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2024-04-20 17:38:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001721 2530 bp mRNA linear PRI 16-MAY-2013
DEFINITION Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript
variant 2, mRNA.
ACCESSION NM_001721
VERSION NM_001721.6 GI:156523233
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2530)
AUTHORS Cenni,B., Gutmann,S. and Gottar-Guillier,M.
TITLE BMX and its role in inflammation, cardiovascular disease, and
cancer
JOURNAL Int. Rev. Immunol. 31 (2), 166-173 (2012)
PUBMED 22449076
REMARK GeneRIF: This review characterizes the role of BMX in inflamamtion,
cardiovascular disease and cancer.
Review article
REFERENCE 2 (bases 1 to 2530)
AUTHORS Gottar-Guillier,M., Dodeller,F., Huesken,D., Iourgenko,V.,
Mickanin,C., Labow,M., Gaveriaux,S., Kinzel,B., Mueller,M.,
Alitalo,K., Littlewood-Evans,A. and Cenni,B.
TITLE The tyrosine kinase BMX is an essential mediator of inflammatory
arthritis in a kinase-independent manner
JOURNAL J. Immunol. 186 (10), 6014-6023 (2011)
PUBMED 21471444
REMARK GeneRIF: study concludes that BMX is an essential component of
inflammatory cytokine signaling and that catalytic, as well as
noncatalytic functions of BMX are involved
REFERENCE 3 (bases 1 to 2530)
AUTHORS Guryanova,O.A., Wu,Q., Cheng,L., Lathia,J.D., Huang,Z., Yang,J.,
MacSwords,J., Eyler,C.E., McLendon,R.E., Heddleston,J.M., Shou,W.,
Hambardzumyan,D., Lee,J., Hjelmeland,A.B., Sloan,A.E., Bredel,M.,
Stark,G.R., Rich,J.N. and Bao,S.
TITLE Nonreceptor tyrosine kinase BMX maintains self-renewal and
tumorigenic potential of glioblastoma stem cells by activating
STAT3
JOURNAL Cancer Cell 19 (4), 498-511 (2011)
PUBMED 21481791
REMARK GeneRIF: Constitutively active STAT3 rescued the effects of BMX
downregulation, supporting that BMX signals through STAT3 in
glioblastoma stem cells (GSCs).
REFERENCE 4 (bases 1 to 2530)
AUTHORS Zhang,Z., Zhu,W., Zhang,J. and Guo,L.
TITLE Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells
from apoptosis induced by radiation
JOURNAL Cancer Biol. Ther. 11 (7), 690-698 (2011)
PUBMED 21339702
REMARK GeneRIF: Etk/BMX may play a role in protection of NPC cells from
apoptosis.
REFERENCE 5 (bases 1 to 2530)
AUTHORS Guo,S., Sun,F., Guo,Z., Li,W., Alfano,A., Chen,H., Magyar,C.E.,
Huang,J., Chai,T.C., Qiu,S. and Qiu,Y.
TITLE Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and
predicts poor prognosis in patients with cystectomy
JOURNAL PLoS ONE 6 (3), E17778 (2011)
PUBMED 21408190
REMARK GeneRIF: Deregulation of ETK may attribute to the elevated activity
of STAT3 and AKT frequently detected in bladder cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2530)
AUTHORS Saharinen,P., Ekman,N., Sarvas,K., Parker,P., Alitalo,K. and
Silvennoinen,O.
TITLE The Bmx tyrosine kinase induces activation of the Stat signaling
pathway, which is specifically inhibited by protein kinase Cdelta
JOURNAL Blood 90 (11), 4341-4353 (1997)
PUBMED 9373245
REFERENCE 7 (bases 1 to 2530)
AUTHORS Ekman,N., Lymboussaki,A., Vastrik,I., Sarvas,K., Kaipainen,A. and
Alitalo,K.
TITLE Bmx tyrosine kinase is specifically expressed in the endocardium
and the endothelium of large arteries
JOURNAL Circulation 96 (6), 1729-1732 (1997)
PUBMED 9323053
REFERENCE 8 (bases 1 to 2530)
AUTHORS Kaukonen,J., Lahtinen,I., Laine,S., Alitalo,K. and Palotie,A.
