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2024-04-25 02:02:00, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002342 2283 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3)
(LTBR), transcript variant 1, mRNA.
ACCESSION NM_002342
VERSION NM_002342.2 GI:402534563
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2283)
AUTHORS Upadhyay,V. and Fu,Y.X.
TITLE Lymphotoxin signalling in immune homeostasis and the control of
microorganisms
JOURNAL Nat. Rev. Immunol. 13 (4), 270-279 (2013)
PUBMED 23524463
REMARK GeneRIF: Studies indicate roles for Lymphotoxin-alpha (LTalpha) and
lymphotoxin-beta receptor (LTbetaR) pathway in innate and adaptive
immune responses to microorganisms.
Review article
REFERENCE 2 (bases 1 to 2283)
AUTHORS Kim,S.K., Lee,J.Y., Jeong Park,H., Chung,J.H., Suh,J.S., Hahn,W.H.,
Cho,B.S. and Kim,M.J.
TITLE Association between lymphotoxin beta receptor gene polymorphisms
and IgA nephropathy in Korean children
JOURNAL Immunol. Invest. 41 (5), 447-457 (2012)
PUBMED 22417320
REMARK GeneRIF: LTBR gene polymorphisms may be associated with risk of IgA
nephropathy in Korean children
REFERENCE 3 (bases 1 to 2283)
AUTHORS Remouchamps,C., Boutaffala,L., Ganeff,C. and Dejardin,E.
TITLE Biology and signal transduction pathways of the
Lymphotoxin-alphabeta/LTbetaR system
JOURNAL Cytokine Growth Factor Rev. 22 (5-6), 301-310 (2011)
PUBMED 22152226
REMARK Review article
REFERENCE 4 (bases 1 to 2283)
AUTHORS Summers deLuca,L., Ng,D., Gao,Y., Wortzman,M.E., Watts,T.H. and
Gommerman,J.L.
TITLE LTbetaR signaling in dendritic cells induces a type I IFN response
that is required for optimal clonal expansion of CD8+ T cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (5), 2046-2051 (2011)
PUBMED 21245292
REMARK GeneRIF: show that a cognate interaction between LTalphabeta on
CD4(+) helper T cells and LTbeta receptor on DCs results in unique
signals that are necessary for optimal CD8(+) T-cell expansion via
a type I IFN-dependent mechanism
REFERENCE 5 (bases 1 to 2283)
AUTHORS Fava,R.A., Kennedy,S.M., Wood,S.G., Bolstad,A.I., Bienkowska,J.,
Papandile,A., Kelly,J.A., Mavragani,C.P., Gatumu,M., Skarstein,K.
and Browning,J.L.
TITLE Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal
glands and improves corneal integrity in the NOD model of Sjogren's
syndrome
JOURNAL Arthritis Res. Ther. 13 (6), R182 (2011)
PUBMED 22044682
REMARK GeneRIF: Results suggest that blockade of lymphotoxin-beta receptor
(LTBR) pathways may have therapeutic potential for treatment of
Sjogren's syndrome.
REFERENCE 6 (bases 1 to 2283)
AUTHORS Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
Yagita,H. and Okumura,K.
TITLE TRAF5, an activator of NF-kappaB and putative signal transducer for
the lymphotoxin-beta receptor
JOURNAL J. Biol. Chem. 271 (25), 14661-14664 (1996)
PUBMED 8663299
REFERENCE 7 (bases 1 to 2283)
AUTHORS Browning,J.L., Miatkowski,K., Sizing,I., Griffiths,D., Zafari,M.,
Benjamin,C.D., Meier,W. and Mackay,F.
TITLE Signaling through the lymphotoxin beta receptor induces the death
of some adenocarcinoma tumor lines
JOURNAL J. Exp. Med. 183 (3), 867-878 (1996)
PUBMED 8642291
REFERENCE 8 (bases 1 to 2283)
AUTHORS Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
Marynen,P.
TITLE Isolation and regional assignment of human chromosome 12p cDNAs
JOURNAL Genomics 29 (1), 44-52 (1995)
PUBMED 8530100
REFERENCE 9 (bases 1 to 2283)
AUTHORS Crowe,P.D., VanArsdale,T.L., Walter,B.N., Ware,C.F., Hession,C.,
Ehrenfels,B., Browning,J.L., Din,W.S., Goodwin,R.G. and Smith,C.A.
