2024-04-25 15:15:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002229 1832 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens jun B proto-oncogene (JUNB), mRNA. ACCESSION NM_002229 VERSION NM_002229.2 GI:44921611 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1832) AUTHORS Perez-Benavente,B., Garcia,J.L., Rodriguez,M.S., Pineda-Lucena,A., Piechaczyk,M., Font de Mora,J. and Farras,R. TITLE GSK3-SCF(FBXW7) targets JunB for degradation in G2 to preserve chromatid cohesion before anaphase JOURNAL Oncogene 32 (17), 2189-2199 (2013) PUBMED 22710716 REMARK GeneRIF: A novel mechanism by which mitosis progression and chromatid cohesion are regulated through GSK3/SCF(FBXW7)-mediated proteolysis of JunB. REFERENCE 2 (bases 1 to 1832) AUTHORS Ramachandran,A., Gangopadhyay,S.S., Krishnan,R., Ranpura,S.A., Rajendran,K., Ram-Mohan,S., Mulone,M., Gong,E.M. and Adam,R.M. TITLE JunB mediates basal- and TGFbeta1-induced smooth muscle cell contractility JOURNAL PLoS ONE 8 (1), E53430 (2013) PUBMED 23308222 REMARK GeneRIF: JunB regulates visceral smooth muscle cell contractility through effects on both myosin and the actin cytoskeleton. REFERENCE 3 (bases 1 to 1832) AUTHORS Kanno,T., Kamba,T., Yamasaki,T., Shibasaki,N., Saito,R., Terada,N., Toda,Y., Mikami,Y., Inoue,T., Kanematsu,A., Nishiyama,H., Ogawa,O. and Nakamura,E. TITLE JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma JOURNAL Oncogene 31 (25), 3098-3110 (2012) PUBMED 22020339 REMARK GeneRIF: Study confirmed that JunB was upregulated in VHL-defective clear-cell renal-cell carcinoma (ccRCC) specimens by immunostaining. Short-hairpin RNA (shRNA)-mediated knockdown of JunB in 786-O and A498 VHL null ccRCC cells suppressed their invasiveness. REFERENCE 4 (bases 1 to 1832) AUTHORS Jiang,H., Schwertz,H., Schmid,D.I., Jones,B.B., Kriesel,J., Martinez,M.L., Weyrich,A.S., Zimmerman,G.A. and Kraiss,L.W. TITLE Different mechanisms preserve translation of programmed cell death 8 and JunB in virus-infected endothelial cells JOURNAL Arterioscler. Thromb. Vasc. Biol. 32 (4), 997-1004 (2012) PUBMED 22328780 REMARK GeneRIF: Different mechanisms preserve translation of programmed cell death 8 and JunB in poliovirus-infected endothelial cells. REFERENCE 5 (bases 1 to 1832) AUTHORS Lee,K.H. and Kim,J.R. TITLE Regulation of HGF-mediated cell proliferation and invasion through NF-kappaB, JunB, and MMP-9 cascades in stomach cancer cells JOURNAL Clin. Exp. Metastasis 29 (3), 263-272 (2012) PUBMED 22252121 REMARK GeneRIF: up-regulation of JunB induced by HGF might play an important role in the regulation of cell proliferation and cell invasion through MMP-9 expression. REFERENCE 6 (bases 1 to 1832) AUTHORS Hsu,J.C., Bravo,R. and Taub,R. TITLE Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration JOURNAL Mol. Cell. Biol. 12 (10), 4654-4665 (1992) PUBMED 1406655 REFERENCE 7 (bases 1 to 1832) AUTHORS Zafarullah,M., Martel-Pelletier,J., Cloutier,J.M., Gedamu,L. and Pelletier,J.P. TITLE Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte JOURNAL FEBS Lett. 306 (2-3), 169-172 (1992) PUBMED 1633872 REFERENCE 8 (bases 1 to 1832) AUTHORS Mollinedo,F., Vaquerizo,M.J. and Naranjo,J.R. TITLE Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes JOURNAL Biochem. J. 273 (PT 2), 477-479 (1991) PUBMED 1899335 REFERENCE 9 (bases 1 to 1832) AUTHORS Nomura,N., Ide,M., Sasamoto,S., Matsui,M., Date,T. and Ishizaki,R. TITLE Isolation of human cDNA clones of jun-related genes, jun-B and jun-D JOURNAL Nucleic Acids Res. 18 (10), 3047-3048 (1990) PUBMED 2112242 REFERENCE 10 (bases 1 to 1832) AUTHORS Schutte,J., Viallet,J., Nau,M., Segal,S., Fedorko,J. and Minna,J. TITLE jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun JOURNAL Cell 59 (6), 987-997 (1989) PUBMED 2513129 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC009466.1. On Mar 4, 2004 this sequence version replaced gi:4504808. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009466.1 [ECO:0000332] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..1832 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.2" gene 1..1832 /gene="JUNB" /gene_synonym="AP-1" /note="jun B proto-oncogene" /db_xref="GeneID:3726" /db_xref="HGNC:6205" /db_xref="HPRD:01303" /db_xref="MIM:165161" exon 1..1816 /gene="JUNB" /gene_synonym="AP-1" /inference="alignment:Splign:1.39.8" variation 60 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:186033622" variation 68 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:17886698" variation 80 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="t" /db_xref="dbSNP:17883538" variation 153 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="c" /db_xref="dbSNP:11539925" variation 171 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:11539926" variation 270 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:371222383" CDS 277..1320 /gene="JUNB" /gene_synonym="AP-1" /note="activator protein 1" /codon_start=1 /product="transcription factor jun-B" /protein_id="NP_002220.1" /db_xref="GI:4504809" /db_xref="CCDS:CCDS12280.1" /db_xref="GeneID:3726" /db_xref="HGNC:6205" /db_xref="HPRD:01303" /db_xref="MIM:165161" /translation="
MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
" misc_feature 289..1047 /gene="JUNB" /gene_synonym="AP-1" /note="Jun-like transcription factor; Region: Jun; pfam03957" /db_xref="CDD:146538" misc_feature 580..582 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 580..582 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02619" misc_feature 580..582 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03100" misc_feature 586..588 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 586..588 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02619" misc_feature 586..588 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03100" misc_feature 625..627 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 1027..1029 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 1039..1041 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 1039..1041 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1051..1053 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P17275.1); phosphorylation site" misc_feature 1051..1053 /gene="JUNB" /gene_synonym="AP-1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1072..1263 /gene="JUNB" /gene_synonym="AP-1" /note="bZIP transcription factor; Region: bZIP_1; pfam00170" /db_xref="CDD:201054" misc_feature 1078..1161 /gene="JUNB" /gene_synonym="AP-1" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P17275.1); Region: Basic motif (By similarity)" misc_feature 1162..1248 /gene="JUNB" /gene_synonym="AP-1" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P17275.1); Region: Leucine-zipper (By similarity)" variation 302 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:373960755" STS 314..391 /gene="JUNB" /gene_synonym="AP-1" /standard_name="PMC186344P1" /db_xref="UniSTS:271701" variation 328 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:377693229" variation 388 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:377194147" variation 419 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:202243098" variation 475 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:144512497" variation 493 /gene="JUNB" /gene_synonym="AP-1" /replace="g" /replace="t" /db_xref="dbSNP:367885167" variation 548 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:372072460" variation 593..594 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:11539924" variation 632 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:199665194" variation 696 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:17883257" variation 703 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:370193677" variation 750 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="c" /db_xref="dbSNP:2229510" variation 847 /gene="JUNB" /gene_synonym="AP-1" /replace="g" /replace="t" /db_xref="dbSNP:12151069" variation 894 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:17881800" variation 921 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:368830120" variation 934 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:373004953" variation 953 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="c" /db_xref="dbSNP:111454909" variation 964 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:17880705" variation 979 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:113612911" variation 1017 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:113134178" variation 1025 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:377604283" variation 1053 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:201546490" variation 1111 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="c" /db_xref="dbSNP:374496104" variation 1115..1116 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="gg" /db_xref="dbSNP:374802914" variation 1118 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:202032423" variation 1200 /gene="JUNB" /gene_synonym="AP-1" /replace="g" /replace="t" /db_xref="dbSNP:369161895" variation 1263..1264 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="t" /db_xref="dbSNP:34158781" variation 1287 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:201669552" variation 1314 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:200613192" variation 1327 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:374239125" variation 1357 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="g" /db_xref="dbSNP:376692524" variation 1371 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:371034226" variation 1445 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:375924321" variation 1455 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:17881347" variation 1500 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:376382280" variation 1502..1503 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="cc" /db_xref="dbSNP:71866409" variation 1517 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="t" /db_xref="dbSNP:71672300" STS 1537..1735 /gene="JUNB" /gene_synonym="AP-1" /standard_name="A005B41" /db_xref="UniSTS:10307" STS 1537..1735 /gene="JUNB" /gene_synonym="AP-1" /standard_name="G32220" /db_xref="UniSTS:116826" variation 1624 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="g" /db_xref="dbSNP:1061500" variation 1669..1670 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="c" /db_xref="dbSNP:17886468" variation 1689 /gene="JUNB" /gene_synonym="AP-1" /replace="c" /replace="t" /db_xref="dbSNP:1061595" variation 1693 /gene="JUNB" /gene_synonym="AP-1" /replace="a" /replace="c" /db_xref="dbSNP:1061605" variation 1796..1797 /gene="JUNB" /gene_synonym="AP-1" /replace="" /replace="a" /replace="aaaa" /db_xref="dbSNP:71803883" ORIGIN
