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2024-03-28 18:07:09, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002066                723 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens glycosylphosphatidylinositol anchored molecule like
            (GML), mRNA.
ACCESSION   NM_002066
VERSION     NM_002066.2  GI:169646780
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 723)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat. Res. 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 723)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun. 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 723)
  AUTHORS   Kimura,Y., Furuhata,T., Urano,T., Hirata,K., Nakamura,Y. and
            Tokino,T.
  TITLE     Genomic structure and chromosomal localization of GML (GPI-anchored
            molecule-like protein), a gene induced by p53
  JOURNAL   Genomics 41 (3), 477-480 (1997)
   PUBMED   9169150
REFERENCE   4  (bases 1 to 723)
  AUTHORS   Furuhata,T., Tokino,T., Urano,T. and Nakamura,Y.
  TITLE     Isolation of a novel GPI-anchored gene specifically regulated by
            p53; correlation between its expression and anti-cancer drug
            sensitivity
  JOURNAL   Oncogene 13 (9), 1965-1970 (1996)
   PUBMED   8934543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083841.9 and D84290.1.
            On Mar 7, 2008 this sequence version replaced gi:4504032.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84290.1, BC126338.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC083841.9         52978-53030         c
            54-723              D84290.1           53-722
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..723
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="glycosylphosphatidylinositol anchored molecule
                     like"
                     /db_xref="GeneID:2765"
                     /db_xref="HGNC:4375"
                     /db_xref="HPRD:03844"
                     /db_xref="MIM:602370"
     exon            1..68
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376930130"
     STS             11..681
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /db_xref="UniSTS:486086"
     variation       19
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367459"
     variation       49
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:201122409"
     variation       50
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:55957122"
     variation       63
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:60783500"
     exon            69..163
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:1.39.8"
     STS             73..617
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /db_xref="UniSTS:482138"
     variation       76
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368117158"
     variation       82
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372387223"
     variation       83
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375561355"
     CDS             91..567
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="Glycosylphosphatidylinositol-anchored molecule-like
                     protein; GPI anchored molecule like protein;
                     glycosyl-phosphatidylinositol-anchored molecule-like
                     protein; glycosylphosphatidylinositol anchored molecule
                     like protein"
                     /codon_start=1
                     /product="glycosyl-phosphatidylinositol-anchored
                     molecule-like protein precursor"
                     /protein_id="NP_002057.1"
                     /db_xref="GI:4504033"
                     /db_xref="CCDS:CCDS6391.1"
                     /db_xref="GeneID:2765"
                     /db_xref="HGNC:4375"
                     /db_xref="HPRD:03844"
                     /db_xref="MIM:602370"
                     /translation="
MLLFALLLAMELPLVAASATMRAQWTYSLRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWVCCCNSMVCNAGGPTNLERDMLPDEVTEEELPEGTVRLGVSKLLLSFASIIVSNILP
"
     sig_peptide     91..141
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     142..564
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /product="Glycosyl-phosphatidylinositol-anchored
                     molecule-like protein"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99445.1)"
     misc_feature    175..429
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="Ly-6 antigen / uPA receptor -like domain; occurs
                     singly in GPI-linked cell-surface glycoproteins (Ly-6
                     family,CD59, thymocyte B cell antigen, Sgp-2) or as
                     three-fold repeated domain in urokinase-type plasminogen
                     activator receptor. Topology of these...; Region: LU;
                     cd00117"
                     /db_xref="CDD:29016"
     variation       111
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150336506"
     variation       114
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61729415"
     variation       118
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370445874"
     variation       119
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34441899"
     variation       122
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188114864"
     variation       154
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199525495"
     variation       155
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200642476"
     variation       156
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138131984"
     exon            164..271
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:1.39.8"
     variation       171
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374930378"
     variation       180
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369242046"
     variation       181
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373513004"
     variation       182
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:45437692"
     variation       192
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138944423"
     variation       194
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138790796"
     variation       195
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201733015"
     variation       205
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147246218"
     variation       212
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370005420"
     variation       213
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373358231"
     variation       227
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111371033"
     variation       237
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142334468"
     variation       250
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3764795"
     variation       251
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144676176"
     variation       266
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139347831"
     variation       271
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150041552"
     exon            272..723
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:1.39.8"
     variation       281
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141438947"
     variation       283
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375056481"
     variation       379
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142273167"
     variation       386
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368431597"
     variation       406
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372983219"
     variation       409
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372538137"
     variation       446
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2097573"
     variation       463
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181298814"
     variation       509
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148835436"
     variation       511
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374503896"
     variation       521
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368774634"
     STS             568..698
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /standard_name="RH68307"
                     /db_xref="UniSTS:51678"
     variation       570
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371313765"
     variation       601
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185910108"
     variation       607
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150154295"
     variation       608
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200183265"
     variation       610
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369120924"
     variation       612
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371765242"
     variation       613
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201791514"
     variation       694
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2078674"
     variation       699
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191203130"
     polyA_signal    705..709
                     /gene="GML"
                     /gene_synonym="LY6DL"
ORIGIN      
gtcggcgcgggaggctcagatggctggaggcggcgggcacgcacactgcggggctccgaggggcacaggtccaggctcctgcgtgaagtgatgctcctctttgccttactcctagccatggagctcccattggtggcagccagtgccaccatgcgcgctcagtggacttacagtttgagatgccatgactgtgcggtcataaatgacttcaactgtcccaacattagagtatgtccgtatcatattaggcgctgtatgacaatctccattcgcataaattctcgtgaactacttgtttataagaactgtacaaacaactgcacatttgtatatgcagctgaacagcctcctgaagccccaggaaaaatcttcaaaactaatagcttctactgggtttgttgttgtaatagcatggtttgcaatgcaggaggacctactaatcttgaaagggacatgttacccgatgaagtaactgaggaggagcttccagaaggaactgtgaggctgggggtatcaaaactgttgctgagttttgcctctatcatagtcagcaatatattgccatgaggaccccaccttggagggtctgaccatcttcacctgttccgcagagaaatgttgctctccattattcccttctaagccagagacccttatccactgctcctctaggtggcccatttatggtttgttgtaagagaaaaattaaaaaaatattgttta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2765 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:2765 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:2765 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: TAS
            GeneID:2765 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:2765 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: TAS
            GeneID:2765 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA

by @meso_cacase at DBCLS
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