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2024-04-26 02:17:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001681 4359 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens ATPase, Ca++ transporting, cardiac muscle, slow twitch
2 (ATP2A2), transcript variant a, mRNA.
ACCESSION NM_001681
VERSION NM_001681.3 GI:161377446
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4359)
AUTHORS Arai,M.
TITLE [SERCA2 as a cause and therapeutic target of heart failure]
JOURNAL Nippon Yakurigaku Zasshi 140 (6), 259-264 (2012)
PUBMED 23229631
REMARK GeneRIF: By introducing SERCA2 gene to an experimental heart
failure model, cardiac functions and prognosis were improved and
cardiac remodelling suppressed. SERCA2 is believed to be an
important key to correct molecular network in heart failure.
REFERENCE 2 (bases 1 to 4359)
AUTHORS Earls,L.R., Fricke,R.G., Yu,J., Berry,R.B., Baldwin,L.T. and
Zakharenko,S.S.
TITLE Age-dependent microRNA control of synaptic plasticity in 22q11
deletion syndrome and schizophrenia
JOURNAL J. Neurosci. 32 (41), 14132-14144 (2012)
PUBMED 23055483
REMARK GeneRIF: SERCA2 dysregulation is a pathogenic event in 22q11
deletion syndrome (22q11DS) and schizophrenia.
REFERENCE 3 (bases 1 to 4359)
AUTHORS Bostjancic,E., Zidar,N. and Glavac,D.
TITLE MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in
human myocardial infarction: expression and bioinformatic analysis
JOURNAL BMC Genomics 13, 552 (2012)
PUBMED 23066896
REMARK GeneRIF: The protein SERCA2 expression was decreased and 43 miRNAs
were deregulated in infarcted myocardium compared to corresponding
remote myocardium.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4359)
AUTHORS Dode,L., Andersen,J.P., Leslie,N., Dhitavat,J., Vilsen,B. and
Hovnanian,A.
TITLE Dissection of the functional differences between sarco(endo)plasmic
reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization
of Darier disease (SERCA2) mutants by steady-state and transient
kinetic analyses
JOURNAL J. Biol. Chem. 278 (48), 47877-47889 (2003)
PUBMED 12975374
REMARK GeneRIF: kinetic analysis of SERCA1 and SERCA2 isoforms and the
effects of mutation
REFERENCE 5 (bases 1 to 4359)
AUTHORS Gelebart,P., Martin,V., Enouf,J. and Papp,B.
TITLE Identification of a new SERCA2 splice variant regulated during
monocytic differentiation
JOURNAL Biochem. Biophys. Res. Commun. 303 (2), 676-684 (2003)
PUBMED 12659872
REMARK GeneRIF: A new splice variant is identified that is regulated
during monocytic differentiation.
REFERENCE 6 (bases 1 to 4359)
AUTHORS Zarain-Herzberg,A. and Alvarez-Fernandez,G.
TITLE Sarco(endo)plasmic reticulum Ca2+-ATPase-2 gene: structure and
transcriptional regulation of the human gene
JOURNAL ScientificWorldJournal 2, 1469-1483 (2002)
PUBMED 12805933
REMARK GeneRIF: Structure and transcriptional regulation of the SERCA2
gene.
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 4359)
AUTHORS Sakuntabhai,A., Burge,S., Monk,S. and Hovnanian,A.
TITLE Spectrum of novel ATP2A2 mutations in patients with Darier's
disease
JOURNAL Hum. Mol. Genet. 8 (9), 1611-1619 (1999)
PUBMED 10441323
REFERENCE 8 (bases 1 to 4359)
AUTHORS Toyofuku,T., Curotto Kurzydlowski,K., Narayanan,N. and
MacLennan,D.H.
