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2019-03-23 03:36:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001402               3528 bp    mRNA    linear   PRI 12-MAY-2013
DEFINITION  Homo sapiens eukaryotic translation elongation factor 1 alpha 1
            (EEF1A1), mRNA.
ACCESSION   NM_001402
VERSION     NM_001402.5  GI:83367078
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Yu,X., Liu,X., Liu,T., Hong,K., Lei,J., Yuan,R. and Shao,J.
  TITLE     Identification of a novel binding protein of FAT10: eukaryotic
            translation elongation factor 1A1
  JOURNAL   Dig. Dis. Sci. 57 (9), 2347-2354 (2012)
   PUBMED   22569823
  REMARK    GeneRIF: This study identified eEF1A1 as a FAT10-specific binding
            protein, and when the expression of FAT10 was reduced by siRNA
            knockdown, this resulted in downregulation of eEF1A1 expression in
            hepatoma cells.
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Huang,Y., Hu,J.D., Qi,Y.L., Wu,Y.A., Zheng,J., Chen,Y.Y. and
            Huang,X.L.
  TITLE     [Effect of knocking down eEF1A1 gene on proliferation and apoptosis
            in Jurkat cells and its mechanisms]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (4), 835-841 (2012)
   PUBMED   22931638
  REMARK    GeneRIF: Knocking down eEF1A1 gene has noticeable effects on the
            proliferation inhibition and apoptosis induction of Jurkat cells.
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Lin,W.S., Jiao,B.Y., Wu,Y.L., Chen,W.N. and Lin,X.
  TITLE     Hepatitis B virus X protein blocks filamentous actin bundles by
            interaction with eukaryotic translation elongat ion factor 1 alpha
            1
  JOURNAL   J. Med. Virol. 84 (6), 871-877 (2012)
   PUBMED   22499008
  REMARK    GeneRIF: In Huh-7 hepatoma cells, the hepatitis B virus X protein
            inhibits dimer formation of eEF1A1, hence blocks filamentous actin
            bundling.
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Itagaki,K., Naito,T., Iwakiri,R., Haga,M., Miura,S., Saito,Y.,
            Owaki,T., Kamiya,S., Iyoda,T., Yajima,H., Iwashita,S., Ejiri,S. and
            Fukai,F.
  TITLE     Eukaryotic translation elongation factor 1A induces anoikis by
            triggering cell detachment
  JOURNAL   J. Biol. Chem. 287 (19), 16037-16046 (2012)
   PUBMED   22399298
  REMARK    GeneRIF: Results show a new function of eEF1A that contributes to
            cell regulation, including anoikis.
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Vui-Kee,K., Mohd Dali,A.Z., Mohamed Rose,I., Ghazali,R., Jamal,R.
            and Mokhtar,N.M.
  TITLE     Molecular markers associated with nonepithelial ovarian cancer in
            formalin-fixed, paraffin-embedded specimens by genome wide
            expression profiling
  JOURNAL   Kaohsiung J. Med. Sci. 28 (5), 243-250 (2012)
   PUBMED   22531302
  REMARK    GeneRIF: Overexpression of eukaryotic translation elongation factor
            1 alpha 1 is associated with nonepithelial ovarian cancer.
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
  TITLE     Retropseudogenes constitute the major part of the human elongation
            factor 1 alpha gene family
  JOURNAL   Nucleic Acids Res. 18 (6), 1513-1516 (1990)
   PUBMED   2183196
REFERENCE   7  (bases 1 to 3528)
  AUTHORS   Bec,G., Kerjan,P., Zha,X.D. and Waller,J.P.
  TITLE     Valyl-tRNA synthetase from rabbit liver. I. Purification as a
            heterotypic complex in association with elongation factor 1
  JOURNAL   J. Biol. Chem. 264 (35), 21131-21137 (1989)
   PUBMED   2556394
REFERENCE   8  (bases 1 to 3528)
  AUTHORS   Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
            Hart,G.W.
