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2024-03-29 00:28:50, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001626               5317 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2),
            transcript variant 1, mRNA.
ACCESSION   NM_001626
VERSION     NM_001626.4  GI:339895851
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5317)
  AUTHORS   Fohlin,H., Perez-Tenorio,G., Fornander,T., Skoog,L.,
            Nordenskjold,B., Carstensen,J. and Stal,O.
  TITLE     Akt2 expression is associated with good long-term prognosis in
            oestrogen receptor positive breast cancer
  JOURNAL   Eur. J. Cancer 49 (6), 1196-1204 (2013)
   PUBMED   23305873
  REMARK    GeneRIF: Data indicate that the prognostic value of Akt2 increases
            with higher oestrogen receptor (ER) expression, motivating further
            mechanistic studies on the role of Akt2 in ER+ breast cancer.
REFERENCE   2  (bases 1 to 5317)
  AUTHORS   Choi,K.Y., Ahn,Y.H., Ahn,H.W., Cho,Y.J. and Hong,S.H.
  TITLE     Involvement of Akt2/protein kinase B beta (PKBbeta) in the
            8-Cl-cAMP-induced cancer cell growth inhibition
  JOURNAL   J. Cell. Physiol. 228 (4), 890-902 (2013)
   PUBMED   23018889
  REMARK    GeneRIF: An Akt2/PKBbeta-targeted siRNA inhibited the 8-Cl-cAMP-
            and AICAR-mediated phosphorylation of AMPK and p38 MAPK.
REFERENCE   3  (bases 1 to 5317)
  AUTHORS   Friedrichsen,M., Birk,J.B., Richter,E.A., Ribel-Madsen,R.,
            Pehmoller,C., Hansen,B.F., Beck-Nielsen,H., Hirshman,M.F.,
            Goodyear,L.J., Vaag,A., Poulsen,P. and Wojtaszewski,J.F.
  TITLE     Akt2 influences glycogen synthase activity in human skeletal muscle
            through regulation of NH(2)-terminal (sites 2 + 2a) phosphorylation
  JOURNAL   Am. J. Physiol. Endocrinol. Metab. 304 (6), E631-E639 (2013)
   PUBMED   23321478
  REMARK    GeneRIF: Data suggest that although COOH-terminal dephosphorylation
            is likely necessary for glycogen synthase (GS) activation,
            Akt2-dependent NH2-terminal dephosphorylation is the site for
            'fine-tuning' insulin-mediated GS activation in skeletal muscle.
REFERENCE   4  (bases 1 to 5317)
  AUTHORS   Shen,Y.H., Zhang,L., Ren,P., Nguyen,M.T., Zou,S., Wu,D., Wang,X.L.,
            Coselli,J.S. and LeMaire,S.A.
  TITLE     AKT2 confers protection against aortic aneurysms and dissections
  JOURNAL   Circ. Res. 112 (4), 618-632 (2013)
   PUBMED   23250987
  REMARK    GeneRIF: In cultured human aortic vascular smooth muscle cells,
            AKT2 inhibited the expression of MMP-9 and stimulated the
            expression of TIMP-1 by preventing the binding of transcription
            factor forkhead box protein O1 to the MMP-9 and TIMP-1 promoters.
REFERENCE   5  (bases 1 to 5317)
  AUTHORS   Gillespie,E.F., Raychaudhuri,N., Papageorgiou,K.I., Atkins,S.J.,
            Lu,Y., Charara,L.K., Mester,T., Smith,T.J. and Douglas,R.S.
  TITLE     Interleukin-6 production in CD40-engaged fibrocytes in
            thyroid-associated ophthalmopathy: involvement of Akt and NF-kappaB
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 53 (12), 7746-7753 (2012)
   PUBMED   23092922
  REMARK    GeneRIF: CD40L-provoked signaling results in the production of
            several cytokines. Among these, IL-6 expression is mediated through
            Akt and NF-kappaB pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5317)
  AUTHORS   Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A.