TITLE Identification of Ser38 as the site in cardiac sarcoplasmic
reticulum Ca(2+)-ATPase that is phosphorylated by
Ca2+/calmodulin-dependent protein kinase
JOURNAL J. Biol. Chem. 269 (42), 26492-26496 (1994)
PUBMED 7929371
REFERENCE 9 (bases 1 to 4359)
AUTHORS Otsu,K., Fujii,J., Periasamy,M., Difilippantonio,M., Uppender,M.,
Ward,D.C. and MacLennan,D.H.
TITLE Chromosome mapping of five human cardiac and skeletal muscle
sarcoplasmic reticulum protein genes
JOURNAL Genomics 17 (2), 507-509 (1993)
PUBMED 8406504
REFERENCE 10 (bases 1 to 4359)
AUTHORS Lytton,J. and MacLennan,D.H.
TITLE Molecular cloning of cDNAs from human kidney coding for two
alternatively spliced products of the cardiac Ca2+-ATPase gene
JOURNAL J. Biol. Chem. 263 (29), 15024-15031 (1988)
PUBMED 2844796
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG773489.1, BI553880.1,
M23115.1 and AK000300.1.
This sequence is a reference standard in the RefSeqGene project.
On Nov 30, 2007 this sequence version replaced gi:27886536.
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which
are intracellular pumps located in the sarcoplasmic or endoplasmic
reticula of muscle cells. This enzyme catalyzes the hydrolysis of
ATP coupled with the translocation of calcium from the cytosol into
the sarcoplasmic reticulum lumen, and is involved in regulation of
the contraction/relaxation cycle. Mutations in this gene cause
Darier-White disease, also known as keratosis follicularis, an
autosomal dominant skin disorder characterized by loss of adhesion
between epidermal cells and abnormal keratinization. Alternative
splicing results in multiple transcript variants encoding different
isoforms. [provided by RefSeq, Oct 2008].
Transcript Variant: This variant (a) differs in the 3' coding
region and 3' UTR, resulting in an alternate termination codon,
compared to variant 1. The encoded isoform (a, also known as
SERCA2a, S2a or HK2) has a shorter and distinct C-terminus,
compared to isoform b.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M23115.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-105 BG773489.1 114-218
106-560 BI553880.1 6-460
561-3938 M23115.1 1-3378
3939-4359 AK000300.1 1647-2067
FEATURES Location/Qualifiers
source 1..4359
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.11"
gene 1..4359
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="ATPase, Ca++ transporting, cardiac muscle, slow
twitch 2"
/db_xref="GeneID:488"
/db_xref="HGNC:812"
/db_xref="HPRD:00161"
/db_xref="MIM:108740"
exon 1..681
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 72
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3026432"
misc_feature 108..110
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="upstream in-frame stop codon"
variation 161
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:3026433"
variation 258
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:113677468"
variation 265
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112511600"
variation 473
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:376070657"
variation 546
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372566224"
variation 549
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373966549"
variation 554
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201929640"
CDS 564..3557
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/EC_number="3.6.3.8"
/note="isoform a is encoded by transcript variant a;
ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2;
sarcoplasmic/endoplasmic reticulum calcium ATPase 2;
calcium pump 2; SR Ca(2+)-ATPase 2; calcium-transporting
ATPase sarcoplasmic reticulum type, slow twitch skeletal
muscle isoform; endoplasmic reticulum class 1/2 Ca(2+)
ATPase; cardiac Ca2+ ATPase"
/codon_start=1
/product="sarcoplasmic/endoplasmic reticulum calcium
ATPase 2 isoform a"
/protein_id="NP_001672.1"
/db_xref="GI:4502285"
/db_xref="CCDS:CCDS9143.1"
/db_xref="GeneID:488"
/db_xref="HGNC:812"
/db_xref="HPRD:00161"
/db_xref="MIM:108740"
/translation="
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPAILE
"
misc_feature 573..779
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="Cation transporter/ATPase, N-terminus; Region:
Cation_ATPase_N; pfam00690"
/db_xref="CDD:201397"
misc_feature 675..677
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:06532"
misc_feature 708..770
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 720..3527
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="sarco/endoplasmic reticulum calcium-translocating
P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116"
/db_xref="CDD:200073"
misc_feature 831..893
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 840..1586
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
/db_xref="CDD:201018"
misc_feature 1323..1382
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 1443..1445
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="Nitrated tyrosine; propagated from
UniProtKB/Swiss-Prot (P16615.1); modified site"
misc_feature 1446..1448
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="Nitrated tyrosine; propagated from
UniProtKB/Swiss-Prot (P16615.1); modified site"
