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2024-04-24 06:18:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002305 586 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens lectin, galactoside-binding, soluble, 1 (LGALS1),
mRNA.
ACCESSION NM_002305
VERSION NM_002305.3 GI:85815826
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 586)
AUTHORS Ouyang,J., Plutschow,A., Pogge von Strandmann,E., Reiners,K.S.,
Ponader,S., Rabinovich,G.A., Neuberg,D., Engert,A. and Shipp,M.A.
TITLE Galectin-1 serum levels reflect tumor burden and adverse clinical
features in classical Hodgkin lymphoma
JOURNAL Blood 121 (17), 3431-3433 (2013)
PUBMED 23444403
REMARK GeneRIF: High Galectin-1 expression is associated with Hodgkin
lymphoma.
REFERENCE 2 (bases 1 to 586)
AUTHORS Hiramatsu,H., Takeuchi,K. and Takeuchi,H.
TITLE Involvement of histidine residues in the pH-dependent
beta-galactoside binding activity of human galectin-1
JOURNAL Biochemistry 52 (13), 2371-2380 (2013)
PUBMED 23510298
REMARK GeneRIF: The pH dependence of the beta-galactoside binding activity
of human galectin-1 (hGal-1) was investigated by fluorescence
spectroscopy using lactose as a ligand.
REFERENCE 3 (bases 1 to 586)
AUTHORS Jouve,N., Despoix,N., Espeli,M., Gauthier,L., Cypowyj,S.,
Fallague,K., Schiff,C., Dignat-George,F., Vely,F. and Leroyer,A.S.
TITLE The involvement of CD146 and its novel ligand Galectin-1 in
apoptotic regulation of endothelial cells
JOURNAL J. Biol. Chem. 288 (4), 2571-2579 (2013)
PUBMED 23223580
REMARK GeneRIF: CD146 and its novel ligand Galectin-1 in apoptotic
regulation of endothelial cells
REFERENCE 4 (bases 1 to 586)
AUTHORS Seropian,I.M., Cerliani,J.P., Toldo,S., Van Tassell,B.W.,
Ilarregui,J.M., Gonzalez,G.E., Matoso,M., Salloum,F.N.,
Melchior,R., Gelpi,R.J., Stupirski,J.C., Benatar,A., Gomez,K.A.,
Morales,C., Abbate,A. and Rabinovich,G.A.
TITLE Galectin-1 controls cardiac inflammation and ventricular remodeling
during acute myocardial infarction
JOURNAL Am. J. Pathol. 182 (1), 29-40 (2013)
PUBMED 23142379
REMARK GeneRIF: Galectin-1 controls cardiac inflammation and ventricular
remodeling during acute myocardial infarction.
REFERENCE 5 (bases 1 to 586)
AUTHORS Elantak,L., Espeli,M., Boned,A., Bornet,O., Bonzi,J., Gauthier,L.,
Feracci,M., Roche,P., Guerlesquin,F. and Schiff,C.
TITLE Structural basis for galectin-1-dependent pre-B cell receptor
(pre-BCR) activation
JOURNAL J. Biol. Chem. 287 (53), 44703-44713 (2012)
PUBMED 23124203
REMARK GeneRIF: Hhydrophobic residues from the lambda5-UR is crucial for
the interaction with GAL1 and for pre-BCR clustering.
REFERENCE 6 (bases 1 to 586)
AUTHORS Dawson,S.J. and White,L.A.
TITLE Treatment of Haemophilus aphrophilus endocarditis with
ciprofloxacin
JOURNAL J. Infect. 24 (3), 317-320 (1992)
PUBMED 1602151
REFERENCE 7 (bases 1 to 586)
AUTHORS Goldstone,S.D. and Lavin,M.F.
TITLE Isolation of a cDNA clone, encoding a human beta-galactoside
binding protein, overexpressed during glucocorticoid-induced cell
death
JOURNAL Biochem. Biophys. Res. Commun. 178 (2), 746-750 (1991)
PUBMED 1713454
REFERENCE 8 (bases 1 to 586)
AUTHORS Gitt,M.A. and Barondes,S.H.
