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2024-03-29 20:16:09, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002029               1334 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens formyl peptide receptor 1 (FPR1), transcript variant
            2, mRNA.
ACCESSION   NM_002029
VERSION     NM_002029.3  GI:36951095
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Zhou,C., Zhou,Y., Wang,J., Feng,Y., Wang,H., Xue,J., Chen,Y.,
            Ye,R.D. and Wang,M.W.
  TITLE     V101L of human formyl peptide receptor 1 (FPR1) increases receptor
            affinity and augments the antagonism mediated by cyclosporins
  JOURNAL   Biochem. J. 451 (2), 245-255 (2013)
   PUBMED   23373827
  REMARK    GeneRIF: haplotypic variation in FPR1, especially the SNP p.V101L,
            alters the receptor's response to cyclosporins
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Schneider,E.H., Weaver,J.D., Gaur,S.S., Tripathi,B.K.,
            Jesaitis,A.J., Zelenka,P.S., Gao,J.L. and Murphy,P.M.
  TITLE     The leukocyte chemotactic receptor FPR1 is functionally expressed
            on human lens epithelial cells
  JOURNAL   J. Biol. Chem. 287 (48), 40779-40792 (2012)
   PUBMED   23012360
  REMARK    GeneRIF: FPR1 is functionally expressed on human lens epithelial
            cells.
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Mitchell,M.J. and King,M.R.
  TITLE     Shear-induced resistance to neutrophil activation via the formyl
            peptide receptor
  JOURNAL   Biophys. J. 102 (8), 1804-1814 (2012)
   PUBMED   22768936
  REMARK    GeneRIF: physiological shear forces alter neutrophil activation via
            FP
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Gemperle,C., Schmid,M., Herova,M., Marti-Jaun,J., Wuest,S.J.,
            Loretz,C. and Hersberger,M.
  TITLE     Regulation of the formyl peptide receptor 1 (FPR1) gene in primary
            human macrophages
  JOURNAL   PLoS ONE 7 (11), E50195 (2012)
   PUBMED   23185575
  REMARK    GeneRIF: The expression of the formyl peptide receptor 1 (FPR1)
            gene in primary human macrophages is regulated by cytokines and
            bacterial ligands.
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Miettinen,H.M.
  TITLE     Regulation of human formyl peptide receptor 1 synthesis: role of
            single nucleotide polymorphisms, transcription factors, and
            inflammatory mediators
  JOURNAL   PLoS ONE 6 (12), E28712 (2011)
   PUBMED   22174875
  REMARK    GeneRIF: The expression of FPR1 in myeloid cells is developmentally
            regulated, and the differentiated cells are equipped for immediate
            response to microbial infections.
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Perez,H.D., Holmes,R., Kelly,E., McClary,J., Chou,Q. and
            Andrews,W.H.
  TITLE     Cloning of the gene coding for a human receptor for formyl
            peptides. Characterization of a promoter region and evidence for
            polymorphic expression
  JOURNAL   Biochemistry 31 (46), 11595-11599 (1992)
   PUBMED   1445895
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Graves,V., Gabig,T., McCarthy,L., Strour,E.F., Leemhuis,T. and
            English,D.
  TITLE     Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide
            chemoattractant receptors in human neutrophils
  JOURNAL   Blood 80 (3), 776-787 (1992)
   PUBMED   1322204
  REMARK    Erratum:[Blood 1993 Mar 15;81(6):1668]
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D.
            and Francke,U.
  TITLE     A structural homologue of the N-formyl peptide receptor.
            Characterization and chromosome mapping of a peptide
            chemoattractant receptor family
  JOURNAL   J. Biol. Chem. 267 (11), 7637-7643 (1992)
   PUBMED   1373134
REFERENCE   10 (bases 1 to 1334)
  AUTHORS   Murphy,P.M. and McDermott,D.
  TITLE     Functional expression of the human formyl peptide receptor in
            Xenopus oocytes requires a complementary human factor
  JOURNAL   J. Biol. Chem. 266 (19), 12560-12567 (1991)
   PUBMED   1712023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB993626.1, BC005315.1,
            M60627.1 and BQ016000.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 29, 2003 this sequence version replaced gi:31542793.
