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2024-04-18 21:35:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001943 5677 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens desmoglein 2 (DSG2), mRNA.
ACCESSION NM_001943
VERSION NM_001943.3 GI:189181754
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5677)
AUTHORS Hartlieb,E., Kempf,B., Partilla,M., Vigh,B., Spindler,V. and
Waschke,J.
TITLE Desmoglein 2 is less important than desmoglein 3 for keratinocyte
cohesion
JOURNAL PLoS ONE 8 (1), E53739 (2013)
PUBMED 23326495
REMARK GeneRIF: Specific desmosomal cadherins contribute differently to
keratinocyte cohesion and that Dsg2 compared to Dsg3 is less
important in this context.
REFERENCE 2 (bases 1 to 5677)
AUTHORS Koyama-Nasu,R., Takahashi,R., Yanagida,S., Nasu-Nishimura,Y.,
Oyama,M., Kozuka-Hata,H., Haruta,R., Manabe,E., Hoshino-Okubo,A.,
Omi,H., Yanaihara,N., Okamoto,A., Tanaka,T. and Akiyama,T.
TITLE The cancer stem cell marker CD133 interacts with plakoglobin and
controls desmoglein-2 protein levels
JOURNAL PLoS ONE 8 (1), E53710 (2013)
PUBMED 23326490
REMARK GeneRIF: CD133 interacts with plakoglobin and knockdown of CD133 by
RNA interference (RNAi) results in the downregulation of
desmoglein-2.
REFERENCE 3 (bases 1 to 5677)
AUTHORS Chen,J., Nekrasova,O.E., Patel,D.M., Klessner,J.L., Godsel,L.M.,
Koetsier,J.L., Amargo,E.V., Desai,B.V. and Green,K.J.
TITLE The C-terminal unique region of desmoglein 2 inhibits its
internalization via tail-tail interactions
JOURNAL J. Cell Biol. 199 (4), 699-711 (2012)
PUBMED 23128240
REMARK GeneRIF: The Dsg unique region(DUR) of Dsg2 stabilized Dsg2 at the
cell surface by inhibiting its internalization and promoted strong
intercellular adhesion.
REFERENCE 4 (bases 1 to 5677)
AUTHORS Wadhawan,V., Kolhe,Y.A., Sangith,N., Gautam,A.K. and Venkatraman,P.
TITLE From prediction to experimental validation: desmoglein 2 is a
functionally relevant substrate of matriptase in epithelial cells
and their reciprocal relationship is important for cell adhesion
JOURNAL Biochem. J. 447 (1), 61-70 (2012)
PUBMED 22783993
REMARK GeneRIF: Dsg-2 with a mutation at the predicted cleavage site is
resistant to cleavage by matriptase. Thus Dsg-2 seems to be a
functionally relevant physiological substrate of matriptase.
REFERENCE 5 (bases 1 to 5677)
AUTHORS Gaertner,A., Klauke,B., Stork,I., Niehaus,K., Niemann,G.,
Gummert,J. and Milting,H.
TITLE In vitro functional analyses of arrhythmogenic right ventricular
cardiomyopathy-associated desmoglein-2-missense variations
JOURNAL PLoS ONE 7 (10), E47097 (2012)
PUBMED 23071725
REMARK GeneRIF: an impaired prodomain cleavage and an influence on the
DSG2-properties could be demonstrated for the R46Q-variant leading
to the classification of the variant as a potential
gain-of-function mutant in arrhythmogenic right ventricular
cardiomyopathy
REFERENCE 6 (bases 1 to 5677)
AUTHORS Schafer,S., Stumpp,S. and Franke,W.W.
TITLE Immunological identification and characterization of the desmosomal
cadherin Dsg2 in coupled and uncoupled epithelial cells and in
human tissues
JOURNAL Differentiation 60 (2), 99-108 (1996)
PUBMED 8641550
REFERENCE 7 (bases 1 to 5677)
AUTHORS Simrak,D., Cowley,C.M., Buxton,R.S. and Arnemann,J.
TITLE Tandem arrangement of the closely linked desmoglein genes on human
chromosome 18
JOURNAL Genomics 25 (2), 591-594 (1995)
PUBMED 7790000
REFERENCE 8 (bases 1 to 5677)
AUTHORS Schafer,S., Koch,P.J. and Franke,W.W.
TITLE Identification of the ubiquitous human desmoglein, Dsg2, and the
expression catalogue of the desmoglein subfamily of desmosomal
cadherins
JOURNAL Exp. Cell Res. 211 (2), 391-399 (1994)
PUBMED 8143788
REFERENCE 9 (bases 1 to 5677)
AUTHORS Arnemann,J., Spurr,N.K., Magee,A.I. and Buxton,R.S.
