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2019-03-25 14:59:45, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001935               3913 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens dipeptidyl-peptidase 4 (DPP4), mRNA.
ACCESSION   NM_001935
VERSION     NM_001935.3  GI:47078262
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3913)
  AUTHORS   Khurana,S., Margamuljana,L., Joseph,C., Schouteden,S., Buckley,S.M.
            and Verfaillie,C.M.
  TITLE     Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism
            in hematopoietic stem cell homing and maintenance
  JOURNAL   Blood 121 (14), 2587-2595 (2013)
   PUBMED   23327927
  REMARK    GeneRIF: We identified tissue-factor pathway inhibitor (TFPI) as a
            biological inhibitor of CD26 in murine and human hematopoietic stem
            cells.
REFERENCE   2  (bases 1 to 3913)
  AUTHORS   Raj,V.S., Mou,H., Smits,S.L., Dekkers,D.H., Muller,M.A.,
            Dijkman,R., Muth,D., Demmers,J.A., Zaki,A., Fouchier,R.A.,
            Thiel,V., Drosten,C., Rottier,P.J., Osterhaus,A.D., Bosch,B.J. and
            Haagmans,B.L.
  TITLE     Dipeptidyl peptidase 4 is a functional receptor for the emerging
            human coronavirus-EMC
  JOURNAL   Nature 495 (7440), 251-254 (2013)
   PUBMED   23486063
  REMARK    GeneRIF: identification of dipeptidyl peptidase 4 (DPP4; also known
            as CD26) as a functional receptor for hCoV-EMC
REFERENCE   3  (bases 1 to 3913)
  AUTHORS   Higashibata,T., Naito,M., Mori,A., Ozawa,N., Furuta,M.,
            Tsuchiya,R., Koyama,E., Morita,E., Kawai,S., Okada,R., Yin,G.,
            Wakai,K. and Hamajima,N.
  TITLE     DPP4 genetic variants influence baseline prostate-specific antigen
            levels: the J-MICC study
  JOURNAL   Nagoya J Med Sci 75 (1-2), 73-80 (2013)
   PUBMED   23544270
  REMARK    GeneRIF: DPP4 genetic variants influence baseline PSA levels,
            especially in men aged between 60 and 69.
REFERENCE   4  (bases 1 to 3913)
  AUTHORS   Mahmoudi,M., Hedayat,M., Aghamohammadi,A. and Rezaei,N.
  TITLE     Soluble CD26 and CD30 levels in patients with common variable
            immunodeficiency
  JOURNAL   J Investig Allergol Clin Immunol 23 (2), 120-124 (2013)
   PUBMED   23654079
  REMARK    GeneRIF: There is the association between high levels of soluble
            serum CD26 and CD30 and disease severity.
REFERENCE   5  (bases 1 to 3913)
  AUTHORS   Marfella,R., Sasso,F.C., Rizzo,M.R., Paolisso,P., Barbieri,M.,
            Padovano,V., Carbonara,O., Gualdiero,P., Petronella,P.,
            Ferraraccio,F., Petrella,A., Canonico,R., Campitiello,F., Della
            Corte,A., Paolisso,G. and Canonico,S.
  TITLE     Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic
            foot ulcers in patients with type 2 diabetes
  JOURNAL   Exp Diabetes Res 2012, 892706 (2012)
   PUBMED   23197976
  REMARK    GeneRIF: DPP4 inhibition facilitated wound healing of chronic
            diabetic foot ulcers in type 2 diabetics.
REFERENCE   6  (bases 1 to 3913)
  AUTHORS   Imai,K., Maeda,M., Fujiwara,H., Kariya,M., Takakura,K., Kanzaki,H.
            and Mori,T.
  TITLE     Dipeptidyl peptidase IV as a differentiation marker of the human
            endometrial glandular cells
  JOURNAL   Hum. Reprod. 7 (9), 1189-1194 (1992)
   PUBMED   1362202
REFERENCE   7  (bases 1 to 3913)
  AUTHORS   Misumi,Y., Hayashi,Y., Arakawa,F. and Ikehara,Y.
