Home |
Help |
Advanced search
2024-04-24 17:08:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002344 3143 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens leukocyte receptor tyrosine kinase (LTK), transcript
variant 1, mRNA.
ACCESSION NM_002344
VERSION NM_002344.5 GI:208879421
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3143)
AUTHORS Roll,J.D. and Reuther,G.W.
TITLE ALK-activating homologous mutations in LTK induce cellular
transformation
JOURNAL PLoS ONE 7 (2), E31733 (2012)
PUBMED 22347506
REMARK GeneRIF: aberrant activation of LTK may contribute to neoplastic
cell growth.
REFERENCE 2 (bases 1 to 3143)
AUTHORS Yamada,S., Uchimura,E., Ueda,T., Nomura,T., Fujita,S.,
Matsumoto,K., Funeriu,D.P., Miyake,M. and Miyake,J.
TITLE Identification of twinfilin-2 as a factor involved in neurite
outgrowth by RNAi-based screen
JOURNAL Biochem. Biophys. Res. Commun. 363 (4), 926-930 (2007)
PUBMED 17910947
REFERENCE 3 (bases 1 to 3143)
AUTHORS Li,N., Nakamura,K., Jiang,Y., Tsurui,H., Matsuoka,S., Abe,M.,
Ohtsuji,M., Nishimura,H., Kato,K., Kawai,T., Atsumi,T., Koike,T.,
Shirai,T., Ueno,H. and Hirose,S.
TITLE Gain-of-function polymorphism in mouse and human Ltk: implications
for the pathogenesis of systemic lupus erythematosus
JOURNAL Hum. Mol. Genet. 13 (2), 171-179 (2004)
PUBMED 14695357
REMARK GeneRIF: polymorphic LTKs cause up-regulation of the PI3K pathway
and possibly form one genetic component of susceptibility to
abnormal proliferation of self-reactive B cells in systemic lupus
erythematosus
REFERENCE 4 (bases 1 to 3143)
AUTHORS Espanel,X., Huguenin-Reggiani,M. and Hooft van Huijsduijnen,R.
TITLE The SPOT technique as a tool for studying protein tyrosine
phosphatase substrate specificities
JOURNAL Protein Sci. 11 (10), 2326-2334 (2002)
PUBMED 12237455
REFERENCE 5 (bases 1 to 3143)
AUTHORS Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of human RPE/choroid for the
NEIBank Project: over 6000 non-redundant transcripts, novel genes
and splice variants
JOURNAL Mol. Vis. 8, 205-220 (2002)
PUBMED 12107410
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3143)
AUTHORS Toyoshima,H., Kozutsumi,H., Maru,Y., Hagiwara,K., Furuya,A.,
Mioh,H., Hanai,N., Takaku,F., Yazaki,Y. and Hirai,H.
TITLE Differently spliced cDNAs of human leukocyte tyrosine kinase
receptor tyrosine kinase predict receptor proteins with and without
a tyrosine kinase domain and a soluble receptor protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (12), 5404-5408 (1993)
PUBMED 7685902
REFERENCE 7 (bases 1 to 3143)
AUTHORS Krolewski,J.J. and Dalla-Favera,R.
TITLE The ltk gene encodes a novel receptor-type protein tyrosine kinase
JOURNAL EMBO J. 10 (10), 2911-2919 (1991)
PUBMED 1655406
REFERENCE 8 (bases 1 to 3143)
AUTHORS Krolewski,J.J., Lee,R., Eddy,R., Shows,T.B. and Dalla-Favera,R.
TITLE Identification and chromosomal mapping of new human tyrosine kinase
genes
JOURNAL Oncogene 5 (3), 277-282 (1990)
PUBMED 2156206
REFERENCE 9 (bases 1 to 3143)
AUTHORS Maru,Y., Hirai,H. and Takaku,F.
TITLE Human ltk: gene structure and preferential expression in human
leukemic cells
JOURNAL Oncogene Res. 5 (3), 199-204 (1990)
PUBMED 2320375
REFERENCE 10 (bases 1 to 3143)
AUTHORS Ben-Neriah,Y. and Bauskin,A.R.
