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2024-04-20 23:11:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001504 1670 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens chemokine (C-X-C motif) receptor 3 (CXCR3), transcript
variant 1, mRNA.
ACCESSION NM_001504
VERSION NM_001504.1 GI:4504098
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1670)
AUTHORS Pranzatelli,M.R., Tate,E.D., McGee,N.R., Travelstead,A.L.,
Verhulst,S.J. and Ransohoff,R.M.
TITLE Expression of CXCR3 and its ligands CXCL9, -10 and -11 in
paediatric opsoclonus-myoclonus syndrome
JOURNAL Clin. Exp. Immunol. 172 (3), 427-436 (2013)
PUBMED 23600831
REMARK GeneRIF: CXCR3 expression on CD4(+) T cells was fivefold higher in
those from CSF than blood, but was not increased in paediatric
opsoclonus-myoclonus syndrome.
REFERENCE 2 (bases 1 to 1670)
AUTHORS Bjorkander,S., Heidari-Hamedani,G., Bremme,K., Gunnarsson,I. and
Holmlund,U.
TITLE Peripheral monocyte expression of the chemokine receptors CCR2,
CCR5 and CXCR3 is altered at parturition in healthy women and in
women with systemic lupus erythematosus
JOURNAL Scand. J. Immunol. 77 (3), 200-212 (2013)
PUBMED 23298254
REMARK GeneRIF: Data indicate that women with systemic lupus erythematosus
(SLE) responded similar to pregnancy as did healthy women with
lower percentages of CCR2+, CCR5+ and CXCR3+ monocytes.
REFERENCE 3 (bases 1 to 1670)
AUTHORS Liu,W., Ren,H.Y., Dong,Y.J., Wang,L.H., Yin,Y., Li,Y., Qiu,Z.X.,
Cen,X.N. and Shi,Y.J.
TITLE Bortezomib regulates the chemotactic characteristics of T cells
through downregulation of CXCR3/CXCL9 expression and induction of
apoptosis
JOURNAL Int. J. Hematol. 96 (6), 764-772 (2012)
PUBMED 23179902
REMARK GeneRIF: Bortezomib significantly decreases CXCR3 expression on T
cells & their CD4(+)/CD8(+) subsets in a dose-dependent manner.
REFERENCE 4 (bases 1 to 1670)
AUTHORS Green,L.A., Petrusca,D., Rajashekhar,G., Gianaris,T.,
Schweitzer,K.S., Wang,L., Justice,M.J., Petrache,I. and Clauss,M.
TITLE Cigarette smoke-induced CXCR3 receptor up-regulation mediates
endothelial apoptosis
JOURNAL Am. J. Respir. Cell Mol. Biol. 47 (6), 807-814 (2012)
PUBMED 22936405
REMARK GeneRIF: Protein nitration was required for CXCR3 receptor
up-regulation by cigarette smoke and for CXCR3-induced cell death.
REFERENCE 5 (bases 1 to 1670)
AUTHORS Zhang,X., Feng,J.M., Li,W.Q., Li,J.P., Chen,S.B. and Han,G.X.
TITLE [The role of CXCR3 and its ligand I-TAC in the pathogenesis of
immune thrombocytopenic purpura]
JOURNAL Zhonghua Nei Ke Za Zhi 51 (8), 634-637 (2012)
PUBMED 23158864
REMARK GeneRIF: CXCR3 expression was higher in immune thrombocytopenic
purpura patients (prior to treatment and in remission) than in
healthy controls.
REFERENCE 6 (bases 1 to 1670)
AUTHORS Qin,S., Rottman,J.B., Myers,P., Kassam,N., Weinblatt,M.,
Loetscher,M., Koch,A.E., Moser,B. and Mackay,C.R.
TITLE The chemokine receptors CXCR3 and CCR5 mark subsets of T cells
associated with certain inflammatory reactions
JOURNAL J. Clin. Invest. 101 (4), 746-754 (1998)
PUBMED 9466968
REFERENCE 7 (bases 1 to 1670)
AUTHORS Bonecchi,R., Bianchi,G., Bordignon,P.P., D'Ambrosio,D., Lang,R.,
Borsatti,A., Sozzani,S., Allavena,P., Gray,P.A., Mantovani,A. and
Sinigaglia,F.
