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2019-03-25 14:57:02, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001870               1699 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens carboxypeptidase A3 (mast cell) (CPA3), mRNA.
ACCESSION   NM_001870
VERSION     NM_001870.2  GI:221316748
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Pejler,G., Knight,S.D., Henningsson,F. and Wernersson,S.
  TITLE     Novel insights into the biological function of mast cell
            carboxypeptidase A
  JOURNAL   Trends Immunol. 30 (8), 401-408 (2009)
   PUBMED   19643669
  REMARK    GeneRIF: Role in regulating innate immunity responses and
            regulating secretory granule homeostasis
            Review article
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Chen,Z.Q. and He,S.H.
  TITLE     Cloning and expression of human colon mast cell carboxypeptidase
  JOURNAL   World J. Gastroenterol. 10 (3), 342-347 (2004)
   PUBMED   14760754
  REMARK    GeneRIF: The cDNA encoding human colon mast cell carboxypeptidase
            can be successfully cloned and expressed in E. coli and P.
            pastoris.
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Huang,H., Reed,C.P., Zhang,J.S., Shridhar,V., Wang,L. and
            Smith,D.I.
  TITLE     Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone
            deacetylase inhibitors during differentiation of prostate
            epithelial cancer cells
  JOURNAL   Cancer Res. 59 (12), 2981-2988 (1999)
   PUBMED   10383164
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Dikov,M.M., Springman,E.B., Yeola,S. and Serafin,W.E.
  TITLE     Processing of procarboxypeptidase A and other zymogens in murine
            mast cells
  JOURNAL   J. Biol. Chem. 269 (41), 25897-25904 (1994)
   PUBMED   7929294
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Natsuaki,M., Stewart,C.B., Vanderslice,P., Schwartz,L.B.,
            Natsuaki,M., Wintroub,B.U., Rutter,W.J. and Goldstein,S.M.
  TITLE     Human skin mast cell carboxypeptidase: functional characterization,
            cDNA cloning, and genealogy
  JOURNAL   J. Invest. Dermatol. 99 (2), 138-145 (1992)
   PUBMED   1629626
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Reynolds,D.S., Gurley,D.S. and Austen,K.F.
  TITLE     Cloning and characterization of the novel gene for mast cell
            carboxypeptidase A
  JOURNAL   J. Clin. Invest. 89 (1), 273-282 (1992)
   PUBMED   1729276
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Stevens,R.L., Sugarbaker,D.J.,
            Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of cDNAs that encode human mast cell carboxypeptidase A,
            and comparison of the protein with mouse mast cell carboxypeptidase
            A and rat pancreatic carboxypeptidases
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (23), 9480-9484 (1989)
   PUBMED   2594780
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Goldstein,S.M., Kaempfer,C.E., Kealey,J.T. and Wintroub,B.U.
  TITLE     Human mast cell carboxypeptidase. Purification and characterization
  JOURNAL   J. Clin. Invest. 83 (5), 1630-1636 (1989)
   PUBMED   2708524
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Pascual,R., Burgos,F.J., Salva,M., Soriano,F., Mendez,E. and
            Aviles,F.X.
  TITLE     Purification and properties of five different forms of human
            procarboxypeptidases
  JOURNAL   Eur. J. Biochem. 179 (3), 609-616 (1989)
   PUBMED   2920728
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Goldstein,S.M., Kaempfer,C.E., Proud,D., Schwartz,L.B., Irani,A.M.
            and Wintroub,B.U.
  TITLE     Detection and partial characterization of a human mast cell
            carboxypeptidase
  JOURNAL   J. Immunol. 139 (8), 2724-2729 (1987)
   PUBMED   2443571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG501260.1, M27717.1,
            DR005288.1, BC012613.1 and BF508919.1.
            On Jan 24, 2009 this sequence version replaced gi:4503000.
