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2024-03-29 00:32:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002141               1728 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox A4 (HOXA4), mRNA.
ACCESSION   NM_002141
VERSION     NM_002141.4  GI:148613881
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Gray,S., Pandha,H.S., Michael,A., Middleton,G. and Morgan,R.
  TITLE     HOX genes in pancreatic development and cancer
  JOURNAL   JOP 12 (3), 216-219 (2011)
   PUBMED   21546695
  REMARK    GeneRIF: Studies suggest that HOXA4, HOXA5 and HOXB4 provide the
            spatial information needed to restrict the response to signals from
            the notochord, and not up regulated in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Lillvis,J.H., Erdman,R., Schworer,C.M., Golden,A., Derr,K.,
            Gatalica,Z., Cox,L.A., Shen,J., Vander Heide,R.S., Lenk,G.M.,
            Hlavaty,L., Li,L., Elmore,J.R., Franklin,D.P., Gray,J.L.,
            Garvin,R.P., Carey,D.J., Lancaster,W.D., Tromp,G. and Kuivaniemi,H.
  TITLE     Regional expression of HOXA4 along the aorta and its potential role
            in human abdominal aortic aneurysms
  JOURNAL   BMC Physiol. 11, 9 (2011)
   PUBMED   21627813
  REMARK    GeneRIF: HOXA4 showed nuclear & perinuclear staining in endothelial
            & smooth muscle cells in aorta. Spatial variation in expression in
            human aortas persisted into adulthood. Downregulation of HOXA4
            expression was associated with abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M.,
            Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M.,
            Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E.,
            Orwoll,E.S. and Zmuda,J.M.
  CONSRTM   MrOS Research Group
  TITLE     High-density association study of 383 candidate genes for
            volumetric BMD at the femoral neck and lumbar spine among older men
  JOURNAL   J. Bone Miner. Res. 24 (12), 2039-2049 (2009)
   PUBMED   19453261
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Zangenberg,M., Grubach,L., Aggerholm,A., Silkjaer,T.,
            Juhl-Christensen,C., Nyvold,C.G., Kjeldsen,E., Ommen,H.B. and
            Hokland,P.
  TITLE     The combined expression of HOXA4 and MEIS1 is an independent
            prognostic factor in patients with AML
  JOURNAL   Eur. J. Haematol. 83 (5), 439-448 (2009)
   PUBMED   19563517
  REMARK    GeneRIF: combination of low HOXA4 and low MEIS1 gene expression is
            a favourable predictor for outcome in all AML patients and that the
            expression levels are governed by the methylation state of these
            genes.
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Klausen,C., Leung,P.C. and Auersperg,N.
  TITLE     Cell motility and spreading are suppressed by HOXA4 in ovarian
            cancer cells: possible involvement of beta1 integrin
  JOURNAL   Mol. Cancer Res. 7 (9), 1425-1437 (2009)
   PUBMED   19723874
  REMARK    GeneRIF: Results confirm that HOXA4 inhibits cell motility, show
            that it suppresses cell spreading and filopodia formation while
            enhancing cell-cell adhesion, and suggest a role for beta1 integrin
            in mediating these changes.
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Buettner,R., Yim,S.O., Hong,Y.S., Boncinelli,E. and Tainsky,M.A.
  TITLE     Alteration of homeobox gene expression by N-ras transformation of
            PA-1 human teratocarcinoma cells
  JOURNAL   Mol. Cell. Biol. 11 (7), 3573-3583 (1991)
   PUBMED   1675427
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Ferguson-Smith,A.C., Fienberg,A. and Ruddle,F.H.
  TITLE     Isolation, chromosomal localization, and nucleotide sequence of the
            human HOX 1.4 homeobox
  JOURNAL   Genomics 5 (2), 250-258 (1989)
   PUBMED   2571574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW445008.1, AC004080.2 and
            M74297.1.
