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2024-04-25 20:28:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002027 1710 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens farnesyltransferase, CAAX box, alpha (FNTA),
transcript variant 1, mRNA.
ACCESSION NM_002027
VERSION NM_002027.2 GI:66882377
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1710)
AUTHORS Ghavami,S., Mutawe,M.M., Schaafsma,D., Yeganeh,B., Unruh,H.,
Klonisch,T. and Halayko,A.J.
TITLE Geranylgeranyl transferase 1 modulates autophagy and apoptosis in
human airway smooth muscle
JOURNAL Am. J. Physiol. Lung Cell Mol. Physiol. 302 (4), L420-L428 (2012)
PUBMED 22160308
REMARK GeneRIF: our findings identify Geranylgeranyl transferase 1 as a
key regulator of human airway smooth muscle cell viability
REFERENCE 2 (bases 1 to 1710)
AUTHORS Lipkin,S.M., Chao,E.C., Moreno,V., Rozek,L.S., Rennert,H.,
Pinchev,M., Dizon,D., Rennert,G., Kopelovich,L. and Gruber,S.B.
TITLE Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase
modifies the chemopreventive activity of statins for colorectal
cancer
JOURNAL Cancer Prev Res (Phila) 3 (5), 597-603 (2010)
PUBMED 20403997
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 3 (bases 1 to 1710)
AUTHORS Fontaine-Bisson,B., Alessi,M.C., Saut,N., Fumeron,F., Marre,M.,
Dutour,A., Badens,C., Levy,N., Tichet,J., Juhan-Vague,I.,
Tregouet,D.A., Balkau,B. and Morange,P.E.
TITLE Polymorphisms of the lamina maturation pathway and their
association with the metabolic syndrome: the DESIR prospective
study
JOURNAL J. Mol. Med. 88 (2), 193-201 (2010)
PUBMED 19841875
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
REFERENCE 4 (bases 1 to 1710)
AUTHORS Zhou,J., Vos,C.C., Gjyrezi,A., Yoshida,M., Khuri,F.R., Tamanoi,F.
and Giannakakou,P.
TITLE The protein farnesyltransferase regulates HDAC6 activity in a
microtubule-dependent manner
JOURNAL J. Biol. Chem. 284 (15), 9648-9655 (2009)
PUBMED 19228685
REMARK GeneRIF: FTase, via its tubulin-association, is a critical upstream
regulator of HDAC6 activity
REFERENCE 5 (bases 1 to 1710)
AUTHORS Armstrong,S.A., Hannah,V.C., Goldstein,J.L. and Brown,M.S.
TITLE CAAX geranylgeranyl transferase transfers farnesyl as efficiently
as geranylgeranyl to RhoB
JOURNAL J. Biol. Chem. 270 (14), 7864-7868 (1995)
PUBMED 7713879
REFERENCE 6 (bases 1 to 1710)
AUTHORS Zhang,F.L., Diehl,R.E., Kohl,N.E., Gibbs,J.B., Giros,B., Casey,P.J.
and Omer,C.A.
TITLE cDNA cloning and expression of rat and human protein
geranylgeranyltransferase type-I
JOURNAL J. Biol. Chem. 269 (5), 3175-3180 (1994)
PUBMED 8106351
REFERENCE 7 (bases 1 to 1710)
AUTHORS Andres,D.A., Milatovich,A., Ozcelik,T., Wenzlau,J.M., Brown,M.S.,
Goldstein,J.L. and Francke,U.
TITLE cDNA cloning of the two subunits of human CAAX farnesyltransferase
and chromosomal mapping of FNTA and FNTB loci and related sequences
JOURNAL Genomics 18 (1), 105-112 (1993)
PUBMED 8276393
REFERENCE 8 (bases 1 to 1710)
AUTHORS Omer,C.A., Kral,A.M., Diehl,R.E., Prendergast,G.C., Powers,S.,
Allen,C.M., Gibbs,J.B. and Kohl,N.E.
