2024-03-28 20:49:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002397 6449 bp mRNA linear PRI 05-JUL-2013 DEFINITION Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant 1, mRNA. ACCESSION NM_002397 VERSION NM_002397.4 GI:301069377 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6449) AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M., Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T., Johnson,J.A. and Boerwinkle,E. TITLE Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans JOURNAL Pharmacogenomics J. (2013) In press PUBMED 23400010 REMARK Publication Status: Available-Online prior to print REFERENCE 2 (bases 1 to 6449) AUTHORS Mendez-Vigo,B., Martinez-Zapater,J.M. and Alonso-Blanco,C. TITLE The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic background JOURNAL PLoS Genet. 9 (1), E1003289 (2013) PUBMED 23382706 REFERENCE 3 (bases 1 to 6449) AUTHORS Le Meur,N., Holder-Espinasse,M., Jaillard,S., Goldenberg,A., Joriot,S., Amati-Bonneau,P., Guichet,A., Barth,M., Charollais,A., Journel,H., Auvin,S., Boucher,C., Kerckaert,J.P., David,V., Manouvrier-Hanu,S., Saugier-Veber,P., Frebourg,T., Dubourg,C., Andrieux,J. and Bonneau,D. TITLE MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations JOURNAL J. Med. Genet. 47 (1), 22-29 (2010) PUBMED 19592390 REMARK GeneRIF: These results strongly suggest that haploinsufficiency of MEF2C is responsible for severe mental retardation with stereotypic movements, seizures and/or cerebral malformations. REFERENCE 4 (bases 1 to 6449) AUTHORS Zhu,B., Ramachandran,B. and Gulick,T. TITLE Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain JOURNAL J. Biol. Chem. 280 (31), 28749-28760 (2005) PUBMED 15834131 REMARK GeneRIF: A conserved pattern of alternative splicing in vertebrate MEF2 (myocyte enhancer factor 2) genes generates an acidic activation domain in MEF2 proteins selectively in tissues where MEF2 target genes are highly expressed. (MEF2) REFERENCE 5 (bases 1 to 6449) AUTHORS Zhu,B. and Gulick,T. TITLE Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity JOURNAL Mol. Cell. Biol. 24 (18), 8264-8275 (2004) PUBMED 15340086 REFERENCE 6 (bases 1 to 6449) AUTHORS Molkentin,J.D., Li,L. and Olson,E.N. TITLE Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity JOURNAL J. Biol. Chem. 271 (29), 17199-17204 (1996) PUBMED 8663403 REFERENCE 7 (bases 1 to 6449) AUTHORS Krainc,D., Haas,M., Ward,D.C., Lipton,S.A., Bruns,G. and Leifer,D. TITLE Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved JOURNAL Genomics 29 (3), 809-811 (1995) PUBMED 8575784 REFERENCE 8 (bases 1 to 6449) AUTHORS Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L. TITLE Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23 JOURNAL Genomics 29 (3), 704-711 (1995) PUBMED 8575763 REFERENCE 9 (bases 1 to 6449) AUTHORS McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D., Krainc,D., Lipton,S.A. and Nadal-Ginard,B. TITLE hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors JOURNAL Mol. Cell. Biol. 13 (4), 2564-2577 (1993) PUBMED 8455629 REFERENCE 10 (bases 1 to 6449) AUTHORS Leifer,D., Krainc,D., Yu,Y.T., McDermott,J., Breitbart,R.E., Heng,J., Neve,R.L., Kosofsky,B., Nadal-Ginard,B. and Lipton,S.A. TITLE MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (4), 1546-1550 (1993) PUBMED 7679508 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC377336.1, DC377710.1, L08895.1, AL833268.1 and AC008525.7. On Jul 22, 2010 this sequence version replaced gi:196114943. Summary: This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]. Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 6 encode isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L08895.1, AK312472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-8 DC377336.1 1-8 9-259 DC377710.1 1-251 260-3891 L08895.1 7-3638 3892-3892 AL833268.1 3643-3643 3893-4331 L08895.1 3639-4077 4332-4743 AC008525.7 41254-41665 c 4744-6375 AC008525.7 39622-41253 c 6376-6449 AL833268.1 6128-6201 FEATURES Location/Qualifiers source 1..6449 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5q14.3" gene 1..6449 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="myocyte enhancer factor 2C" /db_xref="GeneID:4208" /db_xref="HGNC:6996" /db_xref="HPRD:02809" /db_xref="MIM:600662" exon 1..512 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" exon 