  TITLE     Mitogenic activation, phosphorylation, and nuclear translocation of
            protein kinase Bbeta
  JOURNAL   J. Biol. Chem. 272 (48), 30491-30497 (1997)
   PUBMED   9374542
REFERENCE   7  (bases 1 to 5317)
  AUTHORS   Cheng,J.Q., Ruggeri,B., Klein,W.M., Sonoda,G., Altomare,D.A.,
            Watson,D.K. and Testa,J.R.
  TITLE     Amplification of AKT2 in human pancreatic cells and inhibition of
            AKT2 expression and tumorigenicity by antisense RNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3636-3641 (1996)
   PUBMED   8622988
REFERENCE   8  (bases 1 to 5317)
  AUTHORS   Cheng,J.Q., Godwin,A.K., Bellacosa,A., Taguchi,T., Franke,T.F.,
            Hamilton,T.C., Tsichlis,P.N. and Testa,J.R.
  TITLE     AKT2, a putative oncogene encoding a member of a subfamily of
            protein-serine/threonine kinases, is amplified in human ovarian
            carcinomas
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (19), 9267-9271 (1992)
   PUBMED   1409633
REFERENCE   9  (bases 1 to 5317)
  AUTHORS   Jones,P.F., Jakubowicz,T. and Hemmings,B.A.
  TITLE     Molecular cloning of a second form of rac protein kinase
  JOURNAL   Cell Regul. 2 (12), 1001-1009 (1991)
   PUBMED   1801921
REFERENCE   10 (bases 1 to 5317)
  AUTHORS   Staal,S.P.
  TITLE     Molecular cloning of the akt oncogene and its human homologues AKT1
            and AKT2: amplification of AKT1 in a primary human gastric
            adenocarcinoma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (14), 5034-5037 (1987)
   PUBMED   3037531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN351354.1, BC040028.1,
            BC120994.1, AK122839.1, AC118344.2 and BM675176.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 14, 2011 this sequence version replaced gi:126273601.
            
            Summary: This gene is a putative oncogene encoding a protein
            belonging to a subfamily of serine/threonine kinases containing
            SH2-like (Src homology 2-like) domains. The gene was shown to be
            amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines
            and 2 of 15 primary ovarian tumors. Overexpression contributes to
            the malignant phenotype of a subset of human ductal pancreatic
            cancers. The encoded protein is a general protein kinase capable of
            phophorylating several known proteins. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314619.1, M77198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                CN351354.1         1-35
            36-1332             BC040028.1         1-1297
            1333-1778           BC120994.1         1079-1524
            1779-3282           AK122839.1         2950-4453
            3283-3900           AC118344.2         136121-136738
            3901-5293           AC118344.2         136739-138131
            5294-5317           BM675176.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..5317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.1-q13.2"
     gene            1..5317
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="v-akt murine thymoma viral oncogene homolog 2"
                     /db_xref="GeneID:208"
                     /db_xref="HGNC:392"
                     /db_xref="HPRD:01262"
                     /db_xref="MIM:164731"
     exon            1..215
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            216..345
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    273..275
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="upstream in-frame stop codon"
     CDS             300..1745
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; rac
                     protein kinase beta; RAC-beta serine/threonine-protein
                     kinase; murine thymoma viral (v-akt) homolog-2; PKB beta;
                     RAC-PK-beta; protein kinase Akt-2; protein kinase B beta"
                     /codon_start=1
                     /product="RAC-beta serine/threonine-protein kinase isoform
                     1"
                     /protein_id="NP_001617.1"
                     /db_xref="GI:4502023"
                     /db_xref="CCDS:CCDS12552.1"
                     /db_xref="GeneID:208"
                     /db_xref="HGNC:392"
                     /db_xref="HPRD:01262"
                     /db_xref="MIM:164731"
                     /translation="
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
"
     misc_feature    315..620
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="Akt pleckstrin homology (PH) domain; Region:
                     PH_Akt; cd01241"
                     /db_xref="CDD:176317"
     misc_feature    order(339..341,345..347,366..368,372..380)
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:176317"
     misc_feature    675..677
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P31751.2); phosphorylation site"
