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2019-03-24 20:39:06, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002223              12568 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2),
            mRNA.
ACCESSION   NM_002223
VERSION     NM_002223.2  GI:95147334
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12568)
  AUTHORS   Staats,K.A., Bogaert,E., Hersmus,N., Jaspers,T., Luyten,T.,
            Bultynck,G., Parys,J.B., Hisatsune,C., Mikoshiba,K., Van Damme,P.,
            Robberecht,W. and Van Den Bosch,L.
  TITLE     Neuronal overexpression of IP(3) receptor 2 is detrimental in
            mutant SOD1 mice
  JOURNAL   Biochem. Biophys. Res. Commun. 429 (3-4), 210-213 (2012)
   PUBMED   23131553
  REMARK    GeneRIF: These data suggest that ER Ca(2+) released by IP(3)
            receptors may be detrimental in amyotrophic lateral sclerosis and
            that motor neurons are vulnerable to impaired Ca(2+) metabolism.
REFERENCE   2  (bases 1 to 12568)
  AUTHORS   Wu,X., Scelo,G., Purdue,M.P., Rothman,N., Johansson,M., Ye,Y.,
            Wang,Z., Zelenika,D., Moore,L.E., Wood,C.G., Prokhortchouk,E.,
            Gaborieau,V., Jacobs,K.B., Chow,W.H., Toro,J.R., Zaridze,D.,
            Lin,J., Lubinski,J., Trubicka,J., Szeszenia-Dabrowska,N.,
            Lissowska,J., Rudnai,P., Fabianova,E., Mates,D., Jinga,V.,
            Bencko,V., Slamova,A., Holcatova,I., Navratilova,M., Janout,V.,
            Boffetta,P., Colt,J.S., Davis,F.G., Schwartz,K.L., Banks,R.E.,
            Selby,P.J., Harnden,P., Berg,C.D., Hsing,A.W., Grubb,R.L. III,
            Boeing,H., Vineis,P., Clavel-Chapelon,F., Palli,D., Tumino,R.,
            Krogh,V., Panico,S., Duell,E.J., Quiros,J.R., Sanchez,M.J.,
            Navarro,C., Ardanaz,E., Dorronsoro,M., Khaw,K.T., Allen,N.E.,
            Bueno-de-Mesquita,H.B., Peeters,P.H., Trichopoulos,D.,
            Linseisen,J., Ljungberg,B., Overvad,K., Tjonneland,A., Romieu,I.,
            Riboli,E., Stevens,V.L., Thun,M.J., Diver,W.R., Gapstur,S.M.,
            Pharoah,P.D., Easton,D.F., Albanes,D., Virtamo,J., Vatten,L.,
            Hveem,K., Fletcher,T., Koppova,K., Cussenot,O., Cancel-Tassin,G.,
            Benhamou,S., Hildebrandt,M.A., Pu,X., Foglio,M., Lechner,D.,
            Hutchinson,A., Yeager,M., Fraumeni,J.F. Jr., Lathrop,M.,
            Skryabin,K.G., McKay,J.D., Gu,J., Brennan,P. and Chanock,S.J.
  TITLE     A genome-wide association study identifies a novel susceptibility
            locus for renal cell carcinoma on 12p11.23
  JOURNAL   Hum. Mol. Genet. 21 (2), 456-462 (2012)
   PUBMED   22010048
REFERENCE   3  (bases 1 to 12568)
  AUTHORS   Ju,Y.K., Liu,J., Lee,B.H., Lai,D., Woodcock,E.A., Lei,M.,
            Cannell,M.B. and Allen,D.G.
  TITLE     Distribution and functional role of inositol 1,4,5-trisphosphate
            receptors in mouse sinoatrial node
  JOURNAL   Circ. Res. 109 (8), 848-857 (2011)
   PUBMED   21852551
  REMARK    GeneRIF: Functional IP3R2s are expressed in the mouse sinoatrial
            node and could serve as an additional divalent calcium
            ion-dependent mechanism in modulating cardiac pacemaker.