  TITLE     Murine elongation factor 1 alpha (EF-1 alpha) is
            posttranslationally modified by novel amide-linked
            ethanolamine-phosphoglycerol moieties. Addition of
            ethanolamine-phosphoglycerol to specific glutamic acid residues on
            EF-1 alpha
  JOURNAL   J. Biol. Chem. 264 (24), 14334-14341 (1989)
   PUBMED   2569467
REFERENCE   9  (bases 1 to 3528)
  AUTHORS   Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
  TITLE     Isolation and characterization of the human chromosomal gene for
            polypeptide chain elongation factor-1 alpha
  JOURNAL   J. Biol. Chem. 264 (10), 5791-5798 (1989)
   PUBMED   2564392
REFERENCE   10 (bases 1 to 3528)
  AUTHORS   Motorin,Yu.A., Wolfson,A.D., Orlovsky,A.F. and Gladilin,K.L.
  TITLE     Mammalian valyl-tRNA synthetase forms a complex with the first
            elongation factor
  JOURNAL   FEBS Lett. 238 (2), 262-264 (1988)
   PUBMED   3169261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC066893.1, AJ420488.1 and AL603910.6.
            On Dec 8, 2005 this sequence version replaced gi:25453469.
            
            Summary: This gene encodes an isoform of the alpha subunit of the
            elongation factor-1 complex, which is responsible for the enzymatic
            delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1)
            is expressed in brain, placenta, lung, liver, kidney, and pancreas,
            and the other isoform (alpha 2) is expressed in brain, heart and
            skeletal muscle. This isoform is identified as an autoantigen in
            66% of patients with Felty syndrome. This gene has been found to
            have multiple copies on many chromosomes, some of which, if not
            all, represent different pseudogenes. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066893.1, EF219140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1747              BC066893.1         1-1747
            1748-2631           AJ420488.1         1708-2591
            2632-2632           AL603910.6         110144-110144       c
            2633-3528           AJ420488.1         2593-3488
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..3528
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="eukaryotic translation elongation factor 1 alpha 1"
                     /db_xref="GeneID:1915"
                     /db_xref="HGNC:3189"
                     /db_xref="HPRD:00559"
                     /db_xref="MIM:130590"
     exon            1..33
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="predominant transcription initiation site"
     exon            34..207
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    40..42
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="upstream in-frame stop codon"
     CDS             64..1452
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="cervical cancer suppressor 3; eukaryotic
                     translation elongation factor 1 alpha 1-like 14; leukocyte
                     receptor cluster (LRC) member 7; CTCL tumor antigen;
                     prostate tumor-inducing protein 1; EF1a-like protein;
                     glucocorticoid receptor AF-1 specific elongation factor;
                     elongation factor 1 alpha subunit; elongation factor Tu;
                     EF-1-alpha-1; eukaryotic elongation factor 1 A-1;
                     leukocyte receptor cluster member 7"
                     /codon_start=1
                     /product="elongation factor 1-alpha 1"
                     /protein_id="NP_001393.1"
                     /db_xref="GI:4503471"
                     /db_xref="CCDS:CCDS4980.1"
                     /db_xref="GeneID:1915"
                     /db_xref="HGNC:3189"
                     /db_xref="HPRD:00559"
                     /db_xref="MIM:130590"
                     /translation="
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
"
     misc_feature    64..1359
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="elongation factor 1- alpha; Provisional; Region:
                     PTZ00141"
                     /db_xref="CDD:185474"
     misc_feature    88..777
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="Elongation Factor 1-alpha (EF1-alpha) protein
                     family; Region: EF1_alpha; cd01883"
                     /db_xref="CDD:206670"
     misc_feature    103..126
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    order(106..108,112..114,124..129,136..138,145..150,
                     289..294,346..351,418..423,568..570,580..582)
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:206670"
     misc_feature    order(112..114,118..129,520..525,529..531,643..651)
