2024-03-29 00:28:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001626 5317 bp mRNA linear PRI 02-JUN-2013 DEFINITION Homo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2), transcript variant 1, mRNA. ACCESSION NM_001626 VERSION NM_001626.4 GI:339895851 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5317) AUTHORS Fohlin,H., Perez-Tenorio,G., Fornander,T., Skoog,L., Nordenskjold,B., Carstensen,J. and Stal,O. TITLE Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer JOURNAL Eur. J. Cancer 49 (6), 1196-1204 (2013) PUBMED 23305873 REMARK GeneRIF: Data indicate that the prognostic value of Akt2 increases with higher oestrogen receptor (ER) expression, motivating further mechanistic studies on the role of Akt2 in ER+ breast cancer. REFERENCE 2 (bases 1 to 5317) AUTHORS Choi,K.Y., Ahn,Y.H., Ahn,H.W., Cho,Y.J. and Hong,S.H. TITLE Involvement of Akt2/protein kinase B beta (PKBbeta) in the 8-Cl-cAMP-induced cancer cell growth inhibition JOURNAL J. Cell. Physiol. 228 (4), 890-902 (2013) PUBMED 23018889 REMARK GeneRIF: An Akt2/PKBbeta-targeted siRNA inhibited the 8-Cl-cAMP- and AICAR-mediated phosphorylation of AMPK and p38 MAPK. REFERENCE 3 (bases 1 to 5317) AUTHORS Friedrichsen,M., Birk,J.B., Richter,E.A., Ribel-Madsen,R., Pehmoller,C., Hansen,B.F., Beck-Nielsen,H., Hirshman,M.F., Goodyear,L.J., Vaag,A., Poulsen,P. and Wojtaszewski,J.F. TITLE Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH(2)-terminal (sites 2 + 2a) phosphorylation JOURNAL Am. J. Physiol. Endocrinol. Metab. 304 (6), E631-E639 (2013) PUBMED 23321478 REMARK GeneRIF: Data suggest that although COOH-terminal dephosphorylation is likely necessary for glycogen synthase (GS) activation, Akt2-dependent NH2-terminal dephosphorylation is the site for 'fine-tuning' insulin-mediated GS activation in skeletal muscle. REFERENCE 4 (bases 1 to 5317) AUTHORS Shen,Y.H., Zhang,L., Ren,P., Nguyen,M.T., Zou,S., Wu,D., Wang,X.L., Coselli,J.S. and LeMaire,S.A. TITLE AKT2 confers protection against aortic aneurysms and dissections JOURNAL Circ. Res. 112 (4), 618-632 (2013) PUBMED 23250987 REMARK GeneRIF: In cultured human aortic vascular smooth muscle cells, AKT2 inhibited the expression of MMP-9 and stimulated the expression of TIMP-1 by preventing the binding of transcription factor forkhead box protein O1 to the MMP-9 and TIMP-1 promoters. REFERENCE 5 (bases 1 to 5317) AUTHORS Gillespie,E.F., Raychaudhuri,N., Papageorgiou,K.I., Atkins,S.J., Lu,Y., Charara,L.K., Mester,T., Smith,T.J. and Douglas,R.S. TITLE Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-kappaB JOURNAL Invest. Ophthalmol. Vis. Sci. 53 (12), 7746-7753 (2012) PUBMED 23092922 REMARK GeneRIF: CD40L-provoked signaling results in the production of several cytokines. Among these, IL-6 expression is mediated through Akt and NF-kappaB pathways. Publication Status: Online-Only REFERENCE 6 (bases 1 to 5317) AUTHORS Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A. TITLE Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta JOURNAL J. Biol. Chem. 272 (48), 30491-30497 (1997) PUBMED 9374542 REFERENCE 7 (bases 1 to 5317) AUTHORS Cheng,J.Q., Ruggeri,B., Klein,W.M., Sonoda,G., Altomare,D.A., Watson,D.K. and Testa,J.R. TITLE Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3636-3641 (1996) PUBMED 8622988 REFERENCE 8 (bases 1 to 5317) AUTHORS Cheng,J.Q., Godwin,A.K., Bellacosa,A., Taguchi,T., Franke,T.F., Hamilton,T.C., Tsichlis,P.N. and Testa,J.R. TITLE AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (19), 9267-9271 (1992) PUBMED 1409633 REFERENCE 9 (bases 1 to 5317) AUTHORS Jones,P.F., Jakubowicz,T. and Hemmings,B.A. TITLE Molecular cloning of a second form of rac protein kinase JOURNAL Cell Regul. 2 (12), 1001-1009 (1991) PUBMED 1801921 REFERENCE 10 (bases 1 to 5317) AUTHORS Staal,S.P. TITLE Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (14), 5034-5037 (1987) PUBMED 3037531 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN351354.1, BC040028.1, BC120994.1, AK122839.1, AC118344.2 and BM675176.1. This sequence is a reference standard in the RefSeqGene project. On Jul 14, 2011 this sequence version replaced gi:126273601. Summary: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314619.1, M77198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-35 CN351354.1 1-35 36-1332 BC040028.1 1-1297 1333-1778 BC120994.1 1079-1524 1779-3282 AK122839.1 2950-4453 3283-3900 AC118344.2 136121-136738 3901-5293 AC118344.2 136739-138131 5294-5317 BM675176.1 1-24 c FEATURES Location/Qualifiers source 1..5317 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.1-q13.2" gene 1..5317 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="v-akt murine thymoma viral oncogene homolog 2" /db_xref="GeneID:208" /db_xref="HGNC:392" /db_xref="HPRD:01262" /db_xref="MIM:164731" exon 1..215 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 216..345 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" misc_feature 273..275 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="upstream in-frame stop codon" CDS 300..1745 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /EC_number="2.7.11.1" /note="isoform 1 is encoded by transcript variant 1; rac protein kinase beta; RAC-beta serine/threonine-protein kinase; murine thymoma viral (v-akt) homolog-2; PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B beta" /codon_start=1 /product="RAC-beta serine/threonine-protein kinase isoform 1" /protein_id="NP_001617.1" /db_xref="GI:4502023" /db_xref="CCDS:CCDS12552.1" /db_xref="GeneID:208" /db_xref="HGNC:392" /db_xref="HPRD:01262" /db_xref="MIM:164731" /translation="