REFERENCE   4  (bases 1 to 12568)
  AUTHORS   Heid,I.M., Jackson,A.U., Randall,J.C., Winkler,T.W., Qi,L.,
            Steinthorsdottir,V., Thorleifsson,G., Zillikens,M.C.,
            Speliotes,E.K., Magi,R., Workalemahu,T., White,C.C.,
            Bouatia-Naji,N., Harris,T.B., Berndt,S.I., Ingelsson,E.,
            Willer,C.J., Weedon,M.N., Luan,J., Vedantam,S., Esko,T.,
            Kilpelainen,T.O., Kutalik,Z., Li,S., Monda,K.L., Dixon,A.L.,
            Holmes,C.C., Kaplan,L.M., Liang,L., Min,J.L., Moffatt,M.F.,
            Molony,C., Nicholson,G., Schadt,E.E., Zondervan,K.T., Feitosa,M.F.,
            Ferreira,T., Lango Allen,H., Weyant,R.J., Wheeler,E., Wood,A.R.,
            Estrada,K., Goddard,M.E., Lettre,G., Mangino,M., Nyholt,D.R.,
            Purcell,S., Smith,A.V., Visscher,P.M., Yang,J., McCarroll,S.A.,
            Nemesh,J., Voight,B.F., Absher,D., Amin,N., Aspelund,T., Coin,L.,
            Glazer,N.L., Hayward,C., Heard-Costa,N.L., Hottenga,J.J.,
            Johansson,A., Johnson,T., Kaakinen,M., Kapur,K., Ketkar,S.,
            Knowles,J.W., Kraft,P., Kraja,A.T., Lamina,C., Leitzmann,M.F.,
            McKnight,B., Morris,A.P., Ong,K.K., Perry,J.R., Peters,M.J.,
            Polasek,O., Prokopenko,I., Rayner,N.W., Ripatti,S., Rivadeneira,F.,
            Robertson,N.R., Sanna,S., Sovio,U., Surakka,I., Teumer,A., van
            Wingerden,S., Vitart,V., Zhao,J.H., Cavalcanti-Proenca,C.,
            Chines,P.S., Fisher,E., Kulzer,J.R., Lecoeur,C., Narisu,N.,
            Sandholt,C., Scott,L.J., Silander,K., Stark,K., Tammesoo,M.L.,
            Teslovich,T.M., Timpson,N.J., Watanabe,R.M., Welch,R.,
            Chasman,D.I., Cooper,M.N., Jansson,J.O., Kettunen,J.,
            Lawrence,R.W., Pellikka,N., Perola,M., Vandenput,L., Alavere,H.,
            Almgren,P., Atwood,L.D., Bennett,A.J., Biffar,R., Bonnycastle,L.L.,
            Bornstein,S.R., Buchanan,T.A., Campbell,H., Day,I.N., Dei,M.,
            Dorr,M., Elliott,P., Erdos,M.R., Eriksson,J.G., Freimer,N.B.,
            Fu,M., Gaget,S., Geus,E.J., Gjesing,A.P., Grallert,H., Grassler,J.,
            Groves,C.J., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Havulinna,A.S., Herzig,K.H., Hicks,A.A., Hui,J., Igl,W.,
            Jousilahti,P., Jula,A., Kajantie,E., Kinnunen,L., Kolcic,I.,
            Koskinen,S., Kovacs,P., Kroemer,H.K., Krzelj,V., Kuusisto,J.,
            Kvaloy,K., Laitinen,J., Lantieri,O., Lathrop,G.M., Lokki,M.L.,
            Luben,R.N., Ludwig,B., McArdle,W.L., McCarthy,A., Morken,M.A.,
            Nelis,M., Neville,M.J., Pare,G., Parker,A.N., Peden,J.F.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Pouta,A.,
            Ridderstrale,M., Samani,N.J., Saramies,J., Sinisalo,J., Smit,J.H.,
            Strawbridge,R.J., Stringham,H.M., Swift,A.J., Teder-Laving,M.,
            Thomson,B., Usala,G., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Volpato,C.B., Wallaschofski,H., Walters,G.B., Widen,E., Wild,S.H.,
            Willemsen,G., Witte,D.R., Zgaga,L., Zitting,P., Beilby,J.P.,
            James,A.L., Kahonen,M., Lehtimaki,T., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Stumvoll,M., Tonjes,A.,
            Viikari,J., Balkau,B., Ben-Shlomo,Y., Bergman,R.N., Boeing,H.,
            Smith,G.D., Ebrahim,S., Froguel,P., Hansen,T., Hengstenberg,C.,
            Hveem,K., Isomaa,B., Jorgensen,T., Karpe,F., Khaw,K.T., Laakso,M.,
            Lawlor,D.A., Marre,M., Meitinger,T., Metspalu,A., Midthjell,K.,
            Pedersen,O., Salomaa,V., Schwarz,P.E., Tuomi,T., Tuomilehto,J.,
            Valle,T.T., Wareham,N.J., Arnold,A.M., Beckmann,J.S., Bergmann,S.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Collins,F.S.,
            Eiriksdottir,G., Gudnason,V., Gyllensten,U., Hamsten,A.,
            Hattersley,A.T., Hofman,A., Hu,F.B., Illig,T., Iribarren,C.,
            Jarvelin,M.R., Kao,W.H., Kaprio,J., Launer,L.J., Munroe,P.B.,
            Oostra,B., Penninx,B.W., Pramstaller,P.P., Psaty,B.M.,
            Quertermous,T., Rissanen,A., Rudan,I., Shuldiner,A.R., Soranzo,N.,
            Spector,T.D., Syvanen,A.C., Uda,M., Uitterlinden,A., Volzke,H.,
            Vollenweider,P., Wilson,J.F., Witteman,J.C., Wright,A.F.,
            Abecasis,G.R., Boehnke,M., Borecki,I.B., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., North,K.E., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., Hirschhorn,J.N., Assimes,T.L.,
            Wichmann,H.E., Thorsteinsdottir,U., van Duijn,C.M., Stefansson,K.,
            Cupples,L.A., Loos,R.J., Barroso,I., McCarthy,M.I., Fox,C.S.,
            Mohlke,K.L. and Lindgren,C.M.