            
            Summary: Three different forms of human pancreatic
            procarboxypeptidase A have been isolated. This gene encodes a form
            which is obtained as a binary complex of a procarboxypeptidase A
            with proproteinase E and functions as a secretory granule
            metalloexopeptidase. [provided by RefSeq, Jan 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012613.1, M27717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BG501260.1         2-53
            53-563              M27717.1           1-511
            564-628             DR005288.1         514-578
            629-1680            BC012613.1         592-1643
            1681-1699           BF508919.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1699
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="carboxypeptidase A3 (mast cell)"
                     /db_xref="GeneID:1359"
                     /db_xref="HGNC:2298"
                     /db_xref="MIM:114851"
     exon            1..120
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       6
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373285078"
     CDS             53..1306
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /EC_number="3.4.17.1"
                     /note="mast cell carboxypeptidase A; tissue
                     carboxypeptidase A"
                     /codon_start=1
                     /product="mast cell carboxypeptidase A precursor"
                     /protein_id="NP_001861.2"
                     /db_xref="GI:221316749"
                     /db_xref="CCDS:CCDS3138.1"
                     /db_xref="GeneID:1359"
                     /db_xref="HGNC:2298"
                     /db_xref="MIM:114851"
                     /translation="
MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
"
     sig_peptide     53..97
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     98..1303
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /product="mast cell carboxypeptidase A"
     misc_feature    131..364
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="Carboxypeptidase activation peptide; Region:
                     Propep_M14; pfam02244"
                     /db_xref="CDD:190256"
     misc_feature    392..1291
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="Peptidase M14 carboxypeptidase subfamily A/B-like;
                     Carboxypeptidase B subgroup; Region: M14_CPB; cd03871"
                     /db_xref="CDD:199852"
     misc_feature    order(578..580,587..589,803..805,962..964,1124..1126,
                     1133..1135,1139..1141)
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="putative active site [active]"
                     /db_xref="CDD:199852"
     misc_feature    order(578..580,587..589,962..964)
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:199852"
     variation       56
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111593746"
     variation       71
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143377024"
     variation       95
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199499869"
     variation       109
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370509092"
     variation       110
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111765977"
     variation       111
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148382472"
     exon            121..196
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       136
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140527015"
     variation       140
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200479513"
     variation       152
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145828911"
     variation       156
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145785078"
     variation       170
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375410605"
     variation       196
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199942135"
     exon            197..321
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       214
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376722929"
     variation       221
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142834901"
     variation       229
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146101762"
     variation       230
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138685459"
     variation       237
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75478109"
     variation       241
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:17850953"
     variation       293
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2270523"
     variation       298
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114531478"
     exon            322..424
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       386
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376999632"
     variation       400
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138751736"
     variation       411
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733455"
     variation       415
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370991073"
     exon            425..526
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       428
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192753847"
     variation       435
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75229139"
     variation       444
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368209657"
     variation       453
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146235151"
     variation       477
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374800491"
     variation       496
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200383775"
     variation       497
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111881854"
     variation       499
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367753806"
     variation       509
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372213795"
     variation       511
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377284175"
     variation       517
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:61733456"
     exon            527..628
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       554
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144291888"
     variation       564
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12489516"
     variation       566
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149768841"
     variation       580
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149879184"
     variation       581
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192487183"
     variation       584
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145845146"
     variation       615
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149006068"
     exon            629..739
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       646
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200899484"
     variation       664
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78356818"
     variation       672
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138401564"
     variation       677
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141357361"
     variation       708
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145039073"
     exon            740..830
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       743
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370747287"
     variation       746
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:116686228"
     variation       760