TITLE The human gene (DSG2) coding for HDGC, a second member of the
desmoglein subfamily of the desmosomal cadherins, is, like DSG1
coding for desmoglein DGI, assigned to chromosome 18
JOURNAL Genomics 13 (2), 484-486 (1992)
PUBMED 1612610
REFERENCE 10 (bases 1 to 5677)
AUTHORS Koch,P.J., Goldschmidt,M.D., Walsh,M.J., Zimbelmann,R. and
Franke,W.W.
TITLE Complete amino acid sequence of the epidermal desmoglein precursor
polypeptide and identification of a second type of desmoglein gene
JOURNAL Eur. J. Cell Biol. 55 (2), 200-208 (1991)
PUBMED 1935985
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN347023.1, DC417739.1,
BC099657.3, CN395083.1, BC022413.1, DR158777.1 and BC014581.1.
This sequence is a reference standard in the RefSeqGene project.
On May 30, 2008 this sequence version replaced gi:116534897.
Summary: Desmosomes are cell-cell junctions between epithelial,
myocardial, and certain other cell types. This gene product is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. This
second family member is expressed in colon, colon carcinoma, and
other simple and stratified epithelial-derived cell lines.
Mutations in this gene have been associated with arrhythmogenic
right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK308408.1, Z26317.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-165 CN347023.1 3-167
166-738 DC417739.1 28-600
739-3595 BC099657.3 562-3418
3596-4040 CN395083.1 267-711
4041-4488 BC022413.1 297-744
4489-5074 DR158777.1 147-732
5075-5677 BC014581.1 798-1400
FEATURES Location/Qualifiers
source 1..5677
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q12.1"
gene 1..5677
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="desmoglein 2"
/db_xref="GeneID:1829"
/db_xref="HGNC:3049"
/db_xref="MIM:125671"
exon 1..233
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
CDS 189..3545
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="HDGC; cadherin family member 5"
/codon_start=1
/product="desmoglein-2 preproprotein"
/protein_id="NP_001934.2"
/db_xref="GI:116534898"
/db_xref="CCDS:CCDS42423.1"
/db_xref="GeneID:1829"
/db_xref="HGNC:3049"
/db_xref="MIM:125671"
/translation="
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS
"
sig_peptide 189..257
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 258..3542
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/product="desmoglein-2 proprotein"
mat_peptide 336..3542
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/product="desmoglein-2"
misc_feature 372..653
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(372..377,540..542,546..548,639..641,645..650)
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 675..992
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(696..701,870..872,876..878,978..980,984..989)
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1014..1277
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1035..1040,1209..1211,1215..1217)
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1362..1673
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1383..1388,1548..1550,1554..1556,1659..1661,
1665..1670)
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 2016..2090
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
transmembrane region"
misc_feature 2226..2228
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14126.2); phosphorylation site"
misc_feature 2226..2228
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2295..2297
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14126.2); phosphorylation site"
misc_feature <2541..2714
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/note="Cadherin cytoplasmic region; Region: Cadherin_C;
pfam01049"
/db_xref="CDD:163601"
misc_feature 2829..2924
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 1"
misc_feature 2925..3014
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 2"
misc_feature 3015..3092
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 3"
misc_feature 3090..3092
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3093..3164
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 4"
misc_feature 3165..3251
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 5"
misc_feature 3225..3227
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3252..3341
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14126.2);
Region: Desmoglein repeat 6"
misc_feature 3540..3542
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14126.2); phosphorylation site"
