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2020-10-24 06:28:35, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001618               4001 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens poly (ADP-ribose) polymerase 1 (PARP1), mRNA.
ACCESSION   NM_001618
VERSION     NM_001618.3  GI:156523967
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Zhao,W., Hu,L., Xu,J., Shen,H., Hu,Z., Ma,H., Shu,Y., Shao,Y. and
            Yin,Y.
  TITLE     Polymorphisms in the base excision repair pathway modulate
            prognosis of platinum-based chemotherapy in advanced non-small cell
            lung cancer
  JOURNAL   Cancer Chemother. Pharmacol. 71 (5), 1287-1295 (2013)
   PUBMED   23479135
  REMARK    GeneRIF: XRCC1 Arg399Gln, PARP1 Va1762Ala and APE1 Asp148Glu SNPs
            in the base excision repair pathway may influence the prognosis of
            advanced non-small cell lung cancer patients following
            platinum-based chemotherapy
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Michels,J., Vitale,I., Galluzzi,L., Adam,J., Olaussen,K.A.,
            Kepp,O., Senovilla,L., Talhaoui,I., Guegan,J., Enot,D.P.,
            Talbot,M., Robin,A., Girard,P., Orear,C., Lissa,D.,
            Sukkurwala,A.Q., Garcia,P., Behnam-Motlagh,P., Kohno,K., Wu,G.S.,
            Brenner,C., Dessen,P., Saparbaev,M., Soria,J.C., Castedo,M. and
            Kroemer,G.
  TITLE     Cisplatin resistance associated with PARP hyperactivation
  JOURNAL   Cancer Res. 73 (7), 2271-2280 (2013)
   PUBMED   23554447
  REMARK    GeneRIF: PARP hyperactivation is associated with cisplatin
            resistance in non-small cell lung carcinoma.
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Tchurikov,N.A., Kretova,O.V., Fedoseeva,D.M., Sosin,D.V.,
            Grachev,S.A., Serebraykova,M.V., Romanenko,S.A., Vorobieva,N.V. and
            Kravatsky,Y.V.
  TITLE     DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding
            sites flank coordinately expressed domains in human chromosomes
  JOURNAL   PLoS Genet. 9 (4), E1003429 (2013)
   PUBMED   23593027
  REMARK    GeneRIF: our data suggest a novel type of gene regulation: a
            coordinated transcription or silencing of gene clusters delimited
            by DSB hot spots as well as PARP1 and HNRNPa2B1 binding sites.
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Loganathan,R., Selvaduray,K.R., Nesaretnam,K. and
            Radhakrishnan,A.K.
  TITLE     Tocotrienols promote apoptosis in human breast cancer cells by
            inducing poly(ADP-ribose) polymerase cleavage and inhibiting
            nuclear factor kappa-B activity
  JOURNAL   Cell Prolif. 46 (2), 203-213 (2013)
   PUBMED   23510475
  REMARK    GeneRIF: Apoptosis in breast cancer cells is induced by PARP
            cleavage following vitamin E treatment.
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Leak,R.K., Zhang,L., Luo,Y., Li,P., Zhao,H., Liu,X., Ling,F.,
            Jia,J., Chen,J. and Ji,X.
  TITLE     Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and
            p53-dependent prodeath pathways after ischemic injury
  JOURNAL   Stroke 44 (4), 1124-1134 (2013)
   PUBMED   23429506
  REMARK    GeneRIF: PRX2 battles poly(ADP-ribose) polymerase 1- and
            p53-dependent prodeath pathways after ischemic injury
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Schreiber,V., Molinete,M., Boeuf,H., de Murcia,G. and Menissier-de
            Murcia,J.
  TITLE     The human poly(ADP-ribose) polymerase nuclear localization signal
            is a bipartite element functionally separate from DNA binding and
            catalytic activity
  JOURNAL   EMBO J. 11 (9), 3263-3269 (1992)
   PUBMED   1505517
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Baumgartner,M., Schneider,R., Auer,B., Herzog,H., Schweiger,M. and
            Hirsch-Kauffmann,M.