            On Jun 6, 2007 this sequence version replaced gi:84043949.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M74297.1, M74297.1, BI521357.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AW445008.1         133-386             c
            255-255             AC004080.2         3896-3896           c
            256-386             AW445008.1         1-131               c
            387-465             M74297.1           340-418
            466-466             AC004080.2         3685-3685           c
            467-760             M74297.1           420-713
            761-1728            AC004080.2         1877-2844           c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..1728
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /note="homeobox A4"
                     /db_xref="GeneID:3201"
                     /db_xref="HGNC:5105"
                     /db_xref="MIM:142953"
     STS             1..1602
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /db_xref="UniSTS:484641"
     exon            1..663
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /inference="alignment:Splign:1.39.8"
     STS             31..269
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="REN100463"
                     /db_xref="UniSTS:425260"
     CDS             48..1010
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /note="homeo box A4; Hox-1.4-like protein; Dfd-like
                     protein; homeobox protein Hox-1D; homeobox protein
                     Hox-1.4"
                     /codon_start=1
                     /product="homeobox protein Hox-A4"
                     /protein_id="NP_002132.3"
                     /db_xref="GI:148613882"
                     /db_xref="CCDS:CCDS5405.1"
                     /db_xref="GeneID:3201"
                     /db_xref="HGNC:5105"
                     /db_xref="MIM:142953"
                     /translation="
MTMSSFLINSNYIEPKFPPFEEYAQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAYPAAALYPAHGAADTAYPYGYRGGASPGRPPQPEQPPAQAKGPAHGLHASHVLQPQLPPPLQPRAVPPAAPRRCEAAPATPGVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI
"
     misc_feature    627..644
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00056.3);
                     Region: Antp-type hexapeptide"
     misc_feature    693..869
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(693..707,711..713,762..764,780..782,819..821,
                     825..830,837..842,846..854,858..863)
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(699..701,708..710,828..830,837..842,849..851)
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             95..355
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="REN100462"
                     /db_xref="UniSTS:425259"
     variation       119
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050271"
     variation       164
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1050272"
     variation       232
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77150951"
     STS             609..956
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="Hoxa4"
                     /db_xref="UniSTS:547734"
     exon            664..1728
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /inference="alignment:Splign:1.39.8"
     STS             722..900
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="HOXA4"
                     /db_xref="UniSTS:278530"
     STS             794..1051
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="REN100457"
                     /db_xref="UniSTS:425254"
     variation       848
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1063494"
     STS             1023..1218
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="G10625"
                     /db_xref="UniSTS:39624"
     STS             1027..1430
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="D7S2834"
                     /db_xref="UniSTS:8898"
     STS             1028..1288
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="REN100456"
                     /db_xref="UniSTS:425253"
     STS             1058..1632
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="ECD11377"
                     /db_xref="UniSTS:292413"
     variation       1264
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1801085"
     STS             1286..1537
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /standard_name="REN100455"
                     /db_xref="UniSTS:425252"
     variation       1599
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:14447"
     polyA_signal    1689..1694
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
     polyA_signal    1710..1715
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
     polyA_site      1728
                     /gene="HOXA4"
                     /gene_synonym="HOX1; HOX1D"
ORIGIN      
aaaacgacaacgcgagaaaaattagtatttttgcacttcacaaattaatgaccatgagctcgtttttgataaactccaactacatcgagcccaagttccctcccttcgaggagtacgcgcagcacagcggctcgggcggcgcagacggcggcccgggcgggggccccggctaccagcagcccccagcgcccccgacccagcacctgccgctgcagcagccccagctccctcacgcgggcggcggccgagagcccactgcctcctactacgcgccgcggaccgcccgcgagcccgcctaccctgctgccgcgctgtaccccgcgcatggggccgcggacaccgcctacccctatggctaccgcggcggcgccagccccgggcggccgccccagcccgagcagcccccggcgcaagccaagggcccagcgcacggcctgcatgcgagccacgtcctgcagccccagctgccgccgcccctgcagcctcgcgccgtgcccccagcggccccgcggcgctgcgaggcggcccccgccaccccaggcgtcccggcagggggcagcgcccccgcgtgcccgctgctcttggccgacaagagcccgctgggcctgaagggcaaggagcccgtggtgtacccctggatgaagaagatccatgtcagcgccgttaaccccagttataacggaggggagcctaagcgctctcgaaccgcctacacccggcagcaggtcttggagctggagaaggagttccacttcaatcgatacctgacccggcggcgccgcatcgagatcgcccacacgctctgtttgtctgagcgccaggtcaagatctggtttcagaaccggaggatgaagtggaagaaagaccacaaactgcccaacaccaagatgcgatcctccaattcggcctcggcctctgccggcccaccagggaaagcacaaactcagagcccacacctccatccccacccccacccgagcacctccacacccgttccctcctccatataatcttctagagatcttaaccagtttctatcccttacctgcttttctcttctcttctcctgctccgttcctcatccacccctccccatctggaccataatagacaccaaaacaaacccaaattggtgaaaagaataatcaaaaagaagacattatccggttaagagtctgtgctggttgccacccaagagagaacagttgtccaggatgctggctggtggaacaacctgctggcccgaaacaaggctgccaggtgtggatacctgagaaggactacttggtatcaaatacttttgagatggctacagtcagctagctggacagcccatgctgagtggggacatacacttgcatctttgttgaaagcagaagaagacagaccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaagcttgtatttaactgaataaatgagtagacattgtggacctcacaagattatttaattcttaagatgtgtagaccttgatggtaggtgtgacatgttagtttttcttacttgcatttatttaagacactgttacagagatactgttgtccccttctggggcacggtctttggggagaggggagtgcatttagacttatgtggaactgtacaaattgtgatgtggctacatagaaagccatgtgctaagaataaactccatttaaaaaacattaaaaatctaagattca
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3201 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3201 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3201 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3201 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
            GeneID:3201 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3201 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
            GeneID:3201 -> Cellular component: GO:0005634 [nucleus] evidence: IEA

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