TITLE BMX tyrosine kinase gene is expressed in granulocytes and myeloid
leukaemias
JOURNAL Br. J. Haematol. 94 (3), 455-460 (1996)
PUBMED 8790141
REFERENCE 9 (bases 1 to 2530)
AUTHORS Robinson,D., He,F., Pretlow,T. and Kung,H.J.
TITLE A tyrosine kinase profile of prostate carcinoma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (12), 5958-5962 (1996)
PUBMED 8650201
REFERENCE 10 (bases 1 to 2530)
AUTHORS Tamagnone,L., Lahtinen,I., Mustonen,T., Virtaneva,K., Francis,F.,
Muscatelli,F., Alitalo,R., Smith,C.I., Larsson,C. and Alitalo,K.
TITLE BMX, a novel nonreceptor tyrosine kinase gene of the
BTK/ITK/TEC/TXK family located in chromosome Xp22.2
JOURNAL Oncogene 9 (12), 3683-3688 (1994)
PUBMED 7970727
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BQ226991.1, BC016652.2 and
AF045459.1.
On Aug 28, 2007 this sequence version replaced gi:156071489.
Summary: This gene encodes a non-receptor tyrosine kinase belonging
to the Tec kinase family. The protein contains a PH-like domain,
which mediates membrane targeting by binding to
phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain
that binds to tyrosine-phosphorylated proteins and functions in
signal transduction. The protein is implicated in several signal
transduction pathways including the Stat pathway, and regulates
differentiation and tumorigenicity of several types of cancer
cells. Multiple alternatively spliced variants, encoding the same
protein, have been identified.[provided by RefSeq, Sep 2009].
Transcript Variant: This variant (2) has an alternate 5' UTR exon,
as compared to variant 1. Both variants 1 and 2 encode the same
protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC016652.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 BQ226991.1 23-32
11-2509 BC016652.2 28-2526
2510-2530 AF045459.1 2584-2604
FEATURES Location/Qualifiers
source 1..2530
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.2"
gene 1..2530
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="BMX non-receptor tyrosine kinase"
/db_xref="GeneID:660"
/db_xref="HGNC:1079"
/db_xref="HPRD:02111"
/db_xref="MIM:300101"
exon 1..102
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
misc_feature 43..45
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="upstream in-frame stop codon"
variation 78
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:372756198"
variation 97
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:375709435"
exon 103..249
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
CDS 112..2139
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/EC_number="2.7.10.2"
/note="NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine
kinase; epithelial and endothelial tyrosine kinase; bone
marrow tyrosine kinase gene in chromosome X protein;
BTK-like on X chromosome"
/codon_start=1
/product="cytoplasmic tyrosine-protein kinase BMX"
/protein_id="NP_001712.1"
/db_xref="GI:4502435"
/db_xref="CCDS:CCDS14168.1"
/db_xref="GeneID:660"
/db_xref="HGNC:1079"
/db_xref="HPRD:02111"
/db_xref="MIM:300101"
/translation="
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
"
misc_feature 127..438
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="Tec pleckstrin homology (PH) domain; Region:
PH_Tec; cd01238"
/db_xref="CDD:176314"
misc_feature order(148..150,154..159,163..168,184..186,196..198,
229..231,265..267)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="inositol phosphate binding site [chemical binding];
other site"
/db_xref="CDD:176314"
misc_feature 229..231
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02859"
misc_feature 448..555
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="Bruton's tyrosine kinase Cys-rich motif; Region:
BTK; smart00107"
/db_xref="CDD:128417"
misc_feature 757..759
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P51813.1); phosphorylation site"
misc_feature 757..759
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01746"
misc_feature 757..759
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02248"
misc_feature 757..759
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02786"
misc_feature 781..783
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P51813.1); phosphorylation site"
misc_feature 781..783
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01746"
misc_feature 781..783
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02248"
misc_feature 781..783
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02786"
misc_feature 835..837
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 979..1293
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="Src homology 2 (SH2) domain found in Tec protein,
Bmx; Region: SH2_Tec_Bmx; cd10399"
/db_xref="CDD:198262"
misc_feature order(1018..1020,1075..1077)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198262"
misc_feature order(1237..1239,1261..1266)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198262"
misc_feature 1345..2112
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="Catalytic domain of the Protein Tyrosine Kinases,
Bruton's tyrosine kinase and Bone marrow kinase on the X
chromosome; Region: PTKc_Btk_Bmx; cd05113"
/db_xref="CDD:173657"
misc_feature 1360..2109
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="Protein tyrosine kinase; Region: Pkinase_Tyr;
pfam07714"
/db_xref="CDD:203736"
