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2024-04-23 18:17:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002015 5738 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens forkhead box O1 (FOXO1), mRNA.
ACCESSION NM_002015
VERSION NM_002015.3 GI:133930787
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5738)
AUTHORS Lei,C.Q., Zhang,Y., Xia,T., Jiang,L.Q., Zhong,B. and Shu,H.B.
TITLE FoxO1 negatively regulates cellular antiviral response by promoting
degradation of IRF3
JOURNAL J. Biol. Chem. 288 (18), 12596-12604 (2013)
PUBMED 23532851
REMARK GeneRIF: FoxO1 negatively regulates cellular antiviral response by
promoting IRF3 ubiquitination and degradation, providing a
previously unknown mechanism for control of type I IFN induction
and cellular antiviral response.
REFERENCE 2 (bases 1 to 5738)
AUTHORS Trinh,D.L., Scott,D.W., Morin,R.D., Mendez-Lago,M., An,J.,
Jones,S.J., Mungall,A.J., Zhao,Y., Schein,J., Steidl,C.,
Connors,J.M., Gascoyne,R.D. and Marra,M.A.
TITLE Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
JOURNAL Blood 121 (18), 3666-3674 (2013)
PUBMED 23460611
REMARK GeneRIF: FOXO1 mutation is a novel prognostic factor that plays an
important role in diffuse large B-cell lymphoma pathogenesis.
REFERENCE 3 (bases 1 to 5738)
AUTHORS Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A,
Hewitt AW, Koehn D, Hysi PG, Ramdas WD, Zeller T, Vithana EN,
Cornes BK, Tay WT, Tai ES, Cheng CY, Liu J, Foo JN, Saw SM,
Thorleifsson G, Stefansson K, Dimasi DP, Mills RA, Mountain J, Ang
W, Hoehn R, Verhoeven VJ, Grus F, Wolfs R, Castagne R, Lackner KJ,
Springelkamp H, Yang J, Jonasson F, Leung DY, Chen LJ, Tham CC,
Rudan I, Vatavuk Z, Hayward C, Gibson J, Cree AJ, MacLeod A, Ennis
S, Polasek O, Campbell H, Wilson JF, Viswanathan AC, Fleck B, Li X,
Siscovick D, Taylor KD, Rotter JI, Yazar S, Ulmer M, Li J, Yaspan
BL, Ozel AB, Richards JE, Moroi SE, Haines JL, Kang JH, Pasquale
LR, Allingham RR, Ashley-Koch A, Mitchell P, Wang JJ, Wright AF,
Pennell C, Spector TD, Young TL, Klaver CC, Martin NG, Montgomery
GW, Anderson MG, Aung T, Willoughby CE, Wiggs JL, Pang CP,
Thorsteinsdottir U, Lotery AJ, Hammond CJ, van Duijn CM, Hauser MA,
Rabinowitz YS, Pfeiffer N, Mackey DA, Craig JE, Macgregor S and
Wong TY.
CONSRTM NEIGHBOR Consortium
TITLE Genome-wide association analyses identify multiple loci associated
with central corneal thickness and keratoconus
JOURNAL Nat. Genet. 45 (2), 155-163 (2013)
PUBMED 23291589
REMARK GeneRIF: 2 central corneal thickness-associated loci, FOXO1 and
FNDC3B, confer relatively large risks for keratoconus.
REFERENCE 4 (bases 1 to 5738)
AUTHORS Zaballos,M.A. and Santisteban,P.
TITLE FOXO1 controls thyroid cell proliferation in response to TSH and
IGF-I and is involved in thyroid tumorigenesis
JOURNAL Mol. Endocrinol. 27 (1), 50-62 (2013)
PUBMED 23160481
REMARK GeneRIF: Important role of FoxO1 in mediating the effects of TSH
and IGF-I on thyroid cell proliferation.
