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2024-04-20 05:41:12, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001557               2880 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens chemokine (C-X-C motif) receptor 2 (CXCR2), transcript
            variant 1, mRNA.
ACCESSION   NM_001557
VERSION     NM_001557.3  GI:269973857
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2880)
  AUTHORS   Zeng,Z., Shaffer,J.R., Wang,X., Feingold,E., Weeks,D.E., Lee,M.,
            Cuenco,K.T., Wendell,S.K., Weyant,R.J., Crout,R., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association studies of pit-and-fissure- and
            smooth-surface caries in permanent dentition
  JOURNAL   J. Dent. Res. 92 (5), 432-437 (2013)
   PUBMED   23470693
REFERENCE   2  (bases 1 to 2880)
  AUTHORS   Ravindran,A., Sawant,K.V., Sarmiento,J., Navarro,J. and
            Rajarathnam,K.
  TITLE     Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor
  JOURNAL   J. Biol. Chem. 288 (17), 12244-12252 (2013)
   PUBMED   23479735
  REMARK    GeneRIF: Chemokine CXCL1 dimer is a potent agonist for the CXCR2
            receptor.
REFERENCE   3  (bases 1 to 2880)
  AUTHORS   Saintigny,P., Massarelli,E., Lin,S., Ahn,Y.H., Chen,Y., Goswami,S.,
            Erez,B., O'Reilly,M.S., Liu,D., Lee,J.J., Zhang,L., Ping,Y.,
            Behrens,C., Solis Soto,L.M., Heymach,J.V., Kim,E.S., Herbst,R.S.,
            Lippman,S.M., Wistuba,I.I., Hong,W.K., Kurie,J.M. and Koo,J.S.
  TITLE     CXCR2 expression in tumor cells is a poor prognostic factor and
            promotes invasion and metastasis in lung adenocarcinoma
  JOURNAL   Cancer Res. 73 (2), 571-582 (2013)
   PUBMED   23204236
  REMARK    GeneRIF: CXCR2 axis gene expression profiles in human NSCLC cell
            lines and lung adenocarcinomas defined a cluster driven by CXCL5
            and associated with smoking, poor prognosis, and RAS pathway
            activation.
REFERENCE   4  (bases 1 to 2880)
  AUTHORS   Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
            JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
            Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
            Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
            Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
            Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
            Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
            LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
            J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
            Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
            CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
            Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
            Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
            S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
            Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
            RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
            Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
            Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
            Cho JH.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 2880)
  AUTHORS   Dwyer,J., Hebda,J.K., Le Guelte,A., Galan-Moya,E.M., Smith,S.S.,
            Azzi,S., Bidere,N. and Gavard,J.
  TITLE     Glioblastoma cell-secreted interleukin-8 induces brain endothelial
            cell permeability via CXCR2
  JOURNAL   PLoS ONE 7 (9), E45562 (2012)
   PUBMED   23029099
  REMARK    GeneRIF: Glioblastoma cell-secreted interleukin-8 induces brain
            endothelial cell permeability via CXCR2.
REFERENCE   6  (bases 1 to 2880)
  AUTHORS   Morris,S.W., Nelson,N., Valentine,M.B., Shapiro,D.N., Look,A.T.,
            Kozlosky,C.J., Beckmann,M.P. and Cerretti,D.P.
  TITLE     Assignment of the genes encoding human interleukin-8 receptor types
            1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
  JOURNAL   Genomics 14 (3), 685-691 (1992)
   PUBMED   1427896
REFERENCE   7  (bases 1 to 2880)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J. Biol. Chem. 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   8  (bases 1 to 2880)
  AUTHORS   Murphy,P.M. and Tiffany,H.L.
  TITLE     Cloning of complementary DNA encoding a functional human
            interleukin-8 receptor
  JOURNAL   Science 253 (5025), 1280-1283 (1991)
   PUBMED   1891716
REFERENCE   9  (bases 1 to 2880)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
REFERENCE   10 (bases 1 to 2880)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J. Biol. Chem. 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA670033.1, L19593.1,
            AC124768.4 and AJ710879.1.
