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2024-04-25 19:39:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001343 4617 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens Dab, mitogen-responsive phosphoprotein, homolog 2
(Drosophila) (DAB2), transcript variant 1, mRNA.
ACCESSION NM_001343
VERSION NM_001343.3 GI:349585057
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4617)
AUTHORS Kottgen,A., Albrecht,E., Teumer,A., Vitart,V., Krumsiek,J.,
Hundertmark,C., Pistis,G., Ruggiero,D., O'Seaghdha,C.M., Haller,T.,
Yang,Q., Tanaka,T., Johnson,A.D., Kutalik,Z., Smith,A.V., Shi,J.,
Struchalin,M., Middelberg,R.P., Brown,M.J., Gaffo,A.L., Pirastu,N.,
Li,G., Hayward,C., Zemunik,T., Huffman,J., Yengo,L., Zhao,J.H.,
Demirkan,A., Feitosa,M.F., Liu,X., Malerba,G., Lopez,L.M., van der
Harst,P., Li,X., Kleber,M.E., Hicks,A.A., Nolte,I.M., Johansson,A.,
Murgia,F., Wild,S.H., Bakker,S.J., Peden,J.F., Dehghan,A.,
Steri,M., Tenesa,A., Lagou,V., Salo,P., Mangino,M., Rose,L.M.,
Lehtimaki,T., Woodward,O.M., Okada,Y., Tin,A., Muller,C.,
Oldmeadow,C., Putku,M., Czamara,D., Kraft,P., Frogheri,L.,
Thun,G.A., Grotevendt,A., Gislason,G.K., Harris,T.B., Launer,L.J.,
McArdle,P., Shuldiner,A.R., Boerwinkle,E., Coresh,J., Schmidt,H.,
Schallert,M., Martin,N.G., Montgomery,G.W., Kubo,M., Nakamura,Y.,
Tanaka,T., Munroe,P.B., Samani,N.J., Jacobs,D.R. Jr., Liu,K.,
D'Adamo,P., Ulivi,S., Rotter,J.I., Psaty,B.M., Vollenweider,P.,
Waeber,G., Campbell,S., Devuyst,O., Navarro,P., Kolcic,I.,
Hastie,N., Balkau,B., Froguel,P., Esko,T., Salumets,A., Khaw,K.T.,
Langenberg,C., Wareham,N.J., Isaacs,A., Kraja,A., Zhang,Q.,
Wild,P.S., Scott,R.J., Holliday,E.G., Org,E., Viigimaa,M.,
Bandinelli,S., Metter,J.E., Lupo,A., Trabetti,E., Sorice,R.,
Doring,A., Lattka,E., Strauch,K., Theis,F., Waldenberger,M.,
Wichmann,H.E., Davies,G., Gow,A.J., Bruinenberg,M., Stolk,R.P.,
Kooner,J.S., Zhang,W., Winkelmann,B.R., Boehm,B.O., Lucae,S.,
Penninx,B.W., Smit,J.H., Curhan,G., Mudgal,P., Plenge,R.M.,
Portas,L., Persico,I., Kirin,M., Wilson,J.F., Mateo Leach,I., van
Gilst,W.H., Goel,A., Ongen,H., Hofman,A., Rivadeneira,F.,
Uitterlinden,A.G., Imboden,M., von Eckardstein,A., Cucca,F.,
Nagaraja,R., Piras,M.G., Nauck,M., Schurmann,C., Budde,K.,
Ernst,F., Farrington,S.M., Theodoratou,E., Prokopenko,I.,
Stumvoll,M., Jula,A., Perola,M., Salomaa,V., Shin,S.Y.,
Spector,T.D., Sala,C., Ridker,P.M., Kahonen,M., Viikari,J.,
Hengstenberg,C., Nelson,C.P., Meschia,J.F., Nalls,M.A., Sharma,P.,
Singleton,A.B., Kamatani,N., Zeller,T., Burnier,M., Attia,J.,
Laan,M., Klopp,N., Hillege,H.L., Kloiber,S., Choi,H., Pirastu,M.,
Tore,S., Probst-Hensch,N.M., Volzke,H., Gudnason,V., Parsa,A.,
Schmidt,R., Whitfield,J.B., Fornage,M., Gasparini,P.,
Siscovick,D.S., Polasek,O., Campbell,H., Rudan,I., Bouatia-Naji,N.,
Metspalu,A., Loos,R.J., van Duijn,C.M., Borecki,I.B., Ferrucci,L.,
Gambaro,G., Deary,I.J., Wolffenbuttel,B.H., Chambers,J.C., Marz,W.,
Pramstaller,P.P., Snieder,H., Gyllensten,U., Wright,A.F., Navis,G.,
Watkins,H., Witteman,J.C., Sanna,S., Schipf,S., Dunlop,M.G.,
Tonjes,A., Ripatti,S., Soranzo,N., Toniolo,D., Chasman,D.I.,
Raitakari,O., Kao,W.H., Ciullo,M., Fox,C.S., Caulfield,M.,
Bochud,M. and Gieger,C.
