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2024-04-19 00:38:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001488 1886 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens transcriptional adaptor 2A (TADA2A), transcript
variant 1, mRNA.
ACCESSION NM_001488
VERSION NM_001488.3 GI:68509269
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1886)
AUTHORS Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K,
Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson
MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis
J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM,
Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova
N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R,
Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen
Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C,
Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A,
Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher
D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G,
Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A,
Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S,
Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney
LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D,
Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J,
Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V,
McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod
SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson
S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC,
Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA,
Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi
G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P,
Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS,
van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF,
Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B,
Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT,
Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G,
Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA.
CONSRTM Australian Cancer Study; Australian Ovarian Cancer Study Group
TITLE GWAS meta-analysis and replication identifies three new
susceptibility loci for ovarian cancer
JOURNAL Nat. Genet. 45 (4), 362-370 (2013)
PUBMED 23535730
REFERENCE 2 (bases 1 to 1886)
AUTHORS Huang,J., Zhang,L., Liu,W., Liao,Q., Shi,T., Xiao,L., Hu,F. and
Qiu,X.
TITLE CCDC134 interacts with hADA2a and functions as a regulator of
hADA2a in acetyltransferase activity, DNA damage-induced apoptosis
and cell cycle arrest
JOURNAL Histochem. Cell Biol. 138 (1), 41-55 (2012)
PUBMED 22644376
REMARK GeneRIF: CCDC134 increased the PCAF-dependent K320 acetylation of
p53 and p53 protein stability in the presence of hADA2a
overexpression.
REFERENCE 3 (bases 1 to 1886)
AUTHORS Ruano,G., Thompson,P.D., Kane,J.P., Pullinger,C.R., Windemuth,A.,
Seip,R.L., Kocherla,M., Holford,T.R. and Wu,A.H.
TITLE Physiogenomic analysis of statin-treated patients: domain-specific
counter effects within the ACACB gene on low-density lipoprotein
cholesterol?
JOURNAL Pharmacogenomics 11 (7), 959-971 (2010)
PUBMED 20602615
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 1886)
AUTHORS Yang,M., Waterman,M.L. and Brachmann,R.K.
TITLE hADA2a and hADA3 are required for acetylation, transcriptional
activity and proliferative effects of beta-catenin
JOURNAL Cancer Biol. Ther. 7 (1), 120-128 (2008)
PUBMED 18059173
REMARK GeneRIF: hADA2a and hADA3 as crucial cofactors of beta-catenin that
are likely involved in the assembly of transactivation-competent
beta-catenin complexes at Wnt target genes.
REFERENCE 5 (bases 1 to 1886)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 6 (bases 1 to 1886)
AUTHORS Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
TITLE Histone-like TAFs within the PCAF histone acetylase complex
JOURNAL Cell 94 (1), 35-44 (1998)
PUBMED 9674425
REFERENCE 7 (bases 1 to 1886)
AUTHORS Henriksson,A., Almlof,T., Ford,J., McEwan,I.J., Gustafsson,J.A. and
Wright,A.P.
TITLE Role of the Ada adaptor complex in gene activation by the
glucocorticoid receptor
JOURNAL Mol. Cell. Biol. 17 (6), 3065-3073 (1997)
PUBMED 9154805
REFERENCE 8 (bases 1 to 1886)
AUTHORS Carter,K.C., Wang,L., Shell,B.K., Zamir,I., Berger,S.L. and
Moore,P.A.
TITLE The human transcriptional adaptor genes TADA2L and GCN5L2
colocalize to chromosome 17q12-q21 and display a similar tissue
expression pattern
JOURNAL Genomics 40 (3), 497-500 (1997)
PUBMED 9073520
REFERENCE 9 (bases 1 to 1886)
AUTHORS Wang,L., Mizzen,C., Ying,C., Candau,R., Barlev,N., Brownell,J.,
Allis,C.D. and Berger,S.L.
TITLE Histone acetyltransferase activity is conserved between yeast and
human GCN5 and is required for complementation of growth and
transcriptional activation
JOURNAL Mol. Cell. Biol. 17 (1), 519-527 (1997)
PUBMED 8972232
REFERENCE 10 (bases 1 to 1886)
AUTHORS Candau,R., Moore,P.A., Wang,L., Barlev,N., Ying,C.Y., Rosen,C.A.
and Berger,S.L.
TITLE Identification of human proteins functionally conserved with the
yeast putative adaptors ADA2 and GCN5
JOURNAL Mol. Cell. Biol. 16 (2), 593-602 (1996)
PUBMED 8552087
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK022767.1, BC011753.2 and
AL526501.3.
On Jul 1, 2005 this sequence version replaced gi:19743888.
Summary: Many DNA-binding transcriptional activator proteins
enhance the initiation rate of RNA polymerase II-mediated gene
transcription by interacting functionally with the general
transcription machinery bound at the basal promoter. Adaptor
proteins are usually required for this activation, possibly to
acetylate and destabilize nucleosomes, thereby relieving chromatin
constraints at the promoter. The protein encoded by this gene is a
transcriptional activator adaptor and has been found to be part of
the PCAF histone acetylase complex. Several alternatively spliced
transcript variants encoding different isoforms of this gene have
been described, but the full-length nature of some of these
variants has not been determined. [provided by RefSeq, Oct 2009].