  CONSRTM   MAGIC
  TITLE     Meta-analysis identifies 13 new loci associated with waist-hip
            ratio and reveals sexual dimorphism in the genetic basis of fat
            distribution
  JOURNAL   Nat. Genet. 42 (11), 949-960 (2010)
   PUBMED   20935629
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2011 Nov;43(11):1164]
REFERENCE   5  (bases 1 to 12568)
  AUTHORS   Arguin,G., Caron,A.Z., Elkoreh,G., Denault,J.B. and Guillemette,G.
  TITLE     The transcription factors NFAT and CREB have different
            susceptibilities to the reduced Ca2+ responses caused by the knock
            down of inositol trisphosphate receptor in HEK 293A cells
  JOURNAL   Cell. Physiol. Biochem. 26 (4-5), 629-640 (2010)
   PUBMED   21063100
  REMARK    GeneRIF: The knock down of IP3R-2 significantly reduced the
            intracellular Ca2+ response and this reduced Ca2+ response did not
            affect the activation of CREB but significantly decreased the
            activation of NFAT.
REFERENCE   6  (bases 1 to 12568)
  AUTHORS   Mayne,M., Holden,C.P., Nath,A. and Geiger,J.D.
  TITLE     Release of calcium from inositol 1,4,5-trisphosphate
            receptor-regulated stores by HIV-1 Tat regulates TNF-alpha
            production in human macrophages
  JOURNAL   J. Immunol. 164 (12), 6538-6542 (2000)
   PUBMED   10843712
REFERENCE   7  (bases 1 to 12568)
  AUTHORS   El-Daher,S.S., Patel,Y., Siddiqua,A., Hassock,S., Edmunds,S.,
            Maddison,B., Patel,G., Goulding,D., Lupu,F., Wojcikiewicz,R.J. and
            Authi,K.S.
  TITLE     Distinct localization and function of (1,4,5)IP(3) receptor
            subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly
            purified human platelet membranes
  JOURNAL   Blood 95 (11), 3412-3422 (2000)
   PUBMED   10828023
  REMARK    Erratum:[Blood 2000 Sep 1;96(5):1684]
REFERENCE   8  (bases 1 to 12568)
  AUTHORS   Futatsugi,A., Kuwajima,G. and Mikoshiba,K.
  TITLE     Muscle-specific mRNA isoform encodes a protein composed mainly of
            the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor
  JOURNAL   Biochem. J. 334 (PT 3), 559-563 (1998)
   PUBMED   9729462
REFERENCE   9  (bases 1 to 12568)
  AUTHORS   Yamamoto-Hino,M., Sugiyama,T., Hikichi,K., Mattei,M.G.,
            Hasegawa,K., Sekine,S., Sakurada,K., Miyawaki,A., Furuichi,T.,
            Hasegawa,M. et al.
  TITLE     Cloning and characterization of human type 2 and type 3 inositol
            1,4,5-trisphosphate receptors
  JOURNAL   Recept. Channels 2 (1), 9-22 (1994)
   PUBMED   8081734
REFERENCE   10 (bases 1 to 12568)
  AUTHORS   Mahaut-Smith,M.P., Sage,S.O. and Rink,T.J.
  TITLE     Receptor-activated single channels in intact human platelets
  JOURNAL   J. Biol. Chem. 265 (18), 10479-10483 (1990)
   PUBMED   1693919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024093.46, D26350.1, BX495410.1, AL711179.1, BP314401.1,
            BP364657.1, BU173910.1, DB144849.1 and AC055720.17.
