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2024-04-18 15:20:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002264 6889 bp mRNA linear PRI 06-MAY-2013
DEFINITION Homo sapiens karyopherin alpha 1 (importin alpha 5) (KPNA1),
transcript variant 1, mRNA.
ACCESSION NM_002264
VERSION NM_002264.3 GI:222144292
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6889)
AUTHORS Zhen,Y., Sorensen,V., Skjerpen,C.S., Haugsten,E.M., Jin,Y.,
Walchli,S., Olsnes,S. and Wiedlocha,A.
TITLE Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and
the importins Kpnalpha1 and Kpnbeta1
JOURNAL Traffic 13 (5), 650-664 (2012)
PUBMED 22321063
REMARK GeneRIF: LRRC59 facilitates transport of cytosolic FGF1 through
nuclear pores by interaction with Kpns and movement of LRRC59 along
the ER and NE membranes
REFERENCE 2 (bases 1 to 6889)
AUTHORS Fielhaber,J.A., Tan,J., Joung,K.B., Attias,O., Huegel,S., Bader,M.,
Roux,P.P. and Kristof,A.S.
TITLE Regulation of karyopherin alpha1 and nuclear import by mammalian
target of rapamycin
JOURNAL J. Biol. Chem. 287 (18), 14325-14335 (2012)
PUBMED 22399302
REMARK GeneRIF: mTOR and protein phosphatase 2A catalytically control the
constitutive nuclear import of latent STAT1 by KPNA1, which are key
modulators of STAT1 expression and apoptosis.
REFERENCE 3 (bases 1 to 6889)
AUTHORS Pumroy,R.A., Nardozzi,J.D., Hart,D.J., Root,M.J. and Cingolani,G.
TITLE Nucleoporin Nup50 stabilizes closed conformation of armadillo
repeat 10 in importin alpha5
JOURNAL J. Biol. Chem. 287 (3), 2022-2031 (2012)
PUBMED 22130666
REMARK GeneRIF: Nucleoporin Nup50 stabilizes closed conformation of
armadillo repeat 10 in importin alpha5.
REFERENCE 4 (bases 1 to 6889)
AUTHORS Shabman,R.S., Gulcicek,E.E., Stone,K.L. and Basler,C.F.
TITLE The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to
karyopherin alpha1 and partially alters its nuclear import
JOURNAL J. Infect. Dis. 204 (SUPPL 3), S904-S910 (2011)
PUBMED 21987768
REMARK GeneRIF: The ability of hnRNP C1/C2 to bind KPNA1 is diminished in
the presence of VP24, and cells transiently expressing VP24
redistribute hnRNP C1/C2 from the nucleus to the cytoplasm.
REFERENCE 5 (bases 1 to 6889)
AUTHORS Takeda,E., Murakami,T., Matsuda,G., Murakami,H., Zako,T., Maeda,M.
and Aida,Y.
TITLE Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear
import of HIV-1 Vpr
JOURNAL PLoS ONE 6 (11), E27815 (2011)
PUBMED 22110766
REMARK GeneRIF: the requirement for and the regulation of CAS in the
functioning of the Vpr-Impalpha complex
REFERENCE 6 (bases 1 to 6889)
AUTHORS Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
TITLE Mutational analysis of cell cycle arrest, nuclear localization and
virion packaging of human immunodeficiency virus type 1 Vpr
JOURNAL J. Virol. 69 (12), 7909-7916 (1995)
PUBMED 7494303
REFERENCE 7 (bases 1 to 6889)
AUTHORS O'Neill,R.E., Jaskunas,R., Blobel,G., Palese,P. and Moroianu,J.
TITLE Nuclear import of influenza virus RNA can be mediated by viral
nucleoprotein and transport factors required for protein import
JOURNAL J. Biol. Chem. 270 (39), 22701-22704 (1995)
PUBMED 7559393
REFERENCE 8 (bases 1 to 6889)
AUTHORS Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
TITLE Active nuclear import of human immunodeficiency virus type 1
preintegration complexes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (14), 6580-6584 (1992)
PUBMED 1631159
REFERENCE 9 (bases 1 to 6889)
AUTHORS Sharova,N. and Bukrinskaya,A.
TITLE p17 and p17-containing gag precursors of input human
immunodeficiency virus are transported into the nuclei of infected
cells
JOURNAL AIDS Res. Hum. Retroviruses 7 (3), 303-306 (1991)
PUBMED 2064827
REFERENCE 10 (bases 1 to 6889)
AUTHORS Mukaigawa,J. and Nayak,D.P.