TITLE Characterization of recombinant human farnesyl-protein transferase:
cloning, expression, farnesyl diphosphate binding, and functional
homology with yeast prenyl-protein transferases
JOURNAL Biochemistry 32 (19), 5167-5176 (1993)
PUBMED 8494894
REFERENCE 9 (bases 1 to 1710)
AUTHORS Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
TITLE Post-translational modifications of p21rho proteins
JOURNAL J. Biol. Chem. 267 (28), 20033-20038 (1992)
PUBMED 1400319
REFERENCE 10 (bases 1 to 1710)
AUTHORS Manne,V., Roberts,D., Tobin,A., O'Rourke,E., De Virgilio,M.,
Meyers,C., Ahmed,N., Kurz,B., Resh,M., Kung,H.F. et al.
TITLE Identification and preliminary characterization of protein-cysteine
farnesyltransferase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (19), 7541-7545 (1990)
PUBMED 2217184
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI913631.1 and BC084566.1.
On Jun 2, 2005 this sequence version replaced gi:4503770.
Summary: Prenyltransferases can attach either a farnesyl group or a
geranylgeranyl group in thioether linkage to the cysteine residue
of proteins with a C-terminal CAAX box. CAAX
geranylgeranyltransferase and CAAX farnesyltransferase are
heterodimers that share the same alpha subunit but have different
beta subunits. This gene encodes the alpha subunit of these
transferases. Alternative splicing results in multiple transcript
variants. Related pseudogenes have been identified on chromosomes
11 and 13. [provided by RefSeq, May 2010].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the functional protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC084566.1, L10413.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-40 BI913631.1 147-186
41-1710 BC084566.1 1-1670
FEATURES Location/Qualifiers
source 1..1710
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11"
gene 1..1710
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="farnesyltransferase, CAAX box, alpha"
/db_xref="GeneID:2339"
/db_xref="HGNC:3782"
/db_xref="HPRD:00607"
/db_xref="MIM:134635"
exon 1..248
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 18
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:28384488"
CDS 49..1188
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/EC_number="2.5.1.59"
/EC_number="2.5.1.58"
/note="protein prenyltransferase alpha subunit repeat
containing 2; FTase-alpha; type I protein
geranyl-geranyltransferase alpha subunit; GGTase-I-alpha;
farnesyl-protein transferase alpha-subunit; ras proteins
prenyltransferase subunit alpha"
/codon_start=1
/product="protein
farnesyltransferase/geranylgeranyltransferase type-1
subunit alpha"
/protein_id="NP_002018.1"
/db_xref="GI:4503771"
/db_xref="CCDS:CCDS6140.1"
/db_xref="GeneID:2339"
/db_xref="HGNC:3782"
/db_xref="HPRD:00607"
/db_xref="MIM:134635"
/translation="
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
"
misc_feature 238..1143
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="farnesyltranstransferase; Region: PLN02789"
/db_xref="CDD:178386"
misc_feature 382..486
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49354.1);
Region: PFTA 1"
misc_feature 391..480
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="Protein prenyltransferase alpha subunit repeat;
Region: PPTA; pfam01239"
/db_xref="CDD:201678"
misc_feature 487..588
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49354.1);
Region: PFTA 2"
misc_feature 496..585
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="Protein prenyltransferase alpha subunit repeat;
Region: PPTA; pfam01239"
/db_xref="CDD:201678"
misc_feature 589..693
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49354.1);
Region: PFTA 3"
misc_feature 598..687
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="Protein prenyltransferase alpha subunit repeat;
Region: PPTA; pfam01239"
/db_xref="CDD:201678"
misc_feature 694..795
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49354.1);
Region: PFTA 4"
misc_feature 700..786
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="Protein prenyltransferase alpha subunit repeat;
Region: PPTA; pfam01239"
/db_xref="CDD:201678"
misc_feature 811..915
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49354.1);
Region: PFTA 5"
misc_feature 820..903
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/note="Protein prenyltransferase alpha subunit repeat;
Region: PPTA; pfam01239"
/db_xref="CDD:201678"
misc_feature 1165..1167
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49354.1); phosphorylation site"
variation 111..112
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace=""
/replace="c"
/db_xref="dbSNP:139428078"
variation 164
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375810129"
variation 207
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370994529"
variation 225
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374602755"
variation 234
