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2024-04-19 09:18:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002254 5431 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens kinesin family member 3C (KIF3C), mRNA.
ACCESSION NM_002254
VERSION NM_002254.6 GI:133930788
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5431)
AUTHORS Davidovic,L., Jaglin,X.H., Lepagnol-Bestel,A.M., Tremblay,S.,
Simonneau,M., Bardoni,B. and Khandjian,E.W.
TITLE The fragile X mental retardation protein is a molecular adaptor
between the neurospecific KIF3C kinesin and dendritic RNA granules
JOURNAL Hum. Mol. Genet. 16 (24), 3047-3058 (2007)
PUBMED 17881655
REMARK GeneRIF: FMRP acts also as a molecular adaptor between RNA granules
and the neurospecific kinesin KIF3C.
REFERENCE 2 (bases 1 to 5431)
AUTHORS Muresan,V., Abramson,T., Lyass,A., Winter,D., Porro,E., Hong,F.,
Chamberlin,N.L. and Schnapp,B.J.
TITLE KIF3C and KIF3A form a novel neuronal heteromeric kinesin that
associates with membrane vesicles
JOURNAL Mol. Biol. Cell 9 (3), 637-652 (1998)
PUBMED 9487132
REFERENCE 3 (bases 1 to 5431)
AUTHORS Sardella,M., Navone,F., Rocchi,M., Rubartelli,A., Viggiano,L.,
Vignali,G., Consalez,G.G., Sitia,R. and Cabibbo,A.
TITLE KIF3C, a novel member of the kinesin superfamily: sequence,
expression, and mapping to human chromosome 2 at 2p23
JOURNAL Genomics 47 (3), 405-408 (1998)
PUBMED 9480755
REFERENCE 4 (bases 1 to 5431)
AUTHORS Yang,Z. and Goldstein,L.S.
TITLE Characterization of the KIF3C neural kinesin-like motor from mouse
JOURNAL Mol. Biol. Cell 9 (2), 249-261 (1998)
PUBMED 9450952
REFERENCE 5 (bases 1 to 5431)
AUTHORS Telford,E.A., Wightman,P., Leek,J., Markham,A.F., Lench,N.J. and
Bonthron,D.T.
TITLE cDNA cloning, genomic organization, and chromosomal localization of
a novel human gene that encodes a kinesin-related protein highly
similar to mouse Kif3C
JOURNAL Biochem. Biophys. Res. Commun. 242 (2), 407-412 (1998)
PUBMED 9446808
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC013449.8, BC092406.1, AC064847.4 and DB303776.1.
On Mar 22, 2007 this sequence version replaced gi:41352704.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BX571741.1, AF035621.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-115 AC013449.8 53046-53160 c
116-803 BC092406.1 1-688
804-804 AC013449.8 52357-52357 c
805-3242 BC092406.1 690-3127
3243-4112 AC064847.4 135419-136288 c
4113-4237 BC092406.1 3998-4122
4238-4917 AC064847.4 134614-135293 c
4918-5431 DB303776.1 1-514 c
FEATURES Location/Qualifiers
source 1..5431
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p23"
gene 1..5431
/gene="KIF3C"
/note="kinesin family member 3C"
/db_xref="GeneID:3797"
/db_xref="HGNC:6321"
/db_xref="HPRD:04164"
/db_xref="MIM:602845"
exon 1..2202
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
variation 150..151
/gene="KIF3C"
/replace="c"
/replace="g"
/db_xref="dbSNP:2165195"
variation 363
/gene="KIF3C"
/replace="a"
/replace="t"
/db_xref="dbSNP:1465877"
variation 451
/gene="KIF3C"
/replace="c"
/replace="t"