513..708 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 517..782 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="Mef2c" /db_xref="UniSTS:143852" misc_feature 556..558 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="upstream in-frame stop codon" CDS 655..2076 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="isoform 1 is encoded by transcript variant 1; myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C" /codon_start=1 /product="myocyte-specific enhancer factor 2C isoform 1" /protein_id="NP_002388.2" /db_xref="GI:19923215" /db_xref="CCDS:CCDS47245.1" /db_xref="GeneID:4208" /db_xref="HGNC:6996" /db_xref="HPRD:02809" /db_xref="MIM:600662" /translation="
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
" misc_feature 658..888 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; Region: MADS_MEF2_like; cd00265" /db_xref="CDD:238165" misc_feature order(658..666,670..672,676..678,691..693,697..699, 709..714,721..726,730..735,742..747,751..756,766..768) /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238165" misc_feature 664..666 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature order(715..717,736..741,748..753,757..762,769..771, 784..786,790..792,796..798,814..816,820..822,838..840, 847..852,859..861,868..873) /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:238165" misc_feature 829..831 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="putative phosphorylation site [posttranslational modification]; other site" /db_xref="CDD:238165" misc_feature 829..831 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[6] /db_xref="HPRD:00277" misc_feature 937..1122 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /note="Holliday junction regulator protein family C-terminal repeat; Region: HJURP_C; pfam12347" /db_xref="CDD:152782" misc_feature 1000..1002 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1009..1011 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1354..1356 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1369..1371 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1408..1410 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1444..1446 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q06413.1); acetylation site" misc_feature 1465..1488 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q06413.1); Region: Beta domain" misc_feature 1531..1533 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by MAPK14; propagated from UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site" misc_feature 1531..1533 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02619" misc_feature 1552..1554 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by MAPK14; propagated from UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site" misc_feature 1552..1554 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02619" misc_feature 1756..1851 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q06413.1); Region: Transcription repressor" misc_feature 1813..1815 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02619" misc_feature 1813..1815 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03952" misc_feature 1840..1842 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by CDK5; propagated from UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site" misc_feature 1840..1842 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00302" misc_feature 1840..1842 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00454" misc_feature 1909..1911 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by MAPK7; propagated from UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site" misc_feature 1948..1953 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="non-experimental evidence, no additional details recorded" /note="Cleavage (Probable); propagated from UniProtKB/Swiss-Prot (Q06413.1); cleavage site" exon 709..912 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 857..1245 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="Mef2c" /db_xref="UniSTS:265602" exon 913..1056 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 928..993 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="Mef2c" /db_xref="UniSTS:498478" exon 1057..1243 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 1070..1238 