Transcript Variant: This variant (1) is the predominant transcript
and encodes the longer isoform (a). Variants 1 and 3 both encode
the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK022767.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-272 AK022767.1 4-275
273-384 BC011753.2 12-123
385-1038 AL526501.3 155-808
1039-1886 BC011753.2 778-1625
FEATURES Location/Qualifiers
source 1..1886
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q12-q21"
gene 1..1886
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="transcriptional adaptor 2A"
/db_xref="GeneID:6871"
/db_xref="HGNC:11531"
/db_xref="MIM:602276"
exon 1..272
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 7
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:76455262"
variation 42
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:189322822"
variation 160
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:829164"
variation 191
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:118185891"
exon 273..394
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 326
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:186419906"
variation 354
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:17138766"
variation 355
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140453764"
variation 362
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201818113"
misc_feature 364..366
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="upstream in-frame stop codon"
CDS 370..1701
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="isoform a is encoded by transcript variant 1;
transcriptional adaptor 2 alpha; transcriptional adapter
2-alpha; ADA2-like protein"
/codon_start=1
/product="transcriptional adapter 2-alpha isoform a"
/protein_id="NP_001479.3"
/db_xref="GI:68509270"
/db_xref="CCDS:CCDS11319.1"
/db_xref="GeneID:6871"
/db_xref="HGNC:11531"
/db_xref="MIM:602276"
/translation="
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG
"
misc_feature 412..561
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Zinc finger, ZZ type. Zinc finger present in ADA2,
a putative transcriptional adaptor, and related proteins.
The ZZ motif coordinates two zinc ions and most likely
participates in ligand binding or molecular scaffolding;
Region: ZZ_ADA2; cd02335"
/db_xref="CDD:30239"
misc_feature order(418..420,427..429,460..462,469..471,493..495,
502..504,532..534,544..546)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Zinc-binding sites [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature order(418..420,427..429,493..495,502..504)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="zinc cluster 1 [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature order(421..423,451..453,457..459,481..483,487..489)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="putative charged binding surface; other site"
/db_xref="CDD:30239"
misc_feature 451..1689
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Histone acetyltransferase complex SAGA/ADA, subunit
ADA2 [Chromatin structure and dynamics]; Region: COG5114"
/db_xref="CDD:34717"
misc_feature order(454..456,505..507,550..552,559..561)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="putative hydrophobic binding surface; other site"
/db_xref="CDD:30239"
misc_feature order(460..462,469..471,532..534,544..546)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="zinc cluster 2 [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature 589..723
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
Tandem copies of the domain bind telomeric DNA tandem
repeatsas part of the capping complex. Binding is sequence
dependent for repeats which contain the G/C rich motif
[C2-3 A (CA)1-6]. The domain is...; Region: SANT; cd00167"
/db_xref="CDD:29107"
misc_feature order(592..594,682..687,691..696,700..708,712..720)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:29107"
misc_feature 1465..1689
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="SWIRM domain; Region: SWIRM; pfam04433"
/db_xref="CDD:203011"
variation 377
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374991405"
variation 378
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369370248"
variation 385
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:7211875"
variation 387
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace=""
/replace="c"
/db_xref="dbSNP:112855394"
exon 395..501
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 402
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:138178971"
variation 420
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:370683055"
variation 421
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:143836210"
variation 422
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200118946"
exon 502..561
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 545
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374099682"
variation 546
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:368270238"
variation 552
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:372228881"
exon 562..653
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 568
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141037954"
variation 587
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:147950347"
variation 600
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:368442122"
variation 611
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="g"
/replace="t"
/db_xref="dbSNP:369092308"
exon 654..811
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 668
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148703392"
variation 681
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:373018253"
variation 687
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:186965965"
variation 692
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="t"
/db_xref="dbSNP:147234139"
variation 712
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:1054865"
variation 718
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:17849432"
variation 779
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:187764026"
variation 793
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:78395792"
variation 802
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:34408045"
exon 812..900
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 816
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:199556759"
variation 828
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:143700497"
variation 884
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374860776"
variation 900
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:377490313"
exon 901..973
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 913
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375889975"
variation 915
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:144064854"
variation 917
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:367698801"