REFERENCE 5 (bases 1 to 5738)
AUTHORS Li,Q., Kannan,A., Das,A., Demayo,F.J., Hornsby,P.J., Young,S.L.,
Taylor,R.N., Bagchi,M.K. and Bagchi,I.C.
TITLE WNT4 acts downstream of BMP2 and functions via beta-catenin
signaling pathway to regulate human endometrial stromal cell
differentiation
JOURNAL Endocrinology 154 (1), 446-457 (2013)
PUBMED 23142810
REMARK GeneRIF: Studies uncovered a linear pathway involving BMP2,
WNT4/beta-catenin, and Forkhead box protein O1 that operates in
human endometrium to critically control decidualization.
REFERENCE 6 (bases 1 to 5738)
AUTHORS Scheidler,S., Fredericks,W.J., Rauscher,F.J. III, Barr,F.G. and
Vogt,P.K.
TITLE The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma
transforms fibroblasts in culture
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (18), 9805-9809 (1996)
PUBMED 8790412
REFERENCE 7 (bases 1 to 5738)
AUTHORS Davis,R.J., Bennicelli,J.L., Macina,R.A., Nycum,L.M., Biegel,J.A.
and Barr,F.G.
TITLE Structural characterization of the FKHR gene and its rearrangement
in alveolar rhabdomyosarcoma
JOURNAL Hum. Mol. Genet. 4 (12), 2355-2362 (1995)
PUBMED 8634710
REFERENCE 8 (bases 1 to 5738)
AUTHORS Sublett,J.E., Jeon,I.S. and Shapiro,D.N.
TITLE The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a
transcriptional activator
JOURNAL Oncogene 11 (3), 545-552 (1995)
PUBMED 7630639
REFERENCE 9 (bases 1 to 5738)
AUTHORS Fredericks,W.J., Galili,N., Mukhopadhyay,S., Rovera,G.,
Bennicelli,J., Barr,F.G. and Rauscher,F.J. III.
TITLE The PAX3-FKHR fusion protein created by the t(2;13) translocation
in alveolar rhabdomyosarcomas is a more potent transcriptional
activator than PAX3
JOURNAL Mol. Cell. Biol. 15 (3), 1522-1535 (1995)
PUBMED 7862145
REFERENCE 10 (bases 1 to 5738)
AUTHORS Galili,N., Davis,R.J., Fredericks,W.J., Mukhopadhyay,S.,
Rauscher,F.J. III, Emanuel,B.S., Rovera,G. and Barr,F.G.
TITLE Fusion of a fork head domain gene to PAX3 in the solid tumour
alveolar rhabdomyosarcoma
JOURNAL Nat. Genet. 5 (3), 230-235 (1993)
PUBMED 8275086
REMARK Erratum:[Nat Genet 1994 Feb;6(2):214]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF032885.1 and AL133318.11.
This sequence is a reference standard in the RefSeqGene project.
On Mar 22, 2007 this sequence version replaced gi:9257221.
Summary: This gene belongs to the forkhead family of transcription
factors which are characterized by a distinct forkhead domain. The
specific function of this gene has not yet been determined;
however, it may play a role in myogenic growth and differentiation.
