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2024-04-24 02:21:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002310 10107 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens leukemia inhibitory factor receptor alpha (LIFR),
transcript variant 2, mRNA.
ACCESSION NM_002310
VERSION NM_002310.5 GI:189095278
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10107)
AUTHORS Conrady,C.D., Zheng,M., van Rooijen,N., Drevets,D.A., Royer,D.,
Alleman,A. and Carr,D.J.
TITLE Microglia and a functional type I IFN pathway are required to
counter HSV-1-driven brain lateral ventricle enlargement and
encephalitis
JOURNAL J. Immunol. 190 (6), 2807-2817 (2013)
PUBMED 23382563
REMARK GeneRIF: Because acute ventricle enlargement is observed in
susceptible CD118-deficient mice, the phenomenon may occur in a
subpopulation of human adults with herpes simplex encephalitis.
REFERENCE 2 (bases 1 to 10107)
AUTHORS Chen,D., Sun,Y., Wei,Y., Zhang,P., Rezaeian,A.H.,
Teruya-Feldstein,J., Gupta,S., Liang,H., Lin,H.K., Hung,M.C. and
Ma,L.
TITLE LIFR is a breast cancer metastasis suppressor upstream of the
Hippo-YAP pathway and a prognostic marker
JOURNAL Nat. Med. 18 (10), 1511-1517 (2012)
PUBMED 23001183
REMARK GeneRIF: findings identify LIFR as a metastasis suppressor that
functions through the Hippo-YAP pathway and has significant
prognostic power.
REFERENCE 3 (bases 1 to 10107)
AUTHORS Chollangi,S., Mather,T., Rodgers,K.K. and Ash,J.D.
TITLE A unique loop structure in oncostatin M determines binding affinity
toward oncostatin M receptor and leukemia inhibitory factor
receptor
JOURNAL J. Biol. Chem. 287 (39), 32848-32859 (2012)
PUBMED 22829597
REMARK GeneRIF: A unique loop structure in oncostatin M determines binding
affinity toward oncostatin M receptor and leukemia inhibitory
factor receptor.
REFERENCE 4 (bases 1 to 10107)
AUTHORS Iorns,E., Ward,T.M., Dean,S., Jegg,A., Thomas,D., Murugaesu,N.,
Sims,D., Mitsopoulos,C., Fenwick,K., Kozarewa,I.,
Naceur-Lombarelli,C., Zvelebil,M., Isacke,C.M., Lord,C.J.,
Ashworth,A., Hnatyszyn,H.J., Pegram,M. and Lippman,M.
TITLE Whole genome in vivo RNAi screening identifies the leukemia
inhibitory factor receptor as a novel breast tumor suppressor
JOURNAL Breast Cancer Res. Treat. 135 (1), 79-91 (2012)
PUBMED 22535017
REMARK GeneRIF: findings show that LIFR is a key novel tumor suppressor,
whose deregulation may drive the transformation of a significant
proportion of human breast cancers
REFERENCE 5 (bases 1 to 10107)
AUTHORS Kang,W.S., Kim,S.K., Park,J.K., Cho,A.R., Park,H.J., Chung,J.H. and
Kim,J.W.
TITLE Association between promoter polymorphisms of the LIFR gene and
schizophrenia with persecutory delusion in a Korean population
JOURNAL Mol Med Rep 5 (1), 270-274 (2012)
PUBMED 21971603
REMARK GeneRIF: A significant association was detected between the LIFR
gene polymorphisms and schizophrenia patients with persecutory
delusion
REFERENCE 6 (bases 1 to 10107)
AUTHORS Schiemann,W.P., Graves,L.M., Baumann,H., Morella,K.K.,
Gearing,D.P., Nielsen,M.D., Krebs,E.G. and Nathanson,N.M.
TITLE Phosphorylation of the human leukemia inhibitory factor (LIF)
receptor by mitogen-activated protein kinase and the regulation of
LIF receptor function by heterologous receptor activation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5361-5365 (1995)
PUBMED 7777512
REFERENCE 7 (bases 1 to 10107)
AUTHORS Gearing,D.P., Druck,T., Huebner,K., Overhauser,J., Gilbert,D.J.,
Copeland,N.G. and Jenkins,N.A.