TITLE Two signals mediate nuclear localization of influenza virus
(A/WSN/33) polymerase basic protein 2
JOURNAL J. Virol. 65 (1), 245-253 (1991)
PUBMED 1985200
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA308391.1, U20620.1,
BC003009.1 and AC083798.14.
On Jan 30, 2009 this sequence version replaced gi:88758610.
Summary: The transport of molecules between the nucleus and the
cytoplasm in eukaryotic cells is mediated by the nuclear pore
complex (NPC), which consists of 60-100 proteins. Small molecules
(up to 70 kD) can pass through the nuclear pore by nonselective
diffusion while larger molecules are transported by an active
process. The protein encoded by this gene belongs to the importin
alpha family, and is involved in nuclear protein import. This
protein interacts with the recombination activating gene 1 (RAG1)
protein and is a putative substrate of the RAG1 ubiquitin ligase.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Nov 2012].
Transcript Variant: This variant (1) lacks an alternate exon
compared to variant 2 and represents the protein-coding transcript.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: S75295.1, BC090864.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-405 DA308391.1 1-405
406-737 U20620.1 71-402
738-1826 BC003009.1 727-1815
1827-3111 U20620.1 1491-2775
3112-6889 AC083798.14 136720-140497 c
FEATURES Location/Qualifiers
source 1..6889
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21"
gene 1..6889
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="karyopherin alpha 1 (importin alpha 5)"
/db_xref="GeneID:3836"
/db_xref="HGNC:6394"
/db_xref="MIM:600686"
exon 1..183
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
misc_feature 18..20
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="upstream in-frame stop codon"
variation 140
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28384492"
exon 184..317
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
CDS 189..1805
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="importin-alpha-S1; importin alpha 5; recombination
activating gene cohort 2; nucleoprotein interactor 1;
SRP1-beta; RAG cohort protein 2; karyopherin subunit
alpha-1"
/codon_start=1
/product="importin subunit alpha-1"
/protein_id="NP_002255.3"
/db_xref="GI:222144293"
/db_xref="CCDS:CCDS3013.1"
/db_xref="GeneID:3836"
/db_xref="HGNC:6394"
/db_xref="MIM:600686"
/translation="
MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL
"
misc_feature 192..476
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Importin beta binding domain; Region: IBB;
pfam01749"
/db_xref="CDD:201951"
misc_feature 213..1736
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Karyopherin (importin) alpha [Intracellular
trafficking and secretion]; Region: SRP1; COG5064"
/db_xref="CDD:34668"
misc_feature 312..341
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Region: nuclear localization signal"
misc_feature 417..539
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: ARM 1, truncated"
misc_feature 540..671
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: ARM 2"
misc_feature 546..911
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature order(621..623,633..635,645..647,738..740,750..752,
759..761,771..773,879..881,888..890,897..902,909..911)
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 633..911
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: NLS binding site (major) (By similarity)"
misc_feature 801..1163
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature 807..923
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: ARM 4"
misc_feature order(876..878,888..890,900..902,993..995,1005..1007,
1014..1016,1026..1028,1131..1133,1140..1142,1149..1154,
1161..1163)
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 921..1499
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: Binding to RAG1"
misc_feature 1140..1406
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: NLS binding site (minor) (By similarity)"
misc_feature 1236..1538
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature order(1254..1256,1266..1268,1278..1280,1371..1373,
1383..1385,1392..1394,1404..1406,1512..1514,1521..1523,
1530..1535)
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 1425..1559