/db_xref="dbSNP:2119105"
variation 496
/gene="KIF3C"
/replace="c"
/replace="t"
/db_xref="dbSNP:2119106"
misc_feature 601..603
/gene="KIF3C"
/note="upstream in-frame stop codon"
CDS 658..3039
/gene="KIF3C"
/note="KIF3C variant protein"
/codon_start=1
/product="kinesin-like protein KIF3C"
/protein_id="NP_002245.4"
/db_xref="GI:41352705"
/db_xref="CCDS:CCDS1719.1"
/db_xref="GeneID:3797"
/db_xref="HGNC:6321"
/db_xref="HPRD:04164"
/db_xref="MIM:602845"
/translation="
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPSTTHASLASASLRPATVADHE
"
misc_feature 682..1752
/gene="KIF3C"
/note="Myosin and Kinesin motor domain. These ATPases
belong to the P-loop NTPase family and provide the driving
force in myosin and kinesin mediated processes; Region:
Motor_domain; cl00286"
/db_xref="CDD:212601"
misc_feature 685..1773
/gene="KIF3C"
/note="Kinesin motor, catalytic domain. ATPase; Region:
KISc; smart00129"
/db_xref="CDD:197527"
misc_feature order(709..714,952..975)
/gene="KIF3C"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:73261"
misc_feature 2545..3036
/gene="KIF3C"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14782.3);
Region: Globular (Potential)"
variation 1766
/gene="KIF3C"
/replace="a"
/replace="g"
/db_xref="dbSNP:1465878"
variation 2070
/gene="KIF3C"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062937"
exon 2203..2304
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
exon 2305..2427
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
variation 2389
/gene="KIF3C"
/replace="c"
/replace="t"
/db_xref="dbSNP:1802132"
exon 2428..2546
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
variation 2545
/gene="KIF3C"
/replace="a"
/replace="g"
/db_xref="dbSNP:1139892"
exon 2547..2663
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
exon 2664..2772
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
exon 2773..2945
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
exon 2946..5431
/gene="KIF3C"
/inference="alignment:Splign:1.39.8"
variation 3243
/gene="KIF3C"
/replace="a"
/replace="t"
/db_xref="dbSNP:2072695"
STS 3398..4254
/gene="KIF3C"
/standard_name="KIF3C_8426"
/db_xref="UniSTS:467738"
STS 3958..4174
/gene="KIF3C"
/standard_name="HSC2CB052"
/db_xref="UniSTS:51408"
STS 4061..4201
/gene="KIF3C"
/standard_name="RH12717"
/db_xref="UniSTS:32747"
variation 4312
/gene="KIF3C"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061449"
STS 5124..5402
/gene="KIF3C"
/db_xref="UniSTS:67245"
STS 5192..5335
/gene="KIF3C"
/standard_name="RH66315"
/db_xref="UniSTS:47688"
variation 5384
/gene="KIF3C"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061485"
polyA_signal 5394..5399
/gene="KIF3C"
polyA_site 5415
/gene="KIF3C"
/note="This is a major polyA site. The 3'-most polyA site
has not been determined."
ORIGIN