TITLE The leukemia inhibitory factor receptor (LIFR) gene is located
within a cluster of cytokine receptor loci on mouse chromosome 15
and human chromosome 5p12-p13
JOURNAL Genomics 18 (1), 148-150 (1993)
PUBMED 8276403
REFERENCE 8 (bases 1 to 10107)
AUTHORS Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
TITLE The IL-6 signal transducer, gp130: an oncostatin M receptor and
affinity converter for the LIF receptor
JOURNAL Science 255 (5050), 1434-1437 (1992)
PUBMED 1542794
REFERENCE 9 (bases 1 to 10107)
AUTHORS Gearing,D.P. and Bruce,A.G.
TITLE Oncostatin M binds the high-affinity leukemia inhibitory factor
receptor
JOURNAL New Biol. 4 (1), 61-65 (1992)
PUBMED 1536831
REFERENCE 10 (bases 1 to 10107)
AUTHORS Gearing,D.P., Thut,C.J., VandeBos,T., Gimpel,S.D., Delaney,P.B.,
King,J., Price,V., Cosman,D. and Beckmann,M.P.
TITLE Leukemia inhibitory factor receptor is structurally related to the
IL-6 signal transducer, gp130
JOURNAL EMBO J. 10 (10), 2839-2848 (1991)
PUBMED 1915266
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA857408.1, X61615.1,
AC010457.7 and BQ008945.1.
This sequence is a reference standard in the RefSeqGene project.
On May 28, 2008 this sequence version replaced gi:189083784.
Summary: This gene encodes a protein that belongs to the type I
cytokine receptor family. This protein combines with a
high-affinity converter subunit, gp130, to form a receptor complex
that mediates the action of the leukemia inhibitory factor, a
polyfunctional cytokine that is involved in cellular
differentiation, proliferation and survival in the adult and the
embryo. Mutations in this gene cause Schwartz-Jampel syndrome type
2, a disease belonging to the group of the bent-bone dysplasias. A
translocation that involves the promoter of this gene,
t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated
with salivary gland pleiomorphic adenoma, a common type of benign
epithelial tumor of the salivary gland. Multiple splice variants
encoding the same protein have been found for this gene. [provided
by RefSeq, Jul 2008].
Transcript Variant: This variant (2) differs in the 5' UTR,
compared to variant 1. Variants 1 and 2 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK308158.1, X61615.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025098 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-11 DA857408.1 1-11
12-3577 X61615.1 26-3591
3578-9438 AC010457.7 45323-51183 c
9439-10107 BQ008945.1 1-669 c
FEATURES Location/Qualifiers
source 1..10107
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p13-p12"
gene 1..10107
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="leukemia inhibitory factor receptor alpha"
/db_xref="GeneID:3977"
/db_xref="HGNC:6597"
/db_xref="HPRD:01048"
/db_xref="MIM:151443"
exon 1..145
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
misc_feature 3
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="alternative transcription start site"
misc_feature 96..98
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="upstream in-frame stop codon"
exon 146..306
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
CDS 165..3458
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="CD118 antigen; LIF receptor"
/codon_start=1
/product="leukemia inhibitory factor receptor precursor"
/protein_id="NP_002301.1"
/db_xref="GI:4504993"
/db_xref="CCDS:CCDS3927.1"
/db_xref="GeneID:3977"
/db_xref="HGNC:6597"
/db_xref="HPRD:01048"
/db_xref="MIM:151443"
/translation="
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
"
sig_peptide 165..296
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
mat_peptide 297..3455
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/product="leukemia inhibitory factor receptor"
misc_feature 1461..1754
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1461..1463,1665..1667,1716..1718)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature 1719..1733
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
Region: WSXWS motif"
