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2024-04-27 09:26:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002265 4276 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens karyopherin (importin) beta 1 (KPNB1), transcript
variant 1, mRNA.
ACCESSION NM_002265
VERSION NM_002265.5 GI:449784877
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4276)
AUTHORS Desmond,C.R., Atwal,R.S., Xia,J. and Truant,R.
TITLE Identification of a karyopherin beta1/beta2 proline-tyrosine
nuclear localization signal in huntingtin protein
JOURNAL J. Biol. Chem. 287 (47), 39626-39633 (2012)
PUBMED 23012356
REMARK GeneRIF: Identification of a karyopherin beta1/beta2
proline-tyrosine nuclear localization signal in huntingtin protein.
REFERENCE 2 (bases 1 to 4276)
AUTHORS Zhen,Y., Sorensen,V., Skjerpen,C.S., Haugsten,E.M., Jin,Y.,
Walchli,S., Olsnes,S. and Wiedlocha,A.
TITLE Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and
the importins Kpnalpha1 and Kpnbeta1
JOURNAL Traffic 13 (5), 650-664 (2012)
PUBMED 22321063
REMARK GeneRIF: LRRC59 facilitates transport of cytosolic FGF1 through
nuclear pores by interaction with Kpns and movement of LRRC59 along
the ER and NE membranes
REFERENCE 3 (bases 1 to 4276)
AUTHORS Depping,R., Schindler,S.G., Jacobi,C., Kirschner,K.M. and Scholz,H.
TITLE Nuclear transport of Wilms' tumour protein Wt1 involves importins
alpha and beta
JOURNAL Cell. Physiol. Biochem. 29 (1-2), 223-232 (2012)
PUBMED 22415091
REMARK GeneRIF: Nuclear translocation of Wilms' tumour protein involves
importins alpha and beta, and a nuclear localisation signal in the
third zinc finger
REFERENCE 4 (bases 1 to 4276)
AUTHORS Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J,
Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalban J,
Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S,
Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D,
Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M,
Booth DR, Broadley S, Brown MA, Browning BL, Browning SR,
Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode
AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P,
Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee
M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E,
Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL,
McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De
Jager PL, Hafler DA and de Bakker PI.
CONSRTM Bayer Pharma MS Genetics Working Group; Steering Committees of
Studies Evaluating IFNbeta-1b and a CCR1-Antagonist; ANZgene
Consortium; GeneMSA; International Multiple Sclerosis Genetics
Consortium
TITLE Genome-wide meta-analysis identifies novel multiple sclerosis
susceptibility loci
JOURNAL Ann. Neurol. 70 (6), 897-912 (2011)
PUBMED 22190364
REFERENCE 5 (bases 1 to 4276)
AUTHORS van der Watt,P.J., Ngarande,E. and Leaner,V.D.
TITLE Overexpression of Kpnbeta1 and Kpnalpha2 importin proteins in
cancer derives from deregulated E2F activity
JOURNAL PLoS ONE 6 (11), E27723 (2011)
PUBMED 22125623
REMARK GeneRIF: Findings suggest that the deregulated activity of E2F in
cancer cells causes increased activation of the Kpnbeta1 and
Kpnalpha2 promoters, leading to elevated levels of these proteins,
and ultimately impacting the cancer phenotype.
REFERENCE 6 (bases 1 to 4276)
AUTHORS O'Neill,R.E., Jaskunas,R., Blobel,G., Palese,P. and Moroianu,J.
TITLE Nuclear import of influenza virus RNA can be mediated by viral
nucleoprotein and transport factors required for protein import
JOURNAL J. Biol. Chem. 270 (39), 22701-22704 (1995)
PUBMED 7559393
REFERENCE 7 (bases 1 to 4276)
AUTHORS Chi,N.C., Adam,E.J. and Adam,S.A.
TITLE Sequence and characterization of cytoplasmic nuclear protein import
factor p97
JOURNAL J. Cell Biol. 130 (2), 265-274 (1995)
PUBMED 7615630
REFERENCE 8 (bases 1 to 4276)
AUTHORS Gorlich,D., Kostka,S., Kraft,R., Dingwall,C., Laskey,R.A.,
Hartmann,E. and Prehn,S.