            On May 13, 2006 this sequence version replaced gi:4504792.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26350.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               AC024093.46        126480-126900
            422-911             D26350.1           423-912
            912-1268            BX495410.1         132-488
            1269-2205           D26350.1           1270-2206
            2206-2588           AL711179.1         232-614
            2589-3299           D26350.1           2590-3300
            3300-3357           BP314401.1         525-582
            3358-3624           D26350.1           3359-3625
            3625-3820           BP364657.1         386-581
            3821-3950           D26350.1           3822-3951
            3951-4516           BU173910.1         236-801
            4517-7952           D26350.1           4518-7953
            7953-8354           DB144849.1         133-534
            8355-8917           D26350.1           8356-8918
            8918-12568          AC055720.17        53146-56796         c
FEATURES             Location/Qualifiers
     source          1..12568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11"
     gene            1..12568
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="inositol 1,4,5-trisphosphate receptor, type 2"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:6181"
                     /db_xref="MIM:600144"
     exon            1..509
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     STS             37..263
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="G05945"
     STS             102..242
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="Cda0me03"
     misc_feature    409..411
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="upstream in-frame stop codon"
     CDS             418..8523
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="inositol 1,4,5-triphosphate receptor, type 2; IP3R
                     2; insP3R2; type 2 InsP3 receptor; IP3 receptor; type 2
                     inositol 1,4,5-trisphosphate receptor"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate receptor type 2"
                     /protein_id="NP_002214.2"
                     /db_xref="GI:95147335"
                     /db_xref="CCDS:CCDS41764.1"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:6181"
                     /db_xref="MIM:600144"
                     /translation="
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH
"
     misc_feature    427..1092
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     Region: Ins145_P3_rec; pfam08709"
                     /db_xref="CDD:204036"
     misc_feature    751..915
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; Region: MIR;
                     smart00472"
                     /db_xref="CDD:197746"
     misc_feature    1111..1713
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="MIR domain; Region: MIR; pfam02815"
                     /db_xref="CDD:202410"
     misc_feature    1210..1224
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     Region: Inositol 1,4,5-trisphosphate binding (By
                     similarity)"
     misc_feature    1297..1443
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; Region: MIR;
                     smart00472"
                     /db_xref="CDD:197746"
     misc_feature    1828..2442
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="RIH domain; Region: RYDR_ITPR; pfam01365"
                     /db_xref="CDD:201750"
     misc_feature    1936..1947
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     Region: Inositol 1,4,5-trisphosphate binding (By
                     similarity)"
     misc_feature    2116..2124
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     Region: Inositol 1,4,5-trisphosphate binding (By
                     similarity)"
     misc_feature    3895..3897
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14571.2); phosphorylation site"
     misc_feature    3958..4482
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="RIH domain; Region: RYDR_ITPR; pfam01365"
                     /db_xref="CDD:201750"
     misc_feature    6160..6441
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="RyR and IP3R Homology associated; Region:
                     RIH_assoc; pfam08454"
                     /db_xref="CDD:149494"
     misc_feature    7099..7161
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     misc_feature    7111..7494
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /note="Protein of unknown function (DUF3792); Region:
                     DUF3792; pfam12670"
                     /db_xref="CDD:205007"
     misc_feature    7198..7260
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     misc_feature    7339..7401
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     misc_feature    7471..7533
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     misc_feature    7600..7662