misc_feature 1449..1502
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 1671..1763
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
Region: Interacts with phospholamban 1 (By similarity)"
misc_feature 1815..2144
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="Putative hydrolase of sodium-potassium ATPase alpha
subunit; Region: Hydrolase_like2; pfam13246"
/db_xref="CDD:205426"
misc_feature 2286..2345
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
Region: Interacts with HAX1"
misc_feature <2352..2696
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="haloacid dehalogenase-like hydrolase; Region: HAD;
pfam12710"
/db_xref="CDD:205034"
misc_feature 2433..2435
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="motif II; other site"
/db_xref="CDD:119389"
misc_feature 2550..2552
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P16615.1); phosphorylation site"
misc_feature 2550..2552
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2832..2891
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 2910..3521
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/note="Cation transporting ATPase, C-terminus; Region:
Cation_ATPase_C; pfam00689"
/db_xref="CDD:201396"
misc_feature 2922..2984
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
Region: Interacts with phospholamban 2 (By similarity)"
misc_feature 2922..2984
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 3045..3113
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 3252..3311
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 3351..3407
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
misc_feature 3453..3515
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P16615.1);
transmembrane region"
variation 631
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:28929478"
variation 636
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:371474055"
variation 644
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3026434"
variation 657
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141335001"
variation 680
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376578138"
exon 682..699
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 692
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:151294187"
exon 700..782
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 770
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:1126489"
exon 783..887
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 870
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376143339"
variation 885
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:121912731"
exon 888..1026
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 890
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:55984131"
variation 955
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:121912738"
exon 1027..1107
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1052
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:367627887"
variation 1069
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200712146"
variation 1077
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372323589"
exon 1108..1193
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1142
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371699814"
variation 1143
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375924802"
variation 1145
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368762109"
exon 1194..1658
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1253
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143310856"
variation 1346
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142721178"
variation 1359
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:376731879"
variation 1366
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:121912733"
variation 1415..1416
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace=""
/replace="g"
/db_xref="dbSNP:34150151"
variation 1430
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201573336"
variation 1433
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373919719"
variation 1494
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200807356"
variation 1547
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146073302"
variation 1579
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803737"
exon 1659..1747
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1659
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199776454"
variation 1695
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:140075244"
variation 1706
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370059850"
variation 1716
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149805414"
variation 1730
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115016152"
exon 1748..1850
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1750
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368310194"
STS 1801..1976
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="ATP2A2"
/db_xref="UniSTS:504208"
variation 1820
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372220719"
exon 1851..1982
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 1886