agtcgggaggcttagctggggccgcagcgcggcggcaacatcactctcgctgccgctgctccgccccatccccttctgtttttctctctcattctccagtggcggcggcggggaaggcggaggcagaggcagcagcagccgcgctggctgcaatgaatgatcccccagcttggggggaggactccaggtgagcctctgccctcgggaggcccgggacccccggccgcccacgaccggcagcccacgctatggatccctagaggaaggaggagaagacagctcgccgcccacccccatcccattttcctcttcctttatctcattgttgccgaagctgtttacggcagcgctccctctgctccagcatggggcgggctccgggcacggctgctcggcaggcgctgctcccgcggcgactgggggattctgcctaattcacctcccagccggtgcagagaggaccggagagcggtggaggcccggactgcagcagcgttggggccacctcccagcgtccccaccctaggaggctgcatgcggattgaagagctgcgcctgggggctgggccggccccgctgatcccgacctagcgagcaggatagcaggaccgcccaggctgcggaggggctcgggggcaggaaggtcagagcagcaagatggccagtaagaccaaggccagcgaggccctcaaggtggtggcccggtgccgccccctcagcaggaaggaggaggctgctggtcacgagcagatcctgaccatggacgtgaaactgggccaggtgaccctgcggaacccccgcgccgccccgggggagctgcccaagaccttcacctttgacgccgtgtatgatgccagctccaagcaggccgacctgtatgacgaaaccgtgaggcccctgatagactccgtgctccagggtttcaatggcacggtgtttgcctatggccagacgggcactggcaagacctataccatgcaggggacctgggtggagcccgagctgcgcggggtcatcccgaatgcctttgagcacatcttcacccacatctcccgctcccagaaccaacagtacctggtccgggcctcctatttggagatctaccaggaagagattcgagacctgctctccaaggagccgggcaagaggctagagctgaaagagaaccccgagactggcgtctacatcaaggacctctcctccttcgtcaccaagaatgtcaaggagattgagcatgtgatgaacctggggaaccagacccgggctgtgggcagcacccacatgaatgaggtcagctcccgctcccatgccatcttcatcatcactgtggagtgcagcgaacgtggctctgatggccaggaccacatccgagtgggcaagctcaacctcgtggacctggctggcagcgagaggcagaacaaggcaggccccaacacagcgggaggggcagccacaccatcctcgggtggcggtggtggcggtggaggcagtggtggtggtgctggtggagagaggcctaaggaagcctccaaaatcaacctctcattatctgccctgggcaacgtgattgctgccctggcgggcaacaggagcacccacattccctaccgggactccaagctgacccggctgctccaggactccctgggggggaatgccaagaccatcatggtagccacactggggccagcttctcacagctacgatgagagcctctccaccttgcgctttgccaaccgagccaagaacatcaagaacaagccccgggtgaacgaggaccccaaggacacactgctgcgggaattccaagaggagattgcccgcctgaaggcccagctggagaagagggggatgctggggaagcggccccggaggaagagcagccgcaggaagaaggccgtgtccgccccgcctgggtaccctgagggcccagtgattgaggcctgggtggcagaagaggaggatgacaacaacaacaaccaccgcccgccccagcccatcctggagtcagccttggagaagaacatggagaattacctgcaggaacagaaggagcggctggaggaggagaaggcagccatccaggatgaccgcagcctggtgagcgaggagaagcagaagctgctggaggagaaggagaagatgctggaggacctgcggcgggaacagcaggccacagagctgcttgcggccaagtacaaggccatggagagcaagctcctcatcgggggcaggaacatcatggatcacaccaacgaacagcagaagatgttggaactgaagaggcaggagattgccgagcagaaacgtcgtgagcgggagatgcagcaggagatgatgctccgggacgaggagactatggagctccggggcacctacacatccctgcagcaggaggtggaggtcaaaaccaagaaactcaagaagctctacgccaagctgcaggcggtgaaggcggagatccaggaccagcatgatgagtatatccgcgtgcggcaggacctggaggaggcgcagaacgagcagacccgcgaactcaagctcaagtacctaatcatcgagaacttcatcccgccggaggagaagaacaagatcatgaaccggcttttcctggactgtgaggaggagcagtggaagttccagccactggtgccagccggcgtcagtagcagccagatgaagaagcggccaacatctgcagtgggctacaagaggcctatcagccagtatgctcgggttgccatggcaatggggtcccaccccaggtacagggctgaaaacataatgtttctggagttggatgtgtcccctccagctgtctttgagatggaattctctcacgaccaagaacaagaccctcgtgcgctacacatggagaggctcatgcgattggacagctttctggaaagaccttccacgtctaaagtccgaaagtccagatcctggtgccagagtcctcagcggcctccaccttccaccacacatgcctccctggcctctgcttctctgcgccctgcaacagtggcggaccatgagtgacaaccatcacgtcaggctgcccatccaatagactcctgggatggggcagccaaccctggctcatctcatctgccgcttggtgcgtgtgcgtgtgcgtgcatgtgcgtgtgcgtgtgtgcaggggtgagaatctggcagatggtgcctctgcctgctcttcttcgcctcctttatttaattcatgttatttattcgcggagctctgttcgtgttggggagatgccctcgcctgagccgtctgggcctaccgtggtcactgcgtagcctctttttcttctgacttgagagctcccccagtcagatctcaggcttgtccccctgtcagctgcctccagaagggaaggtagccagtgcctgagaagacagtcccttttctacccaccgcactccataacctccatcttctcccacactgatggcgagcagcccctgagcactttctgggactgggagactgcttggtgttccctgaggacaagagacatcctgacagtgttgggcatctgctccccgtggacacagccccactctccactttctgagcctcagacaacctcattcagcctcttgggctccttttcaaggacattaataacctcaccaacatagctcatgcccttcagctttgacaagaactcacagcttcccaaactctgctttctgcccaccttggatgggaactgtggaccaagcaattaccatcgccttggaacctgcaggaaatggaacagcaattgagacaacttgaacagtcatcaacggaagtccctccactggattcctttgtttctgtcccctccgaggagtcattttggtcgacaggctctcaaggcaactccccattttcaagaggctgctcctgcctgcttcgatcatttctccctgcagctgcctagaccccgttcacagtgggaggagtcaatgtcattctacccctcgctaaacgaagatattaacatctattgctttttcccttcatctgtcacaggaaacagaagcccaggcacaatcttttccagctttgcctgttacccctgtttctgaattgcatctttaaggtattattttgttgacaatagatcctttattcactagttacgcaaattggttcctagggggatactccttaccttcctttgtgatggcccaaaatgtctctaggtatctcaagtgataagtaaatttctacaaaaaaaaatggttaatgttcattgactggctttttaagtgtatattttggaggacgggtgaagaggtcataacgaaagcaagcgagtgaattaggatttcaaagtgccctaatagtgtgagtctccagttcctagaatatgaagagtgctgtcgttggggtgaaaccatgagactgacagatctgcctgaaatggggggtgtgggaggtggtggcgggggttattctctttccttcaggaaatgaacccttcttacatcattcaagttctgctctgaggatcaagcttgggtctgatttaactcagcgacactgtcatttctgcttcattactggactagagggttgagccacccacttgccatttgctcctgtccttccaggaaatcacaattttcatcagagcccaagagattatttgagactcaggattcagatcagaggttcgactgtggctgggacaggagttgtgtgtagaaattcaccaggtggcctgagcgcagggggacctccagggctgcgttgagcagcctctcccactgacctctttctcgtttgtggacaaagcagcacgtatcacctcattcatcacttggacacatcgcctttgcattgtcttgtcacacctccctcacagtcttatagcacaatatacccaaatcagcccccccagtccgagggctgggcccaaggtatggtcggaggaggagctcctgcctgcggttttgtgtatgtgtgtatgtgtgtgcgtgtttgtgtgcgtgtttacctccacaggggacactctacactcagtgtaagatctgctgggaacagggccaccaggagtggctggatctcagtctctctgtctctctttctctccttttccttttggtgtatcaaatatttgattgacaaagtaagggccttgattaggaccaaattctcgtgtgttgctatggtctttatttaggacaacaattaacaatgcagtggcccattcttgtcactctacacatatgactatacgggacatatgtaatatataaatatatatataaaacattcccctctgtccccttggcttcggatggaggcctttctgttgagctgaaatgcacctgcagctgggtgctgccagcagcttgcaggccccagccctgttccaatcaatgcagttgacaataaaggaatgagtatcgtcacggagttgactgcctt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3797 -> Molecular function: GO:0003774 [motor activity] evidence: TAS
GeneID:3797 -> Molecular function: GO:0003777 [microtubule motor activity] evidence: IEA
GeneID:3797 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:3797 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA
GeneID:3797 -> Biological process: GO:0007018 [microtubule-based movement] evidence: TAS
GeneID:3797 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:3797 -> Biological process: GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] evidence: TAS
GeneID:3797 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:3797 -> Cellular component: GO:0005871 [kinesin complex] evidence: IEA
GeneID:3797 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
by
@meso_cacase at
DBCLS
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