TITLE Genomic sequence and organization of two members of a human lectin
gene family
JOURNAL Biochemistry 30 (1), 82-89 (1991)
PUBMED 1988031
REFERENCE 9 (bases 1 to 586)
AUTHORS Allen,H.J., Sucato,D., Gottstine,S., Kisailus,E., Nava,H.,
Petrelli,N., Castillo,N. and Wilson,D.
TITLE Localization of endogenous beta-galactoside-binding lectin in human
cells and tissues
JOURNAL Tumour Biol. 12 (1), 52-60 (1991)
PUBMED 1996404
REFERENCE 10 (bases 1 to 586)
AUTHORS Sharma,A., Chemelli,R. and Allen,H.J.
TITLE Human splenic galaptin: physicochemical characterization
JOURNAL Biochemistry 29 (22), 5309-5314 (1990)
PUBMED 2383549
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CR456511.1 and BC020675.1.
On Jan 27, 2006 this sequence version replaced gi:6006015.
Summary: The galectins are a family of beta-galactoside-binding
proteins implicated in modulating cell-cell and cell-matrix
interactions. This gene product may act as an autocrine negative
growth factor that regulates cell proliferation. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC020675.1, AV716614.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-30 CR456511.1 1-30
31-586 BC020675.1 1-556
FEATURES Location/Qualifiers
source 1..586
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13.1"
gene 1..586
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="lectin, galactoside-binding, soluble, 1"
/db_xref="GeneID:3956"
/db_xref="HGNC:6561"
/db_xref="HPRD:01040"
/db_xref="MIM:150570"
exon 1..106
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/inference="alignment:Splign:1.39.8"
variation 22..23
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace=""
/replace="g"
/db_xref="dbSNP:34671258"
variation 32..33
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace=""
/replace="tc"
/db_xref="dbSNP:112965625"
misc_feature 53..55
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="upstream in-frame stop codon"
variation 53
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:192445904"
variation 56
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="g"
/db_xref="dbSNP:374232144"
variation 66
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:369718469"
variation 95
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:12403"
CDS 98..505
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="galectin 1; beta-galactoside-binding lectin L-14-I;
lactose-binding lectin 1; galaptin; S-Lac lectin 1; HBL;
HPL; gal-1; HLBP14; 14 kDa lectin; 14 kDa laminin-binding
protein; putative MAPK-activating protein PM12;
beta-galactoside-binding protein 14kDa"
/codon_start=1
/product="galectin-1"
/protein_id="NP_002296.1"
/db_xref="GI:4504981"
/db_xref="CCDS:CCDS13954.1"
/db_xref="GeneID:3956"
/db_xref="HGNC:6561"
/db_xref="HPRD:01040"
/db_xref="MIM:150570"
/translation="
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
"
misc_feature 128..493
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="Galectin/galactose-binding lectin. This domain
exclusively binds beta-galactosides, such as lactose, and
does not require metal ions for activity. GLECT domains
occur as homodimers or tandemly repeated domains. They are
developmentally regulated and may...; Region: GLECT;
cd00070"
/db_xref="CDD:28952"
misc_feature order(134..142,149..151,158..160,368..376,389..391,
395..397,404..406)
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="putative alternate dimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:28952"
misc_feature 182..184
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09382.2); acetylation site"
misc_feature order(230..232,236..238,242..244,275..277,281..283,
302..304,311..313,317..319)
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/note="sugar binding pocket [chemical binding]; other
site"
/db_xref="CDD:28952"
misc_feature 230..244
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09382.2);
Region: Beta-galactoside binding"
misc_feature 302..313
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09382.2);
Region: Beta-galactoside binding"
variation 99
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:376111007"
variation 105
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:113281514"
exon 107..186
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/inference="alignment:Splign:1.39.8"
variation 139
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:138764984"
variation 144
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:11539852"
exon 187..358
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/inference="alignment:Splign:1.39.8"
variation 199
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:376124582"
variation 200
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539849"
variation 205
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:111593545"
variation 226
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:12251"
variation 242
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:370290813"
variation 243
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:111700736"
variation 259
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="g"
/db_xref="dbSNP:11539854"
variation 260
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374050221"
variation 262
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:35767287"
variation 268
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="c"
/db_xref="dbSNP:3208174"
variation 293
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:146257010"
variation 295
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:11539847"
variation 304
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:4887"
variation 310
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:4888"
variation 311
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:139136100"
variation 317
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:112573932"
STS 323..477
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/standard_name="RH48064"
/db_xref="UniSTS:4997"
variation 345
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:11539856"
exon 359..558
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/inference="alignment:Splign:1.39.8"
variation 370
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:375421612"
variation 373
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:370097853"
variation 386
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="c"
/db_xref="dbSNP:143963392"
variation 387
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539850"
variation 391
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:371661457"
variation 392
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:375290542"
STS 397..546
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/standard_name="WI-18867"
/db_xref="UniSTS:12186"
variation 409
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="t"
/db_xref="dbSNP:183894785"
variation 412
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:369424642"
variation 414
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:148625706"
variation 432
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:143385179"
variation 433
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="c"
/db_xref="dbSNP:1803902"
variation 443
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="g"
/db_xref="dbSNP:11704758"
variation 447
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="g"
/db_xref="dbSNP:372067495"
variation 448
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:375124422"
variation 469
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:144209959"
variation 496
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539857"
variation 498
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:11539846"
polyA_signal 528..533
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
variation 529
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="a"
/replace="g"
/db_xref="dbSNP:369951070"
variation 530
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="c"
/replace="t"
/db_xref="dbSNP:199692081"
variation 553
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="g"
/replace="t"
/db_xref="dbSNP:113159676"
variation 555
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
/replace="g"
/replace="t"
/db_xref="dbSNP:111729117"
polyA_site 558
/gene="LGALS1"
/gene_synonym="GAL1; GBP"
ORIGIN
agttaaaagggtgggagcgtccgggggcccatctctctcgggtggagtcttctgacagctggtgcgcctgcccgggaacatcctcctggactcaatcatggcttgtggtctggtcgccagcaacctgaatctcaaacctggagagtgccttcgagtgcgaggcgaggtggctcctgacgctaagagcttcgtgctgaacctgggcaaagacagcaacaacctgtgcctgcacttcaaccctcgcttcaacgcccacggcgacgccaacaccatcgtgtgcaacagcaaggacggcggggcctgggggaccgagcagcgggaggctgtctttcccttccagcctggaagtgttgcagaggtgtgcatcaccttcgaccaggccaacctgaccgtcaagctgccagatggatacgaattcaagttccccaaccgcctcaacctggaggccatcaactacatggcagctgacggtgacttcaagatcaaatgtgtggcctttgactgaaatcagccagcccatggcccccaataaaggcagctgcctctgctccctctgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3956 -> Molecular function: GO:0001948 [glycoprotein binding] evidence: IEA
GeneID:3956 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IMP
GeneID:3956 -> Molecular function: GO:0016936 [galactoside binding] evidence: IEA
GeneID:3956 -> Molecular function: GO:0030395 [lactose binding] evidence: IEA
GeneID:3956 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
GeneID:3956 -> Molecular function: GO:0043236 [laminin binding] evidence: IEA
GeneID:3956 -> Biological process: GO:0002317 [plasma cell differentiation] evidence: IEA
GeneID:3956 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:3956 -> Biological process: GO:0007165 [signal transduction] evidence: IMP
GeneID:3956 -> Biological process: GO:0010812 [negative regulation of cell-substrate adhesion] evidence: IEA
GeneID:3956 -> Biological process: GO:0010977 [negative regulation of neuron projection development] evidence: IEA
GeneID:3956 -> Biological process: GO:0031295 [T cell costimulation] evidence: IEA
GeneID:3956 -> Biological process: GO:0033555 [multicellular organismal response to stress] evidence: IEA
GeneID:3956 -> Biological process: GO:0034120 [positive regulation of erythrocyte aggregation] evidence: IEA
GeneID:3956 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:3956 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:3956 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:3956 -> Biological process: GO:0045445 [myoblast differentiation] evidence: IEA
GeneID:3956 -> Biological process: GO:0048678 [response to axon injury] evidence: IEA
GeneID:3956 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:3956 -> Biological process: GO:0071407 [cellular response to organic cyclic compound] evidence: IEA
GeneID:3956 -> Cellular component: GO:0005578 [proteinaceous extracellular matrix] evidence: IEA
GeneID:3956 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:3956 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
GeneID:3956 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:3956 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:3956 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
GeneID:3956 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
GeneID:3956 -> Cellular component: GO:0031012 [extracellular matrix] evidence: ISS
by
@meso_cacase at
DBCLS
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