GGRNA Home | Help | Advanced search

2024-03-29 19:33:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002273               1802 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA.
ACCESSION   NM_002273
VERSION     NM_002273.3  GI:196162709
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Fortier,A.M., Asselin,E. and Cadrin,M.
  TITLE     Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation
  JOURNAL   J. Biol. Chem. 288 (16), 11555-11571 (2013)
   PUBMED   23449973
  REMARK    GeneRIF: K8/18 expression can influence the phenotype of epithelial
            cancer cells at a transcriptional level and supports the hypothesis
            that keratins play an active role in cancer progression.
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
  TITLE     Keratin 8/18 regulation of glucose metabolism in normal versus
            cancerous hepatic cells through differential modulation of
            hexokinase status and insulin signaling
  JOURNAL   Exp. Cell Res. 319 (4), 474-486 (2013)
   PUBMED   23164509
  REMARK    GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
            and cancerous hepatic cells through differential modulations of
            mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
            Omary,M.B.
  TITLE     Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
            by lysine acetylation
  JOURNAL   J. Cell Biol. 200 (3), 241-247 (2013)
   PUBMED   23358244
  REMARK    GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
            among type II keratins, is up-regulated upon hyperglycemia and
            down-regulated by SIRT2.
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
            Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
  TITLE     Understanding the role of keratins 8 and 18 in neoplastic potential
            of breast cancer derived cell lines
  JOURNAL   PLoS ONE 8 (1), E53532 (2013)
   PUBMED   23341946
  REMARK    GeneRIF: These results indicate the role of K8/18 in modulating
            invasion in breast cancer.
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
  TITLE     An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
            expression in breast papillomas and papillary carcinomas
  JOURNAL   Diagn Pathol 8, 8 (2013)
   PUBMED   23327593
  REMARK    GeneRIF: Report keratin 8 expression in breast papillomas and
            papillary carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
            Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
  TITLE     Distribution of individual components of basement membrane in human
            colon polyps and adenocarcinomas as revealed by monoclonal
            antibodies
  JOURNAL   Int. J. Cancer 50 (4), 562-566 (1992)
   PUBMED   1371500
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
  TITLE     Embryonic simple epithelial keratins 8 and 18: chromosomal location
            emphasizes difference from other keratin pairs
  JOURNAL   New Biol. 2 (5), 464-478 (1990)
   PUBMED   1705144
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
  TITLE     Cloning and sequence of cDNA for human placental cytokeratin 8.
            Regulation of the mRNA in trophoblastic cells by cAMP
  JOURNAL   Mol. Endocrinol. 4 (3), 370-374 (1990)
   PUBMED   1692965
REFERENCE   9  (bases 1 to 1802)
  AUTHORS   Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
            Lane,B., Leigh,I. and Vooijs,P.
  TITLE     Changing patterns of keratin expression during progression of
            cervical intraepithelial neoplasia
  JOURNAL   Am. J. Pathol. 136 (3), 657-668 (1990)
   PUBMED   1690513
REFERENCE   10 (bases 1 to 1802)
  AUTHORS   Krauss,S. and Franke,W.W.
  TITLE     Organization and sequence of the human gene encoding cytokeratin 8
  JOURNAL   Gene 86 (2), 241-249 (1990)
   PUBMED   1691124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA825311.1, BC075839.1 and
            BE300986.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Aug 15, 2008 this sequence version replaced gi:68226427.
            
            Summary: This gene is a member of the type II keratin family
            clustered on the long arm of chromosome 12. Type I and type II
            keratins heteropolymerize to form intermediate-sized filaments in
            the cytoplasm of epithelial cells. The product of this gene
            typically dimerizes with keratin 18 to form an intermediate
            filament in simple single-layered epithelial cells. This protein
            plays a role in maintaining cellular structural integrity and also
            functions in signal transduction and cellular differentiation.
            Mutations in this gene cause cryptogenic cirrhosis. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation in a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and
            3 encode the same isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222941.1, BC063513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DA825311.1         2-56
            56-1758             BC075839.1         1-1703
            1759-1802           BE300986.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1802
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="keratin 8"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="HPRD:01015"
                     /db_xref="MIM:148060"
     exon            1..427
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    14..16
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="upstream in-frame stop codon"
     variation       34
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2070910"
     variation       82..83
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554493"
     variation       100
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065306"
     CDS             104..1555
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="isoform 2 is encoded by transcript variant 2;
                     keratin, type II cytoskeletal 8; cytokeratin 8;
                     cytokeratin-8; type-II keratin Kb8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 8 isoform 2"
                     /protein_id="NP_002264.1"
                     /db_xref="GI:4504919"
                     /db_xref="CCDS:CCDS8841.1"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="HPRD:01015"
                     /db_xref="MIM:148060"
                     /translation="
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
"
     misc_feature    104..373
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Head"
     misc_feature    128..130
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC/PRKCE; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    164..166
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    164..166
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    167..169
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    173..175
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC/PRKCE; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    173..175
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    176..178
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    182..184
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    182..184
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    203..205
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    203..205
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    209..211
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    212..214
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    212..214
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    212..214
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    230..232
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    230..232
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    323..325
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by MAPK; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    323..325
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01496"
     misc_feature    323..325
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02619"
     misc_feature    323..325
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03100"
     misc_feature    323..325
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03479"
     misc_feature    371..1282
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:200948"
     misc_feature    374..1297
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Rod"
     misc_feature    374..481
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 1A"
     misc_feature    404..406
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-malonyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); modified site"
     misc_feature    452..454
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    482..532
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Linker 1"
     misc_feature    533..808
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 1B"
     misc_feature    713..715
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    722..724
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    809..880
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Linker 12"
     misc_feature    860..862
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    875..877
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    881..1297
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 2"
     misc_feature    884..1249
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Necessary for interaction with PNN"
     misc_feature    902..904
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    986..988
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1076..1078
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1091..1093
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1091..1093
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1127..1129
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); other site"
     misc_feature    1142..1144
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1298..1552
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Tail"
     misc_feature    1301..1303
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1331..1333
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1397..1399
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CaMK2 and MAPK; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    1397..1399
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03479"
     misc_feature    1454..1456
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1526..1528
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1526..1528
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1535..1537
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1535..1537
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       155
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554484"
     variation       214
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554498"
     variation       223
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554488"
     variation       354
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554494"
     variation       367
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554492"
     variation       370
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554497"
     exon            428..636
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            637..697
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            698..793
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            794..1084
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       812
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554490"
     variation       908
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554280"
     variation       939
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554499"
     variation       950
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554487"
     variation       1027
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1065311"
     variation       1059
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554486"
     variation       1061
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554483"
     exon            1085..1305
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       1102
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7750"
     variation       1178
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57626370"
     variation       1207
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1065362"
     exon            1306..1364
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1310..1716
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="GDB:277179"
                     /db_xref="UniSTS:156366"
     exon            1365..1796
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1368..1785
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="KRT8_7288"
                     /db_xref="UniSTS:466264"
     variation       1461
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554491"
     STS             1493..1728
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="D17S1697"
                     /db_xref="UniSTS:153850"
     STS             1495..1742
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH79790"
                     /db_xref="UniSTS:88364"
     STS             1509..1634
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH47175"
                     /db_xref="UniSTS:57916"
     variation       1653
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1065710"
     polyA_signal    1767..1772
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
     polyA_site      1796
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN      
aaaaggccattcctgagagctctcctcaccaagaagcagcttctccgctccttctaggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
            GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
            GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
            GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
            GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.