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199944830"
     variation       761
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199600994"
     variation       762
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374150898"
     variation       799
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141391874"
     variation       815
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370838199"
     variation       824
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150822877"
     variation       826..827
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35324938"
     exon            831..1033
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       851
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138181056"
     variation       870
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143184657"
     variation       881
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147228563"
     variation       900
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140470073"
     variation       901
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200538548"
     variation       912
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200639407"
     variation       917
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144437234"
     variation       946
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368374752"
     variation       947
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144470644"
     variation       964
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369290033"
     variation       967
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201909511"
     variation       970
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374063108"
     variation       991
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146653585"
     variation       1002
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142588358"
     variation       1027
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140411214"
     variation       1031
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367976187"
     exon            1034..1118
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       1053
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139830547"
     variation       1066
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139521475"
     variation       1074
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61747091"
     variation       1075
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146641016"
     variation       1086
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377005273"
     variation       1089
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200305769"
     variation       1090
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199984711"
     variation       1118
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201872849"
     exon            1119..1686
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:1.39.8"
     variation       1182
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373298908"
     variation       1190
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375364662"
     variation       1191
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374679149"
     variation       1203
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148623762"
     variation       1230
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141324442"
     variation       1250
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369125831"
     variation       1252
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61733453"
     variation       1259
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61733454"
     variation       1284
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145833901"
     variation       1298
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112825175"
     STS             1305..1554
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /standard_name="SHGC-77447"
                     /db_xref="UniSTS:1208"
     variation       1349
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375706071"
     STS             1378..1598
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /standard_name="G28614"
                     /db_xref="UniSTS:77210"
     variation       1407
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191632954"
     variation       1447
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183788880"
     variation       1452
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:143922613"
     variation       1513
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:188163066"
     variation       1532
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142056121"
     variation       1569
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150807042"
     variation       1602
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12962"
     polyA_signal    1661..1666
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
     polyA_site      1686
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
ORIGIN      
agggctgaggcataaaactgccagagggtctcaaggcaggcaaagaagaaccatgaggctcatcctgcctgtgggtttgattgctaccactcttgcaattgctcctgtccgctttgacagggagaaggtgttccgcgtgaagccccaggatgaaaaacaagcagacatcataaaggacttggccaaaaccaatgagcttgacttctggtatccaggtgccacccaccacgtagctgctaatatgatggtggatttccgagttagtgagaaggaatcccaagccatccagtctgccttggatcaaaataaaatgcactatgaaatcttgattcatgatctacaagaagagattgagaaacagtttgatgttaaagaagatatcccaggcaggcacagctacgcaaaatacaataattgggaaaagattgtggcttggactgaaaagatgatggataagtatcctgaaatggtctctcgtattaaaattggatctactgttgaagataatccactatatgttctgaagattggggaaaagaatgaaagaagaaaggctatttttacggattgtggcattcacgcacgagaatgggtctccccagcattctgccagtggtttgtctatcaggcaaccaaaacttatgggagaaacaaaattatgaccaaactcttggaccgaatgaatttttacattcttcctgtgttcaatgttgatggatatatttggtcatggacaaagaaccgcatgtggagaaaaaatcgttccaagaaccaaaactccaaatgcatcggcactgacctcaacaggaattttaatgcttcatggaactccattcctaacaccaatgacccatgtgcagataactatcggggctctgcaccagagtccgagaaagagacgaaagctgtcactaatttcattagaagccacctgaatgaaatcaaggtttacatcaccttccattcctactcccagatgctattgtttccctatggatatacatcaaaactgccacctaaccatgaggacttggccaaagttgcaaagattggcactgatgttctatcaactcgatatgaaacccgctacatctatggcccaatagaatcaacaatttacccgatatcaggttcttctttagactgggcttatgacctgggcatcaaacacacatttgcctttgagctccgagataaaggcaaatttggttttctccttccagaatcccggataaagccaacgtgcagagagaccatgctagctgtcaaatttattgccaagtatatcctcaagcatacttcctaaagaactgccctctgtttggaataagccaattaatccttttttgtgcctttcatcagaaagtcaatcttcagttatccccaaatgcagcttctatttcacctgaatccttctcttgctcatttaagtcccatgttactgctgtttgcttttacttactttcagtagcaccataacgaagtagctttaagtgaaaccttttaactacctttctttgctccaagtgaagtttggacccagcagaaagcattattttgaaaggtgatatacagtggggcacagaaaacaaatgaaaaccttcagtttctcacagattttcaccatgtggcttcatcaatttatgtgctaatacaataaaataaaatgcacttaatgctttaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1359 -> Molecular function: GO:0004181 [metallocarboxypeptidase activity] evidence: NAS
            GeneID:1359 -> Molecular function: GO:0004181 [metallocarboxypeptidase activity] evidence: TAS
            GeneID:1359 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:1359 -> Biological process: GO:0002003 [angiotensin maturation] evidence: TAS
            GeneID:1359 -> Biological process: GO:0006508 [proteolysis] evidence: TAS
            GeneID:1359 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:1359 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:1359 -> Cellular component: GO:0030133 [transport vesicle] evidence: IEA
            GeneID:1359 -> Cellular component: GO:0030141 [secretory granule] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001861 -> EC 3.4.17.1

by @meso_cacase at DBCLS
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