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="MEF2C" /db_xref="UniSTS:504947" exon 1244..1291 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" exon 1292..1464 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 1441..1622 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="Mef2c" /db_xref="UniSTS:496803" exon 1465..1488 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" exon 1489..1618 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" exon 1619..1754 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 1725..2026 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="Mef2c" /db_xref="UniSTS:265603" exon 1755..6439 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /inference="alignment:Splign:1.39.8" STS 2595..2822 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="G10647" /db_xref="UniSTS:17885" STS 3060..3952 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="MEF2C_2028" /db_xref="UniSTS:280844" STS 3701..3801 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="SGC30054" /db_xref="UniSTS:69948" STS 4193..4317 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="SGC30495" /db_xref="UniSTS:62611" variation 4331 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /replace="a" /replace="t" /db_xref="dbSNP:201910863" variation 4634 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /replace="g" /replace="t" /db_xref="dbSNP:1050585" STS 6325..6387 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" /standard_name="STS-Z40067" /db_xref="UniSTS:33841" polyA_site 6439 /gene="MEF2C" /gene_synonym="C5DELq14.3; DEL5q14.3" ORIGIN
gagctgttctccttttcccattcgtcttctgtcacttccttcctggacgcagttttctggacgagtctggttacttttaatccgaccggccgctgagagccactttctcctcctcctcctcctcctccttctcttcctcctccttcttcctcctcctcctcctcttccgagcggcctcggcgcgcgcgaatgcgcggccccgcgccccccccctcgcgcgcgctcccctcgcgcgcgcgcacacacgcacacatcgtctccagctctctgctcgctctgctcgcagtcacagacacttgagcacacgcgtacacccagacatcttcgggctgctattggattgactttgaaggttctgtgtgggtcgccgtggctgcatgtttgaatcaggtggagaagcacttcaacgctggacgaagtaaagattattgttgttattttttttttctctctctctctctcttaagaaaggaaaatatcccaaggactaatctgatcgggtcttccttcatcaggaacgaatgcaggaatttgggaactgagctgtgcaagtgctgaagaaggagatttgtttggaggaaacaggaaagagaaagaaaaggaaggaaaaaatacataatttcagggacgagagagagaagaaaaacggggactatggggagaaaaaagattcagattacgaggattatggatgaacgtaacagacaggtgacatttacaaagaggaaatttgggttgatgaagaaggcttatgagctgagcgtgctgtgtgactgtgagattgcgctgatcatcttcaacagcaccaacaagctgttccagtatgccagcaccgacatggacaaagtgcttctcaagtacacggagtacaacgagccgcatgagagccggacaaactcagacatcgtggagacgttgagaaagaagggccttaatggctgtgacagcccagaccccgatgcggacgattccgtaggtcacagccctgagtctgaggacaagtacaggaaaattaacgaagatattgatctaatgatcagcaggcaaagattgtgtgctgttccacctcccaacttcgagatgccagtctccatcccagtgtccagccacaacagtttggtgtacagcaaccctgtcagctcactgggaaaccccaacctattgccactggctcacccttctctgcagaggaatagtatgtctcctggtgtaacacatcgacctccaagtgcaggtaacacaggtggtctgatgggtggagacctcacgtctggtgcaggcaccagtgcagggaacgggtatggcaatccccgaaactcaccaggtctgctggtctcacctggtaacttgaacaagaatatgcaagcaaaatctcctcccccaatgaatttaggaatgaataaccgtaaaccagatctccgagttcttattccaccaggcagcaagaatacgatgccatcagtgtctgaggatgtcgacctgcttttgaatcaaaggataaataactcccagtcggctcagtcattggctaccccagtggtttccgtagcaactcctactttaccaggacaaggaatgggaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcagacctgtcatctctgtctgggtttaacaccgccagcgctcttcaccttggttcagtaactggctggcaacagcaacacctacataacatgccaccatctgccctcagtcagttgggagcttgcactagcactcatttatctcagagttcaaatctctccctgccttctactcaaagcctcaacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatacccacaacacacgcgccacgaggcggggagatctcctgttgacagcttgagcagctgtagcagttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattggactcaccagaccttcgccggacgaaagggaaagtccctcagtcaagcgcatgcgactttctgaaggatgggcaacatgatcagattattacttactagtttttttttttttcttgcagtgtgtgtgtgtgctataccttaatggggaaggggggtcgatatgcattatatgtgccgtgtgtggaaaaaaaaaaagtcaggtactctgttttgtaaaagtacttttaaattgcctcagtgatacagtataaagataaacagaaatgctgagataagcttagcacttgagttgtacaacagaacacttgtacaaaatagattttaaggctaacttcttttcactgttgtgctcctttgcaaaatgtatgttacaatagatagtgtcatgttgcaggttcaacgttatttacatgtaaatagacaaaaggaaacatttgccaaaagcggcagatctttactgaaagagagagcagctgttatgcaacatatagaaaaatgtatagatgcttggacagacccggtaatgggtggccattggtaaatgttaggaacacaccaggtcacctgacatcccaagaatgctcacaaacctgcaggcatatcattggcgtatggcactcattaaaaaggatcagagaccattaaaagaggaccatacctattaaaaaaaaatgtggagttggagggctaacatatttaattaaataaataaataaatctgggtctgcatctcttattaaataaaaatataaaaatatgtacattacattttgcttattttcatataaaaggtaagacagagtttgcaaagcatttgtggctttttgtagtttacttaagccaaaatgtgtttttttccccttgatagcttcgctaatattttaaacagtcctgtaaaaaaccaaaaaggactttttgtatagaaagcactaccctaagccatgaagaactccatgctttgctaaccaagataactgttttctctttgtagaagttttgtttttgaaatgtgtatttctaattatataaaatattaagaatcttttaaaaaaatctgtgaaattaacatgcttgtgtatagctttctaatatatataatattatggtaatagcagaagttttgttatcttaatagcgggaggggggtatatttgtgcagttgcacatttgagtaactattttctttctgttttcttttactctgcttacattttataagtttaaggtcagctgtcaaaaggataacctgtggggttagaacatatcacattgcaacaccctaaattgtttttaatacattagcaatctattgggtcaactgacatccattgtatatactagtttctttcatgctatttttattttgttttttgcatttttatcaaatgcagggcccctttctgatctcaccatttcaccatgcatcttggaattcagtaagtgcatatcctaacttgcccatattctaaatcatctggttggttttcagcctagaatttgatacgctttttagaaatatgcccagaatagaaaagctatgttggggcacatgtcctgcaaatatggccctagaaacaagtgatatggaatttacttggtgaataagttataaattcccacagaagaaaaatgtgaaagactgggtgctagacaagaaggaagcaggtaaagggatagttgctttgtcatccgtttttaattattttaactgacccttgacaatcttgtcagcaatataggactgttgaacaatcccggtgtgtcaggacccccaaatgtcacttctgcataaagcatgtatgtcatctattttttcttcaataaagagatttaatagccatttcaagaaatcccataaagaacctctctatgtccctttttttaatttaaaaaaaatgactcttgtctaatattcgtctataagggattaattttcagaccctttaataagtgagtgccataagaaagtcaatatatattgtttaaaagatatttcagtctaggaaagattttccttctcttggaatgtgaagatctgtcgattcatctccaatcatatgcattgacatacacagcaaagaagatataggcagtaatatcaacactgctatatcatgtgtaggacatttcttatccattttttctcttttacttgcatagttgctatgtgtttctcattgtaaaaggctgccgctgggtggcagaagccaagagaccttattaactaggctatatttttcttaacttgatctgaaatccacaattagaccacaatgcacctttggttgtatccataaaggatgctagcctgccttgtactaatgttttatatattaaaaaaaaaaaatctatcaaccatttcatatatatcccactactcaaggtatccatggaacatgaaagaataacatttatgcagaggaaaaacaaaaacatccctgaaaatatacacactcatacacacacacgcacaggggaataaaataagaaaatcattttcctcaccatagacttgatcccatccttacaacccatccttctaacttgatgtgtataaaatatgcaaacatttcacaaatgttctttgtcatttcaaaatactttagtatatcaatatcagtagataccagtgggtgggaaagggtcattacatgaaaatatgaagaaatagccatattagttttttaacctgcaatttgcctcagcaacaaagaaaaagtgaatttttaatgctgaagataaagtaagctaaagtaccagcagaagccttggctatttatagcagttctgacaatagttttataagaacatgaagagaacagaatcacttgaaaatggatgccagtcatctcttgttcccactactgaattcttataaagtggtggcaagatagggaagggataatctgagaatttttaaaagatgatttaatgagaagaagcacaattttgattttgatgagtcactttctgtaaacaatcttggtctatctttacccttataccttatctgtaatttaccatttattgtatttgcaaagctagtatggtttttaatcacagtaaatcctttgtattccagactttagggcagagccctgagggagtattattttacataacccgtcctagagtaacattttaggcaacattcttcattgcaagtaaaagatccataagtggcattttacacggctgcgagtattgttatatctaatcctattttaaaagatttttggtaatatgaagcttgaatactggtaacagtgatgcaatatacgcaagctgcacaacctgtatattgtatgcattgctgcgtggaggctgtttatttcaacctttttaaaaattgtgttttttagtaaaatggcttattttttcccaaaggtggaatttagcattttgtaatgatgaatataaaaatacctgtcatccccagatcatttaaaagttaactaaagtgagaatgaaaaaacaaaattccaagacactttttaaaagaatgtctgccctcacacacttttatggatttgtttttcttacatacccatcttttaacttagagatagcattttttgccctctttattttgttgtttgtttctccagagagtaaacgctttgtagttctttctttaaaaaacattttttttaaagaagaagaagccacttgaaccctcaataaaggctgttgcctaagcatggcatacttcatctgttctcatttgtgccatctgccgtgatgtcgtcacttttatggcgttaatttcctgccactacagatcttttgaagattgctggaatactggtgtctgttagaatgcttcagactacagatgtaattaaaggcttttcttaatatgttttaaccaaagatgtggagcaatccaagccacatatcttctacatcaaatttttccattttggttattttcataatctggtattgcattttgccttccctgttcatacctcaaattgattcatacctcagtttaattcagagaggtcagttaagtgacggattctgttgtggtttgaatgcagtaccagtgttctcttcgagcaaagtagacctgggtcactgtaggcataggacttggattgcttcagatggtttgctgtatcatttttcttctttttcttttcctggggacttgtttccattaaatgagagtaattaaaatcgcttgtaaatgagggcatacaagcatttgcaacaaatattcaaatagaggctcacagcggcataagctggactttgtcgccactagatgacaagatgttataactaagttaaaccacatctgtgtatctcaagggacttaattcagctgtctgtagtgaataaaagtgggaaattttcaaaagtttctcctgctggaaataaggtataatttgtattttgcagacaattcagtaaagttactggctttcttagtgaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4208 -> Molecular function: GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] evidence: IDA GeneID:4208 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: ISS GeneID:4208 -> Molecular function: GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity] evidence: IDA GeneID:4208 -> Molecular function: GO:0000987 [core promoter proximal region sequence-specific DNA binding] evidence: IEA GeneID:4208 -> Molecular function: GO:0001046 [core promoter sequence-specific DNA binding] evidence: IEA GeneID:4208 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA GeneID:4208 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA GeneID:4208 -> Molecular function: GO:0003680 [AT DNA binding] evidence: IDA GeneID:4208 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA GeneID:4208 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA GeneID:4208 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:4208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4208 -> Molecular function: GO:0033613 [activating transcription factor binding] evidence: IPI GeneID:4208 -> Molecular function: GO:0035198 [miRNA binding] evidence: IDA GeneID:4208 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IEA GeneID:4208 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: ISS GeneID:4208 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI GeneID:4208 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA GeneID:4208 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IDA GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IMP GeneID:4208 -> Biological process: GO:0001568 [blood vessel development] evidence: ISS GeneID:4208 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0001782 [B cell homeostasis] evidence: ISS GeneID:4208 -> Biological process: GO:0001947 [heart looping] evidence: ISS GeneID:4208 -> Biological process: GO:0001958 [endochondral ossification] evidence: ISS GeneID:4208 -> Biological process: GO:0001974 [blood vessel remodeling] evidence: ISS GeneID:4208 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0002467 [germinal center formation] evidence: ISS GeneID:4208 -> Biological process: GO:0002634 [regulation of germinal center formation] evidence: ISS GeneID:4208 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0003138 [primary heart field specification] evidence: ISS GeneID:4208 -> Biological process: GO:0003139 [secondary heart field specification] evidence: ISS GeneID:4208 -> Biological process: GO:0003151 [outflow tract morphogenesis] evidence: ISS GeneID:4208 -> Biological process: GO:0003185 [sinoatrial valve morphogenesis] evidence: ISS GeneID:4208 -> Biological process: GO:0003211 [cardiac ventricle formation] evidence: ISS GeneID:4208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:4208 -> Biological process: GO:0006959 [humoral immune response] evidence: ISS GeneID:4208 -> Biological process: GO:0007399 [nervous system development] evidence: TAS GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: IEP GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: ISS GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: NAS GeneID:4208 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS GeneID:4208 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: ISS GeneID:4208 -> Biological process: GO:0007521 [muscle cell fate determination] evidence: ISS GeneID:4208 -> Biological process: GO:0007611 [learning or memory] evidence: ISS GeneID:4208 -> Biological process: GO:0009615 [response to virus] evidence: IEP GeneID:4208 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IDA GeneID:4208 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: ISS GeneID:4208 -> Biological process: GO:0010694 [positive regulation of alkaline phosphatase activity] evidence: ISS GeneID:4208 -> Biological process: GO:0014033 [neural crest cell differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0014898 [cardiac muscle hypertrophy in response to stress] evidence: IEA GeneID:4208 -> Biological process: GO:0014902 [myotube differentiation] evidence: IEP GeneID:4208 -> Biological process: GO:0021542 [dentate gyrus development] evidence: IEA GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: IEP GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0030220 [platelet formation] evidence: ISS GeneID:4208 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEA GeneID:4208 -> Biological process: GO:0030279 [negative regulation of ossification] evidence: IDA GeneID:4208 -> Biological process: GO:0030318 [melanocyte differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0030501 [positive regulation of bone mineralization] evidence: ISS GeneID:4208 -> Biological process: GO:0030890 [positive regulation of B cell proliferation] evidence: ISS GeneID:4208 -> Biological process: GO:0033197 [response to vitamin E] evidence: IEA GeneID:4208 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS GeneID:4208 -> Biological process: GO:0035984 [cellular response to trichostatin A] evidence: ISS GeneID:4208 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0042100 [B cell proliferation] evidence: ISS GeneID:4208 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS GeneID:4208 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: ISS GeneID:4208 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:4208 -> Biological process: GO:0045652 [regulation of megakaryocyte differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0045663 [positive regulation of myoblast differentiation] evidence: IMP GeneID:4208 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0045669 [positive regulation of osteoblast differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP GeneID:4208 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:4208 -> Biological process: GO:0048643 [positive regulation of skeletal muscle tissue development] evidence: IMP GeneID:4208 -> Biological process: GO:0048666 [neuron development] evidence: ISS GeneID:4208 -> Biological process: GO:0048703 [embryonic viscerocranium morphogenesis] evidence: IEA GeneID:4208 -> Biological process: GO:0050680 [negative regulation of epithelial cell proliferation] evidence: IEA GeneID:4208 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS GeneID:4208 -> Biological process: GO:0051145 [smooth muscle cell differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS GeneID:4208 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS GeneID:4208 -> Biological process: GO:0055012 [ventricular cardiac muscle cell differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0060021 [palate development] evidence: IEA GeneID:4208 -> Biological process: GO:0060025 [regulation of synaptic activity] evidence: ISS GeneID:4208 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: ISS GeneID:4208 -> Biological process: GO:0060297 [regulation of sarcomere organization] evidence: IEA GeneID:4208 -> Biological process: GO:0060536 [cartilage morphogenesis] evidence: IEA GeneID:4208 -> Biological process: GO:0061333 [renal tubule morphogenesis] evidence: ISS GeneID:4208 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS GeneID:4208 -> Biological process: GO:0071277 [cellular response to calcium ion] evidence: ISS GeneID:4208 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IEA GeneID:4208 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA GeneID:4208 -> Biological process: GO:0071374 [cellular response to parathyroid hormone stimulus] evidence: IDA GeneID:4208 -> Biological process: GO:0071498 [cellular response to fluid shear stress] evidence: ISS GeneID:4208 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IDA GeneID:4208 -> Biological process: GO:0071864 [positive regulation of cell proliferation in bone marrow] evidence: IEA GeneID:4208 -> Biological process: GO:0072102 [glomerulus morphogenesis] evidence: ISS GeneID:4208 -> Biological process: GO:0072160 [nephron tubule epithelial cell differentiation] evidence: ISS GeneID:4208 -> Biological process: GO:0090073 [positive regulation of protein homodimerization activity] evidence: ISS GeneID:4208 -> Biological process: GO:2000111 [positive regulation of macrophage apoptotic process] evidence: ISS GeneID:4208 -> Biological process: GO:2000727 [positive regulation of cardiac muscle cell differentiation] evidence: IDA GeneID:4208 -> Biological process: GO:2000987 [positive regulation of behavioral fear response] evidence: ISS GeneID:4208 -> Biological process: GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis] evidence: ISS GeneID:4208 -> Biological process: GO:2001016 [positive regulation of skeletal muscle cell differentiation] evidence: IDA GeneID:4208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:4208 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:4208 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:4208 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:4208 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA GeneID:4208 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA GeneID:4208 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
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@meso_cacase at
DBCLS
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