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2024-03-29 15:48:38, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001359               1251 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens 2,4-dienoyl CoA reductase 1, mitochondrial (DECR1),
            mRNA.
ACCESSION   NM_001359
VERSION     NM_001359.1  GI:4503300
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Chen Z, Tang H, Qayyum R, Schick UM, Nalls MA, Handsaker R, Li J,
            Lu Y, Yanek LR, Keating B, Meng Y, van Rooij FJ, Okada Y, Kubo M,
            Rasmussen-Torvik L, Keller MF, Lange L, Evans M, Bottinger EP,
            Linderman MD, Ruderfer DM, Hakonarson H, Papanicolaou G, Zonderman
            AB, Gottesman O, Thomson C, Ziv E, Singleton AB, Loos RJ, Sleiman
            PM, Ganesh S, McCarroll S, Becker DM, Wilson JG, Lettre G and
            Reiner AP.
  CONSRTM   BioBank Japan Project; CHARGE Consortium
  TITLE     Genome-wide association analysis of red blood cell traits in
            African Americans: the COGENT Network
  JOURNAL   Hum. Mol. Genet. 22 (12), 2529-2538 (2013)
   PUBMED   23446634
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
            Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
  TITLE     Proteomic analysis identifies dysfunction in cellular transport,
            energy, and protein metabolism in different brain regions of
            atypical frontotemporal lobar degeneration
  JOURNAL   J. Proteome Res. 11 (4), 2533-2543 (2012)
   PUBMED   22360420
  REMARK    GeneRIF: A protein encoded by this locus was found to be
            differentially expressed in postmortem brains from patients with
            atypical frontotemporal lobar degeneration.
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS ONE 5 (9), E12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Hosgood,H.D. III, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Moe,K.T., Woon,F.P., De Silva,D.A., Wong,P., Koh,T.H., Kingwell,B.,
            Chin-Dusting,J. and Wong,M.C.
  TITLE     Association of acute ischemic stroke with the MTHFR C677T
            polymorphism but not with NOS3 gene polymorphisms in a Singapore
            population
  JOURNAL   Eur. J. Neurol. 15 (12), 1309-1314 (2008)
   PUBMED   19049547
  REMARK    GeneRIF: The TT genotype of C677T polymorphism in the MTHFR gene
            contributes to genetic susceptibility of acute ischemic stroke in a
            Singapore population.
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   Koivuranta,K.T., Hakkola,E.H. and Hiltunen,J.K.
  TITLE     Isolation and characterization of cDNA for human 120 kDa
            mitochondrial 2,4-dienoyl-coenzyme A reductase
  JOURNAL   Biochem. J. 304 (PT 3), 787-792 (1994)
   PUBMED   7818482
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Luo,M.J., Smeland,T.E., Shoukry,K. and Schulz,H.
  TITLE     Delta 3,5, delta 2,4-dienoyl-CoA isomerase from rat liver
            mitochondria. Purification and characterization of a new enzyme
            involved in the beta-oxidation of unsaturated fatty acids
  JOURNAL   J. Biol. Chem. 269 (4), 2384-2388 (1994)
   PUBMED   8300563
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Smeland,T.E., Nada,M., Cuebas,D. and Schulz,H.
  TITLE     NADPH-dependent beta-oxidation of unsaturated fatty acids with
            double bonds extending from odd-numbered carbon atoms
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (15), 6673-6677 (1992)
   PUBMED   1495956
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Nishimaki-Mogami,T., Tanaka,A., Minegishi,K. and Takahashi,A.
  TITLE     Effect of sorbic acid feeding on peroxisomes and sorboyl-CoA
            metabolizing enzymes in mouse liver. Selective induction of
            2,4-dienoyl-CoA hydratase
  JOURNAL   Biochem. Pharmacol. 42 (2), 239-246 (1991)
   PUBMED   1859445
REFERENCE   10 (bases 1 to 1251)
  AUTHORS   Dommes,V., Baumgart,C. and Kunau,W.H.