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     misc_feature    7981..8043
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14571.2);
                     transmembrane region"
     variation       488
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230371"
     exon            510..580
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            581..696
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            697..783
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            784..942
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            943..1041
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1042..1125
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1126..1272
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       1215
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230383"
     exon            1273..1368
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1369..1413
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1414..1565
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1566..1665
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1666..1826
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     STS             1720..1922
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="TIGR-A002T05"
     variation       1775
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230384"
     STS             1781..1935
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="G54108"
     exon            1827..1968
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            1969..2130
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            2131..2303
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            2304..2423
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            2424..2609
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       2433
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2291263"
     variation       2472
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2291264"
     exon            2610..2861
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       2679
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2230378"
     variation       2775
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230379"
     exon            2862..3006
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            3007..3157
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       3111
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230380"
     exon            3158..3351
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       3300
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230372"
     exon            3352..3481
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            3482..3539
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            3540..3705
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            3706..3879
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       3846
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2230373"
     exon            3880..3969
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            3970..4095
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            4096..4218
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            4219..4419
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            4420..4671
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       4542
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230374"
     variation       4656
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230377"
     exon            4672..4797
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            4798..4926
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       4824
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230375"
     variation       4899
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230376"
     exon            4927..5047
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5048..5238
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5239..5381
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5382..5490
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5491..5599
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       5592
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230381"
     exon            5600..5787
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5788..5971
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            5972..6228
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     variation       6110
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230382"
     exon            6229..6429
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            6430..6540
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            6541..6636
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            6637..6759
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            6760..6867