TITLE Leukocytes express a novel gene encoding a putative transmembrane
protein-kinase devoid of an extracellular domain
JOURNAL Nature 333 (6174), 672-676 (1988)
PUBMED 2836739
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK296892.1, D16105.1 and
CA394397.1.
On Oct 7, 2008 this sequence version replaced gi:166158929.
Summary: The protein encoded by this gene is a member of the
ros/insulin receptor family of tyrosine kinases. Tyrosine-specific
phosphorylation of proteins is a key to the control of diverse
pathways leading to cell growth and differentiation. Multiple
transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq, Oct 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D16105.1, AK314006.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-303 AK296892.1 1-303
304-3066 D16105.1 223-2985
3067-3143 CA394397.1 508-584
FEATURES Location/Qualifiers
source 1..3143
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15.1-q21.1"
gene 1..3143
/gene="LTK"
/gene_synonym="TYK1"
/note="leukocyte receptor tyrosine kinase"
/db_xref="GeneID:4058"
/db_xref="HGNC:6721"
/db_xref="HPRD:01052"
/db_xref="MIM:151520"
exon 1..221
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(87)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11631555"
misc_feature 122..124
/gene="LTK"
/gene_synonym="TYK1"
/note="upstream in-frame stop codon"
variation complement(133)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372897286"
variation complement(148)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202179022"
variation complement(149)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139430007"
variation complement(163)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200386770"
variation complement(174)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201187554"
CDS 179..2773
/gene="LTK"
/gene_synonym="TYK1"
/EC_number="2.7.10.1"
/note="isoform 1 precursor is encoded by transcript
variant 1; leukocyte tyrosine kinase receptor; protein
tyrosine kinase 1"
/codon_start=1
/product="leukocyte tyrosine kinase receptor isoform 1
precursor"
/protein_id="NP_002335.2"
/db_xref="GI:42544153"
/db_xref="CCDS:CCDS10077.1"
/db_xref="GeneID:4058"
/db_xref="HGNC:6721"
/db_xref="HPRD:01052"
/db_xref="MIM:151520"
/translation="
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
"
sig_peptide 179..226
/gene="LTK"
/gene_synonym="TYK1"
mat_peptide 227..2770
/gene="LTK"
/gene_synonym="TYK1"
/product="leukocyte tyrosine kinase receptor isoform 1"
misc_feature 296..298
/gene="LTK"
/gene_synonym="TYK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1451..1525
/gene="LTK"
/gene_synonym="TYK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P29376.3);
transmembrane region"
misc_feature 1685..2515
/gene="LTK"
/gene_synonym="TYK1"
/note="Catalytic domain of the Protein Tyrosine Kinases,
Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
Region: PTKc_ALK_LTK; cd05036"
/db_xref="CDD:133168"
misc_feature 1706..2509
/gene="LTK"
/gene_synonym="TYK1"
/note="Protein tyrosine kinase; Region: Pkinase_Tyr;
pfam07714"
/db_xref="CDD:203736"
misc_feature order(1724..1738,1748..1750,1802..1804,1808..1810,
1946..1957,1964..1969,2105..2107,2117..2122,2126..2128,
2168..2170,2222..2236,2261..2263,2363..2365)
/gene="LTK"
/gene_synonym="TYK1"
/note="active site"
/db_xref="CDD:133168"
misc_feature order(1724..1729,1733..1738,1748..1750,1802..1804,
1808..1810,1946..1957,1964..1969,2117..2122,2126..2128,
2168..2170)
/gene="LTK"
/gene_synonym="TYK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133168"
misc_feature order(2105..2107,2117..2119,2222..2236,2261..2263,
2363..2365)
/gene="LTK"
/gene_synonym="TYK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:133168"
misc_feature 2165..2242
/gene="LTK"
/gene_synonym="TYK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133168"
misc_feature 2192..2194
/gene="LTK"
/gene_synonym="TYK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P29376.3); phosphorylation site"
misc_feature 2207..2209
/gene="LTK"
/gene_synonym="TYK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P29376.3); phosphorylation site"
variation complement(179..180)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:67686933"
variation complement(208)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:150347278"
exon 222..365
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(237)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371616916"
variation complement(256)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:58650201"
variation complement(262)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:56063273"
variation complement(265)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199595844"
variation complement(297)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374021880"
variation complement(299)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140343272"
variation complement(303)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2305030"
variation complement(306..307)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:71431816"
variation complement(325)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144899424"
variation complement(330)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372292312"
variation complement(341)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368397565"
exon 366..537
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(366)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377388642"
variation complement(374)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201734476"
variation complement(398)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374997462"
variation complement(410)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370330041"
variation complement(439)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140771942"
variation complement(442)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377098802"
variation complement(478)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372924578"
variation complement(488)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199617843"
variation complement(537)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201107692"
exon 538..688
