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2024-04-20 22:14:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002009 3936 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens fibroblast growth factor 7 (FGF7), mRNA.
ACCESSION NM_002009
VERSION NM_002009.3 GI:219842354
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3936)
AUTHORS Canady,J., Arndt,S., Karrer,S. and Bosserhoff,A.K.
TITLE Increased KGF expression promotes fibroblast activation in a double
paracrine manner resulting in cutaneous fibrosis
JOURNAL J. Invest. Dermatol. 133 (3), 647-657 (2013)
PUBMED 23096718
REMARK GeneRIF: Increased KGF expression promotes fibroblast activation in
a double paracrine manner resulting in cutaneous fibrosis.
REFERENCE 2 (bases 1 to 3936)
AUTHORS Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
Peeters,R.P. and Naitza,S.
TITLE A meta-analysis of thyroid-related traits reveals novel loci and
gender-specific differences in the regulation of thyroid function
JOURNAL PLoS Genet. 9 (2), E1003266 (2013)
PUBMED 23408906
REFERENCE 3 (bases 1 to 3936)
AUTHORS Kim,T.I., Poulin,E.J., Blask,E., Bukhalid,R., Whitehead,R.H.,
Franklin,J.L. and Coffey,R.J.
TITLE Myofibroblast keratinocyte growth factor reduces tight junctional
integrity and increases claudin-2 levels in polarized Caco-2 cells
JOURNAL Growth Factors 30 (5), 320-332 (2012)
PUBMED 22946653
REMARK GeneRIF: results implicate pericryptal myofibroblast-derived
paracrine KGF and largely autocrine amphiregulin in the
upregulation of claudin-2 in Caco-2 epithelial monolayers and
consequent disruption of tight junction integrity
REFERENCE 4 (bases 1 to 3936)
AUTHORS Sun,Z., Yu,X., Wu,W., Jia,D., Chen,Y., Ji,L., Liu,X., Peng,X.,
Li,Y., Yang,L., Ruan,Y., Gu,J., Ren,S. and Zhang,S.
TITLE Fibroblast growth factor 7 inhibits cholesterol 7alpha-hydroxylase
gene expression in hepatocytes
JOURNAL Biochem. Biophys. Res. Commun. 423 (4), 775-780 (2012)
PUBMED 22713451
REMARK GeneRIF: these data suggest that FGF7 is a novel regulator of
CYP7A1 expression in hepatocytes and may prevent hepatocytes from
accumulating toxic bile acids during liver injury and fibrosis.
REFERENCE 5 (bases 1 to 3936)
AUTHORS Cai,Y.J., Wang,W.S., Liang,H.Y., Sun,L.H., Teitelbaum,D.H. and
Yang,H.
TITLE Keratinocyte growth factor up-regulates Interleukin-7 expression
following intestinal ischemia/reperfusion in vitro and in vivo
JOURNAL Int J Clin Exp Pathol 5 (6), 569-580 (2012)
PUBMED 22949940
REMARK GeneRIF: Keratinocyte growth factor up-regulates Interleukin-7
expression following intestinal ischemia/reperfusion in vitro and
in vivo.
REFERENCE 6 (bases 1 to 3936)
AUTHORS Ishibashi,T., Bottaro,D.P., Chan,A., Miki,T. and Aaronson,S.A.
TITLE Expression cloning of a human dual-specificity phosphatase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (24), 12170-12174 (1992)
PUBMED 1281549
REFERENCE 7 (bases 1 to 3936)
AUTHORS Kelley,M.J., Pech,M., Seuanez,H.N., Rubin,J.S., O'Brien,S.J. and
Aaronson,S.A.
TITLE Emergence of the keratinocyte growth factor multigene family during
the great ape radiation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (19), 9287-9291 (1992)
PUBMED 1409637
REFERENCE 8 (bases 1 to 3936)
AUTHORS Miki,T., Bottaro,D.P., Fleming,T.P., Smith,C.L., Burgess,W.H.,
Chan,A.M. and Aaronson,S.A.