  TITLE     Molecular cloning and sequence analysis of human dipeptidyl
            peptidase IV, a serine proteinase on the cell surface
  JOURNAL   Biochim. Biophys. Acta 1131 (3), 333-336 (1992)
   PUBMED   1352704
REFERENCE   8  (bases 1 to 3913)
  AUTHORS   Tanaka,T., Camerini,D., Seed,B., Torimoto,Y., Dang,N.H.,
            Kameoka,J., Dahlberg,H.N., Schlossman,S.F. and Morimoto,C.
  TITLE     Cloning and functional expression of the T cell activation antigen
            CD26
  JOURNAL   J. Immunol. 149 (2), 481-486 (1992)
   PUBMED   1352530
  REMARK    Erratum:[J Immunol. 1993 Mar 1;150(5):2090. PMID: 8094732]
REFERENCE   9  (bases 1 to 3913)
  AUTHORS   Darmoul,D., Lacasa,M., Baricault,L., Marguet,D., Sapin,C.,
            Trotot,P., Barbat,A. and Trugnan,G.
  TITLE     Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like
            colon cancer cell lines HT-29 and Caco-2. Cloning of the complete
            human coding sequence and changes of dipeptidyl peptidase IV mRNA
            levels during cell differentiation
  JOURNAL   J. Biol. Chem. 267 (7), 4824-4833 (1992)
   PUBMED   1347043
REFERENCE   10 (bases 1 to 3913)
  AUTHORS   Gorvel,J.P., Ferrero,A., Chambraud,L., Rigal,A., Bonicel,J. and
            Maroux,S.
  TITLE     Expression of sucrase-isomaltase and dipeptidylpeptidase IV in
            human small intestine and colon
  JOURNAL   Gastroenterology 101 (3), 618-625 (1991)
   PUBMED   1677636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065265.1.
            On May 7, 2004 this sequence version replaced gi:18765693.
            
            Summary: The protein encoded by this gene is identical to adenosine
            deaminase complexing protein-2, and to the T-cell activation
            antigen CD26. It is an intrinsic membrane glycoprotein and a serine
            exopeptidase that cleaves X-proline dipeptides from the N-terminus
            of polypeptides. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065265.1, X60708.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3913              BC065265.1         1-3913
FEATURES             Location/Qualifiers
     source          1..3913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..3913
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="dipeptidyl-peptidase 4"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:3009"
                     /db_xref="HPRD:02187"
                     /db_xref="MIM:102720"
     exon            1..567
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    532..534
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="upstream in-frame stop codon"
     CDS             562..2862
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /EC_number="3.4.14.5"
                     /note="dipeptidylpeptidase IV (CD26, adenosine deaminase
                     complexing protein 2); T-cell activation antigen CD26;
                     dipeptidylpeptidase 4; ADCP-2; DPP IV; dipeptidyl
                     peptidase IV"
                     /codon_start=1
                     /product="dipeptidyl peptidase 4"
                     /protein_id="NP_001926.2"
                     /db_xref="GI:18765694"
                     /db_xref="CCDS:CCDS2216.1"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:3009"
                     /db_xref="HPRD:02187"
                     /db_xref="MIM:102720"
                     /translation="
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
"
     misc_feature    580..645
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P27487.2);
                     transmembrane region"
     misc_feature    883..1995
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     Region: DPPIV_N; pfam00930"
                     /db_xref="CDD:201511"
     misc_feature    <1753..2853
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
                     [Amino acid transport and metabolism]; Region: DAP2;
                     COG1506"
                     /db_xref="CDD:31695"
     misc_feature    2236..2850
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="Prolyl oligopeptidase family; Region: Peptidase_S9;
                     pfam00326"
                     /db_xref="CDD:201156"
     exon            568..655
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     STS             570..1355
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="GDB:207675"
                     /db_xref="UniSTS:156121"
     variation       580
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1129598"
     variation       585
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17574"
     variation       642
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17575"
     exon            656..754