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
" misc_feature 315..620 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="Akt pleckstrin homology (PH) domain; Region: PH_Akt; cd01241" /db_xref="CDD:176317" misc_feature order(339..341,345..347,366..368,372..380) /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="putative phosphoinositide binding site [chemical binding]; other site" /db_xref="CDD:176317" misc_feature 675..677 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 675..677 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[6] misc_feature 753..1526 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 765..1733 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase B; Region: STKc_PKB; cd05571" /db_xref="CDD:173662" misc_feature order(771..776,780..785,795..797,834..836,840..842, 876..878,885..887,936..938,984..995,1005..1007,1011..1013, 1023..1025,1122..1124,1128..1130,1134..1139,1143..1145, 1173..1178,1185..1187,1227..1250,1323..1325,1341..1343, 1350..1352,1614..1616,1626..1628) /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="active site" /db_xref="CDD:173662" misc_feature order(771..776,780..782,795..797,834..836,840..842, 936..938,984..995,1005..1007,1122..1124,1128..1130, 1134..1139,1143..1145,1173..1178,1614..1616) /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173662" misc_feature order(783..785,876..878,885..887,1005..1007,1011..1013, 1023..1025,1122..1124,1128..1130,1134..1136,1185..1187, 1227..1250,1323..1325,1341..1343,1350..1352,1626..1628) /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173662" misc_feature 987..995 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31751.2); Region: Inhibitor binding" misc_feature 1128..1136 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31751.2); Region: Inhibitor binding" misc_feature 1173..1244 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="activation loop (A-loop); other site" /db_xref="CDD:173662" misc_feature 1173..1178 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31751.2); Region: Inhibitor binding" misc_feature 1224..1226 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by PDPK1; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 1224..1226 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[6] /db_xref="HPRD:05556" misc_feature 1638..1640 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 1650..1652 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="turn motif phosphorylation site [posttranslational modification]; other site" /db_xref="CDD:173662" misc_feature 1650..1652 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 1650..1652 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[6] misc_feature 1707..1724 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /note="hydrophobic motif (HM); other site" /db_xref="CDD:173662" misc_feature 1719..1721 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 1719..1721 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[6] /db_xref="HPRD:05556" misc_feature 1719..1721 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1725..1727 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1731..1733 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P31751.2); phosphorylation site" misc_feature 1731..1733 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 346..474 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" STS 475..597 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /standard_name="AKT2" /db_xref="UniSTS:277960" exon 475..586 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" STS 537..775 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /standard_name="MARC_6978-6979:992007604:1" /db_xref="UniSTS:231294" exon 587..740 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 741..872 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" variation 851 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="a" /replace="g" /db_xref="dbSNP:1138528" exon 873..938 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 939..1007 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 1008..1130 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" variation 1092 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="a" /replace="t" /db_xref="dbSNP:1804324" exon 