2024-03-29 20:16:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002029 1334 bp mRNA linear PRI 02-JUN-2013 DEFINITION Homo sapiens formyl peptide receptor 1 (FPR1), transcript variant 2, mRNA. ACCESSION NM_002029 VERSION NM_002029.3 GI:36951095 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1334) AUTHORS Zhou,C., Zhou,Y., Wang,J., Feng,Y., Wang,H., Xue,J., Chen,Y., Ye,R.D. and Wang,M.W. TITLE V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins JOURNAL Biochem. J. 451 (2), 245-255 (2013) PUBMED 23373827 REMARK GeneRIF: haplotypic variation in FPR1, especially the SNP p.V101L, alters the receptor's response to cyclosporins REFERENCE 2 (bases 1 to 1334) AUTHORS Schneider,E.H., Weaver,J.D., Gaur,S.S., Tripathi,B.K., Jesaitis,A.J., Zelenka,P.S., Gao,J.L. and Murphy,P.M. TITLE The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells JOURNAL J. Biol. Chem. 287 (48), 40779-40792 (2012) PUBMED 23012360 REMARK GeneRIF: FPR1 is functionally expressed on human lens epithelial cells. REFERENCE 3 (bases 1 to 1334) AUTHORS Mitchell,M.J. and King,M.R. TITLE Shear-induced resistance to neutrophil activation via the formyl peptide receptor JOURNAL Biophys. J. 102 (8), 1804-1814 (2012) PUBMED 22768936 REMARK GeneRIF: physiological shear forces alter neutrophil activation via FP REFERENCE 4 (bases 1 to 1334) AUTHORS Gemperle,C., Schmid,M., Herova,M., Marti-Jaun,J., Wuest,S.J., Loretz,C. and Hersberger,M. TITLE Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages JOURNAL PLoS ONE 7 (11), E50195 (2012) PUBMED 23185575 REMARK GeneRIF: The expression of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages is regulated by cytokines and bacterial ligands. REFERENCE 5 (bases 1 to 1334) AUTHORS Miettinen,H.M. TITLE Regulation of human formyl peptide receptor 1 synthesis: role of single nucleotide polymorphisms, transcription factors, and inflammatory mediators JOURNAL PLoS ONE 6 (12), E28712 (2011) PUBMED 22174875 REMARK GeneRIF: The expression of FPR1 in myeloid cells is developmentally regulated, and the differentiated cells are equipped for immediate response to microbial infections. REFERENCE 6 (bases 1 to 1334) AUTHORS Perez,H.D., Holmes,R., Kelly,E., McClary,J., Chou,Q. and Andrews,W.H. TITLE Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression JOURNAL Biochemistry 31 (46), 11595-11599 (1992) PUBMED 1445895 REFERENCE 7 (bases 1 to 1334) AUTHORS Graves,V., Gabig,T., McCarthy,L., Strour,E.F., Leemhuis,T. and English,D. TITLE Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils JOURNAL Blood 80 (3), 776-787 (1992) PUBMED 1322204 REMARK Erratum:[Blood 1993 Mar 15;81(6):1668] REFERENCE 8 (bases 1 to 1334) AUTHORS Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C. TITLE Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19 JOURNAL Genomics 13 (2), 437-440 (1992) PUBMED 1612600 REFERENCE 9 (bases 1 to 1334) AUTHORS Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D. and Francke,U. TITLE A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family JOURNAL J. Biol. Chem. 267 (11), 7637-7643 (1992) PUBMED 1373134 REFERENCE 10 (bases 1 to 1334) AUTHORS Murphy,P.M. and McDermott,D. TITLE Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor JOURNAL J. Biol. Chem. 266 (19), 12560-12567 (1991) PUBMED 1712023 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB993626.1, BC005315.1, M60627.1 and BQ016000.1. This sequence is a reference standard in the RefSeqGene project. On Sep 29, 2003 this sequence version replaced gi:31542793. Summary: This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB993626.1, BC005315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-7 CB993626.1 28-34 8-1087 BC005315.1 1-1080 1088-1214 M60627.1 1054-1180 1215-1314 BC005315.1 1208-1307 1315-1334 BQ016000.1 1-20 c FEATURES Location/Qualifiers source 1..1334 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.4" gene 1..1334 /gene="FPR1" /gene_synonym="FMLP; FPR" /note="formyl peptide receptor 1" /db_xref="GeneID:2357" /db_xref="HGNC:3826" /db_xref="HPRD:00646" /db_xref="MIM:136537" exon 1..84 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="alignment:Splign:1.39.8" exon 85..1317 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="alignment:Splign:1.39.8" CDS 96..1148 /gene="FPR1" /gene_synonym="FMLP; FPR" /note="fMLP receptor; N-formylpeptide chemoattractant receptor" /codon_start=1 /product="fMet-Leu-Phe receptor" /protein_id="NP_002020.1" /db_xref="GI:4503779" /db_xref="CCDS:CCDS12839.1" /db_xref="GeneID:2357" /db_xref="HGNC:3826" /db_xref="HPRD:00646" /db_xref="MIM:136537" /translation="
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