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(567)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200377822"
variation complement(594)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371228281"
variation complement(597)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200347907"
variation complement(638)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142529901"
variation complement(655)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148848607"
exon 689..835
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(721)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:113941585"
variation complement(805..806)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="gtggcgggg"
/db_xref="dbSNP:71812607"
variation complement(806..807)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="gtggcgggg"
/db_xref="dbSNP:5812191"
variation complement(813..814)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="ggtggcggg"
/db_xref="dbSNP:34293426"
variation complement(821..822)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:71431815"
exon 836..992
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(858)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55739813"
variation complement(906)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192402541"
exon 993..1175
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1017)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371555228"
exon 1176..1274
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1181)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145538913"
variation complement(1183)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150023038"
variation complement(1184)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140090710"
variation complement(1211)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147526720"
variation complement(1248)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144944868"
variation complement(1249)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200847666"
variation complement(1259)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371209349"
exon 1275..1427
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1279)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377698700"
variation complement(1283)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201581050"
variation complement(1289)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141049740"
variation complement(1305)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:150610943"
variation complement(1327)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376133874"
variation complement(1328)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55683312"
exon 1428..1523
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1435)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:10152795"
variation complement(1444)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56043216"
variation complement(1482)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:75763687"
variation complement(1506)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370151127"
exon 1524..1719
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1530)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369605018"
variation complement(1566)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144738418"
variation complement(1596)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141709767"
variation complement(1599)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375275942"
variation complement(1615..1616)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:67673520"
variation complement(1623)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138694693"
variation complement(1625)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144810530"
variation complement(1642)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141101544"
variation complement(1654)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138110106"
variation complement(1687)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150296915"
exon 1720..1810
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1734)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140093948"
variation complement(1767)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201571079"
variation complement(1781)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35932273"
variation complement(1784)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199980818"
variation complement(1790)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199633928"
variation complement(1799)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144319704"
exon 1811..1875
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1813)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370616929"
variation complement(1822)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199965576"
variation complement(1826)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200508070"
variation complement(1830)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201486520"
variation complement(1831)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375203744"
variation complement(1854)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141718457"
variation complement(1867)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373419915"
exon 1876..2005
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1883)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:148513655"
variation complement(1885)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368274639"
variation complement(1902)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377126031"
variation complement(1909)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372785537"
variation complement(1924)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372702626"
variation complement(1934)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202096075"
variation complement(1935)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144858308"
variation complement(1936)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368562166"
variation complement(1964)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375596775"
variation complement(1969)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370064896"