Translocation of this gene with PAX3 has been associated with
alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF032885.1, U02310.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2498 AF032885.1 1-2498
2499-4336 AF032885.1 2500-4337
4337-5738 AL133318.11 39120-40521 c
FEATURES Location/Qualifiers
source 1..5738
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q14.1"
gene 1..5738
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/note="forkhead box O1"
/db_xref="GeneID:2308"
/db_xref="HGNC:3819"
/db_xref="HPRD:00645"
/db_xref="MIM:136533"
exon 1..1015
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="alignment:Splign:1.39.8"
CDS 386..2353
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/note="forkhead, Drosophila, homolog of, in
rhabdomyosarcoma; forkhead box protein O1A"
/codon_start=1
/product="forkhead box protein O1"
/protein_id="NP_002006.2"
/db_xref="GI:9257222"
/db_xref="CCDS:CCDS9371.1"
/db_xref="GeneID:2308"
/db_xref="HGNC:3819"
/db_xref="HPRD:00645"
/db_xref="MIM:136533"
/translation="
MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
"
misc_feature 455..457
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKB/AKT1 or PKB/AKT2 and SGK1;
propagated from UniProtKB/Swiss-Prot (Q12778.2);
phosphorylation site"
misc_feature 455..457
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01261"
misc_feature 857..859
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="DNA-binding; propagated from UniProtKB/Swiss-Prot
(Q12778.2); DNA binding site"
misc_feature 863..1105
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/note="Forkhead (FH), also known as a 'winged helix'. FH
is named for the Drosophila fork head protein, a
transcription factor which promotes terminal rather than
segmental development. This family of transcription factor
domains, which bind to B-DNA as...; Region: FH; cd00059"
/db_xref="CDD:28941"
misc_feature 878..880
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="DNA-binding; propagated from UniProtKB/Swiss-Prot
(Q12778.2); DNA binding site"
misc_feature order(971..976,1016..1018,1025..1030,1082..1084)
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28941"
misc_feature 1016..1039
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: DNA-binding"
misc_feature 1019..1021
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by STK4/MST1; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1058..1060
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="DNA-binding; propagated from UniProtKB/Swiss-Prot
(Q12778.2); DNA binding site"
misc_feature 1085..1096
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: DNA-binding"
misc_feature 1130..1132
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK1; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1136..1144
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: Nuclear localization signal"
misc_feature 1151..1153
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKB/AKT1 and SGK1; propagated
from UniProtKB/Swiss-Prot (Q12778.2); phosphorylation
site"
misc_feature 1151..1153
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01261"
misc_feature 1151..1153
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03995"
misc_feature 1232..2074
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: Sufficient for interaction with NLK (By
similarity)"
misc_feature 1244..1246
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q12778.2); phosphorylation site"
misc_feature 1340..1342
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKB/AKT1; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1340..1342
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01261"
misc_feature 1349..1351
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1 and SGK1; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1349..1351
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05886"
misc_feature 1358..1360
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1358..1360
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05418"
misc_feature 1370..1372