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206670"
     misc_feature    order(124..126,253..255,262..267,271..273,277..279,
                     283..291,295..297,328..330,334..336,340..348,352..354,
                     361..363)
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="EF1Balpha binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206670"
     misc_feature    226..228
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6,N6-dimethyllysine; propagated from
                     UniProtKB/Swiss-Prot (P68104.1); methylation site"
     misc_feature    259..291
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206670"
     misc_feature    277..279
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    319..321
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    334..345
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    340..396
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206670"
     misc_feature    520..531
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    556..558
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6,N6-dimethyllysine; propagated from
                     UniProtKB/Swiss-Prot (P68104.1); methylation site"
     misc_feature    643..651
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    763..765
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="S-nitrosylation site; modified site"
     misc_feature    787..1059
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="EF1_alpha_II: this family represents the domain II
                     of elongation factor 1-alpha (EF-1a) that is found in
                     archaea and all eukaryotic lineages. EF-1A is very
                     abundant in the cytosol, where it is involved in the
                     GTP-dependent binding of aminoacyl-tRNAs to...; Region:
                     EF1_alpha_II; cd03693"
                     /db_xref="CDD:239664"
     misc_feature    961..963
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by TGFBR1; propagated from
                     UniProtKB/Swiss-Prot (P68104.1); phosphorylation site"
     misc_feature    964..966
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="5-glutamyl glycerylphosphorylethanolamine;
                     propagated from UniProtKB/Swiss-Prot (P68104.1);
                     phosphorylation site"
     misc_feature    1066..1359
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /note="Domain III of EF-1. Eukaryotic elongation factor 1
                     (EF-1) is responsible for the GTP-dependent binding of
                     aminoacyl-tRNAs to ribosomes. EF-1 is composed of four
                     subunits: the alpha chain, which binds GTP and
                     aminoacyl-tRNAs, the gamma chain that probably...; Region:
                     EF1_alpha_III; cd03705"
                     /db_xref="CDD:239676"
     misc_feature    1183..1185
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="5-glutamyl glycerylphosphorylethanolamine;
                     propagated from UniProtKB/Swiss-Prot (P68104.1);
                     phosphorylation site"
     misc_feature    1294..1296
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glutathionylation site; modified site"
     misc_feature    1357..1359
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PASK; propagated from
                     UniProtKB/Swiss-Prot (P68104.1); phosphorylation site"
     misc_feature    1357..1359
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     STS             126..548
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="MARC_24185-24186:1034710364:1"
                     /db_xref="UniSTS:268853"
     exon            208..387
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     variation       326
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556658"
     variation       334
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11550816"
     variation       338
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550792"
     variation       355
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550789"
     variation       360
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556654"
     variation       365
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11550840"
     variation       366
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550851"
     variation       375
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11556662"
     variation       381
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11556702"
     variation       383
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550818"
     exon            388..684
