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2020-10-24 07:20:26, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001813               8630 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens centromere protein E, 312kDa (CENPE), mRNA.
ACCESSION   NM_001813
VERSION     NM_001813.2  GI:71061467
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8630)
  AUTHORS   Weng,M.T., Lee,J.H., Wei,S.C., Li,Q., Shahamatdar,S., Hsu,D.,
            Schetter,A.J., Swatkoski,S., Mannan,P., Garfield,S., Gucek,M.,
            Kim,M.K., Annunziata,C.M., Creighton,C.J., Emanuele,M.J.,
            Harris,C.C., Sheu,J.C., Giaccone,G. and Luo,J.
  TITLE     Evolutionarily conserved protein ERH controls CENP-E mRNA splicing
            and is required for the survival of KRAS mutant cancer cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (52), E3659-E3667 (2012)
   PUBMED   23236152
  REMARK    GeneRIF: Evolutionarily conserved protein ERH controls CENP-E mRNA
            splicing and is required for the survival of KRAS mutant cancer
            cells.
REFERENCE   2  (bases 1 to 8630)
  AUTHORS   Kumar,A. and Purohit,R.
  TITLE     Computational screening and molecular dynamics simulation of
            disease associated nsSNPs in CENP-E
  JOURNAL   Mutat. Res. 738-739, 28-37 (2012)
   PUBMED   22974711
  REMARK    GeneRIF: In this study we investigated the pathogenic effect of 132
            nsSNPs reported in CENP-E using computational platform.
REFERENCE   3  (bases 1 to 8630)
  AUTHORS   Guo,Y., Kim,C., Ahmad,S., Zhang,J. and Mao,Y.
  TITLE     CENP-E--dependent BubR1 autophosphorylation enhances chromosome
            alignment and the mitotic checkpoint
  JOURNAL   J. Cell Biol. 198 (2), 205-217 (2012)
   PUBMED   22801780
  REMARK    GeneRIF: It was shown that the state of CENP-E-dependent BubR1
            autophosphorylation in response to spindle microtubule capture by
            CENP-E is important for kinetochore function in achieving accurate
            chromosome segregation.
REFERENCE   4  (bases 1 to 8630)
  AUTHORS   Sardar,H.S. and Gilbert,S.P.
  TITLE     Microtubule capture by mitotic kinesin centromere protein E
            (CENP-E)
  JOURNAL   J. Biol. Chem. 287 (30), 24894-24904 (2012)
   PUBMED   22637578
  REMARK    GeneRIF: the unusually slow CENP-E microtubule association step
            favors CENP-E binding of stable microtubules over dynamic ones, a
            mechanism that would bias CENP-E binding to kinetochore fibers.
REFERENCE   5  (bases 1 to 8630)
  AUTHORS   Logarinho,E., Maffini,S., Barisic,M., Marques,A., Toso,A.,
            Meraldi,P. and Maiato,H.
  TITLE     CLASPs prevent irreversible multipolarity by ensuring spindle-pole
            resistance to traction forces during chromosome alignment
  JOURNAL   Nat. Cell Biol. 14 (3), 295-303 (2012)
   PUBMED   22307330
  REMARK    GeneRIF: Data show that CENP-E-mediated traction forces on
            misaligned chromosomes are responsible for the irreversible loss of
            spindle-pole integrity in CLASP1/2-depleted cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8630)
  AUTHORS   Wood,K.W., Sakowicz,R., Goldstein,L.S. and Cleveland,D.W.
  TITLE     CENP-E is a plus end-directed kinetochore motor required for
            metaphase chromosome alignment
  JOURNAL   Cell 91 (3), 357-366 (1997)
   PUBMED   9363944
REFERENCE   7  (bases 1 to 8630)
  AUTHORS   Thrower,D.A., Jordan,M.A., Schaar,B.T., Yen,T.J. and Wilson,L.
  TITLE     Mitotic HeLa cells contain a CENP-E-associated minus end-directed
            microtubule motor
  JOURNAL   EMBO J. 14 (5), 918-926 (1995)
   PUBMED   7889940
REFERENCE   8  (bases 1 to 8630)
  AUTHORS   Testa,J.R., Zhou,J.Y., Bell,D.W. and Yen,T.J.