variation complement(1971)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367724896"
variation complement(1980)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373977718"
variation complement(1995)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141010188"
variation complement(1997)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370582280"
exon 2006..2103
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2030)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149973033"
variation complement(2031)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139262290"
variation complement(2038)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201253904"
variation complement(2039)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200355589"
variation complement(2041)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149800453"
variation complement(2044)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140764829"
variation complement(2056)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:75428074"
variation complement(2057)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201789947"
variation complement(2077)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201048749"
variation complement(2083)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138900025"
variation complement(2087)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368975307"
variation complement(2100)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377092265"
variation complement(2103)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200215271"
exon 2104..2196
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2114)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145997165"
variation complement(2118)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142613322"
variation complement(2136)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148048753"
variation complement(2137)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143606508"
variation complement(2138)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148814029"
variation complement(2145)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372848485"
variation complement(2146)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:68185454"
variation complement(2146)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368900972"
variation complement(2151)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367918796"
variation complement(2167)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371592300"
variation complement(2184)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138393348"
variation complement(2186)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374062033"
variation complement(2190)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377404643"
variation complement(2195)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201289718"
variation complement(2196)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55876255"
exon 2197..2298
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2203)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372223410"
variation complement(2211)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142798669"
variation complement(2212..2213)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:67754618"
variation complement(2215)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:146757784"
variation complement(2223)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141045322"
variation complement(2233)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140642102"
variation complement(2267)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370182079"
variation complement(2272)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375465862"
variation complement(2289)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372800939"
variation complement(2290)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142986350"
variation complement(2298)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2278658"
exon 2299..2433
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2304)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148593397"
variation complement(2315)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368310218"
variation complement(2331)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145702407"
variation complement(2337)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375669533"
variation complement(2349)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200739696"
variation complement(2357)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143635378"
variation complement(2358)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199935291"
variation complement(2387)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140077464"
variation complement(2399)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370375739"
variation complement(2400)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142515948"
variation complement(2411)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55900837"
exon 2434..2524
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2438)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139153755"
variation complement(2454)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368134355"
variation complement(2462)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370848239"
variation complement(2465)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76282169"
variation complement(2468)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376706397"
variation complement(2477)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373539281"
variation complement(2478)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369598804"
variation complement(2504)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150790185"
variation complement(2505)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375277507"
exon 2525..3127
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2530)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141324634"
variation complement(2594)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367898414"