CONSRTM LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
ICBP Consortium; MAGIC Consortium
TITLE Genome-wide association analyses identify 18 new loci associated
with serum urate concentrations
JOURNAL Nat. Genet. 45 (2), 145-154 (2013)
PUBMED 23263486
REFERENCE 2 (bases 1 to 4617)
AUTHORS Yang,Y., Zhang,Q., Xu,F., Chang,C. and Li,X.
TITLE Aberrant promoter methylation of Dab2 gene in myelodysplastic
syndrome
JOURNAL Eur. J. Haematol. 89 (6), 469-477 (2012)
PUBMED 23005040
REMARK GeneRIF: The Dab2 gene is inactivated in part by DNA methylation,
and the suppression of Dab2 expression by DNA methylation may play
a role in the development of myelodysplastic syndrome.
REFERENCE 3 (bases 1 to 4617)
AUTHORS Xiao,S., Charonko,J.J., Fu,X., Salmanzadeh,A., Davalos,R.V.,
Vlachos,P.P., Finkielstein,C.V. and Capelluto,D.G.
TITLE Structure, sulfatide binding properties, and inhibition of platelet
aggregation by a disabled-2 protein-derived peptide
JOURNAL J. Biol. Chem. 287 (45), 37691-37702 (2012)
PUBMED 22977233
REMARK GeneRIF: Data indicate that disabled-2 (Dab2) sulfatide-binding
motif contains two helices when embedded in micelles, reversibly
binds to sulfatides with moderate affinity, lies parallel to the
micelle surface.
REFERENCE 4 (bases 1 to 4617)
AUTHORS Hung,W.S., Huang,C.L., Fan,J.T., Huang,D.Y., Yeh,C.F., Cheng,J.C.
and Tseng,C.P.
TITLE The endocytic adaptor protein Disabled-2 is required for cellular
uptake of fibrinogen
JOURNAL Biochim. Biophys. Acta 1823 (10), 1778-1788 (2012)
PUBMED 22705885
REMARK GeneRIF: These findings thereby define an adaptor-specific
mechanism in the control of fibrinogen uptake and implicate that
DAB2 is the key adaptor in the clathrin-associated endocytic
complexes to mediate fibrinogen internalization.
REFERENCE 5 (bases 1 to 4617)
AUTHORS Kim,J.D., Kang,H., Larrivee,B., Lee,M.Y., Mettlen,M., Schmid,S.L.,
Roman,B.L., Qyang,Y., Eichmann,A. and Jin,S.W.
TITLE Context-dependent proangiogenic function of bone morphogenetic
protein signaling is mediated by disabled homolog 2
JOURNAL Dev. Cell 23 (2), 441-448 (2012)
PUBMED 22898784
REMARK GeneRIF: inhibition of Dab2 decreases phosphorylation of SMAD-1, 5,
and 8
REFERENCE 6 (bases 1 to 4617)
AUTHORS Fazili,Z., Sun,W., Mittelstaedt,S., Cohen,C. and Xu,X.X.