  TITLE     Degradation of unsaturated fatty acids in peroxisomes. Existence of
            a 2,4-dienoyl-CoA reductase pathway
  JOURNAL   J. Biol. Chem. 256 (16), 8259-8262 (1981)
   PUBMED   7263650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF049895.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes an accessory enzyme which participates
            in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA
            esters. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26050.1, BC105080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50648             AF049895.3         72504-123151
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..1251
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="2,4-dienoyl CoA reductase 1, mitochondrial"
                     /db_xref="GeneID:1666"
                     /db_xref="HGNC:2753"
                     /db_xref="HPRD:01959"
                     /db_xref="MIM:222745"
     exon            1..210
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:67780505"
     variation       6
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184703398"
     misc_feature    43..45
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="upstream in-frame stop codon"
     STS             54..1172
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /db_xref="UniSTS:486004"
     variation       66
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375348015"
     variation       92..93
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:147877313"
     variation       99..100
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:72368577"
     variation       106
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370976343"
     variation       126
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201183578"
     variation       128
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370712697"
     variation       140
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145402130"
     CDS             142..1149
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /EC_number="1.3.1.34"
                     /note="4-enoyl-CoA reductase; short chain
                     dehydrogenase/reductase family 18C, member 1;
                     2,4-dienoyl-CoA reductase, mitochondrial"
                     /codon_start=1
                     /product="2,4-dienoyl-CoA reductase, mitochondrial
                     precursor"
                     /protein_id="NP_001350.1"
                     /db_xref="GI:4503301"
                     /db_xref="CCDS:CCDS6250.1"
                     /db_xref="GeneID:1666"
                     /db_xref="HGNC:2753"
                     /db_xref="HPRD:01959"
                     /db_xref="MIM:222745"
                     /translation="
MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
"
     transit_peptide 142..243
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
     mat_peptide     244..1146
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /product="2,4-dienoyl-CoA reductase, mitochondrial"
     misc_feature    310..1050
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="Trans-2-enoyl-CoA reductase (TER) and
                     2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR;
                     Region: TER_DECR_SDR_a; cd05369"
                     /db_xref="CDD:187627"
     misc_feature    310..1047
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="short chain dehydrogenase; Provisional; Region:
                     PRK07576"
                     /db_xref="CDD:181043"
     misc_feature    order(337..339,346..354,409..417,487..498,571..579,
                     640..642,724..732,781..783,859..870,874..876)
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:187627"
     misc_feature    order(412..414,496..498,577..588,610..612,616..621,
                     628..630,730..732,736..738,769..771,865..867)
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:187627"
     misc_feature    order(502..504,595..603,607..615,622..627,634..636,
                     646..651,658..663,670..672,682..684,691..693,706..708,
                     736..738,748..759,763..765,772..777,784..789,796..801,
                     805..828,832..834,865..867,937..945,949..957,967..969,
                     976..981,988..990,1003..1005,1009..1026,1030..1050)
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187627"
     misc_feature    order(583..585,736..738,769..771,781..783)
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="active site"
                     /db_xref="CDD:187627"
     misc_feature    order(595..603,607..609,622..627,634..636,649..651,
                     658..663,748..759,763..765,772..777,784..789,796..801,
                     808..810,817..822)
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187627"
     misc_feature    829..831
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q16698.1); acetylation site"
     variation       153
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147670454"
     variation       157
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374823507"
     variation       196
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:68060600"
     variation       205
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140706902"
     exon            211..413
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       218
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145323335"
     variation       271..272
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:72124473"
     variation       277
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376358991"
     variation       301..302
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:72095930"
     variation       310
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11548761"
     variation       315
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145066522"
     variation       318..319
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="a"
                     /replace="gc"
                     /db_xref="dbSNP:66849191"
     variation       330..331
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:71832266"
     variation       332..333
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:72423978"
     STS             350..502
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /standard_name="MARC_4379-4380:991938522:3"
                     /db_xref="UniSTS:231085"
     variation       351..352
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:72384318"
     variation       380..381
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:72228477"
     variation       387
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149094047"
     variation       391
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143138588"
     variation       394..395
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:71891540"
     variation       399