  TITLE     Fluorescence in situ mapping of the human nuclear NAD+
            ADP-ribosyltransferase gene (ADPRT) and two secondary sites to
            human chromosomal bands 1q42, 13q34, and 14q24
  JOURNAL   Cytogenet. Cell Genet. 61 (3), 172-174 (1992)
   PUBMED   1424803
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Simonin,F., Menissier-de Murcia,J., Poch,O., Muller,S.,
            Gradwohl,G., Molinete,M., Penning,C., Keith,G. and de Murcia,G.
  TITLE     Expression and site-directed mutagenesis of the catalytic domain of
            human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is
            critical for activity
  JOURNAL   J. Biol. Chem. 265 (31), 19249-19256 (1990)
   PUBMED   2121735
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Gradwohl,G., Menissier de Murcia,J.M., Molinete,M., Simonin,F.,
            Koken,M., Hoeijmakers,J.H. and de Murcia,G.
  TITLE     The second zinc-finger domain of poly(ADP-ribose) polymerase
            determines specificity for single-stranded breaks in DNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (8), 2990-2994 (1990)
   PUBMED   2109322
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Ogura,T., Nyunoya,H., Takahashi-Masutani,M., Miwa,M., Sugimura,T.
            and Esumi,H.
  TITLE     Characterization of a putative promoter region of the human
            poly(ADP-ribose) polymerase gene: structural similarity to that of
            the DNA polymerase beta gene
  JOURNAL   Biochem. Biophys. Res. Commun. 167 (2), 701-710 (1990)
   PUBMED   2108670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB097441.1, BC037545.1,
            J03473.1 and AK225654.1.
            On Aug 28, 2007 this sequence version replaced gi:11496989.
            
            Summary: This gene encodes a chromatin-associated enzyme,
            poly(ADP-ribosyl)transferase, which modifies various nuclear
            proteins by poly(ADP-ribosyl)ation. The modification is dependent
            on DNA and is involved in the regulation of various important
            cellular processes such as differentiation, proliferation, and
            tumor transformation and also in the regulation of the molecular
            events involved in the recovery of cell from DNA damage. In
            addition, this enzyme may be the site of mutation in Fanconi
            anemia, and may participate in the pathophysiology of type I
            diabetes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225654.1, J03473.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               DB097441.1         1-574
            575-1022            BC037545.1         548-995
            1023-1226           J03473.1           947-1150
            1227-2455           BC037545.1         1200-2428
            2456-3871           J03473.1           2380-3795
            3872-4001           AK225654.1         3837-3966
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41-q42"
     gene            1..4001
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="poly (ADP-ribose) polymerase 1"
                     /db_xref="GeneID:142"
                     /db_xref="HGNC:270"
                     /db_xref="MIM:173870"
     exon            1..291
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       155
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:907187"
     misc_feature    163..165
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="upstream in-frame stop codon"
     variation       166
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11541662"
     CDS             172..3216
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /EC_number="2.4.2.30"
                     /note="poly(ADP-ribose) synthetase; ADP-ribosyltransferase
                     NAD(+); poly (ADP-ribose) polymerase family, member 1;
                     ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
                     polymerase); poly(ADP-ribosyl)transferase;
                     poly(ADP-ribose) polymerase; poly[ADP-ribose] synthase 1;
                     NAD(+) ADP-ribosyltransferase 1; ADP-ribosyltransferase
                     diphtheria toxin-like 1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 1"
                     /protein_id="NP_001609.2"
                     /db_xref="GI:156523968"
                     /db_xref="CCDS:CCDS1554.1"
                     /db_xref="GeneID:142"
                     /db_xref="HGNC:270"
                     /db_xref="MIM:173870"
                     /translation="
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
"
     misc_feature    175..177
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    187..3162
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="poly [ADP-ribose] polymerase; Provisional; Region:
                     PLN03123"
                     /db_xref="CDD:178670"
     misc_feature    205..441
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="Poly(ADP-ribose) polymerase and DNA-Ligase