TITLE Determination of ligand-binding specificity by alternative
splicing: two distinct growth factor receptors encoded by a single
gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (1), 246-250 (1992)
PUBMED 1309608
REFERENCE 9 (bases 1 to 3936)
AUTHORS Aaronson,S.A., Bottaro,D.P., Miki,T., Ron,D., Finch,P.W.,
Fleming,T.P., Ahn,J., Taylor,W.G. and Rubin,J.S.
TITLE Keratinocyte growth factor. A fibroblast growth factor family
member with unusual target cell specificity
JOURNAL Ann. N. Y. Acad. Sci. 638, 62-77 (1991)
PUBMED 1664700
REFERENCE 10 (bases 1 to 3936)
AUTHORS Finch,P.W., Rubin,J.S., Miki,T., Ron,D. and Aaronson,S.A.
TITLE Human KGF is FGF-related with properties of a paracrine effector of
epithelial cell growth
JOURNAL Science 245 (4919), 752-755 (1989)
PUBMED 2475908
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB206350.1, M60828.1 and
AC025919.8.
This sequence is a reference standard in the RefSeqGene project.
On Jan 9, 2009 this sequence version replaced gi:15147344.
Summary: The protein encoded by this gene is a member of the
fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a
variety of biological processes, including embryonic development,
cell growth, morphogenesis, tissue repair, tumor growth and
invasion. This protein is a potent epithelial cell-specific growth
factor, whose mitogenic activity is predominantly exhibited in
keratinocytes but not in fibroblasts and endothelial cells. Studies
of mouse and rat homologs of this gene implicated roles in
morphogenesis of epithelium, reepithelialization of wounds, hair
development and early lung organogenesis. [provided by RefSeq, Jul
2008].
Sequence Note: The RefSeq transcript and protein were derived from
transcript and genomic sequence to make the sequence consistent
with the reference genome assembly. The extent of this RefSeq
transcript is supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M60828.1, S81661.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-507 DB206350.1 84-590
508-1137 M60828.1 424-1053
1138-3936 AC025919.8 63318-66116
FEATURES Location/Qualifiers
source 1..3936
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q21.2"
gene 1..3936
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="fibroblast growth factor 7"
/db_xref="GeneID:2252"
/db_xref="HGNC:3685"
/db_xref="HPRD:01022"
/db_xref="MIM:148180"
exon 1..263
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/inference="alignment:Splign:1.39.8"
variation 15
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:73398286"
exon 264..815
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/inference="alignment:Splign:1.39.8"
variation 276
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:112825172"
variation 312
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:187770313"
variation 333
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:192559607"
variation 407
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:3198207"
STS 423..1044
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="Fgf7"
/db_xref="UniSTS:547901"
misc_feature 455..457
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="upstream in-frame stop codon"
variation 513
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:17478047"
variation 514
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:199507360"
variation 521
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="g"
/replace="t"
/db_xref="dbSNP:374130440"
CDS 530..1114
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="keratinocyte growth factor; heparin-binding growth
factor 7; FGF-7"
/codon_start=1
/product="fibroblast growth factor 7 precursor"
/protein_id="NP_002000.1"
/db_xref="GI:4503705"
/db_xref="CCDS:CCDS10131.1"
/db_xref="GeneID:2252"
/db_xref="HGNC:3685"
/db_xref="HPRD:01022"
/db_xref="MIM:148180"
/translation="
MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
"
sig_peptide 530..622
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
mat_peptide 623..1111
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/product="fibroblast growth factor 7"
misc_feature 728..1102
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="Acidic and basic fibroblast growth factor family;
FGFs are mitogens, which stimulate growth or
differentiation of cells of mesodermal or neuroectodermal
origin. The family plays essential roles in patterning and
differentiation during vertebrate...; Region: FGF;
cd00058"
/db_xref="CDD:28940"
misc_feature order(728..730,737..739,830..832,836..838,842..844,
926..928,950..952,959..976,980..982,1088..1090,1094..1096,