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148550709"
variation 1899
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142934831"
variation 1981
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377388101"
exon 1983..2105
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
exon 2106..2324
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 2162
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200717638"
variation 2241
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:121912734"
variation 2289
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376646545"
variation 2292
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:147733067"
variation 2315
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142649047"
variation 2321
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145018250"
exon 2325..2660
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 2368
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:121912737"
variation 2441
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375770050"
variation 2470
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369787331"
variation 2475
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199966458"
variation 2487
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373030579"
variation 2502
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375145500"
variation 2564
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2302372"
variation 2580
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201077970"
variation 2609
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369366671"
variation 2619
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147575100"
variation 2621
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140766323"
variation 2626
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150123803"
variation 2656
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:387906594"
exon 2661..2881
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 2669
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373988845"
variation 2672
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138478986"
variation 2678
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376862179"
variation 2702
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371236733"
variation 2723
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375843214"
variation 2735
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:56243033"
variation 2747
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368230581"
variation 2765
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:12312588"
variation 2768
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370758992"
variation 2834
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:138116893"
variation 2858
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375096367"
variation 2863
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:121912732"
variation 2865
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371796446"
variation 2867
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367761832"
variation 2868
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:121912736"
variation 2873
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139120653"
exon 2882..3084
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 2894
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142707321"
variation 2912
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372888486"
STS 2934..3167
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="D12S1133E"
/db_xref="UniSTS:151421"
variation 2978
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375186285"
variation 2979
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369170250"
variation 3002
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:188480916"
variation 3062
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146053090"
exon 3085..3170
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 3089
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148307651"
variation 3092
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141422433"
variation 3104
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150843644"
variation 3107
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375275623"
variation 3119
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201414100"
variation 3140
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139307921"
exon 3171..3304
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 3191
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149324360"
variation 3199
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112574072"
variation 3203
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147309970"
variation 3216
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:189309753"
variation 3234
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:146781719"
variation 3245
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/db_xref="dbSNP:121912735"
STS 3252..3389
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="MARC_24304-24305:1030108971:1"
/db_xref="UniSTS:268880"
variation 3260