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by DYRK1A; propagated from
UniProtKB/Swiss-Prot (Q12778.2); phosphorylation site"
misc_feature 1370..1372
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:09018"
misc_feature 1472..1762
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: Required for interaction with RUNX2 (By
similarity)"
misc_feature 1769..1783
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12778.2);
Region: Required for interaction with SIRT1 (By
similarity)"
misc_feature 1898..1900
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1910..1912
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 629
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34733279"
STS 702..1226
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/standard_name="RH74854"
/db_xref="UniSTS:92039"
exon 1016..2367
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="alignment:Splign:1.39.8"
variation 1399
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:3198830"
STS 1596..2012
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/standard_name="PMC25098P1"
/db_xref="UniSTS:272280"
variation 1891
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34650827"
variation 1917
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:70961707"
exon 2368..5738
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/inference="alignment:Splign:1.39.8"
variation 2459
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:3751437"
STS 2530..2859
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/standard_name="D13S1162"
/db_xref="UniSTS:78564"
variation 2985
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200586791"
variation 3026
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace=""
/replace="a"
/db_xref="dbSNP:34885278"
variation 4466
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34972103"
STS 5388..5537
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/standard_name="RH93960"
/db_xref="UniSTS:88229"
variation 5615
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34241243"
polyA_site 5642
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
polyA_signal 5705..5710
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
polyA_site 5738
/gene="FOXO1"
/gene_synonym="FKH1; FKHR; FOXO1A"
ORIGIN
gcagccgccacattcaacaggcagcagcgcagcgggcgcgccgctggggagagcaagcggcccgcggcgtccgtccgtccttccgtccgcggccctgtcagctggagcgcggcgcaggctctgccccggcccggcggctctggccggccgtccagtccgtgcggcggaccccgaggagcctcgatgtggatggccccgcgaagttaagttctgggctcgcgcttccactccgccgcgccttcctcccagtttccgtccgctcgccgcaccggcttcgttcccccaaatctcggaccgtcccttcgcgccccctccccgtccgcccccagtgctgcgttctccccctcttggctctcctgcggctgggggaggggcgggggtcaccatggccgaggcgcctcaggtggtggagatcgacccggacttcgagccgctgccccggccgcgctcgtgcacctggccgctgcccaggccggagtttagccagtccaactcggccacctccagcccggcgccgtcgggcagcgcggctgccaaccccgacgccgcggcgggcctgccctcggcctcggctgccgctgtcagcgccgacttcatgagcaacctgagcttgctggaggagagcgaggacttcccgcaggcgcccggctccgtggcggcggcggtggcggcggcggccgccgcggccgccaccggggggctgtgcggggacttccagggcccggaggcgggctgcctgcacccagcgccaccgcagcccccgccgcccgggccgctgtcgcagcacccgccggtgccccccgccgccgctgggccgctcgcggggcagccgcgcaagagcagctcgtcccgccgcaacgcgtggggcaacctgtcctacgccgacctcatcaccaaggccatcgagagctcggcggagaagcggctcacgctgtcgcagatctacgagtggatggtcaagagcgtgccctacttcaaggataagggtgacagcaacagctcggcgggctggaagaattcaattcgtcataatctgtccctacacagcaagttcattcgtgtgcagaatgaaggaactggaaaaagttcttggtggatgctcaatccagagggtggcaagagcgggaaatctcctaggagaagagctgcatccatggacaacaacagtaaatttgctaagagccgaagccgagctgccaagaagaaagcatctctccagtctggccaggagggtgctggggacagccctggatcacagttttccaaatggcctgcaagccctggctctcacagcaatgatgactttgataactggagtacatttcgccctcgaactagctcaaatgctagtactattagtgggagactctcacccattatgaccgaacaggatgatcttggagaaggggatgtgcattctatggtgtacccgccatctgccgcaaagatggcctctactttacccagtctgtctgagataagcaatcccgaaaacatggaaaatcttttggataatctcaaccttctctcatcaccaacatcattaactgtttcgacccagtcctcacctggcaccatgatgcagcagacgccgtgctactcgtttgcgccaccaaacaccagtttgaattcacccagcccaaactaccaaaaatatacatatggccaatccagcatgagccctttgccccagatgcctatacaaacacttcaggacaataagtcgagttatggaggtatgagtcagtataactgtgcgcctggactcttgaaggagttgctgacttctgactctcctccccataatgacattatgacaccagttgatcctggggtagcccagcccaacagccgggttctgggccagaacgtcatgatgggccctaattcggtcatgtcaacctatggcagccaggcatctcataacaaaatgatgaatcccagctcccatacccaccctggacatgctcagcagacatctgcagttaacgggcgtcccctgccccacacggtaagcaccatgccccacacctcgggtatgaaccgcctgacccaagtgaagacacctgtacaagtgcctctgccccaccccatgcagatgagtgccctggggggctactcctccgtgagcagctgcaatggctatggcagaatgggccttctccaccaggagaagctcccaagtgacttggatggcatgttcattgagcgcttagactgtgacatggaatccatcattcggaatgacctcatggatggagatacattggattttaactttgacaatgtgttgcccaaccaaagcttcccacacagtgtcaagacaacgacacatagctgggtgtcaggctgagggttagtgagcaggttacacttaaaagtacttcagattgtctgacagcaggaactgagagaagcagtccaaagatgtctttcaccaactcccttttagttttcttggttaaaaaaaaaaacaaaaaaaaaaaccctccttttttcctttcgtcagacttggcagcaaagacatttttcctgtacaggatgtttgcccaatgtgtgcaggttatgtgctgctgtagataaggactgtgccattggaaatttcattacaatgaagtgccaaactcactacaccatataattgcagaaaagattttcagatcctggtgtgctttcaagttttgtatataagcagtagatacagattgtatttgtgtgtgtttttggtttttctaaatatccaattggtccaaggaaagtttatactctttttgtaatactgtgatgggcctcatgtcttgataagttaaacttttgtttgtactacctgttttctgcggaactgacggatcacaaagaactgaatctccattctgcatctccattgaacagccttggacctgttcacgttgccacagaattcacatgagaaccaagtagcctgttatcaatctgctaaattaatggacttgttaaacttttggaaaaaaaaagattaaatgccagctttgtacaggtcttttctatttttttttgtttattttgttatttgcaaatttgtacaaacatttaaatggttctaatttccagataaatgatttttgatgttattgttgggacttaagaacatttttggaatagatattgaactgtaataatgttttcttaaaactagagtctactttgttacatagtcagcttgtaaattttgtggaaccacaggtatttggggcagcattcataattttcattttgtattctaactggattagtactaattttatacatgcttaactggtttgtacactttgggatgctacttagtgatgtttctgactaatcttaaatcattgtaattagtacttgcatattcaacgtttcaggccctggttgggcaggaaagtgatgtatagttatggacactttgcgtttcttatttaggataacttaatatgtttttatgtatgtattttaaagaaatttcatctgcttctactgaactatgcgtactgcatagcatcaagtcttctctagagacctctgtagtcctgggaggcctcataatgtttgtagatcagaaaagggagatctgcatctaaagcaatggtcctttgtcaaacgagggattttgatccacttcaccattttgagttgagctttagcaaaagtttcccctcataattctttgctcttgtttcagtccaggtggaggttggttttgtagttctgccttgaggaattatgtcaacactcatacttcatctcattctcccttctgccctgcagattagattacttagcacactgtggaagtttaagtggaaggagggaatttaaaaatgggacttgagtggtttgtagaatttgtgttcataagttcagatgggtagcaaatggaatagaacttacttaaaaattggggagatttatttgaaaaccagctgtaagttgtgcattgagattatgttaaaagccttggcttaagaatttgaaaatttctttagcctgtagcaacctaaactgtaattcctatcattatgttttattactttccaattacctgtaactgacagaccaaattaattggctttgtgtcctatttagtccatcagtattttcaagtcatgtggaaagcccaaagtcatcacaatgaagagaacaggtgcacagcactgttcctcttgtgttcttgagaaggatctaatttttctgtatatagcccacatcacacttgctttgtcttgtatgttaattgcatcttcattggcttggtatttcctaaatgtttaacaagaacacaagtgttcctgataagatttcctacagtaagccagctctattgtaagcttcccactgtgatgatcatttttttgaagattcattgaacagccaccactctatcatcctcattttggggcagtccaagacatagctggttttagaaacccaagttcctctaagcacagcctcccgggtatgtaactgaacttggtgccaaagtacttgtgtactaatttctattactacgtactgtcactttcctcccgtgccattactgcatcataatacaaggaacctcagagcccccatttgttcattaaagaggcaactacagccaaaatcactgttaaaatcttactacttcatggagtagctcttaggaaaatatatcttcctcctgagtctgggtaattatacctctcccaagcccccattgtgtgttgaaatcctgtcatgaatccttggtagctctctgagaacagtgaagtccagggaaaggcatctggtctgtctggaaagcaaacattatgtggcctctggtagtttttttcctgtaagaatactgactttctggagtaatgagtatatatcagttattgtacatgattgctttgtgaaatgtgcaaatgatatcacctatgcagccttgtttgatttattttctctggtttgtactgttattaaaagcatattgtattatagagctattcagatattttaaatataaagatgtattgtttccgtaatatagacgtatggaatatatttaggtaatagatgtattacttggaaagttctgctttgacaaactgacaaagtctaaatgagcacatgtatcccagtgagcagtaaatcaatggaacatcccaagaagaggataaggatgcttaaaatggaaatcattctccaacgatatacaaattggacttgttcaactgctggatatatgctaccaataaccccagccccaacttaaaattcttacattcaagctcctaagagttcttaatttataactaattttaaaagagaagtttcttttctggttttagtttgggaataatcattcattaaaaaaaatgtattgtggtttatgcgaacagaccaacctggcattacagttggcctctccttgaggtgggcacagcctggcagtgtggccaggggtggccatgtaagtcccatcaggacgtagtcatgcctcctgcatttcgctacccgagtttagtaacagtgcagattccacgttcttgttccgatactctgagaagtgcctgatgttgatgtacttacagacacaagaacaatctttgctataattgtataaagccataaatgtacataaattatgtttaaatggcttggtgtctttcttttctaattatgcagaataagctctttattaggaattttttgtgaagctattaaatacttgagttaagtcttgtcagccacaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2308 -> Molecular function: GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] evidence: IEA