  TITLE     Chromosomal localization of the genes encoding the kinetochore
            proteins CENPE and CENPF to human chromosomes 4q24-->q25 and
            1q32-->q41, respectively, by fluorescence in situ hybridization
  JOURNAL   Genomics 23 (3), 691-693 (1994)
   PUBMED   7851898
REFERENCE   9  (bases 1 to 8630)
  AUTHORS   Yen,T.J., Li,G., Schaar,B.T., Szilak,I. and Cleveland,D.W.
  TITLE     CENP-E is a putative kinetochore motor that accumulates just before
            mitosis
  JOURNAL   Nature 359 (6395), 536-539 (1992)
   PUBMED   1406971
REFERENCE   10 (bases 1 to 8630)
  AUTHORS   Yen,T.J., Compton,D.A., Wise,D., Zinkowski,R.P., Brinkley,B.R.,
            Earnshaw,W.C. and Cleveland,D.W.
  TITLE     CENP-E, a novel human centromere-associated protein required for
            progression from metaphase to anaphase
  JOURNAL   EMBO J. 10 (5), 1245-1254 (1991)
   PUBMED   2022189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z15005.1, AU100312.1, BQ434767.1, BQ231878.1, CD644410.1,
            AC079919.5, AL596934.1, AW499901.1, CN418651.1, AA210858.1,
            AA210728.1 and BQ447425.1.
            On Jul 22, 2005 this sequence version replaced gi:4502780.
            
            Summary: Centrosome-associated protein E is a kinesin-like motor
            protein that accumulates in the G2 phase of the cell cycle.  Unlike
            other centrosome-associated proteins, it is not present during
            interphase and first appears at the centromere region of
            chromosomes during prometaphase. CENPE is proposed to be one of the
            motors responsible for mammalian chromosome movement and/or spindle
            elongation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                Z15005.1           1-65
            66-332              AU100312.1         7-273
            333-965             Z15005.1           333-965
            966-1252            BQ434767.1         382-668
            1253-1785           Z15005.1           1253-1785
            1786-2116           BQ231878.1         22-352              c
            2117-2793           Z15005.1           2117-2793
            2794-3189           CD644410.1         306-701
            3190-3978           Z15005.1           3190-3978
            3979-4224           AC079919.5         47376-47621         c
            4225-4692           Z15005.1           4225-4692
            4693-5168           AL596934.1         102-577
            5169-5714           Z15005.1           5169-5714
            5715-5930           AW499901.1         371-586
            5931-6111           Z15005.1           5931-6111
            6112-6358           CN418651.1         155-401
            6359-6608           AA210858.1         110-359
            6609-6658           Z15005.1           6495-6544
            6659-7101           AA210728.1         1-443               c
            7102-8371           Z15005.1           6988-8257
            8372-8630           BQ447425.1         1-259               c
FEATURES             Location/Qualifiers
     source          1..8630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24-q25"
     gene            1..8630
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="centromere protein E, 312kDa"
                     /db_xref="GeneID:1062"
                     /db_xref="HGNC:1856"
                     /db_xref="MIM:117143"
     exon            1..146
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    25..27
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="upstream in-frame stop codon"
     CDS             91..8196
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="Centromere autoantigen E (312kD); kinesin family
                     member 10; kinesin-related protein CENPE; protein
                     phosphatase 1, regulatory subunit 61"
                     /codon_start=1
                     /product="centromere-associated protein E"
                     /protein_id="NP_001804.2"
                     /db_xref="GI:71061468"
                     /db_xref="CCDS:CCDS34042.1"
                     /db_xref="GeneID:1062"
                     /db_xref="HGNC:1856"
                     /db_xref="MIM:117143"
                     /translation="
MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
"
     mat_peptide     91..8184
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /product="Centromere-associated protein E"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02224.2)"