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:117494432"
exon 3305..3422
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 3311
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144955024"
variation 3332
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369415132"
variation 3360
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372102705"
variation 3361
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140022710"
variation 3410
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375047317"
exon 3423..3543
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 3458
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370586048"
variation 3488
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:147558863"
variation 3508
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149024535"
exon 3544..4345
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/inference="alignment:Splign:1.39.8"
variation 3545
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/db_xref="dbSNP:193112984"
variation 3546
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145446976"
variation 3560
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76586905"
variation 3586
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:138115063"
variation 3596
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149534855"
STS 3614..4327
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="ATP2A2__4219"
/db_xref="UniSTS:462756"
variation 3704
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:185567011"
variation 3706
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:61942580"
variation 3769
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75547854"
variation 3854
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace=""
/replace="t"
/db_xref="dbSNP:142616098"
variation 3875
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147195167"
variation 3925
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:114474435"
variation 3926
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:188497964"
variation 3939
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:193082365"
STS 3996..4324
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="D12S2026"
/db_xref="UniSTS:21224"
STS 3996..4248
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="WI-18984"
/db_xref="UniSTS:21223"
variation 4068
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:138779589"
STS 4150..4306
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/standard_name="D12S1188E"
/db_xref="UniSTS:151458"
variation 4150
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:55825821"
variation 4151
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:12638"
polyA_signal 4204..4209
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
variation 4204
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3415"
variation 4217..4218
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace=""
/replace="at"
/db_xref="dbSNP:56170666"
polyA_site 4227
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
variation 4230
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="c"
/db_xref="dbSNP:115224394"
variation 4300
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143926209"
variation 4302
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:9540"
polyA_signal 4324..4329
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
polyA_site 4345
/gene="ATP2A2"
/gene_synonym="ATP2B; DAR; DD; SERCA2"
ORIGIN
ggcagcggccgataaatgctattagagcagccgccgcggagccgtccccgacgccacctccttttccttcgccgcagtttcctccgccgctgtcgggcgtgcggcgctgagggacccgggcgagcgcgccgcgcaccgccccgccggctcgcctccctcgccgcgttccgccctcagtggtctgccgggcgccccctcctccggcccgggcggggcctctgatcgcctcaagagagcggggagggggctcgggggccgcggcctgccctcccggcgggcggctgagggcgagggaggccctcccttctggcgaggggagggagggtgggtcaggagcccccaacccgccctgcggagctcggggccgcgcgaggggcggttgtctgggggagggggcgcggggtgattcagcgcccggcgaggcggaagcggccgcaagaggaggaggggagagcccgtccgcgcctgggctcccggggtggcacgagcccgcggccggagtgcgaggcggaggcgaggaggccgcggggacgggaggcgaggccggccgggcccccgaagccatggagaacgcgcacaccaagacggtggaggaggtgctgggccacttcggcgtcaacgagagtacggggctgagcctggaacaggtcaagaagcttaaggagagatggggctccaacgagttaccggctgaagaaggaaaaaccttgctggaacttgtgattgagcagtttgaagacttgctagttaggattttattactggcagcatgtatatcttttgttttggcttggtttgaagaaggtgaagaaacaattacagcctttgtagaaccttttgtaattttactcatattagtagccaatgcaattgtgggtgtatggcaggaaagaaatgctgaaaatgccatcgaagcccttaaggaatatgagcctgaaatgggcaaagtgtatcgacaggacagaaagagtgtgcagcggattaaagctaaagacatagttcctggtgatattgtagaaattgctgttggtgacaaagttcctgctgatataaggttaacttccatcaaatctaccacactaagagttgaccagtcaattctcacaggtgaatctgtctctgtcatcaagcacactgatcccgtccctgacccacgagctgtcaaccaagataaaaagaacatgctgttttctggtacaaacattgctgctgggaaagctatgggagtggtggtagcaactggagttaacaccgaaattggcaagatccgggatgaaatggtggcaacagaacaggagagaacaccccttcagcaaaaactagatgaatttggggaacagctttccaaagtcatctcccttatttgcattgcagtctggatcataaatattgggcacttcaatgacccggttcatggagggtcctggatcagaggtgctatttactactttaaaattgcagtggccctggctgtagcagccattcctgaaggtctgcctgcagtcatcaccacctgcctggctcttggaactcgcagaatggcaaagaaaaatgccattgttcgaagcctcccgtctgtggaaacccttggttgtacttctgttatctgctcagacaagactggtacacttacaacaaaccagatgtcagtctgcaggatgttcattctggacagagtggaaggtgatacttgttcccttaatgagtttaccataactggatcaacttatgcacctattggagaagtgcataaagatgataaaccagtgaattgtcaccagtatgatggtctggtagaattagcaacaatttgtgctctttgtaatgactctgctttggattacaatgaggcaaagggtgtgtatgaaaaagttggagaagctacagagactgctctcacttgcctagtagagaagatgaatgtatttgataccgaattgaagggtctttctaaaatagaacgtgcaaatgcctgcaactcagtcattaaacagctgatgaaaaaggaattcactctagagttttcacgtgacagaaagtcaatgtcggtttactgtacaccaaataaaccaagcaggacatcaatgagcaagatgtttgtgaagggtgctcctgaaggtgtcattgacaggtgcacccacattcgagttggaagtactaaggttcctatgacctctggagtcaaacagaagatcatgtctgtcattcgagagtggggtagtggcagcgacacactgcgatgcctggccctggccactcatgacaacccactgagaagagaagaaatgcaccttgaggactctgccaactttattaaatatgagaccaatctgaccttcgttggctgcgtgggcatgctggatcctccgagaatcgaggtggcctcctccgtgaagctgtgccggcaagcaggcatccgggtcatcatgatcactggggacaacaagggcactgctgtggccatctgtcgccgcatcggcatcttcgggcaggatgaggacgtgacgtcaaaagctttcacaggccgggagtttgatgaactcaacccctccgcccagcgagacgcctgcctgaacgcccgctgttttgctcgagttgaaccctcccacaagtctaaaatcgtagaatttcttcagtcttttgatgagattacagctatgactggcgatggcgtgaacgatgctcctgctctgaagaaagccgagattggcattgctatgggctctggcactgcggtggctaaaaccgcctctgagatggtcctggcggatgacaacttctccaccattgtggctgccgttgaggaggggcgggcaatctacaacaacatgaaacagttcatccgctacctcatctcgtccaacgtcggggaagttgtctgtattttcctgacagcagcccttggatttcccgaggctttgattcctgttcagctgctctgggtcaatctggtgacagatggcctgcctgccactgcactggggttcaaccctcctgatctggacatcatgaataaacctccccggaacccaaaggaaccattgatcagcgggtggctctttttccgttacttggctattggctgttacgtcggcgctgctaccgtgggtgctgctgcatggtggttcattgctgctgacggtggtccaagagtgtccttctaccagctgagtcatttcctacagtgtaaagaggacaacccggactttgaaggcgtggattgtgcaatctttgaatccccatacccgatgacaatggcgctctctgttctagtaactatagaaatgtgtaacgccctcaacagcttgtccgaaaaccagtccttgctgaggatgcccccctgggagaacatctggctcgtgggctccatctgcctgtccatgtcactccacttcctgatcctctatgtcgaacccttgccactcatcttccagatcacaccgctgaacgtgacccagtggctgatggtgctgaaaatctccttgcccgtgattctcatggatgagacgctcaagtttgtggcccgcaactacctggaacctgcaatactggagtaaccgcttcctaaaccattttgcagaaatgtaagggtgttcggttgcgtgcatgtgcgtttttagcaacacatctaccaaccctgtgcatgactgatgttggggaaaaagaaaagtaaaaaacttcccaactcactttgtgttatgtggaggaaatgtgtattaccaatggggttgttagcttttaaatcaaaatactgattacagatgtacaatttagcttaatcagaaagcctctccagagaagtttggtttctttgctgcaagaggaatgaggctctgtaaccttatctaagaacttggaagccgtcagccaagtcgccacatttctctgcaaaatgtcatagcttatataaatgtacagtattcaattgtaatgcatgccttcggttgtaagtagccagatccctctccagtgacattggaacatgctactttttaattggccctgtacagtttgcttatttataaattcattaaaaacactacaggtgttgaatggttaaaatgtaggcctccagttcattttcagttattttctgagtgtgcagacagctatttcgcactgtattaaatgtaacttatttaatgaaatcagaagcagtagacagatgttggtgcaatacaaatattgtgatgcatttatcttaataaaatgctaaatgtcaatttatcactgcgcatgtttgactttagactgtaaatagagatcagtttgtttctttctgtgctggtaacaatgagcgtcgcacagacatggtttcaggtaaataaatctattctatgataaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:488 -> Molecular function: GO:0005388 [calcium-transporting ATPase activity] evidence: TAS
GeneID:488 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:488 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:488 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IPI
GeneID:488 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:488 -> Molecular function: GO:0044548 [S100 protein binding] evidence: IPI
GeneID:488 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:488 -> Molecular function: GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential] evidence: TAS
GeneID:488 -> Biological process: GO:0002026 [regulation of the force of heart contraction] evidence: IEA
GeneID:488 -> Biological process: GO:0006810 [transport] evidence: TAS
GeneID:488 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: TAS
GeneID:488 -> Biological process: GO:0006984 [ER-nucleus signaling pathway] evidence: IEA
GeneID:488 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
GeneID:488 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:488 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:488 -> Biological process: GO:0010460 [positive regulation of heart rate] evidence: TAS
GeneID:488 -> Biological process: GO:0034220 [ion transmembrane transport] evidence: TAS
GeneID:488 -> Biological process: GO:0045822 [negative regulation of heart contraction] evidence: IEA
GeneID:488 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:488 -> Biological process: GO:0055119 [relaxation of cardiac muscle] evidence: TAS
GeneID:488 -> Biological process: GO:0070296 [sarcoplasmic reticulum calcium ion transport] evidence: TAS
GeneID:488 -> Biological process: GO:0086036 [regulation of cardiac muscle cell membrane potential] evidence: TAS
GeneID:488 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IDA
GeneID:488 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:488 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:488 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:488 -> Cellular component: GO:0016529 [sarcoplasmic reticulum] evidence: IDA
GeneID:488 -> Cellular component: GO:0031095 [platelet dense tubular network membrane] evidence: TAS
GeneID:488 -> Cellular component: GO:0033017 [sarcoplasmic reticulum membrane] evidence: TAS
GeneID:488 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001672 -> EC 3.6.3.8
by
@meso_cacase at
DBCLS
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