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     STS             593..996
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="PMC26240P1"
                     /db_xref="UniSTS:272315"
     STS             594..996
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="GDB:632624"
                     /db_xref="UniSTS:158480"
     exon            685..835
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     variation       765
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11556692"
     STS             820..1657
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="EEF1A1_3552"
                     /db_xref="UniSTS:462171"
     exon            836..1092
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     STS             858..1532
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="ECD01636"
                     /db_xref="UniSTS:282737"
     exon            1093..1327
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     variation       1135
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11550843"
     STS             1139..2102
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="stSG625947"
                     /db_xref="UniSTS:457113"
     STS             1253..1386
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="RH47178"
                     /db_xref="UniSTS:90057"
     exon            1328..3512
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /inference="alignment:Splign:1.39.8"
     STS             1344..1502
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="SHGC-178"
                     /db_xref="UniSTS:91474"
     STS             1351..1477
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="RH65848"
                     /db_xref="UniSTS:84955"
     STS             1375..1532
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="EEF1A1"
                     /db_xref="UniSTS:278329"
     STS             1457..1731
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="D1S3313"
                     /db_xref="UniSTS:63106"
     STS             1513..1717
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="GDB:555019"
                     /db_xref="UniSTS:157667"
     STS             1603..2470
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="ECD01365"
                     /db_xref="UniSTS:282471"
     polyA_signal    1726..1731
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
     STS             1738..1963
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33105"
                     /db_xref="UniSTS:357905"
     STS             1740..1992
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33104"
                     /db_xref="UniSTS:357904"
     polyA_site      1747
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="predominant polyadenylation site"
     STS             1966..2215
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33103"
                     /db_xref="UniSTS:357903"
     STS             2083..3135
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="stSG625946"
                     /db_xref="UniSTS:457112"
     STS             2214..2461
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33102"
                     /db_xref="UniSTS:357902"
     variation       2318
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41501347"
     STS             2459..2724
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33101"
                     /db_xref="UniSTS:357901"
     STS             2701..2969
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33100"
                     /db_xref="UniSTS:357900"
     variation       2740
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1128073"
     STS             2741..2845
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="D11S2560"
                     /db_xref="UniSTS:37928"
     STS             2924..3152
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33099"
                     /db_xref="UniSTS:357899"
     STS             3041..3272
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="REN33098"
                     /db_xref="UniSTS:357898"
     STS             3056..3274
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
                     /standard_name="STS-W63684"
                     /db_xref="UniSTS:65109"
     polyA_signal    3490..3495
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
     polyA_site      3512
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
ORIGIN      