TITLE A lymphotoxin-beta-specific receptor
JOURNAL Science 264 (5159), 707-710 (1994)
PUBMED 8171323
REFERENCE 10 (bases 1 to 2283)
AUTHORS Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
Marynen,P.
TITLE Construction and evaluation of a hncDNA library of human 12p
transcribed sequences derived from a somatic cell hybrid
JOURNAL Genomics 16 (1), 214-218 (1993)
PUBMED 8486360
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA679291.1, L04270.1,
BC026262.1 and AK027080.1.
On Aug 29, 2012 this sequence version replaced gi:4505038.
Summary: This gene encodes a member of the tumor necrosis factor
receptor superfamily. The major ligands of this receptor include
lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily
member 14. The encoded protein plays a role in signalling during
the development of lymphoid and other organs, lipid metabolism,
immune response, and programmed cell death. Activity of this
receptor has also been linked to carcinogenesis. Alternatively
spliced transcript variants encoding multiple isoforms have been
observed. [provided by RefSeq, Aug 2012].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK027080.1, BC026262.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-158 DA679291.1 1-158
159-841 L04270.1 1-683
842-2260 BC026262.1 714-2132
2261-2283 AK027080.1 2126-2148
FEATURES Location/Qualifiers
source 1..2283
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13"
gene 1..2283
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="lymphotoxin beta receptor (TNFR superfamily, member
3)"
/db_xref="GeneID:4055"
/db_xref="HGNC:6718"
/db_xref="HPRD:02988"
/db_xref="MIM:600979"
exon 1..422
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 51
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:12827109"
variation 58
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:12827112"
variation 153
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:10849448"
variation 170
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:180813649"
misc_feature 210..212
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="upstream in-frame stop codon"
variation 243
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41512347"
variation 316
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:112422948"
variation 326
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201263587"
CDS 327..1634
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="isoform 1 precursor is encoded by transcript
variant 1; tumor necrosis factor C receptor; lymphotoxin B
receptor; tumor necrosis factor receptor type III; tumor
necrosis factor receptor 2-related protein"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 3 isoform 1 precursor"
/protein_id="NP_002333.1"
/db_xref="GI:4505039"
/db_xref="CCDS:CCDS8544.1"
/db_xref="GeneID:4055"
/db_xref="HGNC:6718"
/db_xref="HPRD:02988"
/db_xref="MIM:600979"
/translation="
MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
"
sig_peptide 327..407
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 477..764
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(504..533,558..572,675..683)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(504..506,516..518,522..524,561..563,570..572,
600..602)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(588..590,621..623,654..656,720..722,750..752)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(597..602,618..626)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 720..>956
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cl12111"
/db_xref="CDD:209448"
misc_feature order(720..725,849..851,882..884,912..914)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(720..722,750..764)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature order(732..734,762..764,774..776,780..782,822..824,
831..833,861..863)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(762..788,792..794,819..833,933..941)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(858..863,879..887)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
variation 386
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375428958"
exon 423..519
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 442
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:113907340"
variation 482
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11555387"
variation 486
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:147291553"
exon 520..645
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 572
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:41480749"
variation 596
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144676461"
variation 602
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042318"
exon 646..798
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 656
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376062437"
variation 679
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200343421"
variation 699
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371101623"
variation 710
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:41489647"
variation 763
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41393248"
exon 799..895
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 814
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149981490"
variation 827
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199745608"
variation 828
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145130663"
variation 842
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:2364480"
variation 866
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41335846"
variation 870
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:113334413"
variation 872
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144218663"
variation 877
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199917609"
exon 896..993
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 944
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140294576"
variation 965
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="t"
/db_xref="dbSNP:374274216"
variation 970
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368496847"
variation 982
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:185897139"
exon 994..1101
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 1008
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:372316101"
variation 1011
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:41332645"
variation 1014
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:190288182"
variation 1052
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369186345"
variation 1053