exon 234..269
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 270..404
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 405..566
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 567..711
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 712..878
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 879..1016
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 1017..1202
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 1203..1468
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 1469..1611
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 1612..1839
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 1840..2067
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 2068..2189
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 2190..2522
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
exon 2523..5653
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/inference="alignment:Splign:1.39.8"
variation complement(2693)
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042769"
STS 3556..4040
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/db_xref="UniSTS:148229"
STS 3591..3690
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="D18S1242"
/db_xref="UniSTS:61105"
STS 4021..4204
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="G10645"
/db_xref="UniSTS:16256"
STS 4219..4323
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 4305..4393
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 5391..5515
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="RH102141"
/db_xref="UniSTS:96475"
STS 5496..5596
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
/standard_name="G29763"
/db_xref="UniSTS:68868"
polyA_signal 5631..5636
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
polyA_site 5653
/gene="DSG2"
/gene_synonym="ARVC10; ARVD10; CDHF5; CMD1BB; HDGC"
ORIGIN
ctggagccgcgcctttgggttgggctgggctgggccgcgcaaccgccacgggaagacagccctcggggcggggagggagagggtggccgggccggggggaggccggggccagggaggagccgagtgcgcgctcggggcaggcggcggcgcggagcggtgcggcggcgggaggcggaggcgagggtgcgatggcgcggagcccgggacgcgcgtacgccctgctgcttctcctgatctgctttaacgttggaagtggacttcacttacaggtcttaagcacaagaaatgaaaataagctgcttcctaaacatcctcatttagtgcggcaaaagcgcgcctggatcaccgcccccgtggctcttcgggagggagaggatctgtccaagaagaatccaattgccaagatacattctgatcttgcagaagaaagaggactcaaaattacttacaaatacactggaaaagggattacagagccaccttttggtatatttgtctttaacaaagatactggagaactgaatgttaccagcattcttgatcgagaagaaacaccattttttctgctaacaggttacgctttggatgcaagaggaaacaatgtagagaaacccttagagctacgcattaaggttcttgatatcaatgacaacgaaccagtgttcacacaggatgtctttgttgggtctgttgaagagttgagtgcagcacatactcttgtgatgaaaatcaatgcaacagatgcagatgagcccaataccctgaattcgaaaatttcctatagaatcgtatctctggagcctgcttatcctccagtgttctacctaaataaagatacaggagagatttatacaaccagtgttaccttggacagagaggaacacagcagctacactttgacagtagaagcaagagatggcaatggagaagttacagacaaacctgtaaaacaagctcaagttcagattcgtattttggatgtcaatgacaatatacctgtagtagaaaataaagtgcttgaagggatggttgaagaaaatcaagtcaacgtagaagttacgcgcataaaagtgttcgatgcagatgaaataggttctgataattggctggcaaattttacatttgcatcaggaaatgaaggaggttatttccacatagaaacagatgctcaaactaacgaaggaattgtgacccttattaaggaagtagattatgaagaaatgaagaatcttgacttcagtgttattgtcgctaataaagcagcttttcacaagtcgattaggagtaaatacaagcctacacccattcccatcaaggtcaaagtgaaaaatgtgaaagaaggcattcattttaaaagcagcgtcatctcaatttatgttagcgagagcatggatagatcaagcaaaggccaaataattggaaattttcaagcttttgatgaggacactggactaccagcccatgcaagatatgtaaaattagaagatagagataattggatctctgtggattctgtcacatctgaaattaaacttgcaaaacttcctgattttgaatctagatatgttcaaaatggcacatacactgtaaagattgtggccatatcagaagattatcctagaaaaaccatcactggcacagtccttatcaatgttgaagacatcaacgacaactgtcccacactgatagagcctgtgcagacaatctgtcacgatgcagagtatgtgaatgttactgcagaggacctggatggacacccaaacagtggccctttcagtttctccgtcattgacaaaccacctggcatggcagaaaaatggaaaatagcacgccaagaaagtaccagtgtgctgctgcaacaaagtgagaaaaagcttgggagaagtgaaattcagttcctgatttcagacaatcagggttttagttgtcctgaaaagcaggtccttacactcacagtttgtgagtgtctgcatggcagcggctgcagggaagcacagcatgactcctatgtgggcctgggacccgcagcaattgcgctcatgattttggcctttctgctcctgctattggtaccacttttactgctgatgtgccattgcggaaagggcgccaaaggctttacccccatacctggcaccatagagatgctgcatccttggaataatgaaggagcaccacctgaagacaaggtggtgccatcatttctgccagtggatcaagggggcagtctagtaggaagaaatggagtaggaggtatggccaaggaagccacgatgaaaggaagtagctctgcttccattgtcaaagggcaacatgagatgtccgagatggatggaaggtgggaagaacacagaagcctgctttctggtagagctacccagtttacaggggccacaggcgctatcatgaccactgaaaccacgaagaccgcaagggccacaggggcttccagagacatggccggagctcaggcagctgctgttgcactgaacgaagaattcttaagaaattatttcactgataaagcggcctcttacactgaggaagatgaaaatcacacagccaaagattgccttctggtttattctcaggaagaaactgaatcgctgaatgcttctattggttgttgcagttttattgaaggagagctagatgaccgcttcttagatgatttgggacttaaattcaagacactagctgaagtttgcctgggtcaaaaaatagatataaataaggaaattgagcagagacaaaaacctgccacagaaacaagtatgaacacagcttcacattcactctgtgagcaaactatggttaattcagagaatacctactcctctggcagtagcttcccagttccaaaatctttgcaagaagccaatgcagagaaagtaactcaggaaatagtcactgaaagatctgtgtcttctaggcaggcgcaaaaggtagctacacctcttcctgacccaatggcttctagaaatgtgatagcaacagaaacttcctatgtcacagggtccactatgccaccaaccactgtgatcctgggtcctagccagccacagagccttattgtgacagagagggtgtatgctccagcttctaccttggtagatcagccttatgctaatgaaggtacagttgtggtcactgaaagagtaatacagcctcatgggggtggatcgaatcctctggaaggcactcagcatcttcaagatgtaccttacgtcatggtgagggaaagagagagcttccttgcccccagctcaggtgtgcagcctactctggccatgcctaatatagcagtaggacagaatgtgacagtgacagaaagagttctagcacctgcttccactctgcaatccagttaccagattcccactgaaaattctatgacggctaggaacaccacggtgtctggagctggagtccctggccctctgccagattttggtttagaggaatctggtcattctaattctaccataaccacatcttccaccagagttaccaagcatagcactgtacagcattcttactcctaaacagcagtcagccacaaactgacccagagtttaattagcagtgactaatttcatgtttccaatgtacctgatttttcatgagccttacagacacacagagacacatacacattgatcttaaaatttttctcagtcactgatatgcaaaggaccacactgtctctgcttccaggagtattttagaaatgttccacaatttactgaagacatagagatgatgctgctgcttaggtgccttttagcaagctatgcaaacaatcctgataaaacaagatacatagagagtcaatctggcttctgagaatttaccaagtgaacagagtacctagttcatcagccgtccagtaaagcaacccaggaaactgactgggtctctttgcctaccgtattaacattaaacattgatgttctgtattctgtactttactgcacccagcagactttcaacaactcattgatccaaagatacatgcacagtctgagcaccagctatggtgctcataacttctttaagacttgaaccctttcaatctgtgtgattcattaaattggaccattgatgataagaatacacattgtatgtttctgtgcacatgacagtgtgtgtgtgtgcacgtacatactgtatagtcttaaaaatagcattatactggccaggggtggtggctaacgcctgtaatcccagcactttgggaggccgaggcgggtggatcaactgtggtcaggagtttgagatcagccaggccaacctggtgaaaccccgtctctactaaaaatacaaaaattagctgggcgtgatggtgggcgcctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacccgggaggcggaggttgcagtgagccgagatcgcaccattgcactccagtctgggcaacagagtgagattccgtctcaaaaaaaaaaagaaaaggaaaaaaaaatagcattatacctcttccttgtctcaaccgccatgaaaattctgaacactccaaattcagttgaataatccaaaacaaaatttataagtataaaataattttacttcttatagtaatagtatactttaaaaagcctcagggtatattatcttctaaacagctacaattcagtgcagctacattaaccaactatgttctctagttgagaacaactaggcctatttcactgctgtgtagcctcagtgcctaacatgggtgccaaataaatattcgtagaattacactgaattgtaaaaaccattcgtttttgtttacaattgccaaaaatctcaaaaggccctgtatttatgtaattctttgaaattattattttattttgatttctcagttattgactggctgggtgtgacttagtacataagtactcaatattataaaaacctcaaataattgacttgattttacacaacatccttcccttttctacaagttaatttttttacaaatcatttgggttatctcctaaataggttatattttattgcttctagaaacaatgtttcaaaatatatgtgcattatcagtaataatttgtataaatatttcccacaacaattttcataattttcaaagactaatttcttgactgaagatattttgctagggaagtgaaactttaaaattttgtagattttaaaaaatattgttgaatggtgtcatgcaaaggatttatatagtgtgctcccactaactgtacagatcaggacacatatttttagacatctaagtctgtagcttaaatggaggttactcttccatcatctagaattgtttacttagtaattgttgtttcttttattattatagacttactatcagttttattttgccaagtatgcaacaggtatatcactagtatatgaaaatgtaaatatcacttgtgtactcaaacaaaagttggtcttaagcttccaccttgagcagccttggaaacctaacctgcctcttttagcataatcacattttctaaatgattttctttgttcctgaaaaagtgatttgtattagttttacatttgttttttggaagattatatttgtatatgtatcatcataaaatatttaaataaaaagtatctttagagtgaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1829 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:1829 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:1829 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:1829 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:1829 -> Biological process: GO:0007155 [cell adhesion] evidence: IDA
GeneID:1829 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
GeneID:1829 -> Biological process: GO:0086005 [regulation of ventricular cardiac muscle cell action potential] evidence: IMP
GeneID:1829 -> Biological process: GO:0086069 [bundle of His cell to Purkinje myocyte communication] evidence: IMP
GeneID:1829 -> Biological process: GO:0086091 [regulation of heart rate by cardiac conduction] evidence: IMP
GeneID:1829 -> Biological process: GO:0097194 [execution phase of apoptosis] evidence: IDA
GeneID:1829 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:1829 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:1829 -> Cellular component: GO:0005911 [cell-cell junction] evidence: TAS
GeneID:1829 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:1829 -> Cellular component: GO:0030057 [desmosome] evidence: IEA
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