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:141352327"
variation 238
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143321089"
exon 249..334
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 282
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:368366624"
variation 302
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151278515"
variation 319
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140513662"
exon 335..449
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 350
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112910348"
variation 366
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371752527"
variation 374
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368301964"
variation 380
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200186349"
variation 381
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202069696"
variation 390
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150424879"
variation 399
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138334666"
variation 401
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201374782"
variation 407
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200796658"
variation 410
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375845796"
exon 450..554
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 451
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143829409"
variation 457
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200780088"
variation 471
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:76046042"
variation 472
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201464015"
variation 549
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147010452"
exon 555..681
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 568
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375552449"
variation 593
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138168688"
variation 595
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201579996"
variation 599
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201638101"
variation 613
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149513620"
variation 638
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373178685"
variation 648
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199989190"
variation 660
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374653329"
variation 669
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201190121"
exon 682..830
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 714
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368125629"
variation 756
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:144005707"
variation 796
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:1803597"
variation 805
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371393216"
variation 813
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200228527"
exon 831..893
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 863
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148659497"
variation 873
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375620813"
variation 874
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375711846"
exon 894..1065
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
variation 895
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370193930"
variation 907
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369359760"
variation 917
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:141224054"
variation 938
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202246754"
variation 942
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373852144"
variation 975
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:2230266"
variation 1027
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377755753"
variation 1030
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139144868"
exon 1066..1694
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/inference="alignment:Splign:1.39.8"
STS 1114..1308
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/standard_name="RH68982"
/db_xref="UniSTS:91779"
variation 1155
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374000931"
variation 1171
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:191418964"
variation 1189
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:371907116"
STS 1195..1652
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/standard_name="RH27289"
/db_xref="UniSTS:87023"
variation 1237
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:374884999"
variation 1238
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145361728"
STS 1254..1599
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/standard_name="D8S1675"
/db_xref="UniSTS:9626"
STS 1254..1428
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/standard_name="D8S1675"