TITLE Two different subunits of importin cooperate to recognize nuclear
localization signals and bind them to the nuclear envelope
JOURNAL Curr. Biol. 5 (4), 383-392 (1995)
PUBMED 7627554
REFERENCE 9 (bases 1 to 4276)
AUTHORS Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
TITLE Active nuclear import of human immunodeficiency virus type 1
preintegration complexes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (14), 6580-6584 (1992)
PUBMED 1631159
REFERENCE 10 (bases 1 to 4276)
AUTHORS Mukaigawa,J. and Nayak,D.P.
TITLE Two signals mediate nuclear localization of influenza virus
(A/WSN/33) polymerase basic protein 2
JOURNAL J. Virol. 65 (1), 245-253 (1991)
PUBMED 1985200
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB083013.1, BC036703.2,
BQ009884.1, AC015674.12 and AI076614.1.
On Feb 13, 2013 this sequence version replaced gi:24797084.
Summary: Nucleocytoplasmic transport, a signal- and
energy-dependent process, takes place through nuclear pore
complexes embedded in the nuclear envelope. The import of proteins
containing a nuclear localization signal (NLS) requires the NLS
import receptor, a heterodimer of importin alpha and beta subunits
also known as karyopherins. Importin alpha binds the NLS-containing
cargo in the cytoplasm and importin beta docks the complex at the
cytoplasmic side of the nuclear pore complex. In the presence of
nucleoside triphosphates and the small GTP binding protein Ran, the
complex moves into the nuclear pore complex and the importin
subunits dissociate. Importin alpha enters the nucleoplasm with its
passenger protein and importin beta remains at the pore.
Interactions between importin beta and the FG repeats of
nucleoporins are essential in translocation through the pore
complex. The protein encoded by this gene is a member of the
importin beta family. Two transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Feb
2013].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: L38951.1, BC036703.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-100 DB083013.1 1-100
101-3323 BC036703.2 1-3223
3324-3742 BQ009884.1 1-419 c
3743-3922 AC015674.12 113700-113879 c
3923-4276 AI076614.1 1-354 c
FEATURES Location/Qualifiers
source 1..4276
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.32"
gene 1..4276
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="karyopherin (importin) beta 1"
/db_xref="GeneID:3837"
/db_xref="HGNC:6400"
/db_xref="HPRD:04114"
/db_xref="MIM:602738"
exon 1..447
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 45
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:7210381"
variation 93
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:370079188"
variation 98
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:183804084"
variation 147
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="c"
/db_xref="dbSNP:374694042"
variation 165
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:372612441"
misc_feature 282..284
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="upstream in-frame stop codon"
variation 355
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:2277612"
variation 384
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:369383347"
variation 388
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:373283700"
CDS 408..3038
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="isoform 1 is encoded by transcript variant 1;
importin 1; nuclear factor p97; importin 90; importin
beta-1 subunit; importin subunit beta-1; PTAC97;
importin-90; karyopherin subunit beta-1; pore targeting
complex 97 kDa subunit"
/codon_start=1
/product="importin subunit beta-1 isoform 1"
/protein_id="NP_002256.2"
/db_xref="GI:19923142"
/db_xref="CCDS:CCDS11513.1"
/db_xref="GeneID:3837"
/db_xref="HGNC:6400"
/db_xref="HPRD:04114"
/db_xref="MIM:602738"
/translation="
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
"
misc_feature 408..410
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (Q14974.2); acetylation site"
misc_feature 411..3020
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="Karyopherin (importin) beta [Intracellular
trafficking and secretion]; Region: KAP95; COG5215"
/db_xref="CDD:34812"
misc_feature 441..443
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14974.2); phosphorylation site"
misc_feature 468..710
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="Importin-beta N-terminal domain; Region: IBN_N;
pfam03810"
/db_xref="CDD:202774"
misc_feature 777..896
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 1"
misc_feature 909..1028
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 2"
misc_feature 1038..1040
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate; propagated from
UniProtKB/Swiss-Prot (Q14974.2); acetylation site"
misc_feature 1044..1157
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 3"
misc_feature 1356..1478
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 4"
misc_feature 1392..1433
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: IAB-binding"
misc_feature 1407..1664
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: Ran-GTP binding"
misc_feature 1500..1838
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature order(1557..1559,1569..1571,1581..1583,1674..1676,
1686..1688,1695..1697,1707..1709,1812..1814,1821..1823,
1830..1835)
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 1617..1730
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 6"
misc_feature 2211..2330
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 7"
misc_feature 2466..2585
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14974.2);
Region: HEAT 8"
misc_feature 2910..2912
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q14974.2); acetylation site"
misc_feature 3006..3008
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q14974.2); acetylation site"