gagcggccaggccagcctcggagccagcagggagctgggagctgggggaaacgacgccaggaaagctatcgcgccagagagggcgacgggggctcgggaagcctgacagggcttttgcgcacagctgccggctggctgctacccgcccgcgccagcccccgagaacgcgcgaccaggcacccagtccggtcaccgcagcggagagctcgccgctcgctgcagcgaggcccggagcggccccgcagggaccctccccagaccgcctgggccgcccggatgtgcactaaaatggaacagcccttctaccacgacgactcatacacagctacgggatacggccgggcccctggtggcctctctctacacgactacaaactcctgaaaccgagcctggcggtcaacctggccgacccctaccggagtctcaaagcgcctggggctcgcggacccggcccagagggcggcggtggcggcagctacttttctggtcagggctcggacaccggcgcgtctctcaagctcgcctcttcggagctggaacgcctgattgtccccaacagcaacggcgtgatcacgacgacgcctacacccccgggacagtacttttacccccgcgggggtggcagcggtggaggtgcagggggcgcagggggcggcgtcaccgaggagcaggagggcttcgccgacggctttgtcaaagccctggacgatctgcacaagatgaaccacgtgacaccccccaacgtgtccctgggcgctaccggggggcccccggctgggcccgggggcgtctacgccggcccggagccacctcccgtttacaccaacctcagcagctactccccagcctctgcgtcctcgggaggcgccggggctgccgtcgggaccgggagctcgtacccgacgaccaccatcagctacctcccacacgcgccgcccttcgccggtggccacccggcgcagctgggcttgggccgcggcgcctccaccttcaaggaggaaccgcagaccgtgccggaggcgcgcagccgggacgccacgccgccggtgtcccccatcaacatggaagaccaagagcgcatcaaagtggagcgcaagcggctgcggaaccggctggcggccaccaagtgccggaagcggaagctggagcgcatcgcgcgcctggaggacaaggtgaagacgctcaaggccgagaacgcggggctgtcgagtaccgccggcctcctccgggagcaggtggcccagctcaaacagaaggtcatgacccacgtcagcaacggctgtcagctgctgcttggggtcaagggacacgccttctgaacgtcccctgcccctttacggacaccccctcgcttggacggctgggcacacgcctcccactggggtccagggagcaggcggtgggcacccaccctgggacctaggggcgccgcaaaccacactggactccggccctcctaccctgcgcccagtccttccacctcgacgtttacaagcccccccttccacttttttttgtatgttttttttctgctggaaacagactcgattcatattgaatataatatatttgtgtatttaacagggaggggaagagggggcgatcgcggcggagctggccccgccgcctggtactcaagcccgcggggacattgggaaggggacccccgccccctgccctcccctctctgcaccgtactgtggaaaagaaacacgcacttagtctctaaagagtttattttaagacgtgtttgtgtttgtgtgtgtttgttctttttattgaatctatttaagtaaaaaaaaaattggttctttaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:3726 -> Molecular function: GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] evidence: IEA GeneID:3726 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS GeneID:3726 -> Molecular function: GO:0003690 [double-stranded DNA binding] evidence: IEA GeneID:3726 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:3726 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS GeneID:3726 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS GeneID:3726 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:3726 -> Biological process: GO:0001570 [vasculogenesis] evidence: IEA GeneID:3726 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: IEA GeneID:3726 -> Biological process: GO:0001829 [trophectodermal cell differentiation] evidence: IEA GeneID:3726 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: TAS GeneID:3726 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS GeneID:3726 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS GeneID:3726 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS GeneID:3726 -> Biological process: GO:0009416 [response to light stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:3726 -> Biological process: GO:0030316 [osteoclast differentiation] evidence: IEA GeneID:3726 -> Biological process: GO:0032570 [response to progesterone stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0032870 [cellular response to hormone stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0033687 [osteoblast proliferation] evidence: IEA GeneID:3726 -> Biological process: GO:0034097 [response to cytokine stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0042493 [response to drug] evidence: IEA GeneID:3726 -> Biological process: GO:0043434 [response to peptide hormone stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0045597 [positive regulation of cell differentiation] evidence: IEA GeneID:3726 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: TAS GeneID:3726 -> Biological process: GO:0046697 [decidualization] evidence: IEA GeneID:3726 -> Biological process: GO:0051412 [response to corticosterone stimulus] evidence: IEA GeneID:3726 -> Biological process: GO:0051591 [response to cAMP] evidence: IEA GeneID:3726 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IEA GeneID:3726 -> Biological process: GO:0060136 [embryonic process involved in female pregnancy] evidence: IEA GeneID:3726 -> Biological process: GO:0060716 [labyrinthine layer blood vessel development] evidence: IEA GeneID:3726 -> Biological process: GO:0071277 [cellular response to calcium ion] evidence: IEA GeneID:3726 -> Cellular component: GO:0000785 [chromatin] evidence: TAS GeneID:3726 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:3726 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:3726 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
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