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: ARM 9"
misc_feature 1566..1700
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52294.3);
Region: ARM 10, atypical"
exon 318..425
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 426..525
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 526..620
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 621..752
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 753..841
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 842..941
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 942..1105
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 1106..1184
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 1185..1310
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 1311..1438
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
STS 1341..1448
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="A006N14"
/db_xref="UniSTS:36784"
variation 1383
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:15633"
exon 1439..1617
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
exon 1618..6889
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/inference="alignment:Splign:1.39.8"
STS 1689..1809
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="Kpna1"
/db_xref="UniSTS:143720"
variation 1782
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:15660"
polyA_signal 2003..2008
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 2021
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
STS 2142..2244
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="D3S2793E"
/db_xref="UniSTS:150832"
variation 2229..2230
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace=""
/replace="a"
/db_xref="dbSNP:3834790"
variation 2313
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3762637"
STS 2513..2637
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="SHGC-77263"
/db_xref="UniSTS:16030"
variation 2540
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3749210"
STS 2643..2775
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="WI-15791"
/db_xref="UniSTS:14556"
polyA_signal 2667..2672
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
variation 2685
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:10045"
polyA_site 2695
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_signal 2744..2749
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_signal 2749..2754
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 2797
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
variation 2877..2878
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace=""
/replace="t"
/db_xref="dbSNP:3833584"
STS 2933..3062
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="WI-11825"
/db_xref="UniSTS:51372"
polyA_signal 3079..3084
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
STS 3081..3301
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="A006O36"
/db_xref="UniSTS:59984"
polyA_site 3112
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
variation 3422
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11540851"
polyA_signal 3894..3899
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 3917
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 3966
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_signal 4310..4315
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 4334
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 5203
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
STS 6304..6494
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="RH78274"
/db_xref="UniSTS:73121"
STS 6506..6635
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="WI-12216"
/db_xref="UniSTS:83353"
STS 6516..6640
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="SHGC-30180"
/db_xref="UniSTS:81100"
STS 6522..6639
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="SHGC-77266"
/db_xref="UniSTS:76565"
polyA_signal 6635..6640
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 6656
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
STS 6682..6819
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
/standard_name="SHGC-30346"
/db_xref="UniSTS:69794"
polyA_signal 6819..6824
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
polyA_site 6841