            
            Summary: This gene encodes a G protein-coupled receptor of
            mammalian phagocytic cells that is a member of the G-protein
            coupled receptor 1 family. The protein mediates the response of
            phagocytic cells to invasion of the host by microorganisms and is
            important in host defense and inflammation.[provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB993626.1, BC005315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CB993626.1         28-34
            8-1087              BC005315.1         1-1080
            1088-1214           M60627.1           1054-1180
            1215-1314           BC005315.1         1208-1307
            1315-1334           BQ016000.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.4"
     gene            1..1334
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="formyl peptide receptor 1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:3826"
                     /db_xref="HPRD:00646"
                     /db_xref="MIM:136537"
     exon            1..84
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:1.39.8"
     exon            85..1317
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:1.39.8"
     CDS             96..1148
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="fMLP receptor; N-formylpeptide chemoattractant
                     receptor"
                     /codon_start=1
                     /product="fMet-Leu-Phe receptor"
                     /protein_id="NP_002020.1"
                     /db_xref="GI:4503779"
                     /db_xref="CCDS:CCDS12839.1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:3826"
                     /db_xref="HPRD:00646"
                     /db_xref="MIM:136537"
                     /translation="
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
"
     misc_feature    177..245
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    264..998
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:200918"
     misc_feature    279..344
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    396..458
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    516..581
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    711..773
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    822..893
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    951..1010
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21462.3);
                     transmembrane region"
     misc_feature    1077..1079
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1080..1082
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1086..1088
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1089..1091
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1095..1097
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1101..1103
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1107..1109
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     misc_feature    1110..1112
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00182"
     variation       127
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5030878"
     variation       396
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2070745"
     variation       443
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5030879"
     variation       641
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2070746"
     variation       663
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:5030880"
     variation       671
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1042229"
     STS             990..1144
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /standard_name="RH17955"
                     /db_xref="UniSTS:82329"
     variation       1132
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:867228"
     variation       1223
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:867341"
     polyA_signal    1298..1303
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
ORIGIN      
aatcattagagcctgagtcactctccccaggagacccagacctagaactacccagagcaagaccacagctggtgaacagtccaggagcagacaagatggagacaaattcctctctccccacgaacatctctggagggacacctgctgtatctgctggctatctcttcctggatatcatcacttatctggtatttgcagtcacctttgtcctcggggtcctgggcaacgggcttgtgatctgggtggctggattccggatgacacacacagtcaccaccatcagttacctgaacctggccgtggctgacttctgtttcacctccactttgccattcttcatggtcaggaaggccatgggaggacattggcctttcggctggttcctgtgcaaattcgtctttaccatagtggacatcaacttgttcggaagtgtcttcctgatcgccctcattgctctggaccgctgtgtttgcgtcctgcatccagtctggacccagaaccaccgcaccgtgagcctggccaagaaggtgatcattgggccctgggtgatggctctgctcctcacattgccagttatcattcgtgtgactacagtacctggtaaaacggggacagtagcctgcacttttaacttttcgccctggaccaacgaccctaaagagaggataaatgtggccgttgccatgttgacggtgagaggcatcatccggttcatcattggcttcagcgcacccatgtccatcgttgctgtcagttatgggcttattgccaccaagatccacaagcaaggcttgattaagtccagtcgtcccttacgggtcctctcctttgtcgcagcagccttttttctctgctggtccccatatcaggtggtggcccttatagccacagtcagaatccgtgagttattgcaaggcatgtacaaagaaattggtattgcagtggatgtgacaagtgccctggccttcttcaacagctgcctcaaccccatgctctatgtcttcatgggccaggacttccgggagaggctgatccacgcccttcccgccagtctggagagggccctgaccgaggactcaacccaaaccagtgacacagctaccaattctactttaccttctgcagaggtggagttacaggcaaagtgaggagggagctgggggacactttcgagctcccagctccagcttcgtctcaccttgagttaggctgagccacaggcatttcctgcttattttaggattacccactcatcagaaaaaaaaaaaaaagcctttgtgtcccctgatttggggagaataaacagatatgagtttaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2357 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
            GeneID:2357 -> Molecular function: GO:0004982 [N-formyl peptide receptor activity] evidence: IDA
            GeneID:2357 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2357 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
            GeneID:2357 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:2357 -> Biological process: GO:0006935 [chemotaxis] evidence: IEA
            GeneID:2357 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:2357 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
            GeneID:2357 -> Biological process: GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] evidence: TAS
            GeneID:2357 -> Biological process: GO:0007263 [nitric oxide mediated signal transduction] evidence: TAS
            GeneID:2357 -> Cellular component: GO:0005768 [endosome] evidence: TAS
            GeneID:2357 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:2357 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

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