ctttttcgcaacgggtttgccgccagaacacaggtgtcgtgaaaactacccctaaaagccaaaatgggaaaggaaaagactcatatcaacattgtcgtcattggacacgtagattcgggcaagtccaccactactggccatctgatctataaatgcggtggcatcgacaaaagaaccattgaaaaatttgagaaggaggctgctgagatgggaaagggctccttcaagtatgcctgggtcttggataaactgaaagctgagcgtgaacgtggtatcaccattgatatctccttgtggaaatttgagaccagcaagtactatgtgactatcattgatgccccaggacacagagactttatcaaaaacatgattacagggacatctcaggctgactgtgctgtcctgattgttgctgctggtgttggtgaatttgaagctggtatctccaagaatgggcagacccgagagcatgcccttctggcttacacactgggtgtgaaacaactaattgtcggtgttaacaaaatggattccactgagccaccctacagccagaagagatatgaggaaattgttaaggaagtcagcacttacattaagaaaattggctacaaccccgacacagtagcatttgtgccaatttctggttggaatggtgacaacatgctggagccaagtgctaacatgccttggttcaagggatggaaagtcacccgtaaggatggcaatgccagtggaaccacgctgcttgaggctctggactgcatcctaccaccaactcgtccaactgacaagcccttgcgcctgcctctccaggatgtctacaaaattggtggtattggtactgttcctgttggccgagtggagactggtgttctcaaacccggtatggtggtcacctttgctccagtcaacgttacaacggaagtaaaatctgtcgaaatgcaccatgaagctttgagtgaagctcttcctggggacaatgtgggcttcaatgtcaagaatgtgtctgtcaaggatgttcgtcgtggcaacgttgctggtgacagcaaaaatgacccaccaatggaagcagctggcttcactgctcaggtgattatcctgaaccatccaggccaaataagcgccggctatgcccctgtattggattgccacacggctcacattgcatgcaagtttgctgagctgaaggaaaagattgatcgccgttctggtaaaaagctggaagatggccctaaattcttgaagtctggtgatgctgccattgttgatatggttcctggcaagcccatgtgtgttgagagcttctcagactatccacctttgggtcgctttgctgttcgtgatatgagacagacagttgcggtgggtgtcatcaaagcagtggacaagaaggctgctggagctggcaaggtcaccaagtctgcccagaaagctcagaaggctaaatgaatattatccctaatacctgccaccccactcttaatcagtggtggaagaacggtctcagaactgtttgtttcaattggccatttaagtttagtagtaaaagactggttaatgataacaatgcatcgtaaaaccttcagaaggaaaggagaatgttttgtggaccactttggttttcttttttgcgtgtggcagttttaagttattagtttttaaaatcagtactttttaatggaaacaacttgaccaaaaatttgtcacagaattttgagacccattaaaaaagttaaatgagaaacctgtgtgttcctttggtcaacaccgagacatttaggtgaaagacatctaattctggttttacgaatctggaaacttcttgaaaatgtaattcttgagttaacacttctgggtggagaatagggttgttttccccccacataattggaaggggaaggaatatcatttaaagctatgggagggttgctttgattacaacactggagagaaatgcagcatgttgctgattgcctgtcactaaaacaggccaaaaactgagtccttgtgttgcatagaaagcttcatgttgctaaaccaatgttaagtgaatctttggaaacaaaatgtttccaaattactgggatgtgcatgttgaaacgtgggttaaaatgactgggcagtgaaagttgactatttgccatgacataagaaataagtgtagtggctagtgtacaccctatgagtggaagggtccattttgaagtcagtggagtaagctttatgccagtttgatggtttcacaagttctattgagtgctattcagaataggaacaaggttctaatagaaaaagatggcaatttgaagtagctataaaattagactaatctacattgcttttctcctgcagagtctaataccttttatgctttgataattagcagtttgtctacttggtcactaggaatgaaactacatggtaataggcttaacaggtgtaatagcccacttactcctgaatctttaagcatttgtgcatttgaaaaatgcttttcgcgatcttcctgctgggattacaggcatgagccactgtgcctgacctcccatatgtaaaagtgtctaaaggtttttttttggttataaaaggaaaatttttgcttaagtttgaaggataggtaaaattaaaggacatgctttctgtttgtgtgatggtttttaaaaattttttttaagatggagttcttgttgcccaggctagaatgcaatggcaaaatctcactgcaatctcctcctcctgggttcaagcaattctcctacttcagcctcccaagtagctgggattacaggcatgtgctaatttggtgtttttaatagagatgaggtttttccatgttggtcaggctggtctcaaactcctgaccttaggtgatcgcctcggcctcctaaagtgctggaattacaggcatgagccaccatgcctggccaggacatgtgttcttaaggacatgctaagcaggagttaaagcagcccaagagataaggcctcttaaagtgactggcaatgtgtattgctcaagattcaaaggtacttgaattggccatagacaagtctgtaatgaagtgttatcgttttccctcatctgagtctgaattagataaaatgccttcccatcagccagtgctctgaggtatcaagtctaaattgaactagagatttttgtccttagtttctttgctatctaatgtttacacaagtaaatagtctaagatttgctggatgacagaaaaaacaggtaaggcctttaatagatggccaatagatgccctgataatgaaagttgacacctgtaagatttaccagtagagaattcttgacatgcaaggaagcaagatttaactgaaaaattgttcccactggaagcaggaatgagtcagtttacttgcatatactgagattgagattaacttcctgtgaaacccagtgtcttagacaactgtggcttgagcaccacctgctggtattcattacaaacttgctcactacaataaatgaattttaagctttaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1915 -> Molecular function: GO:0003746 [translation elongation factor activity] evidence: TAS
            GeneID:1915 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
            GeneID:1915 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1915 -> Molecular function: GO:0005525 [GTP binding] evidence: TAS
            GeneID:1915 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:1915 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:1915 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:1915 -> Biological process: GO:0006412 [translation] evidence: TAS
            GeneID:1915 -> Biological process: GO:0006414 [translational elongation] evidence: TAS
            GeneID:1915 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:1915 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:1915 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:1915 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
            GeneID:1915 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
            GeneID:1915 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:1915 -> Cellular component: GO:0005853 [eukaryotic translation elongation factor 1 complex] evidence: TAS
            GeneID:1915 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA

by @meso_cacase at DBCLS
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