     misc_feature    675..677
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
     misc_feature    753..1526
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    765..1733
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Protein Kinase B; Region: STKc_PKB; cd05571"
                     /db_xref="CDD:173662"
     misc_feature    order(771..776,780..785,795..797,834..836,840..842,
                     876..878,885..887,936..938,984..995,1005..1007,1011..1013,
                     1023..1025,1122..1124,1128..1130,1134..1139,1143..1145,
                     1173..1178,1185..1187,1227..1250,1323..1325,1341..1343,
                     1350..1352,1614..1616,1626..1628)
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="active site"
                     /db_xref="CDD:173662"
     misc_feature    order(771..776,780..782,795..797,834..836,840..842,
                     936..938,984..995,1005..1007,1122..1124,1128..1130,
                     1134..1139,1143..1145,1173..1178,1614..1616)
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173662"
     misc_feature    order(783..785,876..878,885..887,1005..1007,1011..1013,
                     1023..1025,1122..1124,1128..1130,1134..1136,1185..1187,
                     1227..1250,1323..1325,1341..1343,1350..1352,1626..1628)
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173662"
     misc_feature    987..995
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31751.2);
                     Region: Inhibitor binding"
     misc_feature    1128..1136
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31751.2);
                     Region: Inhibitor binding"
     misc_feature    1173..1244
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173662"
     misc_feature    1173..1178
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31751.2);
                     Region: Inhibitor binding"
     misc_feature    1224..1226
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PDPK1; propagated from
                     UniProtKB/Swiss-Prot (P31751.2); phosphorylation site"
     misc_feature    1224..1226
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:05556"
     misc_feature    1638..1640
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P31751.2); phosphorylation site"
     misc_feature    1650..1652
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:173662"
     misc_feature    1650..1652
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P31751.2); phosphorylation site"
     misc_feature    1650..1652
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
     misc_feature    1707..1724
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:173662"
     misc_feature    1719..1721
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P31751.2); phosphorylation site"
     misc_feature    1719..1721
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:05556"
     misc_feature    1719..1721
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1725..1727
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1731..1733
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P31751.2); phosphorylation site"
     misc_feature    1731..1733
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            346..474
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     STS             475..597
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /standard_name="AKT2"
                     /db_xref="UniSTS:277960"
     exon            475..586
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     STS             537..775
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /standard_name="MARC_6978-6979:992007604:1"
                     /db_xref="UniSTS:231294"
     exon            587..740
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            741..872
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     variation       851
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1138528"
     exon            873..938
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            939..1007
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            1008..1130
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     variation       1092
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1804324"
     exon            1131..1259
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     STS             1185..1332
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /standard_name="SGC30851"
                     /db_xref="UniSTS:8286"
     exon            1260..1474
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            1475..1562
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            1563..1665
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     exon            1666..5300
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /inference="alignment:Splign:1.39.8"