variation complement(2597..2598)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:71973453"
variation complement(2615)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148281714"
variation complement(2634)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372296391"
variation complement(2638)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201855640"
variation complement(2662)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145757122"
variation complement(2667)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199957230"
variation complement(2690)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:56367146"
variation complement(2701)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368306708"
variation complement(2712..2713)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:67078727"
variation complement(2717)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200704162"
variation complement(2737)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143467076"
variation complement(2777..2778)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:66782809"
STS 2796..3029
/gene="LTK"
/gene_synonym="TYK1"
/standard_name="RH80861"
/db_xref="UniSTS:85260"
variation complement(2823)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368427145"
variation complement(2869)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187315130"
variation complement(2968)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368815371"
variation complement(2970)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150595531"
variation complement(3067)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:316617"
polyA_signal 3108..3113
/gene="LTK"
/gene_synonym="TYK1"
polyA_site 3127
/gene="LTK"
/gene_synonym="TYK1"
ORIGIN
ggggtctgaggtgggcgtggccagaccagctttaggtccggggagtgtctcgccagcggcagcacacccctgtaagtggtggccagggctgccgtggcaaaatgagctgtcaactttaggttgacaggggtgtggccgcgaccgcaagggcttttgttgccgggtggacccaacagggatgggctgctggggacagctgctggtgtggttcggagccgcgggcgccattctctgctctagcccggggtcccaggagacttttctgcggtcctcgcccctgccgctggcaagtcccagcccccgggacccgaaagtcagcgccccgcctagtatcttggagccagcctccccgctgaattctccgggcaccgaggggtcttggctgttttctacctgcggggccagcggccggcatgggcccacacagacacaatgtgacggggcgtacgcggggaccagcgtggtggtgaccgtgggggccgccgggcagctgagaggcgtgcagctgtggcgcgtgccgggccctggccagtatctgatctcagcctacggagccgcgggcggcaaaggcgccaagaaccacctgtcgcgggcgcatggcgtcttcgtctcagcaatcttctccctcggtctcggggagtcgctgtacatcctggtggggcagcagggagaggacgcctgtcccggaggtagcccggagagccagctcgtctgcctcggggagtctcgagccgttgaagagcacgcggcgatggatgggagcgaaggggtcccggggtcgcggcgctgggcgggaggtggcgggggtggcgggggcgccacctacgttttccgggtgcgcgctggcgagctggaaccgttgctggtggcggccggaggcggcggtcgggcctacctgaggccgcgggaccgaggccggactcaggcctcccccgagaaactggagaaccgctcggaggcgcccgggagcggcgggagaggcggggcggcaggtggtgggggcggctggacgtcgcgggctccctctccgcaggccggccgctcactgcaggagggggcggagggcggccagggctgctccgaggcttgggcgacccttggctgggccgcggccggcggcttcgggggcggcggcggggcctgcactgcgggcggaggcggcggcggctacagggggggcgacgcttcagagactgacaacctctgggctgatggggaagatggagtatccttcatacaccccagcagcgagctcttcctgcagcctctggcagtcaccgagaaccacggagaggtagagatccgaaggcacctcaactgcagtcactgccctttgagagactgccaatggcaggcagagctccagctggctgaatgcctgtgcccagaaggcatggagctagctgtggataacgtcacctgcatggacctgcacaagcccccaggccctctggttctgatggtggctgtggtggcaacctcaacactgagcctccttatggtgtgtggggtcctgattctggtgaagcagaagaagtggcagggcctgcaggagatgaggctgccgagccctgagcttgagctgagcaagcttcgaacctctgccatcaggacagcccccaatccctattattgccaggtggggcttggcccggcccagtcctggcctctgccaccaggtgtcaccgaggtttccccagccaatgttactctgctcagagccctgggccatggtgcctttggggaggtgtatgagggactggtaattggccttcctggggactccagtcccctgcaggtagctatcaagaccctgccagaactctgctcgcctcaggatgagctggatttcctcatggaggccctcatcatcagcaagtttcgccatcagaacattgtgcggtgtgtggggctcagcctcagggccacccctcgcctcattctgctggaactgatgtctggaggggacatgaagagtttcctgaggcacagtcggccacacctgggccagccatcacctctggtcatgcgggacctgctgcaactggcccaggacatagcccagggctgccactacctggaggaaaatcacttcatccacagggatattgccgcccggaactgcctgctgagctgcgctggacccagccgagtggccaagattggggactttgggatggcacgagatatctaccgggccagttattaccgcaggggggaccgggccttgctcccagtcaagtggatgcccccagaggccttcctggagggcatcttcacatccaagacagattcctggtcttttggggtgctgctctgggagatcttctcactgggctacatgccctatcctgggcgcaccaaccaggaggtgctggacttcgtcgttggaggaggccggatggaccctcctaggggctgcccagggcctgtgtaccgcatcatgacccagtgttggcagcacgagcctgagctccgccctagctttgccagcatcttggagcgtctgcagtactgcactcaggacccggatgtgctgaattcactcctgccaatggagctggggcccaccccagaggaggaagggacttctgggctggggaacagatctttggagtgcctaagacccccacagccccaggaactgagtccagagaagttgaaaagctggggaggtagccctcttggcccctggctgtcctctggcctcaagcccctcaaatccaggggcctccaacctcagaacctttggaatcccacttatcgctcctgagccccaaggggccctgagggtaaggactgaggcactgagggtccctccctatactcctcaggctcctgggtggcctgttatgccagcggcctctgttccctgcagtctgtgctgtgtgtctgggcctgtctcggggctggcctggcagcgctgcacttgccatgctggaaaccagcccaggcctcccagggaagggcccagccacttccagcttttgatcttggggccagaggccgccttacacacaccccaggtgtccatggggagcactggattgctctcccattatgagcatccttcatctgggcagaccccccaccctgcagatgcttctaataaaaagctcttctcatcaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4058 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:4058 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
GeneID:4058 -> Molecular function: GO:0004714 [transmembrane receptor protein tyrosine kinase activity] evidence: IEA
GeneID:4058 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4058 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:4058 -> Biological process: GO:0006915 [apoptotic process] evidence: IMP
GeneID:4058 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:4058 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IEA
GeneID:4058 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:4058 -> Biological process: GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] evidence: IDA
GeneID:4058 -> Biological process: GO:0010976 [positive regulation of neuron projection development] evidence: IMP
GeneID:4058 -> Biological process: GO:0014065 [phosphatidylinositol 3-kinase cascade] evidence: IMP
GeneID:4058 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IMP
GeneID:4058 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4058 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:4058 -> Cellular component: GO:0016020 [membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002335 -> EC 2.7.10.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.