            On Nov 28, 2009 this sequence version replaced gi:29171680.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein-coupled receptor family. This protein is a receptor for
            interleukin 8 (IL8). It binds to IL8 with high affinity, and
            transduces the signal through a G-protein activated second
            messenger system. This receptor also binds to chemokine (C-X-C
            motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth
            stimulating activity, and has been shown to be a major component
            required for serum-dependent melanoma cell growth. This receptor
            mediates neutrophil migration to sites of inflammation. The
            angiogenic effects of IL8 in intestinal microvascular endothelial
            cells are found to be mediated by this receptor. Knockout studies
            in mice suggested that this receptor controls the positioning of
            oligodendrocyte precursors in developing spinal cord by arresting
            their migration. This gene, IL8RA, a gene encoding another high
            affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB,
            form a gene cluster in a region mapped to chromosome 2q33-q36.
            Alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA676024.1, L19593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA670033.1         1-10
            11-1524             L19593.1           1-1514
            1525-2869           AC124768.4         71508-72852
            2870-2880           AJ710879.1         136-146
FEATURES             Location/Qualifiers
     source          1..2880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2880
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="chemokine (C-X-C motif) receptor 2"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:6027"
                     /db_xref="HPRD:00907"
                     /db_xref="MIM:146928"
     exon            1..341
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     variation       62
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201259899"
     variation       66
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202132741"
     variation       109
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200233649"
     variation       116
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201381057"
     variation       117
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201793773"
     variation       123
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200324838"
     variation       129
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201283069"
     variation       132
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199566971"
     variation       153
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200559151"
     variation       162
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844673"
     variation       189
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199734944"
     variation       205
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200640316"
     variation       208
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201651476"
     variation       242
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199648357"
     variation       249
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13027370"
     variation       270
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4674259"
     variation       276
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201887993"
     variation       278
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199864634"
     misc_feature    299..301
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="upstream in-frame stop codon"
     variation       305
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201034122"
     variation       312
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201979333"
     exon            342..393
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     variation       356
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201877059"
     variation       358
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200242599"
     variation       360
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201386473"
     variation       366
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199650637"
     variation       387
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200485079"
     exon            394..2870
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     variation       407
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:55781915"
     variation       412
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201205999"
     CDS             419..1501
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="interleukin 8 receptor, beta; interleukin 8
                     receptor B; CXCR2 gene for IL8 receptor type B;
                     interleukin 8 receptor type 2; chemokine (CXC) receptor 2;
                     high affinity interleukin-8 receptor B; GRO/MGSA receptor;
                     interleukin-8 receptor type B; CXC-R2; CXCR-2; IL-8R B;
                     IL-8 receptor type 2"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 2"
                     /protein_id="NP_001548.1"
                     /db_xref="GI:4504683"
                     /db_xref="CCDS:CCDS2408.1"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:6027"
                     /db_xref="HPRD:00907"
                     /db_xref="MIM:146928"
                     /translation="
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
"
     misc_feature    563..643
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    635..1360
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:200918"
     misc_feature    671..733
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    779..844
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    908..967
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    1043..1111
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    1172..1237
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    1301..1363
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    1457..1459
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1469..1471
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1472..1474
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1475..1477
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       435
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139809702"
     variation       436
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201134932"
     variation       448
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369575199"
     variation       455
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371161134"
     variation       461
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55672388"
     variation       480
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199905091"
     variation       493
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200836817"
     variation       505
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148935180"
     variation       508
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142762038"
     variation       519
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191559601"
     STS             525..951
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC135988P2"
                     /db_xref="UniSTS:270788"
     variation       526
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201373363"
     variation       527
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75759064"
     variation       537
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200402782"
     variation       553
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183812193"
     variation       554
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55678589"
     variation       559
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141285974"
     variation       582
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199770538"
     variation       599
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574748"
     variation       622