variation 419
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="c"
/db_xref="dbSNP:199714840"
exon 448..506
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 494
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:371171060"
exon 507..689
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 596
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:367812711"
variation 602
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:372728539"
variation 615
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:61750353"
variation 618
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:199885874"
variation 623
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:371998597"
variation 654
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:200458673"
variation 689
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:372937397"
exon 690..890
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 698
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:1136612"
variation 710
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:201367880"
variation 816
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:74482416"
variation 818
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:192361570"
variation 824
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:145422566"
variation 835
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:147688413"
variation 854
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:200123721"
variation 858
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:149173509"
variation 869
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:200692809"
variation 884
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:199518298"
exon 891..1043
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 905
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:370600841"
variation 926
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:143335705"
variation 983
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:375360850"
variation 992
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:1136613"
exon 1044..1103
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
exon 1104..1193
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1155
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:140578762"
exon 1194..1304
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1199
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:145900699"
variation 1284..1285
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="c"
/db_xref="dbSNP:35203825"
exon 1305..1406
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1322
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:137864253"
variation 1361
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:142374321"
variation 1364
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:145950162"
exon 1407..1631
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1418
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:369246693"
variation 1421
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:369957359"
variation 1448
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:138445847"
variation 1454
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:373998655"
variation 1455..1456
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="g"
/db_xref="dbSNP:35984944"
variation 1461
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:149283729"
variation 1548
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:199957614"
exon 1632..1823
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1703
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:373504765"
variation 1712
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:377575686"
variation 1751
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:11540824"
variation 1770
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:373649777"
variation 1784
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:373754285"
exon 1824..1954
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1858
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:11540826"
variation 1861
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:186736441"
variation 1866
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:202234934"
exon 1955..2102
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 1955
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:11540825"
variation 2039
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:1136614"
variation 2057
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:111692950"
variation 2075
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:200182905"
variation 2096
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:371931503"
exon 2103..2174
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2112..2113
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="c"
/db_xref="dbSNP:34904500"
variation 2126
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:372705173"
exon 2175..2319
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2177
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:148458554"
variation 2207
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:180862063"
variation 2212
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:369233805"
variation 2252
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:145279930"
exon 2320..2402
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2366
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:150687408"
variation 2390
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:149068819"
exon 2403..2510
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2407
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="g"
/replace="t"
/db_xref="dbSNP:78999663"
variation 2433
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:56696965"
variation 2436
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:368599936"
variation 2441
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:72628350"
variation 2477
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:371651425"
exon 2511..2654
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2540
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:75547905"
variation 2579
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:145340584"
variation 2616
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="c"
/db_xref="dbSNP:147677268"
exon 2655..2760
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2693
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:139770498"
variation 2706..2707
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="g"
/db_xref="dbSNP:34896194"
variation 2724
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:200435017"
exon 2761..2875
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
STS 2809..2937
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/standard_name="STS-H47054"
/db_xref="UniSTS:79462"
variation 2828
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:61750354"
variation 2836
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:375622550"
variation 2845
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:11540827"
exon 2876..3037
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
variation 2897
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:149798768"
variation 2903
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:200805705"
variation 2996
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:373865263"
exon 3038..4272
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/inference="alignment:Splign:1.39.8"
STS 3043..3795
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/standard_name="KPNB1_2429"
/db_xref="UniSTS:280815"
variation 3093
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:78625504"
variation 3206
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:375423595"
variation 3212
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:186102346"
variation 3255
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:190866202"
variation 3256
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:370124590"
variation 3266
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:140734776"
variation 3357
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:8065792"
variation 3359
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="g"
/replace="t"
/db_xref="dbSNP:373034343"
variation 3381
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:8065920"
variation 3419
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:373333049"
variation 3499
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="c"
/db_xref="dbSNP:183449696"
STS 3509..3629
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/standard_name="RH68781"
/db_xref="UniSTS:84862"
variation 3567
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="t"
/db_xref="dbSNP:376451451"
variation 3605
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:143757780"
variation 3617
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:8070379"
variation 3624
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:59388318"
variation 3697
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:8070516"
variation 3701
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:8070520"
variation 3714
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="c"
/db_xref="dbSNP:1136638"
variation 3793..3794
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="t"
/db_xref="dbSNP:371366125"
variation 3806..3812
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="ggttttg"
/db_xref="dbSNP:370386449"
variation 3806..3807
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="gg"
/db_xref="dbSNP:147437271"
variation 3852
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:111736320"
variation 3922
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:12938318"
variation 3926..3927
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="ggc"
/db_xref="dbSNP:368942806"
variation 3929
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="g"
/db_xref="dbSNP:111909537"
variation 4002
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:377604528"
variation 4004
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:187761848"
variation 4009
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:370365372"
variation 4014
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:142967465"
STS 4059..4218
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/standard_name="SHGC-2553"
/db_xref="UniSTS:84945"
variation 4082
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:191906951"
variation 4103
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="g"
/replace="t"
/db_xref="dbSNP:79382496"
variation 4110
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="c"
/replace="t"
/db_xref="dbSNP:3200046"
variation 4116
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="g"
/db_xref="dbSNP:182928451"
STS 4180..4262
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/standard_name="D11S4360"
/db_xref="UniSTS:154700"
variation 4227
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace=""
/replace="a"
/db_xref="dbSNP:76100192"
polyA_signal 4229..4234
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
variation 4229
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
/replace="a"
/replace="t"
/db_xref="dbSNP:377171949"
polyA_site 4272
/gene="KPNB1"
/gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97"
ORIGIN