                     Zn-finger region; Region: zf-PARP; pfam00645"
                     /db_xref="CDD:189650"
     misc_feature    292..294
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09874.4); phosphorylation site"
     misc_feature    460..462
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    484..486
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    517..771
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="Poly(ADP-ribose) polymerase and DNA-Ligase
                     Zn-finger region; Region: zf-PARP; pfam00645"
                     /db_xref="CDD:189650"
     misc_feature    562..564
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    706..708
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09874.4); phosphorylation site"
     misc_feature    790..798
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09874.4);
                     Region: Nuclear localization signal"
     misc_feature    832..849
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09874.4);
                     Region: Nuclear localization signal"
     misc_feature    1006..1167
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="PADR1 (NUC008) domain; Region: PADR1; pfam08063"
                     /db_xref="CDD:191934"
     misc_feature    1273..1275
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); phosphorylation site"
     misc_feature    1288..1743
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09874.4);
                     Region: Automodification domain"
     misc_feature    1333..1554
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="BRCA1 C Terminus (BRCT) domain; Region: BRCT;
                     pfam00533"
                     /db_xref="CDD:201286"
     misc_feature    1798..2106
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="WGR domain of poly(ADP-ribose) polymerase 1 and
                     similar proteins; Region: WGR_PARP1_like; cd08001"
                     /db_xref="CDD:153428"
     misc_feature    1969..1971
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    2032..2034
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P09874.4); acetylation site"
     misc_feature    2155..3162
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="Poly(ADP-ribose) polymerase (parp) catalytic domain
                     catalyses the covalent attachment of ADP-ribose units from
                     NAD+ to itself and to a limited number of other DNA
                     binding proteins,  which decreases their affinity for DNA.
                     Poly(ADP-ribose) polymerase is a...; Region: parp_like;
                     cd01437"
                     /db_xref="CDD:30068"
     misc_feature    order(2155..2343,2350..2427,2440..2508,2530..2553)
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="parp regulatory domain; other site"
                     /db_xref="CDD:30068"
     misc_feature    order(2467..2469,2476..2481,2755..2760,2773..2775,
                     2803..2811,2857..2865,2881..2883,2890..2892,3133..3135)
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="Inhibitor contact residues; inhibition site"
                     /db_xref="CDD:30068"
     misc_feature    order(2467..2469,2479..2481,2755..2763,2785..2787,
                     2797..2805,2857..2859,2881..2883,2890..2892,3133..3135)
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /note="nad+ contact residues [chemical binding]; other
                     site"
                     /db_xref="CDD:30068"
     misc_feature    2515..2517
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09874.4); phosphorylation site"
     exon            292..457
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       333
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3738708"
     variation       414
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1805404"
     exon            458..573
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            574..788
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       693
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:13306125"
     variation       733
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1805409"
     exon            789..888
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            889..1005
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            1006..1182
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       1023
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1805414"
     variation       1171
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3219057"
     exon            1183..1330
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       1227
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1805415"
     variation       1300
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230484"
     variation       1319
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3219062"
     exon            1331..1471
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     STS             1454..1592