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201294973"
     variation       623
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368269858"
     variation       641
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199633255"
     variation       652
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150483744"
     variation       653
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149364972"
     variation       656
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138773569"
     variation       661
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372364370"
     variation       662
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201754155"
     STS             668..1113
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC310709P2"
                     /db_xref="UniSTS:272638"
     variation       688
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200819332"
     variation       690
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199535002"
     variation       692
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142747099"
     variation       731
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201513058"
     STS             737..1372
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P2"
                     /db_xref="UniSTS:271353"
     STS             737..986
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P3"
                     /db_xref="UniSTS:271354"
     variation       737
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200115845"
     variation       766
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147368052"
     variation       784
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201382541"
     variation       814
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199919394"
     variation       826
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376503094"
     variation       827
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369839517"
     variation       848
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141722043"
     variation       851
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201114751"
     STS             874..1396
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="IL8R-1"
                     /db_xref="UniSTS:251622"
     variation       874
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375690914"
     variation       876
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55799208"
     variation       889
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146545386"
     variation       893
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200940650"
     variation       894
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368809767"
     variation       900
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202076117"
     variation       919
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200386344"
     variation       944
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199906283"
     variation       946
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201535541"
     variation       949
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201960181"
     variation       968
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200409575"
     variation       976
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201476763"
     variation       977
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199777583"
     variation       1002
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200413041"
     variation       1012
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201063764"
     variation       1013
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201694058"
     variation       1021
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199692849"
     variation       1034
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200627519"
     variation       1048
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143703189"
     variation       1060
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202054642"
     variation       1068
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199822657"
     variation       1069
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200776607"
     variation       1081
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141723765"
     variation       1087
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228414"
     variation       1095
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141096894"
     variation       1105
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201979852"
     variation       1111
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138670528"
     variation       1112
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201103729"
     variation       1124
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10201766"
     variation       1125
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144013681"
     variation       1129
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201499279"
     variation       1139
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733608"
     variation       1151
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200332183"
     variation       1161
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733609"
     variation       1169
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373547007"
     variation       1170
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199561988"
     variation       1174
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844699"
     STS             1183..1372
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P1"
                     /db_xref="UniSTS:271352"
     variation       1186
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574750"
     variation       1204
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230054"
     variation       1267
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200911312"
     variation       1272
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201881186"
     variation       1277
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201264119"
     variation       1281
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199642674"
     variation       1283
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200726461"
     variation       1284
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186640530"
     variation       1294
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199873547"
     variation       1295..1296
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34747313"
     variation       1298
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141145934"
     variation       1299
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228413"
     variation       1302
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200127100"
     variation       1315
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306439"
     variation       1328
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373633146"
     variation       1331
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201271219"
     variation       1352..1353
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36094489"
     variation       1354
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45606837"
     variation       1360
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143174409"
     variation       1361
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200906463"
     variation       1383
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201872950"
     variation       1386
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200182920"
     variation       1409
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201481173"
     variation       1413
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199632317"
     variation       1414
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844701"
     variation       1435
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201578768"
     variation       1440
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199534482"
     variation       1452
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146279580"
