaaattatggctatgaaagaagaacaagtgcatttggaacaggaaataaaaggagaagtgaaagtactgaataacatcactaatgatctcagactgaaagattgggaacattctcagaccttgagaaatatcactttaattcaaggtcctcctggacccccgggtgaaaaaggagatcgaggtcccactggagaaagtggtccacgaggatttccaggtccaataggtcctccgggtcttaaaggtgatcggggagcaattggctttcctggaagtcgaggactcccaggatatgccggaaggccaggaaattctggaccaaaaggccagaaaggggaaaaggggagtggaaacacattaagaccagtacaactcactgatcatattagggcagggccctcttaagatcaggtgggttgggcgggacatcctctgctaccatctcattaaaaggcccttcacctctggacaagtcatctgcacaactgacttccaagatccttttgtgactcctccaaatgactttggttcccgtgttgtacctgacttccacatggccttctctcctggtccctggtgctgtttgggcctctgctcccatgctcatacctcttcttactccaattactccaccatcacctctctcccctatcacccccagcctggacacctctcatgcacggactggagggctgctccaaccagtcctcagttctctgccacccattgacctagagtcttgaacccaatttaatttattgggttctaggagaactgctgtgttctcaccctaacttggaagagtgatgtttcagtcaagcaaagcgattcctaccatacaatataacacttgtgtgaggctctgtcctaaatatctcaattaccaatatgtggtttggtagtatttctcgccatgctttgctcatgcgcaatgagactacaactagggtgtaaattttaagtatcccatctaaaactcatacaatgataggaaaaatccatttgtttttcatttgatttttactgaggaatcagctcaatcttcaatgaatactggtctctttccaaagcatttttgatcaaagtaaagactgagtcaagggctttttttttttctttttcttgttttaagagacagagccttgttctattgcacaggctggactacacgcattcacctagagtctagaacacaatttaatttattgggttctaggagaactgtcatgagtattgataatatgagagttctttatattcaaacattattctcaaccagagatagggatgtcatagaagaaaatccattcattcaatcattaattcacatgtccattatgtacctccatgagctggacataacagctaataagagataattgtctctggttttacagagctaattgtccctaagagatgtagacaaatgaacaagcaattacaatacatctaagctatactgggggaggaacagggctggataggtatgcagaggagataaaaaaattttaattccttagaatattttttaaaaattgattcttattttaccttctcatcttcttattttccaaattacagcatatatatatatatatatatatatatatatatatatatatatatatatattttttttttttttttttttttttttttaagttttgaagtgtagtcgagcttgggcaatttatccaacccatttaaaccaaaaataaaacttttcatgtattacctggtcatttcaaacaaaaatattttgatcatgaaaaagaataccaatattcttttgttctaaaaatctcttatgggattacatgttatatttttggtttctctctactgatcaacagactacattttcacaactcttctttcctttacgttttaacacacagacccaagattcatactattaagattctagtagaactctagatggtatgcctctgtgtatctcagcatttttattcccactcttgtataatgaacatgttaacacctacctcacagggttgttgtgaggatcaagtaagatattgtgtgtgtgaagatgctctgtgaaatcataaagtcctttaaagatgtaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4481 -> Molecular function: GO:0005044 [scavenger receptor activity] evidence: IEA
            GeneID:4481 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4481 -> Molecular function: GO:0030169 [low-density lipoprotein particle binding] evidence: ISS
            GeneID:4481 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: TAS
            GeneID:4481 -> Biological process: GO:0010744 [positive regulation of macrophage derived foam cell differentiation] evidence: ISS
            GeneID:4481 -> Biological process: GO:0010886 [positive regulation of cholesterol storage] evidence: ISS
            GeneID:4481 -> Biological process: GO:0030301 [cholesterol transport] evidence: ISS
            GeneID:4481 -> Biological process: GO:0034381 [plasma lipoprotein particle clearance] evidence: ISS
            GeneID:4481 -> Biological process: GO:0042221 [response to chemical stimulus] evidence: IEA
            GeneID:4481 -> Biological process: GO:0042953 [lipoprotein transport] evidence: IEA
            GeneID:4481 -> Cellular component: GO:0005581 [collagen] evidence: IEA
            GeneID:4481 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:4481 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:4481 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:4481 -> Cellular component: GO:0030666 [endocytic vesicle membrane] evidence: TAS
            GeneID:4481 -> Cellular component: GO:0034362 [low-density lipoprotein particle] evidence: IEA

by @meso_cacase at DBCLS
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