1100..1102)
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="receptor interaction site; other site"
/db_xref="CDD:28940"
misc_feature order(1031..1036,1049..1051,1061..1063,1079..1081)
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/note="heparin binding site (glycine box) [chemical
binding]; other site"
/db_xref="CDD:28940"
variation 574
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:377679450"
variation 613
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:373498840"
variation 650
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:376909937"
variation 705
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:34531231"
variation 714
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:17850705"
STS 725..1104
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="Fgf7"
/db_xref="UniSTS:265078"
variation 734
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:370236693"
variation 751
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:183624878"
variation 774
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="g"
/replace="t"
/db_xref="dbSNP:143883386"
exon 816..919
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/inference="alignment:Splign:1.39.8"
STS 840..1039
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="Fgf7"
/db_xref="UniSTS:273722"
STS 844..1111
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="FGF7"
/db_xref="UniSTS:253915"
variation 847
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:3959662"
exon 920..3936
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/inference="alignment:Splign:1.39.8"
variation 923
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:148602079"
variation 937
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:142236913"
variation 952
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:202117471"
variation 1085
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:369116662"
variation 1297
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:191726970"
STS 1340..1548
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="G15911"
/db_xref="UniSTS:15791"
variation 1348
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:182299198"
variation 1352
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:187088824"
variation 1370
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:1057636"
variation 1370
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:17142085"
variation 1466
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:35686890"
variation 1520
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:369619368"
variation 1539
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057638"
variation 1616
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="t"
/db_xref="dbSNP:372127537"
variation 1648..1649
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="a"
/db_xref="dbSNP:201603989"
variation 1657
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="t"
/db_xref="dbSNP:200623673"
variation 1669
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:190965118"
variation 1703..1704
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="c"
/db_xref="dbSNP:34169642"
variation 1817
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="g"
/replace="t"
/db_xref="dbSNP:112843832"
variation 1844..1845
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="ac"
/db_xref="dbSNP:201990168"
variation 1846..1847
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="ac"
/db_xref="dbSNP:60927272"
variation 1881
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:60771113"
variation 1905..1906
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="t"
/db_xref="dbSNP:35073573"
variation 1940
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:371359059"
variation 1949
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:12787"
variation 2010
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:182077617"
variation 2027
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:12021"
variation 2044
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:185098313"
variation 2055
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057655"
variation 2075
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="g"
/replace="t"
/db_xref="dbSNP:1057656"
variation 2084..2086
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:1057657"
variation 2084
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace=""
/replace="a"
/db_xref="dbSNP:79465035"
variation 2122
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:190085424"
variation 2162