     variation       1454
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200600788"
     variation       1455
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201772068"
     variation       1456
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141985893"
     variation       1459
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574751"
     variation       1461
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370921619"
     variation       1464
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200917361"
     STS             1477..1676
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="RH69171"
                     /db_xref="UniSTS:15270"
     variation       1477
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201890292"
     variation       1493
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:150629039"
     variation       1496
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373447323"
     variation       1498
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201280885"
     variation       1500
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201597594"
     STS             1505..1707
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="STS-L19593"
                     /db_xref="UniSTS:37178"
     variation       1507
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370198012"
     variation       1516
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199886410"
     variation       1525
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200811589"
     variation       1526
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200375313"
     variation       1531
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200327176"
     variation       1538
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200366084"
     variation       1548
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374087831"
     STS             1554..1770
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="SHGC-35278"
                     /db_xref="UniSTS:8485"
     variation       1570
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202145285"
     variation       1574
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191445302"
     variation       1597
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201610228"
     variation       1615
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138860"
     variation       1628
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1126579"
     variation       1637
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201301122"
     variation       1652
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199662489"
     variation       1657
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200910303"
     variation       1671
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201580582"
     variation       1685
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199529314"
     variation       1689
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184907766"
     variation       1695
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200661535"
     variation       1701
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201497688"
     variation       1709
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200083985"
     variation       1736
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:375176823"
     variation       1746
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200713198"
     variation       1797
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201358180"
     variation       1800
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199960281"
     variation       1823
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201255939"
     variation       1832
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202122610"
     variation       1839
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306441"
     variation       1848
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200944263"
     variation       1852
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202081724"
     variation       1856
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844765"
     variation       1860
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126580"
     variation       1868
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:56176202"
     variation       1874
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144937879"
     variation       1884
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201975844"
     variation       1886
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200358732"
     variation       1887..1888
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11384701"
     variation       1901
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201616246"
     variation       1902
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199720972"
     variation       1908
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56153350"
     variation       1909
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201060551"
     variation       1910
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199684776"
     variation       1912
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200622623"
     variation       1920
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189221075"
     variation       1924
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199863372"
     variation       1975
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200661022"
     variation       1976
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201984059"
     variation       1981
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:56092703"
     variation       2000
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200097337"
     variation       2016
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:55829498"
     variation       2017
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:56175425"
     variation       2024
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201220752"
     variation       2029
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201986384"
     variation       2030
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199944797"
     variation       2055
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201100780"
     variation       2059
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202141075"
     variation       2060
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55638099"
     variation       2061
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200999393"
     variation       2079
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202200545"
     variation       2085
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200317880"
     variation       2096
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201256811"
     variation       2100
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199540825"
     variation       2132
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55647070"
     variation       2135
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200255470"
     variation       2143
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201156584"
     variation       2164
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199725306"
     variation       2182
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201006994"
     variation       2192
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201645636"
     variation       2193
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199632962"
     variation       2197
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185395115"
     variation       2223
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201889090"
     variation       2226
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199869170"
     variation       2228
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200954784"
     variation       2238
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201972373"
     variation       2239
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200083187"
     variation       2245