     variation       1754
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79275829"
     variation       2898
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1142291"
     variation       2902
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1142293"
     variation       2906
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1142294"
     variation       2917
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1142297"
     variation       2919
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1142298"
     STS             4321..4447
                     /gene="AKT2"
                     /gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
                     /standard_name="RH11487"
                     /db_xref="UniSTS:30867"
ORIGIN      
tgggagggggcggtaagcgggggctggggggagggggcggggggggccgcgccgtgctagccgttgggcctgcctcggaggaggcgtcgccgccgccgctgccgctgccggcgccgttgccgctgccgggaaacacaaggaaagggaaccagcgcagcgtggcgatgggcgggggtagagccccgccggagaggctgggcggctgccggtgacagactgtgccctgtccacggtgcctcctgcatgtcctgctgccctgagctgtcccgagctaggtgacagcgtaccacgctgccaccatgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaagacctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggagaggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgccagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtggaccacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatgcgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatggactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtcagcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaagggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatgaagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgagagccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccagacccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccacctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtctcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaacctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggcatcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgaggtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatgtacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgagctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctgcttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgccaaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaagaagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgatgatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggcttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgcgagtgagcagtctgcccacgcagaggacgcacgctcgctgccatcaccgctgggtggttttttccccctaactttttacttagcctttttggtttgtgtccccacccccacctcctcaccccctttccagttcttcttcaggcccctcccagacgcaccccagcggcccctgcagcccctgcctccagcctccagcctcacctttgtgcccagactcgcatttggaagactccacctcccgcccaggcctgggctgttgggcggttggagattcaggttttaatccacacaagccccagtgaggggtgaagcatggcgcctggggcctgcctgagtttctggcctgggtgtcgtgctggtgtctgcctccgcgctgctgcatctggacgaaggctgccttctggtgggacgcgacacccggcagacagtggtgctgccttccaggccccgtggcctaggctcggagtggccaggcacggggcggtccaatcccccacccgctgtccccctatgggggcagaaaagcaataatgtccaggggcaggcaggggcccttgggagctgcagggctgggggttagggctgctccctggtgaatggagtcagatcctaggatctgtaccatggggaaccaggagtggccgggctgggtgccgcctcctggtccggcctcctccccaccaaactgtcctcaccctatggatgaggcaggaggaacatttggggccaaacctgcctgcctcccagccccgtgccttactagggcttccttccagctggccttacctcccgctggaccctgggcctggcctggccccactgggggctatgggctgggctcaccctctcctctgcgggggtggagggccaccagccttggctgttacaatcttacaccggacagtattgggccccatggacttggtcagggaggggtgggggtgggcatctctggtacctattggggtggggggcctctgaaaagggaggctcctaggcccccctcacccctccctctccccagggccccacgttctgcagccttaaggttgaacatgagtgcacgtccatgtcagtgctgtgggactcctgtgcgtgcctcggactgcgtgtgtcggcgggacgcaggcacacgtgggtgtgtgtgcatgtgtgtttgtgtgagggcagcgtgtcctccagtgtgcatggtgtgtgggcttgggccccatccctggcccgagcatttcatcctgtgggggaggggtgctgacctagtgggaggagccccactgtgatccatgagctgccctgcccacgcctcccctccctgtagcaacacctctgggtgtttggagtttagcttttgtgggtttgctctccctatcccatctcctgtactacacagttcatggcagggtggggaggggtggggttggttcgggtgggtgagggtctttttcctctgtgtgcgatgttgttatctgacagttctccgtccctactggcctttctcctcgtcttcatatttgtacggtacaagcaataaagacactcatttcagaccagggcccagcctgcactcacgccagcccaaccactctgggctttgccttggtgatggagtcagacccctgggccccagctcctcctgtactagccgttcccttcagcaaggagggcactgagctcagggtgagggcagctggggtgtgtgcaggagctcaggctggagagggtgggtggagctggtgctgtggggctgaggggtatgggaaggctccccgcatgtgggggtggggtggacagagaccactccaggccctcagtgctgcttaggctaagagaggtggggtggagggacagggctggaagatctgggtagcccagaatgaggagggtgcctgtgctgtcactgaatgagagggagtggttcattccacccggctgccgagcctcagaggggggcattcctatcctgccccacctccctgtttatgctgccacctggaagccttgaggcccccaaattccagtacagacccagtggtgtgttcatggtggcgtggttgctgtcacctgggagctcctgagcgtttggttagaaccctgttcagcttggggtcagccctcccctagtcactgccctttagcctggatgtgtctgggcccctgcacttcccgtgcttgagtcacgtggctgcatggccgggcgctggccggatggaacacctcccccagcaagggaccagggaccagagccctggcctgccctgctgagccctgctgtgcagagggcctggcacagatgaatttgagattttgccgcaaggtgttagcacttcacacccattgagtctttgagattttaagtgaatgtaagcagaaaaagtcagatccaatttacagaaatcagagttagctacagctaggactcgtttggttggggttttttagtttgtctttctaaagtcatgtggaccttaatttaattacaaaagtctaccctggtggtcataaaataggcaggcctatgaagaaaggccttttactcttccatctcatcccagccccgagttgacccacgttgctgctcctcacaccatggtgatgcaggtctcgtagtgtgggcacaggcctggctacctcatctttttagtgcctctctcctcttccacaggatggggtcccacagctgcagcagctggccccgtagttgagcatgtgtggttatcctgtagagcttttcccaagaagggtgtttgaacttagagtcttaataaaatcttaccaaataaattttgagtagaataatcgtcttttgcaatgtacattttaaaaatttcacacattcttttttgtatataaagaacagtgactgggcacagtggctcatgcctgtaatcccagcaatttgggaggccgaggcgggcgggtctcttgaggccaggggttcgagaccagcctgggcatcatagggagaccttcatctctacaaaaaatacaaaaattagctgggcatggtggtgcatgcctgcaatcccagctaacttggaaggctgaggtgaggtgggaagatcacttgagcccaggagtttgaggctgcagtgagctatgattgcggcactgcactgcagcctgggacaatgagactgtgtctctaaaaataaaaaaaaaaaaaacatgatacatgctattaaaaaagacagcaaagcaggagtataagaaaggaaattcacccgaggtcgcagggccttgagtactcattttggtgctgattacctctctgcaaatggacacggcatcataaattggtagtttcctgctctttttgtgtaatcttttccagttaatgtgaagcctctgggggctgccctcgtgcactgatggttgtgtggagtcgggggcggcagtgcgattcccttttagctgctgcatggggggaactcaggctttccagctgcttcctggggttccatggggtagacccctcaaccgcttcagctgccccgttaacaggaattgacttggtttcgtttggtgctaccagcagtcctgtaataaactagctatccatctgtaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
            GeneID:208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:208 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:208 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
            GeneID:208 -> Molecular function: GO:0016301 [kinase activity] evidence: TAS
            GeneID:208 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: ISS
            GeneID:208 -> Biological process: GO:0005978 [glycogen biosynthetic process] evidence: IEA
            GeneID:208 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
            GeneID:208 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
            GeneID:208 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS
            GeneID:208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:208 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IMP
            GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:208 -> Biological process: GO:0008643 [carbohydrate transport] evidence: IEA
            GeneID:208 -> Biological process: GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] evidence: IMP
            GeneID:208 -> Biological process: GO:0010907 [positive regulation of glucose metabolic process] evidence: IMP
            GeneID:208 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
            GeneID:208 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS
            GeneID:208 -> Biological process: GO:0031340 [positive regulation of vesicle fusion] evidence: ISS
            GeneID:208 -> Biological process: GO:0032000 [positive regulation of fatty acid beta-oxidation] evidence: IMP
            GeneID:208 -> Biological process: GO:0032287 [peripheral nervous system myelin maintenance] evidence: IEA
            GeneID:208 -> Biological process: GO:0032859 [activation of Ral GTPase activity] evidence: IEA
            GeneID:208 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
            GeneID:208 -> Biological process: GO:0045444 [fat cell differentiation] evidence: TAS
            GeneID:208 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: IMP
            GeneID:208 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IMP
            GeneID:208 -> Biological process: GO:0046328 [regulation of JNK cascade] evidence: IEA
            GeneID:208 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: TAS
            GeneID:208 -> Biological process: GO:0065002 [intracellular protein transmembrane transport] evidence: ISS
            GeneID:208 -> Biological process: GO:0071156 [regulation of cell cycle arrest] evidence: TAS
            GeneID:208 -> Biological process: GO:0072659 [protein localization to plasma membrane] evidence: IEA
            GeneID:208 -> Biological process: GO:0090314 [positive regulation of protein targeting to membrane] evidence: ISS
            GeneID:208 -> Biological process: GO:2000147 [positive regulation of cell motility] evidence: IMP
            GeneID:208 -> Biological process: GO:2001275 [positive regulation of glucose import in response to insulin stimulus] evidence: IEA
            GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
            GeneID:208 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS
            GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:208 -> Cellular component: GO:0005938 [cell cortex] evidence: ISS
            GeneID:208 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA
            GeneID:208 -> Cellular component: GO:0032587 [ruffle membrane] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001617 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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