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:183166589"
variation 2178
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064338"
variation 2279
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:188586834"
variation 2306
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:373173503"
variation 2313
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:12440028"
variation 2381
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:192954168"
variation 2470
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:3985843"
variation 2500
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:3985844"
variation 2546
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:183756896"
variation 2547
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="c"
/db_xref="dbSNP:3985845"
variation 2557
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057669"
variation 2564
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057670"
variation 2629
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:3959665"
variation 2757
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:187754231"
variation 2792
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:148009287"
variation 2835
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:192544650"
STS 2868..3060
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/standard_name="SHGC-84206"
/db_xref="UniSTS:104697"
variation 2888
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:183604133"
variation 3034
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:142415531"
variation 3421
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:370478883"
variation 3547
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="g"
/db_xref="dbSNP:146377429"
variation 3590
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:139688996"
variation 3622
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:374010573"
variation 3648
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="a"
/replace="t"
/db_xref="dbSNP:11630629"
variation 3689
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="t"
/db_xref="dbSNP:58284238"
variation 3728
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
/replace="c"
/replace="g"
/db_xref="dbSNP:375278216"
polyA_signal 3908..3913
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
polyA_site 3936
/gene="FGF7"
/gene_synonym="HBGF-7; KGF"
ORIGIN
agttttaattgcttccaatgaggtcagcaaaggtatttatcgaaaagccctgaataaaaggctcacacacacacacaagcacacacgcgctcacacacagagagaaaatccttctgcctgttgatttatggaaacaattatgattctgctggagaacttttcagctgagaaatagtttgtagctacagtagaaaggctcaagttgcaccaggcagacaacagacatggaattcttatatatccagctgttagcaacaaaacaaaagtcaaatagcaaacagcgtcacagcaactgaacttactacgaactgtttttatgaggatttatcaacagagttatttaaggaggaatcctgtgttgttatcaggaactaaaaggataaggctaacaatttggaaagagcaactactctttcttaaatcaatctacaattcacagataggaagaggtcaatgacctaggagtaacaatcaactcaagattcattttcattatgttattcatgaacacccggagcactacactataatgcacaaatggatactgacatggatcctgccaactttgctctacagatcatgctttcacattatctgtctagtgggtactatatctttagcttgcaatgacatgactccagagcaaatggctacaaatgtgaactgttccagccctgagcgacacacaagaagttatgattacatggaaggaggggatataagagtgagaagactcttctgtcgaacacagtggtacctgaggatcgataaaagaggcaaagtaaaagggacccaagagatgaagaataattacaatatcatggaaatcaggacagtggcagttggaattgtggcaatcaaaggggtggaaagtgaattctatcttgcaatgaacaaggaaggaaaactctatgcaaagaaagaatgcaatgaagattgtaacttcaaagaactaattctggaaaaccattacaacacatatgcatcagctaaatggacacacaacggaggggaaatgtttgttgccttaaatcaaaaggggattcctgtaagaggaaaaaaaacgaagaaagaacaaaaaacagcccactttcttcctatggcaataacttaattgcatatggtatataaagaaccagttccagcagggagatttctttaagtggactgttttctttcttctcaaaattttctttccttttattttttagtaatcaagaaaggctggaaaactactgaaaaactgatcaagctggacttgtgcatttatgtttgttttaagacactgcattaaagaaagatttgaaaagtatacacaaaaatcagatttagtaactaaaggttgtaaaaaattgtaaaactggttgtacaatcatgatgttagtaacagtaatttttttcttaaattaatttacccttaagagtatgttagatttgattatctgataatgattatttaaatattcctatctgcttataaaatggctgctataataataataatacagatgttgttatataaggtatatcagacctacaggcttctggcaggatttgtcagataatcaagccacactaactatggaaaatgagcagcattttaaatgctttctagtgaaaaattataatctacttaaactctaatcagaaaaaaaattctcaaaaaaactattatgaaagtcaataaaatagataatttaacaaaagtacaggattagaacatgcttatacctataaataagaacaaaatttctaatgctgctcaagtggaaagggtattgctaaaaggatgtttccaaaaatcttgtatataagatagcaacagtgattgatgataatactgtacttcatcttacttgccacaaaataacattttataaatcctcaaagtaaaattgagaaatctttaagtttttttcaagtaacataatctatctttgtataattcatatttgggaatatggcttttaataatgttcttcccacaaataatcatgcttttttcctatggttacagcattaaactctattttaagttgtttttgaactttattgttttgttatttaagtttatgttatttataaaaaaaaaaccttaataagctgtatctgtttcatatgcttttaattttaaaggaataacaaaactgtctggctcaacggcaagtttccctcccttttctgactgacactaagtctagcacacagcacttgggccagcaaatcctggaaggcagacaaaaataagagcctgaagcaatgcttacaatagatgtctcacacagaacaatacaaatatgtaaaaaatctttcaccacatattcttgccaattaattggatcatataagtaaaatcattacaaatataagtatttacaggattttaaagttagaatatatttgaatgcatgggtagaaaatatcatattttaaaactatgtatatttaaatttagtaattttctaatctctagaaatctctgctgttcaaaaggtggcagcactgaaagttgttttcctgttagatggcaagagcacaatgcccaaaatagaagatgcagttaagaataaggggccctgaatgtcatgaaggcttgaggtcagcctacagataacaggattattacaaggatgaatttccacttcaaaagtctttcattggcagatcttggtagcactttatatgttcaccaatgggaggtcaatatttatctaatttaaaaggtatgctaaccactgtggttttaatttcaaaatatttgtcattcaagtccctttacataaatagtatttggtaatacatttatagatgagagttatatgaaaaggctaggtcaacaaaaacaatagattcatttaattttcctgtggttgacctatacgaccaggatgtagaaaactagaaagaactgcccttcctcagatatactcttgggagagagcatgaatggtattctgaactatcacctgattcaaggactttgctagctaggttttgaggtcaggcttcagtaactgtagtcttgtgagcatattgagggcagaggaggacttagtttttcatatgtgtttccttagtgcctagcagactatctgttcataatcagttttcagtgtgaattcactgaatgtttatagacaaaagaaaatacacactaaaactaatcttcattttaaaagggtaaaacatgactatacagaaatttaaatagaaatagtgtatatacatataaaatacaagctatgttaggaccaaatgctctttgtctatggagttatacttccatcaaattacatagcaatgctgaattaggcaaaaccaacatttagtggtaaatccattcctggtagtataagtcacctaaaaaagacttctagaaatatgtactttaattatttgtttttctcctatttttaaatttattatgcaaattttagaaaataaaatttgctctagttacacacctttagaattctagaatattaaaactgtaaggggcctccatccctcttactcatttgtagtctaggaaattgagattttgatacacctaaggtcacgcagctgggtagatatacagctgtcacaagagtctagatcagttagcacatgctttctactcttcgattattagtattattagctaatggtctttggcatgtttttgttttttatttctgttgagatatagcctttacatttgtacacaaatgtgactatgtcttggcaatgcacttcatacacaatgactaatctatactgtgatgatttgactcaaaaggagaaaagaaattatgtagttttcaattctgattcctattcaccttttgtttatgaatggaaagctttgtgcaaaatatacatataagcagagtaagccttttaaaaatgttctttgaaagataaaattaaatacatgagtttctaacaattaga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2252 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2252 -> Molecular function: GO:0008083 [growth factor activity] evidence: IEA
GeneID:2252 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA
GeneID:2252 -> Molecular function: GO:0042056 [chemoattractant activity] evidence: IDA
GeneID:2252 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:2252 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:2252 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IGI
GeneID:2252 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:2252 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IGI
GeneID:2252 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:2252 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:2252 -> Biological process: GO:0009611 [response to wounding] evidence: TAS
GeneID:2252 -> Biological process: GO:0010463 [mesenchymal cell proliferation] evidence: IDA
GeneID:2252 -> Biological process: GO:0010838 [positive regulation of keratinocyte proliferation] evidence: IDA
GeneID:2252 -> Biological process: GO:0031069 [hair follicle morphogenesis] evidence: IEA
GeneID:2252 -> Biological process: GO:0031532 [actin cytoskeleton reorganization] evidence: IDA
GeneID:2252 -> Biological process: GO:0034394 [protein localization to cell surface] evidence: IDA
GeneID:2252 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:2252 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:2252 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:2252 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:2252 -> Biological process: GO:0050679 [positive regulation of epithelial cell proliferation] evidence: IDA
GeneID:2252 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:2252 -> Biological process: GO:0050918 [positive chemotaxis] evidence: IDA
GeneID:2252 -> Biological process: GO:0051549 [positive regulation of keratinocyte migration] evidence: IDA
GeneID:2252 -> Biological process: GO:0051781 [positive regulation of cell division] evidence: IEA
GeneID:2252 -> Biological process: GO:0060445 [branching involved in salivary gland morphogenesis] evidence: IEA
GeneID:2252 -> Biological process: GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] evidence: IDA
GeneID:2252 -> Biological process: GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] evidence: IEA
GeneID:2252 -> Biological process: GO:0061033 [secretion by lung epithelial cell involved in lung growth] evidence: IDA
GeneID:2252 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:2252 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
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@meso_cacase at
DBCLS
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