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148007184"
variation 1064
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372115715"
variation 1093
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:141647006"
exon 1102..1127
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 1105
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150503607"
exon 1128..1356
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 1146
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35681405"
variation 1186
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:74400611"
variation 1212
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555386"
variation 1228
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144056108"
variation 1235
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147770937"
variation 1239
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140869621"
variation 1247
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201042007"
variation 1253
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:34407931"
variation 1258
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144755581"
variation 1283
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148530627"
variation 1285
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370657088"
variation 1321
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804534"
variation 1331
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374220510"
variation 1340
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:368425660"
exon 1357..2268
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 1394
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375470015"
variation 1466
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:202215602"
variation 1507
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142824360"
variation 1518
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3764872"
variation 1613
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:376201696"
variation 1635
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369367670"
variation 1636
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:12354"
variation 1651
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:371743773"
variation 1676
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374817713"
variation 1719
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:367847000"
variation 1732
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:41355445"
variation 1733
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:3203555"
variation 1747
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:184319376"
variation 1753
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:71584824"
variation 1760
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35986933"
variation 1819
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:12820636"
variation 1882
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149078929"
variation 1942
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:71584825"
variation 1980
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:3764870"
variation 2010
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:181205105"
STS 2046..2177
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/standard_name="D12S1911"
/db_xref="UniSTS:14505"
polyA_signal 2244..2249
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
variation 2259
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:3176984"
variation 2264
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180974"
polyA_site 2268
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
ORIGIN
gctttcccggccgcccctcccgccccgcatcgaggcagacaagcctgttcctcttccctgggctgcgattgcgacaggccggcctggctcccagcgctccctgtccccgccccgcggccagctcgctccactcccacttcctgagctccgccatgggagccctggaggcccggcctggccgctcccggccctggggtgcacatcggccctgagtcccgtcccaggctctgggctcgggcagccgccgccaccgctgcccaggacgtcgggcctcctgccttcctcccaggcccccacgttgctggccgcctggccgagtggccgccatgctcctgccttgggccacctctgcccccggcctggcctgggggcctctggtgctgggcctcttcgggctcctggcagcatcgcagccccaggcggtgcctccatatgcgtcggagaaccagacctgcagggaccaggaaaaggaatactatgagccccagcaccgcatctgctgctcccgctgcccgccaggcacctatgtctcagctaaatgtagccgcatccgggacacagtttgtgccacatgtgccgagaattcctacaacgagcactggaactacctgaccatctgccagctgtgccgcccctgtgacccagtgatgggcctcgaggagattgccccctgcacaagcaaacggaagacccagtgccgctgccagccgggaatgttctgtgctgcctgggccctcgagtgtacacactgcgagctactttctgactgcccgcctggcactgaagccgagctcaaagatgaagttgggaagggtaacaaccactgcgtcccctgcaaggccgggcacttccagaatacctcctcccccagcgcccgctgccagccccacaccaggtgtgagaaccaaggtctggtggaggcagctccaggcactgcccagtccgacacaacctgcaaaaatccattagagccactgcccccagagatgtcaggaaccatgctgatgctggccgttctgctgccactggccttctttctgctccttgccaccgtcttctcctgcatctggaagagccacccttctctctgcaggaaactgggatcgctgctcaagaggcgtccgcagggagagggacccaatcctgtagctggaagctgggagcctccgaaggcccatccatacttccctgacttggtacagccactgctacccatttctggagatgtttccccagtatccactgggctccccgcagccccagttttggaggcaggggtgccgcaacagcagagtcctctggacctgaccagggagccgcagttggaacccggggagcagagccaggtggcccacggtaccaatggcattcatgtcaccggcgggtctatgactatcactggcaacatctacatctacaatggaccagtactggggggaccaccgggtcctggagacctcccagctacccccgaacctccataccccattcccgaagagggggaccctggccctcccgggctctctacaccccaccaggaagatggcaaggcttggcacctagcggagacagagcactgtggtgccacaccctctaacaggggcccaaggaaccaatttatcacccatgactgactgagtctgagaaaaggcagaagaaggggggcacaagggcaccttctcccttgaggctgccctgcccacgtgggattcacaggggcctgagtagggcccggggaagcagagccctaagggattaaggctcagacacctctgagagcaggtgggcactggctgggtacggtgccctccacaggactctccctactgcctgagcaaacctgaggcctcccggcagacccacccaccccctggggctgctcagcctcaggcacggacagggcacatgataccaactgctgcccactacggcacgccgcaccggagcacggcaccgagggagccgccacacggtcacctgcaaggacgtcacgggcccctctaaaggattcgtggtgctcatccccaagcttcagagaccctttggggttccacacttcacgtggactgaggtagaccctgcatgaagatgaaattatagggaggacgctccttccctcccctcctagaggagaggaaagggagtcattaacaactagggggttgggtaggattcctaggtatggggaagagttttggaaggggaggaaaatggcaagtgtatttatattgtaaccacatgcaaataaaaagaatgggacctagataaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4055 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4055 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:4055 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:4055 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4055 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:4055 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:4055 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:4055 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IMP
GeneID:4055 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:4055 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:4055 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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