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            6868..7060
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7061..7186
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7187..7362
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7363..7527
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7528..7723
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7724..7816
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7817..7947
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            7948..8113
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            8114..8274
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            8275..8436
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     exon            8437..12568
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /inference="alignment:Splign:1.39.8"
     STS             8807..9141
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="D12S2033"
                     /db_xref="UniSTS:14787"
     variation       9015
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2570"
     variation       9378
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1049376"
     variation       9613
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1049377"
     variation       9903
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375899814"
     STS             10634..10788
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="G54108"
                     /db_xref="UniSTS:109345"
     STS             10647..10849
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="A002T05"
                     /db_xref="UniSTS:69407"
     variation       10763
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8311"
     STS             10778..10919
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="RH18155"
                     /db_xref="UniSTS:209607"
     variation       11309
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1049380"
     variation       11633
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1049381"
     variation       11896
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1049382"
     STS             12306..12532
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="D12S1411"
                     /db_xref="UniSTS:20647"
     STS             12327..12467
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /standard_name="D12S1185E"
                     /db_xref="UniSTS:51860"
     variation       12348
                     /gene="ITPR2"
                     /gene_synonym="IP3R2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9442"
ORIGIN      
cttccagctcccgccgggcggctgtgacggccgcagcgggtcgcagagcagggagtggacacggagtggggagcggagagggaaggaggaggaggaggagcaaaggtgttggagagaaaacttcagaaaggaacaggaaacctgccggggaggcggcggcggctgcggcttctctgggcgcctgggctgcgctcttcgcggggtgtccgcagctgcggcttggccccggtctggcttccccggcgcgcacgcacggctgagccgcgacgctcagtggctcgggccgtgccctccgccgcggctcttggccgctgtagtcccgcgatccgatccgcttctgccgcggcggctccctggagagagggcggcgagggcgcagggaagaagagggacgtccactgtggaacatgaagcagcatgactgagaaaatgtccagcttcctctacataggggacatcgtgtccctgtacgcggagggctcggtcaacggcttcatcagcaccttggggttagtggatgacagatgtgtggtgcacccagaggccggggaccttgccaaccctcccaagaagttcagagactgccttttcaaggtgtgccctatgaacagatattctgcccagaagcaatattggaaagcaaagcaagccaaacaagggaaccacaccgaggcagccttgctgaagaaactacagcacgctgcagaactggaacaaaaacaaaatgaatcggagaataagaaactgttgggagaaattgtaaaatacagtaatgttatacaactactgcatataaaaagcaacaaatatcttactgtcaacaagagattacctgctttactggagaagaatgccatgcgtgtgtccttggatgctgcaggaaatgaagggtcttggttttatattcatccgttctggaaactgagaagcgagggtgacaatattgttgtaggagataaagttgttttgatgcctgtgaatgcagggcagccactacatgccagcaacatagagcttcttgataacccagggtgtaaagaggtgaatgctgtcaattgcaacaccagctggaaaatcactttattcatgaaatatagttcctatcgagaggatgtattaaaaggaggggacgttgttagattatttcatgcggaacaagagaagtttttgacttgtgatgaatatgagaaaaaacagcacattttccttcgtacgaccttgcgccaatcagctacttctgctactagttctaaagcactctgggaaatagaggtggttcatcatgacccatgccgtgggggtgcaggacagtggaacagcttgttcagatttaagcatcttgcaactggaaactatttagctgcagagcttaatcctgattatcgagatgcccaaaatgaaggaaaaaatgtgagagatggagtccctccaacttcaaagaaaaaacgccaggcaggggagaagatcatgtatactttggtttcagtcccgcatggcaatgacattgcatccctttttgaactagatgccacaactcttcagagagctgactgcctggttccaaggaactcatatgttcggttaaggcatttatgcaccaacacatgggtaaccagtactagtatccccatagacacagatgaagagaggcctgttatgttaaagattggaacctgccaaaccaaagaagataaagaagcgttcgcaatcgtgtctgttccactgtctgaagttcgagacttagactttgccaatgatgccaataaagtactagcgaccacagttaaaaagctagaaaacggcacaataactcagaatgaaaggaggtttgtaaccaaattattggaagatctcatattctttgttgctgatgtgcctaataatggacaagaagttctggatgtggttatcactaagccaaaccgagagcgtcaaaaattgatgagggaacaaaacatactggcacaggtatttggaattcttaaagcaccctttaaagagaaagcaggagaaggctcgatgctgagacttgaagatctgggggatcaaagatatgcaccctacaagtacatgctgcggctctgttaccgcgtcctgagacactcgcagcaggattaccggaaaaatcaggaatatattgctaagaatttctgtgtcatgcagtcccagattggctatgatattttggcagaagatactatcacagctttgttgcacaacaacagaaaactactagagaaacatatcacagcaaaagaaatagaaacatttgtcagtttactcaggagaaatcgggagccaaggtttttggattatttgtcagatctgtgtgtgtctaataccactgctatccctgtaactcaagaactcatctgtaaatttatgttgagtccaggcaatgcagacattctcattcaaactaaggtggtctcaatgcaagcagacaaccccatggagagctccatcctttcagatgacattgatgatgaagaagtttggctctattggattgacagcaacaaggaacctcatggcaaagctatcaggcaccttgctcaagaggcaaaagaaggcaccaaagctgacttagaagttcttacctattacaggtaccagctaaacctctttgcaaggatgtgcttggatcgccagtatctggccataaaccagatttctacacagctgtctgtagacctgatcctgcggtgtgtgtcggatgagagcctgccgttcgacctccgagcgtccttctgtcgcctcatgctccacatgcacgttgaccgggatccccaggagtccgtggtgcctgttcgctatgccaggctctggacagaaatccccacaaagatcacaattcatgaatatgattctataacagactcttccagaaatgatatgaagaggaaatttgccctgacaatggaatttgttgaagaatatttgaaagaagttgtaaaccagccctttccttttggggataaagaaaaaaataaactgacatttgaggtggtccacttggctcggaatcttatatactttggattttatagtttcagtgagttattaaggctaacaagaacacttctggctattttagacattgtacaggcccccatgtcatcatactttgaaagattaagcaaatttcaagatggaggaaacaatgtgatgagaaccattcatggggtgggagagatgatgacccagatggtactcagtagaggctccatcttccccatgagcgtgccggatgtgccacccagcatccacccgagcaagcaagggagccccaccgagcacgaggatgtgactgtgatggacaccaagctgaagatcattgagattttgcagtttatcctgagtgtcagactggattataggatctcatatatgctgtcaatatataagaaggagtttggagaggacaatgacaatgcggagacatctgccagtggatctccagacactttactaccatcagctattgttcctgatatagatgaaattgcagctcaggcagaaactatgtttgcgggaagaaaagaaaaaaatccagttcaacttgacgatgaaggaggcaggacgtttttacgggtcctcattcatctgatcatgcacgactacccgcctttgctgtctggagccctgcagctgttgtttaagcacttcagccagagggcagaggttttacaggcatttaagcaggtgcaattactggtgtctaatcaagacgtagataactacaagcaaatcaaggcagatctagaccagcttcgactgacagtagaaaagtctgagctatgggtggagaagagcagcaactatgagaatggagaaataggggaaagtcaagtgaaaggtggtgaagagccaattgaggaatcaaacattttaagtccagtgcaggatggaacaaagaaacctcagattgacagcaacaagagcaataactaccggattgtaaaggagattttgatcaggctaagtaaactctgtgtgcagaataaaaagtgtcggaatcaacatcaacgattactgaaaaatatgggggcgcattcggtggtgttggatcttctgcagataccctatgaaaagaatgatgaaaagatgaatgaagtaatgaatctagcccatacatttctgcagaatttctgtcgaggaaatccacagaatcaagttcttcttcataaacatctgaatttgtttttaactccaggtctccttgaagcagaaaccatgcggcacatcttcatgaacaattaccatctgtgcaacgaaattagcgagagagttgtacaacactttgtgcactgcattgagacacatggccgccacgtggagtacctgaggtttttgcaaacaattgtaaaagcagatggtaaatatgtgaagaaatgccaggatatggtaatgacagagttgataaatgggggtgaagacgtgctgatattttacaatgatagagcatcatttccaatccttctccatatgatgtgttcagagagagaccgaggggatgagagtggccccttagcctaccacatcaccctggtggagttgctggcagcatgcacagaggggaaaaatgtctacactgaaatcaagtgtaattcccttctcccgctggacgacatagtgagggtggtgacccatgacgactgcatccctgaggttaaaattgcttatgtgaactttgttaatcactgttatgttgacactgaagtggaaatgaaagaaatctatacaagtaaccacatttggaaattatttgagaacttcttggtggatatggcaagggtttgcaacacaactacagacaggaaacatgcagacatctttttggaaaagtgtgttactgagtcaataatgaatattgtgagcggcttctttaattctcccttttcagacaatagtaccagcctccagacacatcagccagtttttattcagctactgcaatctgccttcagaatttacaattgcacctggccaaacccagcgcagaaagcctcagtggaatcctgtatcagaactttggctgaagtggcaaaaaatcgtggaattgccattccagtggatttggacagccaagttaatactcttttcatgaagagccattcaaatatggtgcagagagcagcaatgggttggagactatcagctcgctctgggccacgctttaaggaagctcttggagggcctgcttgggattacagaaatattattgaaaagttacaggatgtagtggcctccttggagcaccagttcagcccaatgatgcaggctgaattctcagtgttggttgatgtattgtacagtccagaactgctgttccctgagggaagcgatgcaagaataagatgtggcgctttcatgtcgaagttgattaatcatacaaagaaactaatggagaaagaagaaaaactgtgcattaaaattcttcagacattacgagaaatgttagagaagaaagacagctttgtggaagagggtaacacattaagaaagatacttctgaatcgatactttaaaggtgattatagtattggtgtgaatggacacctatcaggagcctactccaaaactgcacaggtgggaggaagcttttctggacaagattcagataagatggggatatcaatgtcagacattcagtgtctgctggataaagaaggtgcatcagaacttgtcatcgatgttatagtgaacaccaaaaatgacagaattttttcagaaggcattttcctcggcattgccttgcttgaaggaggaaatacacaaacacagtattctttctaccagcagttgcatgaacaaaaaaagtcagaaaaattctttaaagttctctatgatcgaatgaaggctgctcagaaagaaataagatcaacagtgacagttaataccatagatttaggtaacaaaaaaagggacgatgacaatgaattgatgacatctggtccacgaatgagagtaagagattcaacactacatttaaaagagggaatgaaagggcaattaacagaagcttcttcagcaacatccaaagcatattgtgtatacagaagagaaatggatccagaaatagacattatgtgcacaggaccagaagcgggaaacactgaggaaaaatccgcagaggaagtaacaatgagtcccgcaattgccatcatgcagccaatactgagatttcttcagttactgtgtgagaatcacaaccgggaattgcagaacttcttgaggaatcaaaacaacaaaacaaattacaacctagtctgtgagacccttcagtttctggactgcatttgtggaagtacaaccggtggcctgggcctgttgggtctctacatcaatgagaagaatgtagcgctggtcaaccagaacctggagagcttgactgagtattgccagggcccttgccatgaaaatcagacctgtatcgctacacatgagtctaatgggattgatatcatcattgctttgattctgaatgacataaaccctcttggtaaataccgaatggacctggtgctccagctaaagaacaatgcatctaaacttttgctggccattatggaaagcagacatgacagtgagaatgcagaaagaattctttttaacatgagacccagagaactggtggatgtgatgaagaatgcctataaccaaggattggaatgtgaccatggggatgatgagggtggagatgatggtgtttctccaaaagatgttggacacaatatctatattctggcccatcagttggcccgccacaataaactgttgcagcagatgctcaaaccaggatcggatccagatgaaggagatgaagccttaaagtattatgccaaccacactgcacagattgagattgtccggcatgataggaccatggaacaaatagtttttcctgtccccaatatatgtgaatacctcactcgagaatccaagtgccgtgtgttcaatacaactgaaagggatgaacaaggaagtaaagtgaatgactttttccagcaaacagaagatctctacaatgaaatgaagtggcagaagaaaatcaggaataaccctgcactgttctggttctcgaggcacatctctctctgggggagcatttccttcaacctggctgtgttcatcaatttagctgttgctctcttctacccatttggggatgatggagatgaaggtacactttctccattgttctcggttcttctttggatagcagttgcgatctgcacatctatgctgtttttcttctccaagcctgtgggtattcggccgtttcttgtatcaataatgctcagatcaatatatacaataggtcttgggcctacattaatacttcttggtgcagctaatctttgtaataaaattgtttttctggtgagttttgttggaaatcgtggcacgttcacccgtgggtaccgagcagtcatcctggatatggcctttctctatcacgtggcgtatgtcctggtttgcatgctgggcctttttgtccatgaattcttctatagcttcctgctttttgatttggtgtacagggaagagactttgctgaatgtcataaaaagtgtcacacgaaatggccgctctattattctaactgcagtcctggctctcatcctcgtctacctgttttccattattgggttcctttttttgaaggatgacttcactatggaagttgataggctgaaaaaccgaactcctgttacaggcagtcatcaagtgcctactatgactttaactaccatgatggaagcatgtgccaaggagaactgttcacccacaattccagcttcaaatacagctgatgaagagtatgaagatggaattgaaaggacgtgtgacactctccttatgtgcattgtcaccgtgctgaaccagggcctcaggaatggcggtggtgtgggggatgtgctaagaaggccatcgaaagatgagcccttgtttgctgcccgagtggtttatgaccttcttttttatttcattgttatcattattgttctgaacttgatttttggtgttatcatcgatacttttgctgatctcagaagcgaaaaacagaaaaaagaagaaattctaaagacaacttgtttcatctgtggacttgagagagacaagtttgataataaaacggtttcatttgaggagcacattaagtcagaacacaatatgtggcattatttgtacttcatagtcctggtgaaagttaaagacccaacagaatacactggacctgaaagttatgtggctcaaatgattgtggagaagaatttggattggtttcctcggatgcgagccatgtccctcgttagcaatgaaggcgacagtgagcaaaatgaaattcggagccttcaggagaagttggaatcgaccatgagtctggtcaaacagctgtcgggtcagctggcggagctcaaggagcagatgacagaacaaaggaagaataagcagagactgggcttcctcggatcaaacacaccccatgtgaatcatcacatgccaccacactgataccatggggggaagccgtgactagcctttcatcagtgtcctgcctgatcactgaataaagaactgagatggaggggagtgaacagtgcctattgttgaaaagttaaaaacaaccaagtgccaagatgttgagtgggttagctccgagaacaatttataactgtgttttcatggttgcgaagacctaacctcaaatgcatctgctagaaagcgtacatcacacattcgcaatgcatcaggaagaaaaggcttgcccaaaaggctggagagggcagggagcggcaggatggaaggagacacggggcagggagaactctcttctgctaaatcgataggagtcagttttgtcttaaatgctgactacagccactgacatggttggctggaatttctttcttttaattgtggcatataggtttgtgacacaagaagtcatactttggtggctaagttttactaaggaaaataactgaaaagattaaaagtgagagctgaaaagagaaatgataatgcttccaaactgtagctgtcacagggcaatttctttatttataacatgaagcacaatggatttacagctctaggaacttagtactttggagcttttgcctctcacactgacaacataacaggatgtgattgccttctctgggattcagacaggctctgtcaatgtggagcacaaaaggagattttcatataacttgttaaaaacatgttctaagtcatgtataggctaagattttaagaagatctgggggaataaaaagccaacagtaagccccaggaaagggttttttgagaccatatgtatgctattaaaatatattgagattaatacatgaaaatgcttaaaagtgataggaattattgagaaacttatgatggtggcattgccttttataaacatggagtgaaagccatttgactcaacgtttgctgtgcttaaagaattgcttcaggacccgagcgtttttatgtatgctgttcctgcagttaggaaaaaaaaatccaagaaatgtattgaatactcaagaaaatgccacatttcaattacatatttaaaactgtatctgtaagggcttttcaaaatgtagcaagataaaaatctcttattcaaattgtttttgtattaaatcatgcactcagaatttgtcgagggagagaataacctggtgtgttcaggttattcttagagactacacatttggaatagcagagcaaaatatggataatgaaagtgttgggaaaaaagtgatgtgacagggagtgaagacacttgataccagactctgggagatactctgcaagttgacctggcctctcccccacaggaacaaaacactgcctccagagtctttaaattctcagttatcaacgccaaggtttaaggtctagatagggtttgctatagggtttgctctgacaatttttaaagcttttggattgttctaacatagcttaagctattggttcc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//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3709 -> Molecular function: GO:0005220 [inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] evidence: IEA
            GeneID:3709 -> Molecular function: GO:0015085 [calcium ion transmembrane transporter activity] evidence: TAS
            GeneID:3709 -> Molecular function: GO:0035091 [phosphatidylinositol binding] evidence: IEA
            GeneID:3709 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA
            GeneID:3709 -> Biological process: GO:0006112 [energy reserve metabolic process] evidence: TAS
            GeneID:3709 -> Biological process: GO:0006810 [transport] evidence: TAS
            GeneID:3709 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:3709 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:3709 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS
            GeneID:3709 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:3709 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:3709 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:3709 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:3709 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:3709 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:3709 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:3709 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:3709 -> Biological process: GO:0050796 [regulation of insulin secretion] evidence: TAS
            GeneID:3709 -> Biological process: GO:0071320 [cellular response to cAMP] evidence: IEA
            GeneID:3709 -> Biological process: GO:0071361 [cellular response to ethanol] evidence: IEA
            GeneID:3709 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
            GeneID:3709 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:3709 -> Cellular component: GO:0005938 [cell cortex] evidence: IEA
            GeneID:3709 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:3709 -> Cellular component: GO:0031095 [platelet dense tubular network membrane] evidence: TAS
            GeneID:3709 -> Cellular component: GO:0033017 [sarcoplasmic reticulum membrane] evidence: IMP

by @meso_cacase at DBCLS
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