misc_feature order(1719..1724,1728..1733)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature <1830..2021
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cl00065"
/db_xref="CDD:206813"
misc_feature 2334..2651
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2334..2336,2571..2573,2616..2618)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2619..2624,2628..2633)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2664..2738
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
transmembrane region"
misc_feature 2769..2795
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
Region: Box 1 motif"
misc_feature 2943..2945
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42702.1); phosphorylation site"
misc_feature 3294..3296
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:01496"
variation 192
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729732"
exon 307..421
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 422..561
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 510
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729734"
exon 562..725
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 726..900
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 901..1155
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1156..1285
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1286..1455
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1456..1601
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1602..1764
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1765..1835
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1836..2049
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 1896
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="g"
/db_xref="dbSNP:3729740"
exon 2050..2229
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 2155
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729744"
exon 2230..2331
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2332..2499
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2500..2661
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2662..2755
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2756..2834
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2835..10090
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
STS 3233..3482
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH41252"
/db_xref="UniSTS:90279"
STS 3346..3560
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH93532"
/db_xref="UniSTS:89153"
variation 3452
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729751"
STS 3456..3558
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="PMC311006P4"
/db_xref="UniSTS:272831"
STS 3462..3556
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="human.LIFR"
/db_xref="UniSTS:181772"
variation 3775
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:201394596"
variation 3820
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="g"
/db_xref="dbSNP:1005017"
variation 4418
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042795"
STS 4432..5311
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="LIFR_185"
/db_xref="UniSTS:277451"
variation 5012
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="g"
/db_xref="dbSNP:1428604"
variation 5072
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042798"
variation 5073
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042799"
STS 5079..5224
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="STS-R38064"
/db_xref="UniSTS:65610"
STS 5233..5327
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="SHGC-60516"
/db_xref="UniSTS:30425"
polyA_site 5254
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
STS 6866..6985
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH48815"
/db_xref="UniSTS:2234"
polyA_signal 7086..7091
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
polyA_site 7114
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
STS 7298..7437
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S1675E"