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201363519"
     variation       2289
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:55868412"
     variation       2303
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201963170"
     variation       2312
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200257699"
     variation       2339
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148989011"
     variation       2345
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201872518"
     variation       2354
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200180099"
     variation       2371
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201377420"
     variation       2383
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17844705"
     variation       2386
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200480096"
     variation       2389
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201754329"
     variation       2395
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199528804"
     variation       2396
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200594925"
     variation       2408
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201770115"
     variation       2440
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199764281"
     variation       2448
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55824260"
     variation       2453
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17844706"
     variation       2480
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844707"
     variation       2484
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56035337"
     variation       2555
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201107545"
     STS             2572..2756
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="RH78907"
                     /db_xref="UniSTS:35029"
     variation       2572
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202047158"
     variation       2573
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199884990"
     variation       2587
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200811552"
     variation       2613
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201795975"
     variation       2646
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200077824"
     variation       2647
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574752"
     variation       2649
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375016461"
     variation       2650
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201967136"
     variation       2653
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72955950"
     variation       2655..2656
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="cttaatgc"
                     /db_xref="dbSNP:148832762"
     variation       2655
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201473254"
     variation       2728
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147749945"
     variation       2729
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200153685"
     variation       2752
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201283841"
     variation       2766
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199647047"
     variation       2773
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200784640"
     variation       2794
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201741488"
     variation       2819
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199516582"
     variation       2847
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181068104"
ORIGIN      
aggttcaaaacattcagagacagaaggtggatagacaaatctccaccttcagactggtaggctcctccagaagccatcagacaggaagatgtgaaaatccccagcactcatcccagaatcactaagtggcacctgtcctgggccaaagtcccaggacagacctcattgttcctctgtgggaatacctccccaggagggcatcctggatttcccccttgcaacccaggtcagaagtttcatcgtcaaggttgtttcatcttttttttcctgtctaacagctctgactaccacccaaccttgaggcacagtgaagacatcggtggccactccaataacagcaggtcacagctgctcttctggaggtgtcctacaggtgaaaagcccagcgacccagtcaggatttaagtttacctcaaaaatggaagattttaacatggagagtgacagctttgaagatttctggaaaggtgaagatcttagtaattacagttacagctctaccctgcccccttttctactagatgccgccccatgtgaaccagaatccctggaaatcaacaagtattttgtggtcattatctatgccctggtattcctgctgagcctgctgggaaactccctcgtgatgctggtcatcttatacagcagggtcggccgctccgtcactgatgtctacctgctgaacctagccttggccgacctactctttgccctgaccttgcccatctgggccgcctccaaggtgaatggctggatttttggcacattcctgtgcaaggtggtctcactcctgaaggaagtcaacttctatagtggcatcctgctactggcctgcatcagtgtggaccgttacctggccattgtccatgccacacgcacactgacccagaagcgctacttggtcaaattcatatgtctcagcatctggggtctgtccttgctcctggccctgcctgtcttacttttccgaaggaccgtctactcatccaatgttagcccagcctgctatgaggacatgggcaacaatacagcaaactggcggatgctgttacggatcctgccccagtcctttggcttcatcgtgccactgctgatcatgctgttctgctacggattcaccctgcgtacgctgtttaaggcccacatggggcagaagcaccgggccatgcgggtcatctttgctgtcgtcctcatcttcctgctctgctggctgccctacaacctggtcctgctggcagacaccctcatgaggacccaggtgatccaggagacctgtgagcgccgcaatcacatcgaccgggctctggatgccaccgagattctgggcatccttcacagctgcctcaaccccctcatctacgccttcattggccagaagtttcgccatggactcctcaagattctagctatacatggcttgatcagcaaggactccctgcccaaagacagcaggccttcctttgttggctcttcttcagggcacacttccactactctctaagacctcctgcctaagtgcagccccgtggggttcctcccttctcttcacagtcacattccaagcctcatgtccactggttcttcttggtctcagtgtcaatgcagcccccattgtggtcacaggaagtagaggaggccacgttcttactagtttcccttgcatggtttagaaagcttgccctggtgcctcaccccttgccataattactatgtcatttgctggagctctgcccatcctgcccctgagcccatggcactctatgttctaagaagtgaaaatctacactccagtgagacagctctgcatactcattaggatggctagtatcaaaagaaagaaaatcaggctggccaacggggtgaaaccctgtctctactaaaaatacaaaaaaaaaaaaaaattagccgggcgtggtggtgagtgcctgtaatcacagctacttgggaggctgagatgggagaatcacttgaacccgggaggcagaggttgcagtgagccgagattgtgcccctgcactccagcctgagcgacagtgagactctgtctcagtccatgaagatgtagaggagaaactggaactctcgagcgttgctgggggggattgtaaaatggtgtgaccactgcagaagacagtatggcagctttcctcaaaacttcagacatagaattaacacatgatcctgcaattccacttataggaattgacccacaagaaatgaaagcagggacttgaacccatatttgtacaccaatattcatagcagcttattcacaagacccaaaaggcagaagcaacccaaatgttcatcaatgaatgaatgaatggctaagcaaaatgtgatatgtacctaacgaagtatccttcagcctgaaagaggaatgaagtactcatacatgttacaacacggacgaaccttgaaaactttatgctaagtgaaataagccagacatcaacagataaatagtttatgattccacctacatgaggtactgagagtgaacaaatttacagagacagaaagcagaacagtgattaccagggactgaggggaggggagcatgggaagtgacggtttaatgggcacagggtttatgtttaggatgttgaaaaagttctgcagataaacagtagtgatagttgtaccgcaatgtgacttaatgccactaaattgacacttaaaaatggtttaaatggtcaattttgttatgtatattttatatcaatttaaaaaaaaacctgagccccaaaaggtattttaatcaccaaggctgattaaaccaaggctagaaccacctgcctatattttttgttaaatgatttcattcaatatcttttttttaataaaccatttttacttgggtgtttataaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3579 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0004918 [interleukin-8 receptor activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3579 -> Molecular function: GO:0016494 [C-X-C chemokine receptor activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0019959 [interleukin-8 binding] evidence: IPI
            GeneID:3579 -> Biological process: GO:0002407 [dendritic cell chemotaxis] evidence: TAS
            GeneID:3579 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:3579 -> Biological process: GO:0006935 [chemotaxis] evidence: IDA
            GeneID:3579 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
            GeneID:3579 -> Biological process: GO:0006968 [cellular defense response] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007165 [signal transduction] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: IEA
            GeneID:3579 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:3579 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: IDA
            GeneID:3579 -> Biological process: GO:0031623 [receptor internalization] evidence: IDA
            GeneID:3579 -> Biological process: GO:0038112 [interleukin-8-mediated signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0042119 [neutrophil activation] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:3579 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:3579 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0016020 [membrane] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0042629 [mast cell granule] evidence: IDA

by @meso_cacase at DBCLS
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