" misc_feature 177..245 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 264..998 /gene="FPR1" /gene_synonym="FMLP; FPR" /note="7 transmembrane receptor (rhodopsin family); Region: 7tm_1; pfam00001" /db_xref="CDD:200918" misc_feature 279..344 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 396..458 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 516..581 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 711..773 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 822..893 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 951..1010 /gene="FPR1" /gene_synonym="FMLP; FPR" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P21462.3); transmembrane region" misc_feature 1077..1079 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1080..1082 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1086..1088 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1089..1091 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1095..1097 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1101..1103 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1107..1109 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" misc_feature 1110..1112 /gene="FPR1" /gene_synonym="FMLP; FPR" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00182" variation 127 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="c" /replace="t" /db_xref="dbSNP:5030878" variation 396 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="c" /replace="g" /db_xref="dbSNP:2070745" variation 443 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="c" /replace="t" /db_xref="dbSNP:5030879" variation 641 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="a" /replace="c" /db_xref="dbSNP:2070746" variation 663 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="a" /replace="t" /db_xref="dbSNP:5030880" variation 671 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1042229" STS 990..1144 /gene="FPR1" /gene_synonym="FMLP; FPR" /standard_name="RH17955" /db_xref="UniSTS:82329" variation 1132 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="a" /replace="c" /db_xref="dbSNP:867228" variation 1223 /gene="FPR1" /gene_synonym="FMLP; FPR" /replace="a" /replace="g" /db_xref="dbSNP:867341" polyA_signal 1298..1303 /gene="FPR1" /gene_synonym="FMLP; FPR" ORIGIN
aatcattagagcctgagtcactctccccaggagacccagacctagaactacccagagcaagaccacagctggtgaacagtccaggagcagacaagatggagacaaattcctctctccccacgaacatctctggagggacacctgctgtatctgctggctatctcttcctggatatcatcacttatctggtatttgcagtcacctttgtcctcggggtcctgggcaacgggcttgtgatctgggtggctggattccggatgacacacacagtcaccaccatcagttacctgaacctggccgtggctgacttctgtttcacctccactttgccattcttcatggtcaggaaggccatgggaggacattggcctttcggctggttcctgtgcaaattcgtctttaccatagtggacatcaacttgttcggaagtgtcttcctgatcgccctcattgctctggaccgctgtgtttgcgtcctgcatccagtctggacccagaaccaccgcaccgtgagcctggccaagaaggtgatcattgggccctgggtgatggctctgctcctcacattgccagttatcattcgtgtgactacagtacctggtaaaacggggacagtagcctgcacttttaacttttcgccctggaccaacgaccctaaagagaggataaatgtggccgttgccatgttgacggtgagaggcatcatccggttcatcattggcttcagcgcacccatgtccatcgttgctgtcagttatgggcttattgccaccaagatccacaagcaaggcttgattaagtccagtcgtcccttacgggtcctctcctttgtcgcagcagccttttttctctgctggtccccatatcaggtggtggcccttatagccacagtcagaatccgtgagttattgcaaggcatgtacaaagaaattggtattgcagtggatgtgacaagtgccctggccttcttcaacagctgcctcaaccccatgctctatgtcttcatgggccaggacttccgggagaggctgatccacgcccttcccgccagtctggagagggccctgaccgaggactcaacccaaaccagtgacacagctaccaattctactttaccttctgcagaggtggagttacaggcaaagtgaggagggagctgggggacactttcgagctcccagctccagcttcgtctcaccttgagttaggctgagccacaggcatttcctgcttattttaggattacccactcatcagaaaaaaaaaaaaaagcctttgtgtcccctgatttggggagaataaacagatatgagtttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:2357 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS GeneID:2357 -> Molecular function: GO:0004982 [N-formyl peptide receptor activity] evidence: IDA GeneID:2357 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:2357 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS GeneID:2357 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS GeneID:2357 -> Biological process: GO:0006935 [chemotaxis] evidence: IEA GeneID:2357 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:2357 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS GeneID:2357 -> Biological process: GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] evidence: TAS GeneID:2357 -> Biological process: GO:0007263 [nitric oxide mediated signal transduction] evidence: TAS GeneID:2357 -> Cellular component: GO:0005768 [endosome] evidence: TAS GeneID:2357 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:2357 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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