misc_feature order(1378..1392,1402..1404,1438..1440,1444..1446,
1576..1587,1594..1596,1717..1719,1729..1734,1738..1740,
1768..1773,1822..1836,1861..1863,1963..1965)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="active site"
/db_xref="CDD:173657"
misc_feature order(1378..1383,1402..1404,1438..1440,1576..1587,
1594..1596,1729..1731,1738..1740,1768..1773)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173657"
misc_feature order(1717..1719,1729..1731,1822..1836,1861..1863,
1963..1965)
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173657"
misc_feature 1768..1842
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173657"
misc_feature 1807..1809
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC and autocatalysis;
propagated from UniProtKB/Swiss-Prot (P51813.1);
phosphorylation site"
misc_feature 1807..1809
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1897..1920
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P51813.1);
Region: CAV1-binding"
variation 125
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367942269"
variation 138
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:371855296"
variation 188
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374784538"
variation 228
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200725402"
exon 250..354
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 274
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375412828"
exon 355..436
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 375
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:141827642"
variation 394
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369144737"
variation 406
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150627254"
exon 437..556
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 447
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139766625"
variation 454
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372642389"
variation 463
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:377713371"
variation 493..494
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="g"
/db_xref="dbSNP:67912403"
variation 493
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149800709"
exon 557..621
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 557
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:200226983"
variation 565
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377338599"
exon 622..863
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:202245028"
variation 746
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:147917241"
variation 751
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199940605"
variation 752
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139052738"
variation 753
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145626834"
variation 765
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201145902"
variation 798
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375433794"
variation 805
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369745985"
variation 829
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:371837504"
variation 845
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:199628600"
exon 864..941
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 935..936
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="t"
/db_xref="dbSNP:67357360"
exon 942..995
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 962
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35353387"
exon 996..1050
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1044
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374177999"
exon 1051..1130
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
exon 1131..1258
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1146
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:142510571"
variation 1167
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368442241"
variation 1197..1198
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="g"
/db_xref="dbSNP:34621247"
variation 1227
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372383572"
exon 1259..1333
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1299
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:140757047"
variation 1311
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201999800"
exon 1334..1505
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1337
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:201403849"
variation 1376
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:144679519"
variation 1416
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376617024"
exon 1506..1722
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1532
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372808714"
variation 1539
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138641505"
variation 1599
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:181593699"
variation 1623
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201534309"
variation 1653..1654
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="a"
/db_xref="dbSNP:66729913"
variation 1685
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375810047"
variation 1713
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145482201"
exon 1723..1787
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1730