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149901486"
     variation       412
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368779502"
     exon            414..471
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       418
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374362672"
     exon            472..558
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       493
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202215448"
     variation       500
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151187801"
     variation       507
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138725804"
     variation       509
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192012718"
     variation       534
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145305482"
     exon            559..706
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       573
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137904244"
     variation       640
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142348077"
     variation       662
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190568496"
     variation       663
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143170054"
     variation       664
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372630127"
     exon            707..806
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       712
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138952950"
     variation       732
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368539700"
     variation       803..804
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:67418874"
     exon            807..879
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       842
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137876000"
     variation       854
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367738392"
     exon            880..1026
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       885
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149423653"
     variation       893
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144788496"
     variation       949
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372913734"
     variation       952
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:10235"
     STS             954..1230
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /standard_name="RH18400"
                     /db_xref="UniSTS:40291"
     variation       954
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375878524"
     variation       992
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370430849"
     variation       999..1000
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="aca"
                     /db_xref="dbSNP:199693288"
     variation       1001
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148549954"
     variation       1004
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181636748"
     variation       1024
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201405525"
     exon            1027..1089
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       1031
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9495"
     variation       1061..1062
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:72163359"
     variation       1074..1075
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:72410629"
     variation       1077
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377574337"
     exon            1090..1251
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:1.39.8"
     variation       1139
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111307450"
     variation       1140
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:15094"
     variation       1142
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200122846"
     variation       1150
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7162"
     variation       1169
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112034915"
     variation       1170
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149321434"
     variation       1212
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375403201"
     polyA_signal    1234..1239
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
ORIGIN      
acgccgcctgggtcccagtccccgtcccatcccccggcggcctaggcagcgtttccagccccgagaactttgttctttttgtcccgccccctgcgcccaaccgcctgcgccgccttccggcccgagttctggagactcaacatgaagctaccggccagggttttctttactctggggtcccggctgccctgtggcctcgctcctcggaggtttttcagttatgggacaaaaatattatatcaaaacactgaagctttgcaatctaaattcttttcacctcttcaaaaagcgatgctaccacctaatagttttcaaggaaaagtggcattcattactgggggaggtactggccttggtaaaggaatgacaactcttctgtccagcctaggtgctcagtgcgtgatagccagccggaagatggatgttttgaaagctaccgcagaacaaatttcttctcaaactggaaataaggttcatgcaattcagtgtgatgtgagggatcctgatatggttcaaaacactgtgtcagaactgatcaaagttgcaggacatcctaatattgtgataaacaatgcagcagggaattttatttctcctactgaaagactttctcctaatgcttggaaaaccataactgacatagttctaaatggcacagccttcgtgacactagaaattggaaaacaactaattaaagcacagaaaggagcagcatttctttctattactactatctatgctgagactggttcaggttttgtagtaccaagtgcttctgccaaagcaggtgtggaagccatgagcaagtctcttgcagctgaatggggtaaatatggaatgcgattcaatgtgattcaaccagggcctataaaaaccaaaggtgcctttagccgtctggacccaactggaacatttgagaaagaaatgattggcagaattccctgtggtcgcctggggactgtagaagaactcgcaaatcttgctgctttcctttgtagtgattatgcttcttggattaatggagcagtcattaaatttgacggtggagaggaagtacttatttcaggggaattcaacgacctgagaaaggtcaccaaggagcagtgggacaccatagaagaactcatcaggaagacaaaaggttcctaagaccactttggccttcatcttggttacagaaaagggaatagaaatgaaacaaattatctctcatcttttgactatttcaagtctaataaattcttaattaac
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1666 -> Molecular function: GO:0008670 [2,4-dienoyl-CoA reductase (NADPH) activity] evidence: IDA
            GeneID:1666 -> Molecular function: GO:0016651 [oxidoreductase activity, acting on NAD(P)H] evidence: TAS
            GeneID:1666 -> Molecular function: GO:0070402 [NADPH binding] evidence: IDA
            GeneID:1666 -> Biological process: GO:0006635 [fatty acid beta-oxidation] evidence: IDA
            GeneID:1666 -> Biological process: GO:0006635 [fatty acid beta-oxidation] evidence: TAS
            GeneID:1666 -> Biological process: GO:0044255 [cellular lipid metabolic process] evidence: TAS
            GeneID:1666 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:1666 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IDA
            GeneID:1666 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:1666 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:1666 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:1666 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:1666 -> Cellular component: GO:0005739 [mitochondrion] evidence: NAS
            GeneID:1666 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001350 -> EC 1.3.1.34

by @meso_cacase at DBCLS
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