variation 960
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148661084"
variation 971
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142136696"
exon 974..1037
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1031
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:367602386"
exon 1038..1081
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1042
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:150744923"
variation 1081
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="t"
/db_xref="dbSNP:371661972"
exon 1082..1192
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1085
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:184173195"
variation 1094
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376421675"
variation 1112
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201607716"
variation 1119
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:139151064"
variation 1172
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:143994775"
variation 1189
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:188630265"
exon 1193..1264
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1218
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:376616299"
exon 1265..1397
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1271
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:377297752"
variation 1275
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:35001882"
variation 1298
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200169209"
variation 1310
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146413054"
variation 1315
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:142392695"
variation 1385
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:149845906"
exon 1398..1441
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1408
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:145834935"
variation 1422
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="g"
/replace="t"
/db_xref="dbSNP:2522969"
variation 1433
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:117373044"
variation 1439
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:375609348"
exon 1442..1515
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1448
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369901141"
variation 1455
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:143738207"
variation 1494
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:150499579"
variation 1501..1502
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace=""
/replace="a"
/db_xref="dbSNP:36089271"
exon 1516..1840
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1572
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:370986458"
variation 1595
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373768236"
variation 1604
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:186687337"
variation 1611
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148115672"
variation 1617
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142394717"
variation 1687
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376913298"
variation 1700
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:80260728"
variation 1714
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:370551134"
variation 1722
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:192676041"
variation 1748
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201449135"
variation 1770
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:376358646"
polyA_site 1840
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
ORIGIN
tttcccgctcagccctggagcgcgtagctctaccaagaatggccactgtgccagatgcccctgaccagcgttgcccatttgaatttcctagcaggccccccaaagtaggtatttcagtaccctgttagagctgaggcgcaggtaaaatgactggcccaggccggtcccaccccgtaaggatttgaacgttggctccacaactcgggagcctgcgcctttcctcctcccaacgtggactcctgcccggcgaagtgcctcacttccttctcccgggagtcatcaagctttggtgtatgtgttggccggttctgaagtcttgaagaagctctgctgaggaagaccaaagcagcactcgttgccaattagggaatggaccgtttgggtccctttagcaatgatccctctgataagccaccttgccgaggctgctcctcctacctcatggagccttatatcaagtgtgctgaatgtgggccacctccttttttcctctgcttgcagtgtttcactcgaggctttgagtacaagaaacatcaaagcgatcatacttatgaaataatgacttcagattttcctgtccttgatcccagctggactgctcaagaagaaatggcccttttagaagctgtgatggactgtggctttggaaattggcaggatgtagccaatcaaatgtgcaccaagaccaaggaggagtgtgagaagcactatatgaagcatttcatcaataaccctctgtttgcatctaccctgctgaacctgaaacaagcagaggaagcaaaaactgctgacacagccattccatttcactctacagatgaccctccccgacctacctttgactccttgctttctcgggacatggccgggtacatgccagctcgagcagatttcattgaggaatttgacaattatgcagaatgggacttgagagacattgattttgttgaagatgactcggacattttacatgctctgaagatggctgtggtagatatctatcattccaggttaaaggagagacaaagacgaaaaaaaattataagagaccatggattaatcaaccttagaaagtttcaattaatggaacggcggtatcccaaggaggtccaggacctgtatgaaacaatgaggcgatttgcaagaattgtggggccagtggaacatgacaaattcattgaaagccatgcattggaatttgaactccgaagggaaatcaagaggctccaagaatacaggacagcaggcattaccaatttttgtagtgccagaacctacgatcacctcaagaagacacgggaggaagagcgccttaaacgcactatgctctcagaagttctccagtatatccaggacagtagtgcttgccagcagtggctccgccggcaagctgacattgattccggcctgagtccttccattccaatggcttcgaattcaggtagacggagtgcaccacccttgaacctcactggcctccctggcacagagaagctgaatgaaaaagaaaaggagctctgtcagatggtgaggttggtccctggagcctatttagaatacaaatctgctctattgaacgaatgtaacaagcaaggaggcttaagactggcgcaggcaagagcactcatcaagatagatgtgaacaaaacccggaaaatctatgatttcctcatcagagaaggatacatcactaaaggctaaggctccaagagcttgggatcagaagtcagaagtttggaatgtggtgggtcaaaggacaatatgggtgggcattctggagagttgtttttcagctgaattctcatggtgaaaacaggggaaaggacaaaggaaaccttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6871 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6871 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:6871 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:6871 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: TAS
GeneID:6871 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:6871 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:6871 -> Biological process: GO:0001932 [regulation of protein phosphorylation] evidence: IEA
GeneID:6871 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6871 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:6871 -> Biological process: GO:0031063 [regulation of histone deacetylation] evidence: IEA
GeneID:6871 -> Biological process: GO:0031647 [regulation of protein stability] evidence: IEA
GeneID:6871 -> Biological process: GO:0043966 [histone H3 acetylation] evidence: IDA
GeneID:6871 -> Biological process: GO:0090043 [regulation of tubulin deacetylation] evidence: IEA
GeneID:6871 -> Cellular component: GO:0000125 [PCAF complex] evidence: IDA
GeneID:6871 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:6871 -> Cellular component: GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] evidence: IEA
GeneID:6871 -> Cellular component: GO:0005694 [chromosome] evidence: IEA
GeneID:6871 -> Cellular component: GO:0072686 [mitotic spindle] evidence: IEA
by
@meso_cacase at
DBCLS
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