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="RH70493"
                     /db_xref="UniSTS:3628"
     exon            1472..1714
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            1715..1783
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            1784..1916
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            1917..2112
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2010
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1059011"
     variation       2085
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306137"
     exon            2113..2241
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            2242..2325
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2253
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306138"
     exon            2326..2448
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2346
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306119"
     STS             2408..2525
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="D1S2048E"
                     /db_xref="UniSTS:151523"
     exon            2449..2577
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2456
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1136410"
     exon            2578..2676
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2651
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1136420"
     exon            2677..2829
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2816
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11541664"
     exon            2830..2957
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2894
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1059040"
     exon            2958..3019
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     variation       2990
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3219145"
     exon            3020..3134
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     exon            3135..3985
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /inference="alignment:Splign:1.39.8"
     STS             3159..3809
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="ADPRT_3241"
                     /db_xref="UniSTS:462018"
     STS             3192..3436
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="SHGC-76015"
                     /db_xref="UniSTS:23752"
     variation       3231
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3219147"
     variation       3250
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1064578"
     STS             3306..3464
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="RH11161"
                     /db_xref="UniSTS:91506"
     variation       3311
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306133"
     variation       3487
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1804317"
     variation       3586
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3219148"
     STS             3727..3840
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="G07110"
                     /db_xref="UniSTS:82324"
     variation       3781
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:34588544"
     variation       3823
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8679"
     STS             3828..3960
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /standard_name="SHGC-30345"
                     /db_xref="UniSTS:34448"
     variation       3960
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3219149"
     polyA_signal    3961..3966
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
     polyA_site      3985
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PPOL"
ORIGIN      
aggcatcagcaatctatcagggaacggcggtggccggtgcggcgtgttcggtggcggctctggccgctcaggcgcctgcggctgggtgagcgcacgcgaggcggcgaggcggcagcgtgtttctaggtcgtggcgtcgggcttccggagctttggcggcagctaggggaggatggcggagtcttcggataagctctatcgagtcgagtacgccaagagcgggcgcgcctcttgcaagaaatgcagcgagagcatccccaaggactcgctccggatggccatcatggtgcagtcgcccatgtttgatggaaaagtcccacactggtaccacttctcctgcttctggaaggtgggccactccatccggcaccctgacgttgaggtggatgggttctctgagcttcggtgggatgaccagcagaaagtcaagaagacagcggaagctggaggagtgacaggcaaaggccaggatggaattggtagcaaggcagagaagactctgggtgactttgcagcagagtatgccaagtccaacagaagtacgtgcaaggggtgtatggagaagatagaaaagggccaggtgcgcctgtccaagaagatggtggacccggagaagccacagctaggcatgattgaccgctggtaccatccaggctgctttgtcaagaacagggaggagctgggtttccggcccgagtacagtgcgagtcagctcaagggcttcagcctccttgctacagaggataaagaagccctgaagaagcagctcccaggagtcaagagtgaaggaaagagaaaaggcgatgaggtggatggagtggatgaagtggcgaagaagaaatctaaaaaagaaaaagacaaggatagtaagcttgaaaaagccctaaaggctcagaacgacctgatctggaacatcaaggacgagctaaagaaagtgtgttcaactaatgacctgaaggagctactcatcttcaacaagcagcaagtgccttctggggagtcggcgatcttggaccgagtagctgatggcatggtgttcggtgccctccttccctgcgaggaatgctcgggtcagctggtcttcaagagcgatgcctattactgcactggggacgtcactgcctggaccaagtgtatggtcaagacacagacacccaaccggaaggagtgggtaaccccaaaggaattccgagaaatctcttacctcaagaaattgaaggttaaaaaacaggaccgtatattccccccagaaaccagcgcctccgtggcggccacgcctccgccctccacagcctcggctcctgctgctgtgaactcctctgcttcagcagataagccattatccaacatgaagatcctgactctcgggaagctgtcccggaacaaggatgaagtgaaggccatgattgagaaactcggggggaagttgacggggacggccaacaaggcttccctgtgcatcagcaccaaaaaggaggtggaaaagatgaataagaagatggaggaagtaaaggaagccaacatccgagttgtgtctgaggacttcctccaggacgtctccgcctccaccaagagccttcaggagttgttcttagcgcacatcttgtccccttggggggcagaggtgaaggcagagcctgttgaagttgtggccccaagagggaagtcaggggctgcgctctccaaaaaaagcaagggccaggtcaaggaggaaggtatcaacaaatctgaaaagagaatgaaattaactcttaaaggaggagcagctgtggatcctgattctggactggaacactctgcgcatgtcctggagaaaggtgggaaggtcttcagtgccacccttggcctggtggacatcgttaaaggaaccaactcctactacaagctgcagcttctggaggacgacaaggaaaacaggtattggatattcaggtcctggggccgtgtgggtacggtgatcggtagcaacaaactggaacagatgccgtccaaggaggatgccattgagcacttcatgaaattatatgaagaaaaaaccgggaacgcttggcactccaaaaatttcacgaagtatcccaaaaagttctaccccctggagattgactatggccaggatgaagaggcagtgaagaagctgacagtaaatcctggcaccaagtccaagctccccaagccagttcaggacctcatcaagatgatctttgatgtggaaagtatgaagaaagccatggtggagtatgagatcgaccttcagaagatgcccttggggaagctgagcaaaaggcagatccaggccgcatactccatcctcagtgaggtccagcaggcggtgtctcagggcagcagcgactctcagatcctggatctctcaaatcgcttttacaccctgatcccccacgactttgggatgaagaagcctccgctcctgaacaatgcagacagtgtgcaggccaaggtggaaatgcttgacaacctgctggacatcgaggtggcctacagtctgctcaggggagggtctgatgatagcagcaaggatcccatcgatgtcaactatgagaagctcaaaactgacattaaggtggttgacagagattctgaagaagccgagatcatcaggaagtatgttaagaacactcatgcaaccacacacaatgcgtatgacttggaagtcatcgatatctttaagatagagcgtgaaggcgaatgccagcgttacaagccctttaagcagcttcataaccgaagattgctgtggcacgggtccaggaccaccaactttgctgggatcctgtcccagggtcttcggatagccccgcctgaagcgcccgtgacaggctacatgtttggtaaagggatctatttcgctgacatggtctccaagagtgccaactactgccatacgtctcagggagacccaataggcttaatcctgttgggagaagttgcccttggaaacatgtatgaactgaagcacgcttcacatatcagcaagttacccaagggcaagcacagtgtcaaaggtttgggcaaaactacccctgatccttcagctaacattagtctggatggtgtagacgttcctcttgggaccgggatttcatctggtgtgaatgacacctctctactatataacgagtacattgtctatgatattgctcaggtaaatctgaagtatctgctgaaactgaaattcaattttaagacctccctgtggtaattgggagaggtagccgagtcacacccggtggctctggtatgaattcacccgaagcgcttctgcaccaactcacctggccgctaagttgctgatgggtagtacctgtactaaaccacctcagaaaggattttacagaaacgtgttaaaggttttctctaacttctcaagtcccttgttttgtgttgtgtctgtggggaggggttgttttggggttgtttttgttttttcttgccaggtagataaaactgacatagagaaaaggctggagagagattctgttgcatagactagtcctatggaaaaaaccaagcttcgttagaatgtctgccttactggtttccccagggaaggaaaaatacacttccacccttttttctaagtgttcgtctttagttttgattttggaaagatgttaagcatttatttttagttaaaaataaaaactaatttcatactatttagattttcttttttatcttgcacttattgtcccctttttagttttttttgtttgcctcttgtggtgaggggtgtgggaagaccaaaggaaggaacgctaacaatttctcatacttagaaacaaaaagagctttccttctccaggaatactgaacatgggagctcttgaaatatgtagtattaaaagttgcatttgaaattcttgactttcttatgggcacttttgtcttccaaattaaaactctaccacaaatatacttacccaagggctaatagtaatactcgattaaaaatgcagatgccttctctaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:142 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:142 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: IDA
            GeneID:142 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: TAS
            GeneID:142 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:142 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:142 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:142 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:142 -> Molecular function: GO:0051287 [NAD binding] evidence: IEA
            GeneID:142 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:142 -> Biological process: GO:0000723 [telomere maintenance] evidence: IEA
            GeneID:142 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
            GeneID:142 -> Biological process: GO:0006284 [base-excision repair] evidence: IEA
            GeneID:142 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
            GeneID:142 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: TAS
            GeneID:142 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:142 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:142 -> Biological process: GO:0006471 [protein ADP-ribosylation] evidence: IDA
            GeneID:142 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS
            GeneID:142 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:142 -> Biological process: GO:0016540 [protein autoprocessing] evidence: IEA
            GeneID:142 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IDA
            GeneID:142 -> Biological process: GO:0040009 [regulation of growth rate] evidence: IEA
            GeneID:142 -> Biological process: GO:0042769 [DNA damage response, detection of DNA damage] evidence: IEA
            GeneID:142 -> Biological process: GO:0070212 [protein poly-ADP-ribosylation] evidence: IDA
            GeneID:142 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:142 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
            GeneID:142 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:142 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
            GeneID:142 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001609 -> EC 2.4.2.30

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.