/gene="KPNA1"
/gene_synonym="IPOA5; NPI-1; RCH2; SRP1"
ORIGIN
gcactgcgaacgccggctgagctgagtctcgctgctcggtgcgaggcggcggagagcgaggcctggtgagcaccgccgaggcgcgggccagctcttcgaggttgtgcgcgggagtggcacggcgggcgggcgagcgaggggctaacttcagcggtggcaccgggatcggttgccttgagcctgaaatcatgaccaccccaggaaaagagaactttcgcctgaaaagttacaagaacaaatctctgaatcccgatgagatgcgcaggaggagggaggaagaaggactgcagttacgaaagcagaaaagagaagagcagttattcaagcggagaaatgttgctacagcagaagaagaaacagaagaagaagttatgtcagatggaggctttcatgaggctcagattagtaacatggagatggcaccaggtggtgtcatcacttctgacatgattgaaatgatattttccaaaagcccagagcaacagctttcagcaacacagaaattcaggaagctgctttcaaaagaacctaaccctcctattgatgaagttatcagcacaccaggagtagtggccaggtttgtggagttcctcaaacgaaaagagaattgtacactgcagtttgaatcagcttgggtactgacaaatattgcttcaggaaattctcttcagacccgaattgtgattcaggcaggagctgtgcccatcttcatagagttgctcagctcagagtttgaagatgtccaggaacaggcagtctgggctcttggcaacattgctggagatagtaccatgtgcagggactatgtcttagactgcaatatccttccccctcttttgcagttattttcaaagcaaaaccgcctgaccatgacccggaatgcagtatgggctttgtctaatctctgtagagggaaaagtccacctccagaatttgcaaaggtttctccatgtctgaatgtgctttcctggttgctgtttgtcagtgacactgatgtactggctgatgcctgctgggccctctcatatctatcagatggacccaatgataaaattcaagcggtcatcgatgcgggagtatgtaggagacttgtggaactgctgatgcataatgattataaagtggtttctcctgctttgcgagctgtgggaaacattgtcacaggggatgatattcagacacaggtaattctgaattgctcagctctgcagagtttattgcatttgctgagtagcccaaaggaatctatcaaaaaggaagcatgttggacgatatctaatattacagctggaaatagggcacagatccagactgtgatagatgccaacattttcccagccctcattagtattttacaaactgctgaatttcggacaagaaaagaagcagcttgggccatcacaaatgcaacttctggaggatcagctgaacagatcaagtacctagtagaactgggttgtatcaagccgctctgtgatctcctcacggtcatggactctaagattgtacaggttgccctaaatggcttggaaaatatcctgaggcttggagaacaggaagccaaaaggaatggcactggcattaacccttactgtgctttgattgaagaagcttatggtctggataaaattgagttcttacagagtcatgaaaaccaggagatctaccaaaaggcctttgatcttattgagcattacttcgggaccgaagatgaagacagcagcattgcaccccaggttgaccttaaccagcagcagtacatcttccaacagtgtgaggctcctatggaaggtttccagctttgaagcaatactctgctttcacgtacctgtgtcagaccaggctacccagtcgagtcctcttgtggagcccacagtcctcatggagctaacttctcaaatgttttccataatactgtttgcgctcatttgcttgccttgcgcacctgctctcttacacacatctggaaaacctccggctctctgtggtggaatacccttctaataaaagggtaaccagaacggcccactctcttttacggaaaaatccctaggctttggagatccgcacttacattagagttatgggaatatacacatattaatgtggctccctttttcttgtgggggaataaaagaggactcctcctcattccctttaacatgggggaaaaaactgacattaaaagatgagactaaatctttatcttgaattttacacaactacttacgacaagggagatgtttagacctgttgtgtatacttcagagtacttttcatgagttcttccacagtgaacccttggattacctggtggctttttctagccagatttgcattaatccttactgagattggatggttttctttcctctattggcgccattcttcagatattaaagttaaaccatccactccctcaccttcagccttcagtgaatgtgctttctagttgtcaggaatgctgaagaattaacactttgactcctaaatgtgatactggtttgtagattcccttagagcagaaaggagaggggcacatattaatttgtatcgcttttgcttctctttggtcttttgtgtcttagaatttggaagtggttcatttctgttgctggtatgaggatttcgaatacttagtaatcgaaaaccatatcctgtaatttaataaaaaaaactaaggacgaaaaaaccctccaattttcccaaatgcaatcagtgtaactaggggctgtgtttctgcattaaaataaatgtttcaggctttgtggtcctgatcaaggtcctcattaaaaaattggagttcaccctaggtgcttttcccctctgtgactggcagataacacatacttttgaaagtaactttgggatttttttcttaggtgcagctcgattctaatcttttcatgctgcacacgattcctttaatgtagcatccttatctgaaagaaataaccatcttctcaacatgacctgcttaacccaaataagaacagtgatcttataacctcattgtttcctaatcattttatttcatctcctgctagtactgtgccgcttccccctccccccacacaaaataaaaacagtatctgccttctggctcatttaatgatgactgcaatctgtacctgcaaatggcgcttccagtactgtgttcagtgatccacatttgtgcttggactggaatgaaaaaatacgcttaattgccaagacaactgcaaatgagttcaatacgacttctcggtgctagttggccatcttgactcaatgttgggatacactaccagagaagatttttttgttgatgtgctgttcaaagtgaattctgaaggaaaaggttgctcacctctgtttcagagcatacccttttaaacctttttagacttgtcctcttctagaattcattataaccccaaagtgtaaaaactatttggaagttgcccctgacaagctattatacatctctggtaaatcctgctgaatgtaagggatattcagagcttttcatacctcatcatgatgttatttaagcagccaacttatgtgacctgatttaaacttttaaaaaatccacttcattcaaactagaaagagtcaaagacaaaggacatttatcagccaagagtgtgacgcattcttcgcatctagtctgtagtagtgtctgtgctctgggatggataccgtctgatgtctgtttgttattgatggcgcagccactgcaaaactagtcaactcccatctataactgttactttttctagtgctgctttgtgctgagagaacattttagtttactgcacttgacctgtaaaagactgattctttgtaattttagggataaattaggtggttaatttaaagaagaaatttcaatgttgcctttacatcacattaaaatataacttctttcagaaggataatagaagcactgattcatagtaaaaatcttgtttttagctttgacttttttgtggctgttttttaaaattgtaaattactagtaacatgtcatttctataggatgttttaaattatgtaccttccattggatagttaaaataatttcattttataagccaatttgagtgggaaagatacaaagcacacagttgtctccccacattaggaagagtagtgtgcattcagacattcggaatttttgctagtagttggagatgtttcagtgagtgaattaaaacaaagtctatttaactgacgtgatctattttgtgtctaaaacagaggaatttatcttgtcctagaagttcatgaactataagatctaagtttttttttcttttttaacaataaaatgattttttcttaaagtatcaaagttggaattggctaaaagtgaagtagcataactcagatatgttggaacttggtactgaagcaggctttttggtaacagaaatgacattttaaggggtaactgtatatcctgtttttagttctttgcctctcagattctgttaacttagtttaaattcactgaataccctaccactaaggcgttgctcattacaaaagcatgttaatttcaatacaggaaaactcttttgtagttttatatatggattggggaaagtgactttgttttacttttcctttttattcccctccatcctccaaacttccaatctatattatttgtaatgagaactttggtgggggaaaaaaagcattaagagaattttggatgtaaaggcatctggtatctgatggaccagcaggtagatgtggttggattgagaaattttgggtaaggtagatgatagaagaaagagattttaggagacacagttctctgtggaacactttctttcatgttcctgtaactaattgatcaagacccttttaaacgcttatctttgtcagttccgcttttgaaaaaactattgccctaggattgtttcttccatatgacagatgaaggttattggctctgagtcatttttggcattatcgtcacagataaaaagattggcaattaatctcataaaaaatctgaattattccagattgctgccgatttttgcctaagaaacaatatgtaagtatattttataaaccaaactttgtcaaccaattctattgtacgtctacccacaggcaactttgaatttacttctctagtgctaaataaacatttcagcgatttaatcccccaacttgggggatgcattatgaaaaggttttcctggagtcaaggggtttttctttctcgctagttttgtgaaaatttttatatcaataggcaaatcattataactttttaggggttgatggtttttaagtatattggaaattgtggtgtctaaggatgatgttcagtgaagaaaagggatccacttttagaaaccagcattgtttgctttcaactttcatactgtatgctaactcctacgttccaaaatgtgctcatttgcagacacaggtatgcctatatacatggaagtctcaaatctgaatttttatccatctcaatatgaccatttctctctgttgtgagctgaacagattaagtatatatctgccaggttgggaaatattttggtctatcttttcctgtcatcagaacttaatttaaaaaaattatcaaaggtcagatgtgactactacagtaagttggctatcataaagaatattccataaaatgttttatctgccatacaaaattactgggtttatggccggatgtggtggctcatgcctgtaatcccagcagttcaggattacaggttatatacaggttataacaatggataccaggacatcagaatatctgataaagcaaatatttatatgctaatttaaaatatcaaattgctactggacataaaatacatctggaagcttggggtaagaagaaagaaaagaagtgttccgttctgttttcaactaagggtaaacgaagtcccagagtgttttccctgtaggtcaaattaaggtaacatgtctttatttgatcatctattgtacaccagatacctggctaagggctttccttttttctcatgtagtcttccaaatgttctttgataattgtcactatattatagatgacaaagtgaagacttacgagaaattactttgccccaaggttacaacacttagatggctgtccaagggcggggaagagccctgcaaattctgtgtcttgaagaaagcagtggccacgcagtagttccgtgcccaggatctcccagaactagacttggcaaccacagctgggccagccttttttgttagaccattcttcctgactcctgcttaccatcagcacccttaaaatgacgaaatcaggcttaagttgcttttaggttacacagactggagtgtaggccctctcaggccaaacatctttcctcttctgtggtgctaaaattctgtatgaccagacaagtatggtaataggttttttttttttttttttttgtgcaaatgattttgtgtttagtaaaataatggctaaacacatggatccattcaaacgcacaaatgtggaaagtattgacacggaaggaaaggctttgaagaattactgcctcaggaagcagtgccatggatgcgaatttaacacagtctacttcttcctaaaggaatatcatcccaaggaatgtcaaaaattaaaatcaccttttaatgtactggttgttgagtgtttctgctttacctcaagtcattctgaccactctacatcctgcttcaaagtgttctgacacttagatttggaatggctctaatgattctttgtacttgaatgtggtctgtcaggccatgggtgagtgccttgcacatagtagacattcaataaatactaaatgaaggaatatgcatgcatctttgtgatgttagtaaagggtgcttgataaaagaaaat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3836 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3836 -> Molecular function: GO:0008139 [nuclear localization sequence binding] evidence: TAS
GeneID:3836 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IEA
GeneID:3836 -> Biological process: GO:0000018 [regulation of DNA recombination] evidence: TAS
GeneID:3836 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: TAS
GeneID:3836 -> Biological process: GO:0006607 [NLS-bearing substrate import into nucleus] evidence: TAS
GeneID:3836 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:3836 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:3836 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:3836 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS
GeneID:3836 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:3836 -> Biological process: GO:0042307 [positive regulation of protein import into nucleus] evidence: ISS
GeneID:3836 -> Biological process: GO:0075733 [intracellular transport of viral material] evidence: TAS
GeneID:3836 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:3836 -> Cellular component: GO:0005643 [nuclear pore] evidence: TAS
GeneID:3836 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:3836 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:3836 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:3836 -> Cellular component: GO:0030425 [dendrite] evidence: ISS
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