     misc_feature    106..1098
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="Kinesin motor, catalytic domain. ATPase; Region:
                     KISc; smart00129"
                     /db_xref="CDD:197527"
     misc_feature    106..1077
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="Kinesin motor domain, CENP-E/KIP2-like subgroup,
                     involved in chromosome movement and/or spindle elongation
                     during mitosis. This catalytic (head) domain has ATPase
                     activity and belongs to the larger group of P-loop
                     NTPases. Kinesins are...; Region: KISc_CENP_E; cd01374"
                     /db_xref="CDD:30096"
     misc_feature    order(130..132,346..348,355..357,361..372,793..795)
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:30096"
     misc_feature    order(940..942,949..951,958..960)
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="microtubule interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:30096"
     misc_feature    1354..1356
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1450..1452
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1921..1923
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3721..3723
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3784..6303
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="Chromosome segregation ATPases [Cell division and
                     chromosome partitioning]; Region: Smc; COG1196"
                     /db_xref="CDD:31389"
     misc_feature    3892..3894
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    5113..7812
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     pfam02463"
                     /db_xref="CDD:202246"
     misc_feature    6466..7518
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02224.2);
                     Region: Kinetochore-binding domain"
     misc_feature    7618..8184
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02224.2);
                     Region: Globular autoinhibitory domain (By similarity)"
     misc_feature    7912..7914
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8005..8007
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8029..8031
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q02224.2); phosphorylation site"
     misc_feature    8041..8043
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8050..8052
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            147..238
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     variation       155
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11552738"
     exon            239..328
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            329..447
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     variation       333
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2290943"
     exon            448..567
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            568..649
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            650..717
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            718..783
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            784..835
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            836..923
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            924..1053
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1054..1173
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1174..1332
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1333..1480
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1481..1569
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1570..1737
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1738..1812
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1813..1932
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            1933..2055
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            2056..2221
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     variation       2115
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2251634"
     exon            2222..2376
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            2377..2691
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            2692..2964
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            2965..3123
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            3124..3327