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            755..846
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            847..927
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            928..980
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            981..1053
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1054..1174
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1175..1335
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     STS             1277..1588
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="GDB:456160"
                     /db_xref="UniSTS:157476"
     exon            1336..1448
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1449..1584
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1585..1629
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1630..1737
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     variation       1700
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150619694"
     exon            1738..1805
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1806..1859
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            1860..1981
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     variation       1871
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1129599"
     exon            1982..2029
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2030..2128
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     variation       2036
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848907"
     exon            2129..2198
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2199..2393
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2394..2448
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2449..2548
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     variation       2496
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17848910"
     variation       2522
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149643982"
     exon            2549..2613
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2614..2686
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2687..2760
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     exon            2761..3900
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:1.39.8"
     STS             3025..3124
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="RH47162"
                     /db_xref="UniSTS:15204"
     STS             3054..3214
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="SHGC-118"
                     /db_xref="UniSTS:9518"
     variation       3108
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13821"
     STS             3211..3543
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="SHGC-12694"
                     /db_xref="UniSTS:80816"
     STS             3384..3582
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="DPP4"
                     /db_xref="UniSTS:505438"
     variation       3607
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11537990"
     STS             3631..3796
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /standard_name="RH17451"
                     /db_xref="UniSTS:672"
     polyA_signal    3874..3879
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
     polyA_site      3900
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
ORIGIN      
ctttcactggcaagagacggagtcctgggtttcagttccagttgcctgcggtgggctgtgtgagtttgccaaagtcccctgccctctctgggtctcggttccctcgcctgtccacgtgaggttggaggagctgaacgccgacgtcatttttagctaagagggagcagggtccccgagtcgccggcccagggtctgcgcatccgaggccgcgcgccctttcccctcccccacggctcctccgggccccgcactctgcgccccggctgccgcccagcgccctacaccgccctcagggggccctcgcgggctccccccggccgggatgccagtgccccgcgccacgcgcgcctgctcccgcgccgcctgccctgcagcctgcccgcggcgcctttatacccagcgggctcggcgctcactaatgtttaactcggggccgaaacttgccagcggcgagtgactccaccgcccggagcagcggtgcaggacgcgcgtctccgccgcccgcggtgacttctgcctgcgctccttctctgaacgctcacttccgaggagacgccgacgatgaagacaccgtggaaggttcttctgggactgctgggtgctgctgcgcttgtcaccatcatcaccgtgcccgtggttctgctgaacaaaggcacagatgatgctacagctgacagtcgcaaaacttacactctaactgattacttaaaaaatacttatagactgaagttatactccttaagatggatttcagatcatgaatatctctacaaacaagaaaataatatcttggtattcaatgctgaatatggaaacagctcagttttcttggagaacagtacatttgatgagtttggacattctatcaatgattattcaatatctcctgatgggcagtttattctcttagaatacaactacgtgaagcaatggaggcattcctacacagcttcatatgacatttatgatttaaataaaaggcagctgattacagaagagaggattccaaacaacacacagtgggtcacatggtcaccagtgggtcataaattggcatatgtttggaacaatgacatttatgttaaaattgaaccaaatttaccaagttacagaatcacatggacggggaaagaagatataatatataatggaataactgactgggtttatgaagaggaagtcttcagtgcctactctgctctgtggtggtctccaaacggcacttttttagcatatgcccaatttaacgacacagaagtcccacttattgaatactccttctactctgatgagtcactgcagtacccaaagactgtacgggttccatatccaaaggcaggagctgtgaatccaactgtaaagttctttgttgtaaatacagactctctcagctcagtcaccaatgcaacttccatacaaatcactgctcctgcttctatgttgataggggatcactacttgtgtgatgtgacatgggcaacacaagaaagaatttctttgcagtggctcaggaggattcagaactattcggtcatggatatttgtgactatgatgaatccagtggaagatggaactgcttagtggcacggcaacacattgaaatgagtactactggctgggttggaagatttaggccttcagaacctcattttacccttgatggtaatagcttctacaagatcatcagcaatgaagaaggttacagacacatttgctatttccaaatagataaaaaagactgcacatttattacaaaaggcacctgggaagtcatcgggatagaagctctaaccagtgattatctatactacattagtaatgaatataaaggaatgccaggaggaaggaatctttataaaatccaacttagtgactatacaaaagtgacatgcctcagttgtgagctgaatccggaaaggtgtcagtactattctgtgtcattcagtaaagaggcgaagtattatcagctgagatgttccggtcctggtctgcccctctatactctacacagcagcgtgaatgataaagggctgagagtcctggaagacaattcagctttggataaaatgctgcagaatgtccagatgccctccaaaaaactggacttcattattttgaatgaaacaaaattttggtatcagatgatcttgcctcctcattttgataaatccaagaaatatcctctactattagatgtgtatgcaggcccatgtagtcaaaaagcagacactgtcttcagactgaactgggccacttaccttgcaagcacagaaaacattatagtagctagctttgatggcagaggaagtggttaccaaggagataagatcatgcatgcaatcaacagaagactgggaacatttgaagttgaagatcaaattgaagcagccagacaattttcaaaaatgggatttgtggacaacaaacgaattgcaatttggggctggtcatatggagggtacgtaacctcaatggtcctgggatcgggaagtggcgtgttcaagtgtggaatagccgtggcgcctgtatcccggtgggagtactatgactcagtgtacacagaacgttacatgggtctcccaactccagaagacaaccttgaccattacagaaattcaacagtcatgagcagagctgaaaattttaaacaagttgagtacctccttattcatggaacagcagatgataacgttcactttcagcagtcagctcagatctccaaagccctggtcgatgttggagtggatttccaggcaatgtggtatactgatgaagaccatggaatagctagcagcacagcacaccaacatatatatacccacatgagccacttcataaaacaatgtttctctttaccttagcacctcaaaataccatgccatttaaagcttattaaaactcatttttgttttcattatctcaaaactgcactgtcaagatgatgatgatctttaaaatacacactcaaatcaagaaacttaaggttacctttgttcccaaatttcatacctatcatcttaagtagggacttctgtcttcacaacagattattaccttacagaagtttgaattatccggtcgggttttattgtttaaaatcatttctgcatcagctgctgaaacaacaaataggaattgtttttatggaggctttgcatagattccctgagcaggattttaatctttttctaactggactggttcaaatgttgttctcttctttaaagggatggcaagatgtgggcagtgatgtcactagggcagggacaggataagagggattagggagagaagatagcagggcatggctgggaacccaagtccaagcataccaacacgagcaggctactgtcagctcccctcggagaagagctgttcacagccagactggcacagttttctgagaaagactattcaaacagtctcaggaaatcaaatatgcaaagcactgacttctaagtaaaaccacagcagttgaaaagactccaaagaaatgtaagggaaactgccagcaacgcaggcccccaggtgccagttatggctataggtgctacaaaaacacagcaagggtgatgggaaagcattgtaaatgtgcttttaaaaaaaaatactgatgttcctagtgaaagaggcagcttgaaactgagatgtgaacacatcagcttgccctgttaaaagatgaaaatatttgtatcacaaatcttaacttgaaggagtccttgcatcaatttttcttatttcatttctttgagtgtcttaattaaaagaatattttaacttccttggactcattttaaaaaatggaacataaaatacaatgttatgtattattattcccattctacatactatggaatttctcccagtcatttaataaatgtgccttcattttttcagaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1803 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
            GeneID:1803 -> Molecular function: GO:0004177 [aminopeptidase activity] evidence: IEA
            GeneID:1803 -> Molecular function: GO:0004252 [serine-type endopeptidase activity] evidence: IEA
            GeneID:1803 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
            GeneID:1803 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1803 -> Molecular function: GO:0008236 [serine-type peptidase activity] evidence: IDA
            GeneID:1803 -> Molecular function: GO:0008239 [dipeptidyl-peptidase activity] evidence: IDA
            GeneID:1803 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:1803 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA
            GeneID:1803 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:1803 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:1803 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:1803 -> Biological process: GO:0010716 [negative regulation of extracellular matrix disassembly] evidence: IDA
            GeneID:1803 -> Biological process: GO:0031295 [T cell costimulation] evidence: IDA
            GeneID:1803 -> Biological process: GO:0033632 [regulation of cell-cell adhesion mediated by integrin] evidence: IDA
            GeneID:1803 -> Biological process: GO:0042110 [T cell activation] evidence: IDA
            GeneID:1803 -> Biological process: GO:0043542 [endothelial cell migration] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:1803 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0031258 [lamellipodium membrane] evidence: IEA
            GeneID:1803 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA
            GeneID:1803 -> Cellular component: GO:0046581 [intercellular canaliculus] evidence: IEA
            GeneID:1803 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
            GeneID:1803 -> Cellular component: GO:0071438 [invadopodium membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001926 -> EC 3.4.14.5

by @meso_cacase at DBCLS
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