aacggccaatcgtcgtggagcgcggcgcctccgcggagaggtccggtccgaatatccctccgccttcctccctccctcgctccctccctgcgcgccgcctctcactcacagcctcccttccttctttctccctccgcctcccgagcaccagcgcgctctgagctgcccccagggtccctcccccgccgccagcagcccatttggagggaggaagtaagggaagaggagaggaaggggagccggaccgactacccagacagagccggtgaatgggtttgtggtgacccccgccccccaccccaccctcccttcccacccgacccccaacccccatccccagttcgagccgccgcccgaaaggccgggccgtcgtcttaggaggagtcgccgccgccgccacctccgccatggagctgatcaccattctcgagaagaccgtgtctcccgatcggctggagctggaagcggcgcagaagttcctggagcgtgcggccgtggagaacctgcccactttccttgtggaactgtccagagtgctggcaaatccaggaaacagtcaggttgccagagttgcagctggtctacaaatcaagaactctttgacatctaaagatccagatatcaaggcacaatatcagcagaggtggcttgctattgatgctaatgctcgacgagaagtcaagaactatgttttgcagacattgggtacagaaacttaccggcctagttctgcctcacagtgtgtggctggtattgcttgtgcagagatcccagtaaaccagtggccagaactcattcctcagctggtggccaatgtcacaaaccccaacagcacagagcacatgaaggagtcgacattggaagccatcggttatatttgccaagatatagacccagagcagctacaagataaatccaatgagattctgactgccataatccaggggatgaggaaagaagagcctagtaataatgtgaagctagctgctacgaatgcactcctgaactcattggagttcaccaaagcaaactttgataaagagtctgaaaggcactttattatgcaggtggtctgtgaagccacacagtgtccagatacgagggtacgagtggctgctttacagaatctggtgaagataatgtccttatattatcagtacatggagacatatatgggtcctgctctttttgcaatcacaatcgaagcaatgaaaagtgacattgatgaggtggctttacaagggatagaattctggtccaatgtctgtgatgaggaaatggatttggccattgaagcttcagaggcagcagaacaaggacggccccctgagcacaccagcaagttttatgcgaagggagcactacagtatctggttccaatcctcacacagacactaactaaacaggacgaaaatgatgatgacgatgactggaacccctgcaaagcagcaggggtgtgcctcatgcttctggccacctgctgtgaagatgacattgtcccacatgtcctccccttcattaaagaacacatcaagaacccagattggcggtaccgggatgcagcagtgatggcttttggttgtatcttggaaggaccagagcccagtcagctcaaaccactagttatacaggctatgcccaccctaatagaattaatgaaagaccccagtgtagttgttcgagatacagctgcatggactgtaggcagaatttgtgagctgcttcctgaagctgccatcaatgatgtctacttggctcccctgctacagtgtctgattgagggtctcagtgctgaacccagagtggcttcaaatgtgtgctgggctttctccagtctggctgaagctgcttatgaagctgcagacgttgctgatgatcaggaagaaccagctacttactgcttatcttcttcatttgaactcatagttcagaagctcctagagactacagacagacctgatggacaccagaacaacctgaggagttctgcatatgaatctctgatggaaattgtgaaaaacagtgccaaggattgttatcctgctgtccagaaaacgactttggtcatcatggaacgactgcaacaggttcttcagatggagtcacatatccagagcacatccgatagaatccagttcaatgaccttcagtctttactctgtgcaactcttcagaatgttcttcggaaagtgcaacatcaagatgctttgcagatctctgatgtggttatggcctccctgttaaggatgttccaaagcacagctgggtctgggggagtacaagaggatgccctgatggcagttagcacactggtggaagtgttgggtggtgaattcctcaagtacatggaggcctttaaacccttcctgggcattggattaaaaaattatgctgaataccaggtttgtttggcagctgtgggcttagtgggagacttgtgccgtgccctgcaatccaacatcatacctttctgtgacgaggtgatgcagctgcttctggaaaatttggggaatgagaacgtccacaggtctgtgaagccgcagattctgtcagtgtttggtgatattgcccttgctattggaggagagtttaaaaaatacttagaggttgtattgaatactcttcagcaggcctcccaagcccaggtggacaagtcagactatgacatggtggattatctgaatgagctaagggaaagctgcttggaagcctatactggaatcgtccagggattaaagggggatcaggagaacgtacacccggatgtgatgctggtacaacccagagtagaatttattctgtctttcattgaccacattgctggagatgaggatcacacagatggagtagtagcttgtgctgctggactaataggggacttatgtacagcatttgggaaggatgtactgaaattagtagaagctaggccaatgatccatgaattgttaactgaagggcggagatcgaagactaacaaagcaaaaacccttgctacatgggcaacaaaagaactgaggaaactgaagaaccaagcttgatctgttaccattgggatgataacctgaggacccccactggaaatctcccatcttttgaaaaacctggaagtgaggagtgtgcacggatgctgaatgtttgggaatgagaggatgagtgagtgaggcttgaaaacacaccacattgaaaatcctgccacagcagcagccgcagccgccaacagcagcgctgttagtgagctaagtaagcactgacttcgtagaaaaccataacatcggccatcttggaaaagagaaaaacaatggagttacttatttaaaaaaaaagaaagaaagttatctcttcccaggagaggctagaagtagcttttctgtcttttggccagtgccgagtggaatgcctggtttgggggaggaggagggactgggttcagctgtggtgctttgttgtaaaaggcagcctggcctttgctactgaggagaaagatggagcctgggtctcaagcccaccttcgctgtacctttgccacatggtactgtatgcttgccagctagaaggagggtcagggattttttacagtctgagaatgagtgtgtgtgagtgaggcggtatccacattctcaacttcaagtcattgcagtttctttttcccagaaaacaaggggttagatgttgcatttcataaaactaaccgaagttctgtctactgatgcagcacaagagatgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaacacacacacagaggaaagacgctctttaggttttgttttgttttttttttttggttttgttttttgttttttttactctagggaaaacactgacgaatggtcagagctcctatcctgatcttttcatcaaggcgcctttcctaataatatggttcaactgtgaatgtagaagtgggggggaggggggagaaaaagaaaactctggcgttagaggatatagaaaaatataagtacaattgttacaaataacgcagacttcaaaaacaaaaaaatcacaacccaaacaaaccaaaatttaaatgatcagaattggcagcacaaagaaaacgccctctcctgacttgtattgtggcagtctgaacgcccccagaaaattgtgccaaagagtttagaaaaataaatatacaataaaagtaaacacatacacacaaaacagcaaacttcaggtaactattttggattgcaaacaggataaattaaatgttcaaacaatctgataaaataaccatttggaaactgaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3837 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3837 -> Molecular function: GO:0008139 [nuclear localization sequence binding] evidence: TAS
GeneID:3837 -> Molecular function: GO:0008270 [zinc ion binding] evidence: TAS
GeneID:3837 -> Molecular function: GO:0008536 [Ran GTPase binding] evidence: IEA
GeneID:3837 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IEA
GeneID:3837 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:3837 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: TAS
GeneID:3837 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: TAS
GeneID:3837 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IDA
GeneID:3837 -> Biological process: GO:0006607 [NLS-bearing substrate import into nucleus] evidence: TAS
GeneID:3837 -> Biological process: GO:0006610 [ribosomal protein import into nucleus] evidence: IDA
GeneID:3837 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:3837 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:3837 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:3837 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS
GeneID:3837 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:3837 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:3837 -> Biological process: GO:0075733 [intracellular transport of viral material] evidence: TAS
GeneID:3837 -> Cellular component: GO:0005643 [nuclear pore] evidence: TAS
GeneID:3837 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:3837 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3837 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:3837 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
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