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374705811"
variation 1746
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138084152"
variation 1747
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149547172"
exon 1788..1906
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1822
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:144206884"
variation 1903..1904
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="t"
/db_xref="dbSNP:67851080"
exon 1907..2064
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 1935
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:201616812"
variation 1939..1940
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace=""
/replace="g"
/db_xref="dbSNP:66972815"
variation 1976
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:143079475"
exon 2065..2521
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/inference="alignment:Splign:1.39.8"
variation 2117
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371758778"
variation 2167
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375904293"
variation 2233
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:12010477"
STS 2284..2366
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
/standard_name="DXS7016"
/db_xref="UniSTS:53386"
polyA_signal 2490..2495
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
polyA_site 2521
/gene="BMX"
/gene_synonym="ETK; PSCTK2; PSCTK3"
ORIGIN
gggaatatgagtgatggtgcctcaaagcagtaactttttgcttagagcttgagagtcaaagttaaggacccacatgtatacttcggctctagcgagtctaaggatgataatatggatacaaaatctattctagaagaacttcttctcaaaagatcacagcaaaagaagaaaatgtcaccaaataattacaaagaacggctttttgttttgaccaaaacaaacctttcctactatgaatatgacaaaatgaaaaggggcagcagaaaaggatccattgaaattaagaaaatcagatgtgtggagaaagtaaatctcgaggagcagacgcctgtagagagacagtacccatttcagattgtctataaagatgggcttctctatgtctatgcatcaaatgaagagagccgaagtcagtggttgaaagcattacaaaaagagataaggggtaacccccacctgctggtcaagtaccatagtgggttcttcgtggacgggaagttcctgtgttgccagcagagctgtaaagcagccccaggatgtaccctctgggaagcatatgctaatctgcatactgcagtcaatgaagagaaacacagagttcccaccttcccagacagagtgctgaagatacctcgggcagttcctgttctcaaaatggatgcaccatcttcaagtaccactctagcccaatatgacaacgaatcaaagaaaaactatggctcccagccaccatcttcaagtaccagtctagcgcaatatgacagcaactcaaagaaaatctatggctcccagccaaacttcaacatgcagtatattccaagggaagacttccctgactggtggcaagtaagaaaactgaaaagtagcagcagcagtgaagatgttgcaagcagtaaccaaaaagaaagaaatgtgaatcacaccacctcaaagatttcatgggaattccctgagtcaagttcatctgaagaagaggaaaacctggatgattatgactggtttgctggtaacatctccagatcacaatctgaacagttactcagacaaaagggaaaagaaggagcatttatggttagaaattcgagccaagtgggaatgtacacagtgtccttatttagtaaggctgtgaatgataaaaaaggaactgtcaaacattaccacgtgcatacaaatgctgagaacaaattatacctggcagaaaactactgttttgattccattccaaagcttattcattatcatcaacacaattcagcaggcatgatcacacggctccgccaccctgtgtcaacaaaggccaacaaggtccccgactctgtgtccctgggaaatggaatctgggaactgaaaagagaagagattaccttgttgaaggagctgggaagtggccagtttggagtggtccagctgggcaagtggaaggggcagtatgatgttgctgttaagatgatcaaggagggctccatgtcagaagatgaattctttcaggaggcccagactatgatgaaactcagccatcccaagctggttaaattctatggagtgtgttcaaaggaataccccatatacatagtgactgaatatataagcaatggctgcttgctgaattacctgaggagtcacggaaaaggacttgaaccttcccagctcttagaaatgtgctacgatgtctgtgaaggcatggccttcttggagagtcaccaattcatacaccgggacttggctgctcgtaactgcttggtggacagagatctctgtgtgaaagtatctgactttggaatgacaaggtatgttcttgatgaccagtatgtcagttcagtcggaacaaagtttccagtcaagtggtcagctccagaggtgtttcattacttcaaatacagcagcaagtcagacgtatgggcatttgggatcctgatgtgggaggtgttcagcctggggaagcagccctatgacttgtatgacaactcccaggtggttctgaaggtctcccagggccacaggctttaccggccccacctggcatcggacaccatctaccagatcatgtacagctgctggcacgagcttccagaaaagcgtcccacatttcagcaactcctgtcttccattgaaccacttcgggaaaaagacaagcattgaagaagaaattaggagtgctgataagaatgaatatagatgctggccagcattttcattcattttaaggaaagtagcaaggcataatgtaatttagctagtttttaatagtgttctctgtattgtctattatttagaaatgaacaaggcaggaaacaaaagattcccttgaaatttagatcaaattagtaattttgtttatgctgctcctgatataacactttccagcctatagcagaagcacattttcagactgcaatatagagactgtgttcatgtgtaaagactgagcagaactgaaaaattacttattggatattcattcttttctttatattgtcattgtcacaacaattaaatatactaccaagtacagaaatgtggaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:660 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
GeneID:660 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
GeneID:660 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:660 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:660 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:660 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:660 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:660 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:660 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:660 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:660 -> Biological process: GO:0006950 [response to stress] evidence: IEA
GeneID:660 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:660 -> Biological process: GO:0007165 [signal transduction] evidence: IDA
GeneID:660 -> Biological process: GO:0007498 [mesoderm development] evidence: TAS
GeneID:660 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
GeneID:660 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:660 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:660 -> Cellular component: GO:0032587 [ruffle membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001712 -> EC 2.7.10.2
by
@meso_cacase at
DBCLS
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