/db_xref="UniSTS:151064"
STS 8241..8517
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S2471"
/db_xref="UniSTS:5248"
STS 8253..8397
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH91753"
/db_xref="UniSTS:89967"
STS 8997..9086
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S1570E"
/db_xref="UniSTS:150998"
STS 9251..9399
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH26031"
/db_xref="UniSTS:87596"
STS 9569..9809
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH65837"
/db_xref="UniSTS:92084"
variation 9648
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046224"
polyA_signal 10066..10071
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
polyA_site 10090
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
ORIGIN
aaatcctaaccctctctcccagaacgtgtctctgctgcaaggcaccgggccctttcgctctgcagaactgcacttgcaagaccattatcaactcctaatcccagctcagaaagggagcctctgcgactcattcatcgccctccaggactgactgcattgcacagatgatggatatttacgtatgtttgaaacgaccatcctggatggtggacaataaaagaatgaggactgcttcaaatttccagtggctgttatcaacatttattcttctatatctaatgaatcaagtaaatagccagaaaaagggggctcctcatgatttgaagtgtgtaactaacaatttgcaagtgtggaactgttcttggaaagcaccctctggaacaggccgtggtactgattatgaagtttgcattgaaaacaggtcccgttcttgttatcagttggagaaaaccagtattaaaattccagctctttcacatggtgattatgaaataacaataaattctctacatgattttggaagttctacaagtaaattcacactaaatgaacaaaacgtttccttaattccagatactccagagatcttgaatttgtctgctgatttctcaacctctacattatacctaaagtggaacgacaggggttcagtttttccacaccgctcaaatgttatctgggaaattaaagttctacgtaaagagagtatggagctcgtaaaattagtgacccacaacacaactctgaatggcaaagatacacttcatcactggagttgggcctcagatatgcccttggaatgtgccattcattttgtggaaattagatgctacattgacaatcttcatttttctggtctcgaagagtggagtgactggagccctgtgaagaacatttcttggatacctgattctcagactaaggtttttcctcaagataaagtgatacttgtaggctcagacataacattttgttgtgtgagtcaagaaaaagtgttatcagcactgattggccatacaaactgccccttgatccatcttgatggggaaaatgttgcaatcaagattcgtaatatttctgtttctgcaagtagtggaacaaatgtagtttttacaaccgaagataacatatttggaaccgttatttttgctggatatccaccagatactcctcaacaactgaattgtgagacacatgatttaaaagaaattatatgtagttggaatccaggaagggtgacagcgttggtgggcccacgtgctacaagctacactttagttgaaagtttttcaggaaaatatgttagacttaaaagagctgaagcacctacaaacgaaagctatcaattattatttcaaatgcttccaaatcaagaaatatataattttactttgaatgctcacaatccgctgggtcgatcacaatcaacaattttagttaatataactgaaaaagtttatccccatactcctacttcattcaaagtgaaggatattaattcaacagctgttaaactttcttggcatttaccaggcaactttgcaaagattaattttttatgtgaaattgaaattaagaaatctaattcagtacaagagcagcggaatgtcacaatcaaaggagtagaaaattcaagttatcttgttgctctggacaagttaaatccatacactctatatacttttcggattcgttgttctactgaaactttctggaaatggagcaaatggagcaataaaaaacaacatttaacaacagaagccagtccttcaaaggggcctgatacttggagagagtggagttctgatggaaaaaatttaataatctattggaagcctttacccattaatgaagctaatggaaaaatactttcctacaatgtatcgtgttcatcagatgaggaaacacagtccctttctgaaatccctgatcctcagcacaaagcagagatacgacttgataagaatgactacatcatcagcgtagtggctaaaaattctgtgggctcatcaccaccttccaaaatagcgagtatggaaattccaaatgatgatctcaaaatagaacaagttgttgggatgggaaaggggattctcctcacctggcattacgaccccaacatgacttgcgactacgtcattaagtggtgtaactcgtctcggtcggaaccatgccttatggactggagaaaagttccctcaaacagcactgaaactgtaatagaatctgatgagtttcgaccaggtataagatataattttttcctgtatggatgcagaaatcaaggatatcaattattacgctccatgattggatatatagaagaattggctcccattgttgcaccaaattttactgttgaggatacttctgcagattcgatattagtaaaatgggaagacattcctgtggaagaacttagaggctttttaagaggatatttgttttactttggaaaaggagaaagagacacatctaagatgagggttttagaatcaggtcgttctgacataaaagttaagaatattactgacatatcccagaagacactgagaattgctgatcttcaaggtaaaacaagttaccacctggtcttgcgagcctatacagatggtggagtgggcccggagaagagtatgtatgtggtgacaaaggaaaattctgtgggattaattattgccattctcatcccagtggcagtggctgtcattgttggagtggtgacaagtatcctttgctatcggaaacgagaatggattaaagaaaccttctaccctgatattccaaatccagaaaactgtaaagcattacagtttcaaaagagtgtctgtgagggaagcagtgctcttaaaacattggaaatgaatccttgtaccccaaataatgttgaggttctggaaactcgatcagcatttcctaaaatagaagatacagaaataatttccccagtagctgagcgtcctgaagatcgctctgatgcagagcctgaaaaccatgtggttgtgtcctattgtccacccatcattgaggaagaaataccaaacccagccgcagatgaagctggagggactgcacaggttatttacattgatgttcagtcgatgtatcagcctcaagcaaaaccagaagaagaacaagaaaatgaccctgtaggaggggcaggctataagccacagatgcacctccccattaattctactgtggaagatatagctgcagaagaggacttagataaaactgcgggttacagacctcaggccaatgtaaatacatggaatttagtgtctccagactctcctagatccatagacagcaacagtgagattgtctcatttggaagtccatgctccattaattcccgacaatttttgattcctcctaaagatgaagactctcctaaatctaatggaggagggtggtcctttacaaacttttttcagaacaaaccaaacgattaacagtgtcaccgtgtcacttcagtcagccatctcaataagctcttactgctagtgttgctacatcagcactgggcattcttggagggatcctgtgaagtattgttaggaggtgaacttcactacatgttaagttacactgaaagtgttcatgtgcttttaatgtagtctaaaagccaaagtatagtgactcagaatcctcaatccacaaaactcaagattgggagctctttgtgatcaagccaaagaattctcatgtactctaccttcaagaagcatttcaaggctaatacctacttgtacgtacatgtaaaacaaatcccgccgcaactgttttctgttctgttgtttgtggttttctcatgtgtatacttggtggaattgtaagtggatttgcaggccagggagaaaatgtccaagtaacaggtgaagtttatttgcctgacgtttactcctttctagatgaaaaccaagcacagattttaaaacttctaagattattctcctctatccacagcattcacaaaaattaatataatttttaatgtagtgacagcgatttagtgttttgtttgataaagtatgcttatttctgtgcctactgtataatggttatcaaacagttgtctcaggggtacaaactttgaaaacaagtgtgacactgaccagcccaaatcataatcatgttttcttgctgtgataggttttgcaagccttttcattattttttagcttttatgcttgcttccattatttcagttggttgccctaatatttaaaatttacacttctaagactagagacccacattttttaaaaatcattttattttgtgatacagtgacagctttatatgagcaaattcaatattattcataagcatgtaattccagtgacttactatgtgagatgactactaagcaatatctagcagcgttagctgtccatatagttctgattggatttcgttcctcctgaggagaccatgccgttgagcttggctacccaggcagtggtgatctttgacaccttctggtggatgttcctcccactcatgagtcttttcatcatgccacattatctgatccagtcctcacatttttaaatataaaactaaagagagaatgcttcttacaggaacagttacccaagggctgtttcttagtaactgtcataaactgatctgaatccatgggcatacctgtgttgcaggtgcagcaattgcttggtgagctgtgcagaattgattgccttcagcacagcatcctctgcccacccttgtttctcataagcgatgtctggagtgattgtggttcttggaaaagcagaaggaaaaactaaaaagtgtatcttgtattttccctgccctcaggttgcctatgtattttaccttttcatatttaaggcaaaagtacttgaaaattttaagtgtccgaataagatatgtcttttttgtttgttttttttggttgtttgtttgttttttatcatctgagattctgtaatgtatttgcaaataatggatcaattaattttttttgaagctcatattgtatctttttaaaaaccatgttgtggaaaaaagccagagtgacaagtgacaaaatctatttaggttctctgtgtatgaatcctgattttaactgctaggattcagctaaatttctgagctttatgatctgtggaaatttggaatgaaatgcaattcattttgtacatacatagtatattaaaactatataatagttcatagaaatgttcagtaatgaaaaatatatccaatcagagccatccctaaagagtgttctcttgtcttcctttgtatcctctttggctccttcccttagcttccaccccagacatcagacctggggctgccttctctccctgccaaagcttgctgttagcattgtctgcttgccctcaactcctgccttgttccctgttgaaatgtatcaatcccgtactttatctctccaggacaaggataagtgtggctacagtaaaagtttattgctctaaacggcgctaacctgagataatgagaaaaggccagaagagattgtttgatctctgtctgtcaatatatatgcatttcaactgtgaccatctggatccagggccctttctaacctatataacgactcatttgtttggttaatgatgaatatcactggggctcttaagtcctttcgttctatccaagacttcattgtttttttctgtatgaaaaaagtgcagaatatcactcacctttcccctacttttggatcccctacacgaggatcactagcttaatgagaagcagagtaacgctattaagtctgggcaagctccttataagttgctgtgtgcttaaaagaatgtgatttatgtctggggccaaagcagttttccttcttttccctcattgaattcaagacagctagacccttgtgtagatcccaggatattacctctactccccccaacctgtgtgtgtagggagagtaacaacacgggaagaggggagggaagttggaaggagattggtcacatgttcagttgtctgagatactggtaaatgtgcgctgtttgtcaatgaaggttgcatgcctgcatttacaaggtggtctcatactgattgtgctctgtccagttagattcgtggcttctcccttggaagctacaattaaggactagttagaagcagaggctagatgtgttctctccagcccttactaactgggaaaataattgagaaatccctcttttcctcagtgaaagcccagtcattggttagaaaaatctaattgtcaaactagcattatgttccatcatatctgtgggatagtaattcatgtaagacacatttttacctctcttacaagtcaattcacttacaagccagtttcaaatcaagcttcccttgcgaggaatggagatcattatggggcttattatgactacatttcttttatgagtgaccattttaaataattaatattttatttaatattaaattattaaagacttagctagacttttaacattagatgaaccttgtgaatcatatattgcatagattagcacatgtatgcaatctaggtcatcaatttgttgaatttatacagccctagatttgagattgtggccctgagtatctggatagttgagttgtgtgtttatgtgcttatatgatagaggtgctttgttcctgcagcttagaaacagaagcagccattcactgagaagcttaagagaggaagtatcaacctcattttccaaaccagcattactttcaccgctcgtggatctgaaagattacatttagaacatttagtactattacactctcagaaactgtggtaaaaagtcacattttcaaaacttcatgcatattgtattcttgttggaaataagtcctatagtttcttaattgtcttcatgccgtccatatttaacaaacattgcaagtcctttttatatttgggtaattatttgtaatttagtgaaggagactaggggatgttttcttccaaagggaatttaaaatcaattttatggtattttgaaagtaaaatactccttaacgtgtcaatatttttaaaatgttatctcgaagttttctattgctcaggtatataatctaataaaattttttgtttgctctaaggttatttttgctattctctattttgaattatgttaaaatttgtgtgcattttatgaaatgccttttttcttattttgaaagtgtaaaattgggcatctcagagtaaaatgtgggattattagctacaaagactaggcacatcgtgaaagctcagtaactaattttcttgactgagtcctatcccagagtgtcacagattcaacagaattttcctgaagggtgatacacaccaaaatctagcttgtgtggatctgagactattgactcaaagattcaaatctacttcggaagtgactccacggtttgagtgaaaactgaggaaggactcatgcctgtatatcactagatatcttatttctccataattttaagtgttcataatttcttcttctttgatgggtgtgcaactggggcatgtttgtaccagccagcatgtgttctgcccaacagtgtgtccgtgtgtgaggttaactgattcagaactcattctcttgataaactatttcttgaaagcatttattttaagtctttatttcctgctgaaatgaagtttcatgctgtcatgcccatcttatttattctagaagaaaattttcatagaagaaaatgatttatggccaaagttacagaacattcatcttttagacttagccttagaatatcattggaaattacttggcttgaatttggttcgtttttatctttatggattatgtaccagggctattaataatacttaaaccccttattttgctatggtggttagatttttttattccttttcaattagtgctattaattattacatggtcgtattcatgcttattacagatgaactatttttagtgccagtgtaaaggattaagaataacattcaattagttggctatttcaggctttattgtacatggtaatgtttcagggagtgtgatttggtctagaatatatccagatccttgtaattatgatattgggttatgacaggattctattatttttagctatgaatggtgcttatttttccctatattaggaatgttaatatttggattatcagagtccatgttataaacagaatttacctatgcaagacaaattctaactgtgcaacattttcatgagaattaaaagttgtgtgttaaggggaaaaccctctgaatgtttttatgtgtaagtgcctaaagaaccgtagaaacagtacatcaaaagctcttataaaagaaaaactgattgaacattagccagaaacaaaatatgatttacatttttttttttggttgctgggactgaataccctaaaaactaagagatgtgagtggggaaaatgtctaattgataagaaagttgatttatattatatttacatgcatcttctaagattgcctttacagtagccaatcagaactttaaaaaaaaaaaagctaacaacatagatcctatgtgttgcccttaagactaaaatactttgcacacgtgattgaatggctcacttaagttgttgaatttccttatacatttaaagtgtacttccgttaagaattattccattttaaatgggtaactttcagcttccgaactattttcctaaacattccagttgtgtattataaaagatcaaaatatctctaggtggtagtacaattttcatttataacgtggaaaagttaactgttaggtttaacattagtattagtgtttttgcaattgctcatagaaaagaacactgaataatggttttcatacaatttttgtaaaacattcttctcccagtttgattccaaatgcttttccccaaattgtctaatatatcataagctagtgtttccttgtatttaatttttccttccaacacaatatttaggaaaaatatgaataacattgtgagtagcgggagacaacacgaaaaagaaacctttcattgttgtggaggggtaggtgttatgtgattgatgcccttcctggcgtttgttttatcctgttattttctcaaaaaagagcacggctttttcttaaatacatttaaattcagaattgcttgcaaaagattggcctggatagatagacatcctagatttaagatagtaccatcttaaaagtatgttgaaaggtaaaataaatcatttcaaaatacttaactttcctaataaggatgttaggttttcttctctttcattagctggccataagtcaaggtccttataacactaggaaattacctttttttactttcaaaattgcattatagtgaattactgtttacaaaatacacatactgtgaacagatataagtttctgtcttttataaggtttgtagaatgaatgtttttttaaagtgagtattatatgttaaatattttaagttttttataaatactagtaactgtttactaatttttgtttggtcaaatgcttgtaaatgtagctgaaagaagatagggagaaactgcggatcccaaactgttccctttttcatttcttgaaatgttaccactacagacatttttttaaggtgaataaacagttgtgatgtgctgtacctaaaatcatgtttaatcgtataaggaaacatttcaatacacttatacaggaagaaaactatagatgaagtacatgtgtgtgattcagtctgattcacagaattctgagagtaatatggaataaaacaactccacttagatgataactgaagcatttcctgccttgtgaaaatttggattttaaattgctgttagaatgggaaatttggacactttatatcattgtataatttcagaatttagtttctgtatcttttggaaaacatgattatagcaaaaacatagaaaataatctattactaaaacaccataaatgtaaaactagtatgcttggctgttaactctaaagatgttacttatgtctgtttttaaaacatgcatgtatttaacaattttatcatagtattgtcatggaaaaaataaatatattttcttacatcttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3977 -> Molecular function: GO:0004897 [ciliary neurotrophic factor receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0004923 [leukemia inhibitory factor receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0004924 [oncostatin-M receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0005127 [ciliary neurotrophic factor receptor binding] evidence: IPI
GeneID:3977 -> Molecular function: GO:0019838 [growth factor binding] evidence: IPI
GeneID:3977 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:3977 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:3977 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0034097 [response to cytokine stimulus] evidence: IDA
GeneID:3977 -> Biological process: GO:0038165 [oncostatin-M-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0048861 [leukemia inhibitory factor signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:3977 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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