GeneID:2308 -> Molecular function: GO:0003682 [chromatin binding] evidence: ISS
GeneID:2308 -> Molecular function: GO:0003690 [double-stranded DNA binding] evidence: IBA
GeneID:2308 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IBA
GeneID:2308 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2308 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IBA
GeneID:2308 -> Molecular function: GO:0008301 [DNA binding, bending] evidence: IBA
GeneID:2308 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IBA
GeneID:2308 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:2308 -> Molecular function: GO:0051721 [protein phosphatase 2A binding] evidence: ISS
GeneID:2308 -> Biological process: GO:0001568 [blood vessel development] evidence: IBA
GeneID:2308 -> Biological process: GO:0001659 [temperature homeostasis] evidence: ISS
GeneID:2308 -> Biological process: GO:0001678 [cellular glucose homeostasis] evidence: ISS
GeneID:2308 -> Biological process: GO:0006473 [protein acetylation] evidence: ISS
GeneID:2308 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2308 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IBA
GeneID:2308 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: ISS
GeneID:2308 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:2308 -> Biological process: GO:0007389 [pattern specification process] evidence: IBA
GeneID:2308 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IBA
GeneID:2308 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: ISS
GeneID:2308 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:2308 -> Biological process: GO:0009267 [cellular response to starvation] evidence: ISS
GeneID:2308 -> Biological process: GO:0009790 [embryo development] evidence: IBA
GeneID:2308 -> Biological process: GO:0009888 [tissue development] evidence: IBA
GeneID:2308 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: TAS
GeneID:2308 -> Biological process: GO:0032873 [negative regulation of stress-activated MAPK cascade] evidence: IDA
GeneID:2308 -> Biological process: GO:0034599 [cellular response to oxidative stress] evidence: ISS
GeneID:2308 -> Biological process: GO:0035947 [regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:2308 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:2308 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IBA
GeneID:2308 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:2308 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:2308 -> Biological process: GO:0045444 [fat cell differentiation] evidence: ISS
GeneID:2308 -> Biological process: GO:0045599 [negative regulation of fat cell differentiation] evidence: ISS
GeneID:2308 -> Biological process: GO:0045722 [positive regulation of gluconeogenesis] evidence: IEA
GeneID:2308 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:2308 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:2308 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2308 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:2308 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:2308 -> Biological process: GO:0048513 [organ development] evidence: IBA
GeneID:2308 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: IBA
GeneID:2308 -> Biological process: GO:0070417 [cellular response to cold] evidence: ISS
GeneID:2308 -> Biological process: GO:0071732 [cellular response to nitric oxide] evidence: ISS
GeneID:2308 -> Biological process: GO:2000505 [regulation of energy homeostasis] evidence: ISS
GeneID:2308 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:2308 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:2308 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IBA
GeneID:2308 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2308 -> Cellular component: GO:0005739 [mitochondrion] evidence: ISS
GeneID:2308 -> Cellular component: GO:0005829 [cytosol] evidence: ISS
GeneID:2308 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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