TITLE Differential expression of chemokine receptors and chemotactic
responsiveness of type 1 T helper cells (Th1s) and Th2s
JOURNAL J. Exp. Med. 187 (1), 129-134 (1998)
PUBMED 9419219
REFERENCE 8 (bases 1 to 1670)
AUTHORS Loetscher,M., Gerber,B., Loetscher,P., Jones,S.A., Piali,L.,
Clark-Lewis,I., Baggiolini,M. and Moser,B.
TITLE Chemokine receptor specific for IP10 and mig: structure, function,
and expression in activated T-lymphocytes
JOURNAL J. Exp. Med. 184 (3), 963-969 (1996)
PUBMED 9064356
REFERENCE 9 (bases 1 to 1670)
AUTHORS Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
TITLE Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
and GPR14, encoding receptors related to interleukin 8,
neuropeptide Y, and somatostatin receptors
JOURNAL Genomics 29 (2), 335-344 (1995)
PUBMED 8666380
REFERENCE 10 (bases 1 to 1670)
AUTHORS Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
Kaziro,Y.
TITLE Presence of three distinct molecular species of Gi protein alpha
subunit. Structure of rat cDNAs and human genomic DNAs
JOURNAL J. Biol. Chem. 263 (14), 6656-6664 (1988)
PUBMED 2834384
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X95876.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes a G protein-coupled receptor with
selectivity for three chemokines, termed CXCL9/Mig (monokine
induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10
kDa protein) and CXCL11/I-TAC (interferon-inducible T cell
a-chemoattractant). Binding of chemokines to this protein induces
cellular responses that are involved in leukocyte traffic, most
notably integrin activation, cytoskeletal changes and chemotactic
migration. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. One of the
isoforms (CXCR3-B) shows high affinity binding to chemokine,
CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
Transcript Variant: This variant (1) represents the predominant
transcript, and encodes isoform 1 (also known as CXCR3-A). This
isoform functions as a receptor for chemokines CXCL9/Mig,
CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X95876.1, BC034403.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025086, ERS025087 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1670 X95876.1 1-1670
FEATURES Location/Qualifiers
source 1..1670
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..1670
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/note="chemokine (C-X-C motif) receptor 3"
/db_xref="GeneID:2833"
/db_xref="HGNC:4540"
/db_xref="HPRD:02936"
/db_xref="MIM:300574"
exon 1..80
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="alignment:Splign:1.39.8"
CDS 69..1175
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/note="isoform 1 is encoded by transcript variant 1;
chemokine (C-X-C) receptor 3; IP10 receptor; Mig receptor;
G protein-coupled receptor 9; C-X-C chemokine receptor
type 3; CXC-R3; CXCR-3; IP-10 receptor;
interferon-inducible protein 10 receptor"
/codon_start=1
/product="C-X-C chemokine receptor type 3 isoform 1"
/protein_id="NP_001495.1"
/db_xref="GI:4504099"
/db_xref="CCDS:CCDS14416.1"
/db_xref="GeneID:2833"
/db_xref="HGNC:4540"
/db_xref="HPRD:02936"
/db_xref="MIM:300574"
/translation="
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
"
misc_feature 147..149
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/experiment="experimental evidence, no additional details
recorded"
/note="Sulfotyrosine; propagated from UniProtKB/Swiss-Prot
(P49682.2); sulfatation site"
misc_feature 153..155
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/experiment="experimental evidence, no additional details
recorded"
/note="Sulfotyrosine; propagated from UniProtKB/Swiss-Prot
(P49682.2); sulfatation site"
misc_feature 228..308
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 336..398
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 414..1022
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/note="7 transmembrane receptor (rhodopsin family);
Region: 7tm_1; pfam00001"
/db_xref="CDD:200918"
misc_feature 444..509
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 576..635
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 705..767