/db_xref="UniSTS:9627"
variation 1255
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:182388872"
variation 1271
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:111906132"
variation 1303
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142364879"
variation 1412
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146781943"
variation 1513
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377746719"
variation 1576
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:11554712"
variation 1610
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:187422693"
variation 1631
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3196850"
polyA_signal 1666..1671
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
variation 1666
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190378282"
polyA_site 1694
/gene="FNTA"
/gene_synonym="FPTA; PGGT1A; PTAR2"
ORIGIN
gggaggggcggggcctccgccaccacctcagctgcggaccgaggcgagatggcggccaccgagggggtcggggaggctgcgcaagggggcgagcccgggcagccggcgcaacccccgccccagccgcacccaccgccgccccagcagcagcacaaggaagagatggcggccgaggctggggaagccgtggcgtcccccatggacgacgggtttgtgagcctggactcgccctcctatgtcctgtacagggacagagcagaatgggctgatatagatccggtgccgcagaatgatggccccaatcccgtggtccagatcatttatagtgacaaatttagagatgtttatgattacttccgagctgtcctgcagcgtgatgaaagaagtgaacgagcttttaagctaacccgggatgctattgagttaaatgcagccaattatacagtgtggcatttccggagagttcttttgaagtcacttcagaaggatctacatgaggaaatgaactacatcactgcaataattgaggagcagcccaaaaactatcaagtttggcatcataggcgagtattagtggaatggctaagagatccatctcaggagcttgaatttattgctgatattcttaatcaggatgcaaagaattatcatgcctggcagcatcgacaatgggttattcaggaatttaaactttgggataatgagctgcagtatgtggaccaacttctgaaagaggatgtgagaaataactctgtctggaaccaaagatacttcgttatttctaacaccactggctacaatgatcgtgctgtattggagagagaagtccaatacactctggaaatgattaaactagtaccacataatgaaagtgcatggaactatttgaaagggattttgcaggatcgtggtctttccaaatatcctaatctgttaaatcaattacttgatttacaaccaagtcatagttccccctacctaattgcctttcttgtggatatctatgaagacatgctagaaaatcagtgtgacaataaggaagacattcttaataaagcattagagttatgtgaaatcctagctaaagaaaaggacactataagaaaggaatattggagatacattggaagatcccttcaaagcaaacacagcacagaaaatgactcaccaacaaatgtacagcaataacaccatccagaagaacttgatggaatgcttttattttttattaagggaccctgcaggagtttcacacgagagtggtccttccctttgcctgtggtgtaaaagtgcatcacacaggtattgctttttaacaagaactgatgctccttgggtgctgctgctactcagactagctctaagtaatgtgattcttctaaagcaaagtcattggatgggaggaggaagaaaaagtcccataaaggaacttttgtagtcttatcaacatataatctaatcccttagcatcagctcctccctcagtggtacatgcgtcaagatttgtagcagtaataactgcaggtcacttgtatgtaatggatgtgaggtagccgaagtttggttcagtaagcagggaatacagtcgttccatcagagctggtctgcacactcacattatcttgctatcactgtaaccaactaatgccaaaagaacggttttgtaataaaattatagctgtatctaaaaacaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2339 -> Molecular function: GO:0004660 [protein farnesyltransferase activity] evidence: IDA
GeneID:2339 -> Molecular function: GO:0004661 [protein geranylgeranyltransferase activity] evidence: TAS
GeneID:2339 -> Molecular function: GO:0004662 [CAAX-protein geranylgeranyltransferase activity] evidence: IEA
GeneID:2339 -> Molecular function: GO:0004663 [Rab geranylgeranyltransferase activity] evidence: IEA
GeneID:2339 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2339 -> Molecular function: GO:0008017 [microtubule binding] evidence: IDA
GeneID:2339 -> Molecular function: GO:0030548 [acetylcholine receptor regulator activity] evidence: IEA
GeneID:2339 -> Molecular function: GO:0030971 [receptor tyrosine kinase binding] evidence: IEA
GeneID:2339 -> Molecular function: GO:0043014 [alpha-tubulin binding] evidence: IDA
GeneID:2339 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:2339 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:2339 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS
GeneID:2339 -> Biological process: GO:0007603 [phototransduction, visible light] evidence: TAS
GeneID:2339 -> Biological process: GO:0016056 [rhodopsin mediated signaling pathway] evidence: TAS
GeneID:2339 -> Biological process: GO:0018343 [protein farnesylation] evidence: IDA
GeneID:2339 -> Biological process: GO:0018344 [protein geranylgeranylation] evidence: TAS
GeneID:2339 -> Biological process: GO:0022400 [regulation of rhodopsin mediated signaling pathway] evidence: TAS
GeneID:2339 -> Biological process: GO:0045213 [neurotransmitter receptor metabolic process] evidence: IEA
GeneID:2339 -> Biological process: GO:0090044 [positive regulation of tubulin deacetylation] evidence: IDA
GeneID:2339 -> Biological process: GO:0090045 [positive regulation of deacetylase activity] evidence: IDA
GeneID:2339 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:2339 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:2339 -> Cellular component: GO:0005875 [microtubule associated complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002018 -> EC 2.5.1.58
NP_002018 -> EC 2.5.1.59
by
@meso_cacase at
DBCLS
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