1131..1259 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" STS 1185..1332 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /standard_name="SGC30851" /db_xref="UniSTS:8286" exon 1260..1474 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 1475..1562 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 1563..1665 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" exon 1666..5300 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /inference="alignment:Splign:1.39.8" variation 1754 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:79275829" variation 2898 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="c" /replace="g" /db_xref="dbSNP:1142291" variation 2902 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="c" /replace="g" /db_xref="dbSNP:1142293" variation 2906 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="c" /replace="g" /db_xref="dbSNP:1142294" variation 2917 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="g" /replace="t" /db_xref="dbSNP:1142297" variation 2919 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /replace="c" /replace="g" /db_xref="dbSNP:1142298" STS 4321..4447 /gene="AKT2" /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA" /standard_name="RH11487" /db_xref="UniSTS:30867" ORIGIN
tgggagggggcggtaagcgggggctggggggagggggcggggggggccgcgccgtgctagccgttgggcctgcctcggaggaggcgtcgccgccgccgctgccgctgccggcgccgttgccgctgccgggaaacacaaggaaagggaaccagcgcagcgtggcgatgggcgggggtagagccccgccggagaggctgggcggctgccggtgacagactgtgccctgtccacggtgcctcctgcatgtcctgctgccctgagctgtcccgagctaggtgacagcgtaccacgctgccaccatgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaagacctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggagaggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgccagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtggaccacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatgcgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatggactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtcagcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaagggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatgaagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgagagccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccagacccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccacctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtctcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaacctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggcatcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgaggtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatgtacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgagctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctgcttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgccaaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaagaagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgatgatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggcttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgcgagtgagcagtctgcccacgcagaggacgcacgctcgctgccatcaccgctgggtggttttttccccctaactttttacttagcctttttggtttgtgtccccacccccacctcctcaccccctttccagttcttcttcaggcccctcccagacgcaccccagcggcccctgcagcccctgcctccagcctccagcctcacctttgtgcccagactcgcatttggaagactccacctcccgcccaggcctgggctgttgggcggttggagattcaggttttaatccacacaagccccagtgaggggtgaagcatggcgcctggggcctgcctgagtttctggcctgggtgtcgtgctggtgtctgcctccgcgctgctgcatctggacgaaggctgccttctggtgggacgcgacacccggcagacagtggtgctgccttccaggccccgtggcctaggctcggagtggccaggcacggggcggtccaatcccccacccgctgtccccctatgggggcagaaaagcaataatgtccaggggcaggcaggggcccttgggagctgcagggctgggggttagggctgctccctggtgaatggagtcagatcctaggatctgtaccatggggaaccaggagtggccgggctgggtgccgcctcctggtccggcctcctccccaccaaactgtcctcaccctatggatgaggcaggaggaacatttggggccaaacctgcctgcctcccagccccgtgccttactagggcttccttccagctggccttacctcccgctggaccctgggcctggcctggccccactgggggctatgggctgggctcaccctctcctctgcgggggtggagggccaccagccttggctgttacaatcttacaccggacagtattgggccccatggacttggtcagggaggggtgggggtgggcatctctggtacctattggggtggggggcctctgaaaagggaggctcctaggcccccctcacccctccctctccccagggccccacgttctgcagccttaaggttgaacatgagtgcacgtccatgtcagtgctgtgggactcctgtgcgtgcctcggactgcgtgtgtcggcgggacgcaggcacacgtgggtgtgtgtgcatgtgtgtttgtgtgagggcagcgtgtcctccagtgtgcatggtgtgtgggcttgggccccatccctggcccgagcatttcatcctgtgggggaggggtgctgacctagtgggaggagccccactgtgatccatgagctgccctgcccacgcctcccctccctgtagcaacacctctgggtgtttggagtttagcttttgtgggtttgctctccctatcccatctcctgtactacacagttcatggcagggtggggaggggtggggttggttcgggtgggtgagggtctttttcctctgtgtgcgatgttgttatctgacagttctccgtccctactggcctttctcctcgtcttcatatttgtacggtacaagcaataaagacactcatttcagaccagggcccagcctgcactcacgccagcccaaccactctgggctttgccttggtgatggagtcagacccctgggccccagctcctcctgtactagccgttcccttcagcaaggagggcactgagctcagggtgagggcagctggggtgtgtgcaggagctcaggctggagagggtgggtggagctggtgctgtggggctgaggggtatgggaaggctccccgcatgtgggggtggggtggacagagaccactccaggccctcagtgctgcttaggctaagagaggtggggtggagggacagggctggaagatctgggtagcccagaatgaggagggtgcctgtgctgtcactgaatgagagggagtggttcattccacccggctgccgagcctcagaggggggcattcctatcctgccccacctccctgtttatgctgccacctggaagccttgaggcccccaaattccagtacagacccagtggtgtgttcatggtggcgtggttgctgtcacctgggagctcctgagcgtttggttagaaccctgttcagcttggggtcagccctcccctagtcactgccctttagcctggatgtgtctgggcccctgcacttcccgtgcttgagtcacgtggctgcatggccgggcgctggccggatggaacacctcccccagcaagggaccagggaccagagccctggcctgccctgctgagccctgctgtgcagagggcctggcacagatgaatttgagattttgccgcaaggtgttagcacttcacacccattgagtctttgagattttaagtgaatgtaagcagaaaaagtcagatccaatttacagaaatcagagttagctacagctaggactcgtttggttggggttttttagtttgtctttctaaagtcatgtggaccttaatttaattacaaaagtctaccctggtggtcataaaataggcaggcctatgaagaaaggccttttactcttccatctcatcccagccccgagttgacccacgttgctgctcctcacaccatggtgatgcaggtctcgtagtgtgggcacaggcctggctacctcatctttttagtgcctctctcctcttccacaggatggggtcccacagctgcagcagctggccccgtagttgagcatgtgtggttatcctgtagagcttttcccaagaagggtgtttgaacttagagtcttaataaaatcttaccaaataaattttgagtagaataatcgtcttttgcaatgtacattttaaaaatttcacacattcttttttgtatataaagaacagtgactgggcacagtggctcatgcctgtaatcccagcaatttgggaggccgaggcgggcgggtctcttgaggccaggggttcgagaccagcctgggcatcatagggagaccttcatctctacaaaaaatacaaaaattagctgggcatggtggtgcatgcctgcaatcccagctaacttggaaggctgaggtgaggtgggaagatcacttgagcccaggagtttgaggctgcagtgagctatgattgcggcactgcactgcagcctgggacaatgagactgtgtctctaaaaataaaaaaaaaaaaaacatgatacatgctattaaaaaagacagcaaagcaggagtataagaaaggaaattcacccgaggtcgcagggccttgagtactcattttggtgctgattacctctctgcaaatggacacggcatcataaattggtagtttcctgctctttttgtgtaatcttttccagttaatgtgaagcctctgggggctgccctcgtgcactgatggttgtgtggagtcgggggcggcagtgcgattcccttttagctgctgcatggggggaactcaggctttccagctgcttcctggggttccatggggtagacccctcaaccgcttcagctgccccgttaacaggaattgacttggtttcgtttggtgctaccagcagtcctgtaataaactagctatccatctgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS GeneID:208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:208 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA GeneID:208 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA GeneID:208 -> Molecular function: GO:0016301 [kinase activity] evidence: TAS GeneID:208 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: ISS GeneID:208 -> Biological process: GO:0005978 [glycogen biosynthetic process] evidence: IEA GeneID:208 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA GeneID:208 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA GeneID:208 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS GeneID:208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:208 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IMP GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS GeneID:208 -> Biological process: GO:0008643 [carbohydrate transport] evidence: IEA GeneID:208 -> Biological process: GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] evidence: IMP GeneID:208 -> Biological process: GO:0010907 [positive regulation of glucose metabolic process] evidence: IMP GeneID:208 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS GeneID:208 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS GeneID:208 -> Biological process: GO:0031340 [positive regulation of vesicle fusion] evidence: ISS GeneID:208 -> Biological process: GO:0032000 [positive regulation of fatty acid beta-oxidation] evidence: IMP GeneID:208 -> Biological process: GO:0032287 [peripheral nervous system myelin maintenance] evidence: IEA GeneID:208 -> Biological process: GO:0032859 [activation of Ral GTPase activity] evidence: IEA GeneID:208 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP GeneID:208 -> Biological process: GO:0045444 [fat cell differentiation] evidence: TAS GeneID:208 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: IMP GeneID:208 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IMP GeneID:208 -> Biological process: GO:0046328 [regulation of JNK cascade] evidence: IEA GeneID:208 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: TAS GeneID:208 -> Biological process: GO:0065002 [intracellular protein transmembrane transport] evidence: ISS GeneID:208 -> Biological process: GO:0071156 [regulation of cell cycle arrest] evidence: TAS GeneID:208 -> Biological process: GO:0072659 [protein localization to plasma membrane] evidence: IEA GeneID:208 -> Biological process: GO:0090314 [positive regulation of protein targeting to membrane] evidence: ISS GeneID:208 -> Biological process: GO:2000147 [positive regulation of cell motility] evidence: IMP GeneID:208 -> Biological process: GO:2001275 [positive regulation of glucose import in response to insulin stimulus] evidence: IEA GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: TAS GeneID:208 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:208 -> Cellular component: GO:0005938 [cell cortex] evidence: ISS GeneID:208 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA GeneID:208 -> Cellular component: GO:0032587 [ruffle membrane] evidence: ISS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001617 -> EC 2.7.11.1
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