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 834..899
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
misc_feature 963..1031
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49682.2);
transmembrane region"
exon 81..1624
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/inference="alignment:Splign:1.39.8"
STS 662..1076
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/standard_name="PMC135988P3"
/db_xref="UniSTS:270789"
STS 671..1071
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/standard_name="PMC198541P1"
/db_xref="UniSTS:271858"
variation 779
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230438"
STS 1199..1425
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/standard_name="STS-X95876"
/db_xref="UniSTS:34617"
STS 1412..1554
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
/standard_name="RH47042"
/db_xref="UniSTS:71956"
polyA_signal 1602..1607
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
polyA_site 1624
/gene="CXCR3"
/gene_synonym="CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R;
Mig-R; MigR"
ORIGIN
ccaaccacaagcaccaaagcagaggggcaggcagcacaccacccagcagccagagcaccagcccagccatggtccttgaggtgagtgaccaccaagtgctaaatgacgccgaggttgccgccctcctggagaacttcagctcttcctatgactatggagaaaacgagagtgactcgtgctgtacctccccgccctgcccacaggacttcagcctgaacttcgaccgggccttcctgccagccctctacagcctcctctttctgctggggctgctgggcaacggcgcggtggcagccgtgctgctgagccggcggacagccctgagcagcaccgacaccttcctgctccacctagctgtagcagacacgctgctggtgctgacactgccgctctgggcagtggacgctgccgtccagtgggtctttggctctggcctctgcaaagtggcaggtgccctcttcaacatcaacttctacgcaggagccctcctgctggcctgcatcagctttgaccgctacctgaacatagttcatgccacccagctctaccgccgggggcccccggcccgcgtgaccctcacctgcctggctgtctgggggctctgcctgcttttcgccctcccagacttcatcttcctgtcggcccaccacgacgagcgcctcaacgccacccactgccaatacaacttcccacaggtgggccgcacggctctgcgggtgctgcagctggtggctggctttctgctgcccctgctggtcatggcctactgctatgcccacatcctggccgtgctgctggtttccaggggccagcggcgcctgcgggccatgcggctggtggtggtggtcgtggtggcctttgccctctgctggaccccctatcacctggtggtgctggtggacatcctcatggacctgggcgctttggcccgcaactgtggccgagaaagcagggtagacgtggccaagtcggtcacctcaggcctgggctacatgcactgctgcctcaacccgctgctctatgcctttgtaggggtcaagttccgggagcggatgtggatgctgctcttgcgcctgggctgccccaaccagagagggctccagaggcagccatcgtcttcccgccgggattcatcctggtctgagacctcagaggcctcctactcgggcttgtgaggccggaatccgggctcccctttcgcccacagtctgacttccccgcattccaggctcctccctccctctgccggctctggctctccccaatatcctcgctcccgggactcactggcagccccagcaccaccaggtctcccgggaagccaccctcccagctctgaggactgcaccattgctgctccttagctgccaagccccatcctgccgcccgaggtggctgcctggagccccactgcccttctcatttggaaactaaaacttcatcttccccaagtgcggggagtacaaggcatggcgtagagggtgctgccccatgaagccacagcccaggcctccagctcagcagtgactgtggccatggtccccaagacctctatatttgctcttttatttttatgtctaaaatcctgcttaaaacttttcaataaacaagatcgtcaggaccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2833 -> Molecular function: GO:0004950 [chemokine receptor activity] evidence: TAS
GeneID:2833 -> Molecular function: GO:0016494 [C-X-C chemokine receptor activity] evidence: IEA
GeneID:2833 -> Molecular function: GO:0019956 [chemokine binding] evidence: IPI
GeneID:2833 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:2833 -> Biological process: GO:0002685 [regulation of leukocyte migration] evidence: IEA
GeneID:2833 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2833 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
GeneID:2833 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:2833 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:2833 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
GeneID:2833 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: IDA
GeneID:2833 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: IEA
GeneID:2833 -> Biological process: GO:0010818 [T cell chemotaxis] evidence: IEA
GeneID:2833 -> Biological process: GO:0019722 [calcium-mediated signaling] evidence: IEA
GeneID:2833 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:2833 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2833 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:2833 -> Cellular component: GO:0009897 [external side of plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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