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            3328..3486
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            3487..3777
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            3778..3933
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            3934..4224
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            4225..4503
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            4504..4662
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            4663..4947
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            4948..5235
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            5236..5394
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            5395..5553
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            5554..5844
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            5845..6003
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            6004..6294
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            6295..6393
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            6394..6612
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            6613..6810
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     variation       6659
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1049660"
     exon            6811..7014
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7015..7233
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7234..7419
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7420..7532
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7533..7630
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7631..7814
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            7815..8101
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     exon            8102..8612
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /inference="alignment:Splign:1.39.8"
     STS             8123..8283
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /standard_name="STS-Z15005"
                     /db_xref="UniSTS:12315"
     STS             8197..8371
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; PPP1R61"
                     /standard_name="D4S2810"
                     /db_xref="UniSTS:10197"
ORIGIN      
taaatttaaaggcggggcggcctgtgagccctgaagtgccggccgcggagggtcctggccattttcctgggaccagttcagcctgataggatggcggaggaaggagccgtggccgtctgcgtgcgagtgcggccgctgaacagcagagaagaatcacttggagaaactgcccaagtttactggaaaactgacaataatgtcatttatcaagttgatggaagtaaatccttcaattttgatcgtgtctttcatggtaatgaaactaccaaaaatgtgtatgaagaaatagcagcaccaatcatcgattctgccatacaaggctacaatggtactatatttgcctatggacagactgcttcaggaaaaacatataccatgatgggttcagaagatcatttgggagttatacccagggcaattcatgacattttccaaaaaattaagaagtttcctgatagggaatttctcttacgtgtatcttacatggaaatatacaatgaaaccattacagatttactctgtggcactcaaaaaatgaaacctttaattattcgagaagatgtcaataggaatgtgtatgttgctgatctcacagaagaagttgtatatacatcagaaatggctttgaaatggattacaaagggagaaaagagcaggcattatggagaaacaaaaatgaatcaaagaagcagtcgttctcataccatctttaggatgattttggaaagcagagagaagggtgaaccttctaattgtgaaggatctgttaaggtatcccatttgaatttggttgatcttgcaggcagtgaaagagctgctcaaacaggcgctgcaggtgtgcggctcaaggaaggctgtaatataaatcgaagcttatttattttgggacaagtgatcaagaaacttagtgatggacaagttggtggtttcataaattatcgagatagcaagttaacacgaattctccagaattccttgggaggaaatgcaaagacacgtattatctgcacaattactccagtatcttttgatgaaacacttactgctctccagtttgccagtactgctaaatatatgaagaatactccttatgttaatgaggtatcaactgatgaagctctcctgaaaaggtatagaaaagaaataatggatcttaaaaaacaattagaggaggtttctttagagacgcgggctcaggcaatggaaaaagaccaattggcccaacttttggaagaaaaagatttgcttcagaaagtacagaatgagaaaattgaaaacttaacacggatgctggtgacctcttcttccctcacgttgcaacaggaattaaaggctaaaagaaaacgaagagttacttggtgccttggcaaaattaacaaaatgaagaactcaaactatgcagatcaatttaatataccaacaaatataacaacaaaaacacataagctttctataaatttattacgagaaattgatgaatctgtctgttcagagtctgatgttttcagtaacactcttgatacattaagtgagatagaatggaatccagcaacaaagctactaaatcaggagaatatagaaagtgagttgaactcacttcgtgctgactatgataatctggtattagactatgaacaactacgaacagaaaaagaagaaatggaattgaaattaaaagaaaagaatgatttggatgaatttgaggctctagaaagaaaaactaaaaaagatcaagagatgcaactaattcatgaaatttcgaacttaaagaatttagttaagcatgcagaagtatataatcaagatcttgagaatgaactcagttcaaaagtagagctgcttagagaaaaggaagaccagattaagaagctacaggaatacatagactctcaaaagctagaaaatataaaaatggacttgtcatactcattggaaagcattgaagacccaaaacaaatgaagcagactctgtttgatgctgaaactgtagcccttgatgccaagagagaatcagcctttcttagaagtgaaaatctggagctgaaggagaaaatgaaagaacttgcaactacatacaagcaaatggaaaatgatattcagttatatcaaagccagttggaggcaaaaaagaaaatgcaagttgatctggagaaagaattacaatctgcttttaatgagataacaaaactcacctcccttatagatggcaaagttccaaaagatttgctctgtaatttggaattggaaggaaagattactgatcttcagaaagaactaaataaagaagttgaagaaaatgaagctttgcgggaagaagtcattttgctttcagaattgaaatctttaccttctgaagtagaaaggctgaggaaagagatacaagacaaatctgaagagctccatataataacatcagaaaaagataaattgttttctgaagtagttcataaggagagtagagttcaaggtttacttgaagaaattgggaaaacaaaagatgacctagcaactacacagtcgaattataaaagcactgatcaagaattccaaaatttcaaaacccttcatatggactttgagcaaaagtataagatggtccttgaggagaatgagagaatgaatcaggaaatagttaatctctctaaagaagcccaaaaatttgattcgagtttgggtgctttgaagaccgagctttcttacaagacccaagaacttcaggagaaaacacgtgaggttcaagaaagactaaatgagatggaacagctgaaggaacaattagaaaatagagattctacgctgcaaactgtagaaagggagaaaacactgattactgagaaactgcagcaaactttagaagaagtaaaaactttaactcaagaaaaagatgatctaaaacaactccaagaaagcttgcaaattgagagggaccaactcaaaagtgatattcacgatactgttaacatgaatatagatactcaagaacaattacgaaatgctcttgagtctctgaaacaacatcaagaaacaattaatacactaaaatcgaaaatttctgaggaagtttccaggaatttgcatatggaggaaaatacaggagaaactaaagatgaatttcagcaaaagatggttggcatagataaaaaacaggatttggaagctaaaaatacccaaacactaactgcagatgttaaggataatgagataattgagcaacaaaggaagatattttctttaatacaggagaaaaatgaactccaacaaatgttagagagtgttatagcagaaaaggaacaattgaagactgacctaaaggaaaatattgaaatgaccattgaaaaccaggaagaattaagacttcttggggatgaacttaaaaagcaacaagagatagttgcacaagaaaagaaccatgccataaagaaagaaggagagctttctaggacctgtgacagactggcagaagttgaagaaaaactaaaggaaaagagccagcaactccaagaaaaacagcaacaacttcttaatgtacaagaagagatgagtgagatgcagaaaaagattaatgaaatagagaatttaaagaatgaattaaagaacaaagaattgacattggaacatatggaaacagagaggcttgagttggctcagaaacttaatgaaaattatgaggaagtgaaatctataaccaaagaaagaaaagttctaaaggaattacagaagtcatttgaaacagagagagaccaccttagaggatatataagagaaattgaagctacaggcctacaaaccaaagaagaactaaaaattgctcatattcacctaaaagaacaccaagaaactattgatgaactaagaagaagcgtatctgagaagacagctcaaataataaatactcaggacttagaaaaatcccataccaaattacaagaagagatcccagtgcttcatgaggaacaagagttactgcctaatgtgaaagaagtcagtgagactcaggaaacaatgaatgaactggagttattaacagaacagtccacaaccaaggactcaacaacactggcaagaatagaaatggaaaggctcaggttgaatgaaaaatttcaagaaagtcaggaagagataaaatctctaaccaaggaaagagacaaccttaaaacgataaaagaagcccttgaagttaaacatgaccagctgaaagaacatattagagaaactttggctaaaatccaggagtctcaaagcaaacaagaacagtccttaaatatgaaagaaaaagacaatgaaactaccaaaatcgtgagtgagatggagcaattcaaacccaaagattcagcactactaaggatagaaatagaaatgctcggattgtccaaaagacttcaagaaagtcatgatgaaatgaaatctgtagctaaggagaaagatgacctacagaggctgcaagaagttcttcaatctgaaagtgaccagctcaaagaaaacataaaagaaattgtagctaaacacctggaaactgaagaggaacttaaagttgctcattgttgcctgaaagaacaagaggaaactattaatgagttaagagtgaatctttcagagaaggaaactgaaatatcaaccattcaaaagcagttagaagcaatcaatgataaattacagaacaagatccaagagatttatgagaaagaggaacaatttaatataaaacaaattagtgaggttcaggaaaaagtgaatgaactgaaacaattcaaggagcatcgcaaagccaaggattcagcactacaaagtatagaaagtaagatgctcgagttgaccaacagacttcaagaaagtcaagaagaaatacaaattatgattaaggaaaaagaggaaatgaaaagagtacaggaggcccttcagatagagagagaccaactgaaagaaaacactaaagaaattgtagctaaaatgaaagaatctcaagaaaaagaatatcagtttcttaagatgacagctgtcaatgagactcaggagaaaatgtgtgaaatagaacacttgaaggagcaatttgagacccagaagttaaacctggaaaacatagaaacggagaatataaggttgactcagatactacatgaaaaccttgaagaaatgagatctgtaacaaaagaaagagatgaccttaggagtgtggaggagactctcaaagtagagagagaccagctcaaggaaaaccttagagaaactataactagagacctagaaaaacaagaggagctaaaaattgttcacatgcatctgaaggagcaccaagaaactattgataaactaagagggattgtttcagagaaaacaaatgaaatatcaaatatgcaaaaggacttagaacactcaaatgatgccttaaaagcacaggatctgaaaatacaagaggaactaagaattgctcacatgcatctgaaagagcagcaggaaactattgacaaactcagaggaattgtttctgagaagacagataaactatcaaatatgcaaaaagatttagaaaattcaaatgctaaattacaagaaaagattcaagaacttaaggcaaatgaacatcaacttattacgttaaaaaaagatgtcaatgagacacagaaaaaagtgtctgaaatggagcaactaaagaaacaaataaaagaccaaagcttaactctgagtaaattagaaatagagaatttaaatttggctcagaaacttcatgaaaaccttgaagaaatgaaatctgtaatgaaagaaagagataatctaagaagagtagaggagacactcaaactggagagagaccaactcaaggaaagcctgcaagaaaccaaagctagagatctggaaatacaacaggaactaaaaactgctcgtatgctatcaaaagaacacaaagaaactgttgataaacttagagaaaaaatttcagaaaagacaattcaaatttcagacattcaaaaggatttagataaatcaaaagatgaattacagaaaaagatccaagaacttcagaaaaaagaacttcaactgcttagagtgaaagaagatgtcaatatgagtcataaaaaaattaatgaaatggaacagttgaagaagcaatttgaggcccaaaacttatctatgcaaagtgtgagaatggataacttccagttgactaagaaacttcatgaaagccttgaagaaataagaattgtagctaaagaaagagatgagctaaggaggataaaagaatctctcaaaatggaaagggaccaattcatagcaaccttaagggaaatgatagctagagaccgacagaaccaccaagtaaaacctgaaaaaaggttactaagtgatggacaacagcaccttacggaaagcctgagagaaaagtgctctagaataaaagagcttttgaagagatactcagagatggatgatcattatgagtgcttgaatagattgtctcttgacttggagaaggaaattgaattccaaaaagagctttcaatgagagttaaagcaaacctctcacttccctatttacaaaccaaacacattgaaaaactttttactgcaaaccagagatgctccatggaattccacagaatcatgaagaaactgaagtatgtgttaagctatgttacaaaaataaaagaagaacaacatgaatccatcaataaatttgaaatggattttattgatgaagtggaaaagcaaaaggaattgctaattaaaatacagcaccttcaacaagattgtgatgtaccatccagagaattaagggatctcaaattgaaccagaatatggatctacatattgaggaaattctcaaagatttctcagaaagtgagttccctagcataaagactgaatttcaacaagtactaagtaataggaaagaaatgacacagtttttggaagagtggttaaatactcgttttgatatagaaaagcttaaaaatggcatccagaaagaaaatgataggatttgtcaagtgaataacttctttaataacagaataattgccataatgaatgaatcaacagagtttgaggaaagaagtgctaccatatccaaagagtgggaacaggacctgaaatcactgaaagagaaaaatgaaaaactatttaaaaactaccaaacattgaagacttccttggcatctggtgcccaggttaatcctaccacacaagacaataagaatcctcatgttacatcaagagctacacagttaaccacagagaaaattcgagagctggaaaattcactgcatgaagctaaagaaagtgctatgcataaggaaagcaagattataaagatgcagaaagaacttgaggtgactaatgacataatagcaaaacttcaagccaaagttcatgaatcaaataaatgccttgaaaaaacaaaagagacaattcaagtacttcaggacaaagttgctttaggagctaagccatataaagaagaaattgaagatctcaaaatgaagcttgtgaaaatagacctagagaaaatgaaaaatgccaaagaatttgaaaaggaaatcagtgctacaaaagccactgtagaatatcaaaaggaagttataaggctattgagagaaaatctcagaagaagtcaacaggcccaagatacctcagtgatatcagaacatactgatcctcagccttcaaataaacccttaacttgtggaggtggcagcggcattgtacaaaacacaaaagctcttattttgaaaagtgaacatataaggctagaaaaagaaatttctaagttaaagcagcaaaatgaacagctaataaaacaaaagaatgaattgttaagcaataatcagcatctttccaatgaggtcaaaacttggaaggaaagaacccttaaaagagaggctcacaaacaagtaacttgtgagaattctccaaagtctcctaaagtgactggaacagcttctaaaaagaaacaaattacaccctctcaatgcaaggaacggaatttacaagatcctgtgccaaaggaatcaccaaaatcttgtttttttgatagccgatcaaagtctttaccatcacctcatccagttcgctattttgataactcaagtttaggcctttgtccagaggtgcaaaatgcaggagcagagagtgtggattctcagccaggtccttggcacgcctcctcaggcaaggatgtgcctgagtgcaaaactcagtagactcctctttgtcacttctctggagatccagcattccttatttggaaatgactttgtttatgtgtctatccctggtaatgatgttgtagtgcagcttaatttcaattcagtctttactttgccactagagttgaaagataagggaacaggaaatgaatgcattgtggtaatttagaatggtgatagcaataccttcttcttgcatatggtaatacttttaaaagttgaattgttttatttatttgtatattttgtaaagaataaagttattgaaagaaatgtaaagttatctacatgacttagcatattccaaagcataatacatacattaatataaaacatcattttattaacaaaattgtaaatgtttttaataccttacacattcaataaatgtttagtagttctgaatcaccaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1062 -> Molecular function: GO:0003777 [microtubule motor activity] evidence: IMP
            GeneID:1062 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1062 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:1062 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA
            GeneID:1062 -> Molecular function: GO:0043515 [kinetochore binding] evidence: IDA
            GeneID:1062 -> Biological process: GO:0000089 [mitotic metaphase] evidence: TAS
            GeneID:1062 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:1062 -> Biological process: GO:0007018 [microtubule-based movement] evidence: TAS
            GeneID:1062 -> Biological process: GO:0007079 [mitotic chromosome movement towards spindle pole] evidence: TAS
            GeneID:1062 -> Biological process: GO:0007080 [mitotic metaphase plate congression] evidence: TAS
            GeneID:1062 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:1062 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:1062 -> Biological process: GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] evidence: TAS
            GeneID:1062 -> Biological process: GO:0045860 [positive regulation of protein kinase activity] evidence: IMP
            GeneID:1062 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:1062 -> Biological process: GO:0051382 [kinetochore assembly] evidence: NAS
            GeneID:1062 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IDA
            GeneID:1062 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
            GeneID:1062 -> Cellular component: GO:0000778 [condensed nuclear chromosome kinetochore] evidence: IEA
            GeneID:1062 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: IDA
            GeneID:1062 -> Cellular component: GO:0000940 [condensed chromosome outer kinetochore] evidence: TAS
            GeneID:1062 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
            GeneID:1062 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:1062 -> Cellular component: GO:0005819 [spindle] evidence: IEA
            GeneID:1062 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:1062 -> Cellular component: GO:0005871 [kinesin complex] evidence: IEA
            GeneID:1062 -> Cellular component: GO:0005874 [microtubule] evidence: IDA
            GeneID:1062 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA

by @meso_cacase at DBCLS
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