TITLE Disabled-2 inactivation is an early step in ovarian tumorigenicity
JOURNAL Oncogene 18 (20), 3104-3113 (1999)
PUBMED 10340382
REFERENCE 7 (bases 1 to 4617)
AUTHORS Mok,S.C., Chan,W.Y., Wong,K.K., Cheung,K.K., Lau,C.C., Ng,S.W.,
Baldini,A., Colitti,C.V., Rock,C.O. and Berkowitz,R.S.
TITLE DOC-2, a candidate tumor suppressor gene in human epithelial
ovarian cancer
JOURNAL Oncogene 16 (18), 2381-2387 (1998)
PUBMED 9620555
REFERENCE 8 (bases 1 to 4617)
AUTHORS Xu,X.X., Yi,T., Tang,B. and Lambeth,J.D.
TITLE Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
JOURNAL Oncogene 16 (12), 1561-1569 (1998)
PUBMED 9569023
REFERENCE 9 (bases 1 to 4617)
AUTHORS Albertsen,H.M., Smith,S.A., Melis,R., Williams,B., Holik,P.,
Stevens,J. and White,R.
TITLE Sequence, genomic structure, and chromosomal assignment of human
DOC-2
JOURNAL Genomics 33 (2), 207-213 (1996)
PUBMED 8660969
REFERENCE 10 (bases 1 to 4617)
AUTHORS Mok,S.C., Wong,K.K., Chan,R.K., Lau,C.C., Tsao,S.W., Knapp,R.C. and
Berkowitz,R.S.
TITLE Molecular cloning of differentially expressed genes in human
epithelial ovarian cancer
JOURNAL Gynecol. Oncol. 52 (2), 247-252 (1994)
PUBMED 8314147
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB989218.1, AK314381.1,
U53446.1, AF188298.1, AK130136.1 and AI739507.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 5, 2011 this sequence version replaced gi:148491081.
Summary: This gene encodes a mitogen-responsive phosphoprotein. It
is expressed in normal ovarian epithelial cells, but is
down-regulated or absent from ovarian carcinoma cell lines,
suggesting its role as a tumor suppressor. This protein binds to
the SH3 domains of GRB2, an adaptor protein that couples tyrosine
kinase receptors to SOS (a guanine nucleotide exchange factor for
Ras), via its C-terminal proline-rich sequences, and may thus
modulate growth factor/Ras pathways by competing with SOS for
binding to GRB2. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Oct 2011].
Transcript Variant: This variant (1) represents the predominant
transcript, and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U53446.1, BC003064.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-412 CB989218.1 28-439
413-2044 AK314381.1 161-1792
2045-3123 U53446.1 1658-2736
3124-3237 AF188298.1 2618-2731
3238-4597 AK130136.1 1248-2607
4598-4617 AI739507.1 1-20 c
FEATURES Location/Qualifiers
source 1..4617
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p13"
gene 1..4617
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/note="Dab, mitogen-responsive phosphoprotein, homolog 2
(Drosophila)"
/db_xref="GeneID:1601"
/db_xref="HGNC:2662"
/db_xref="MIM:601236"
exon 1..430
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 104
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:3756456"
misc_feature 421..423
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/note="upstream in-frame stop codon"
exon 431..622
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
STS 454..580
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/standard_name="SGC34152"
/db_xref="UniSTS:59438"
variation 461
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:1050903"
CDS 532..2844
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/note="isoform 1 is encoded by transcript variant 1;
disabled homolog 2, mitogen-responsive phosphoprotein;
differentially-expressed protein 2"
/codon_start=1
/product="disabled homolog 2 isoform 1"
/protein_id="NP_001334.2"
/db_xref="GI:148491082"
/db_xref="CCDS:CCDS34149.1"
/db_xref="GeneID:1601"
/db_xref="HGNC:2662"
/db_xref="MIM:601236"
/translation="
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
"
misc_feature 601..603
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01499"
misc_feature 601..603
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01501"
misc_feature 601..603
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01502"
misc_feature 655..1041
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
misc_feature order(673..696,802..822,829..849,895..909,928..942,
967..981,1000..1026)
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/note="PH-like core; other site"
/db_xref="CDD:176275"
misc_feature 1192..1194
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1210..1212
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1219..1872
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Required for localization to clathrin-coated pits
(By similarity)"
misc_feature 1408..1416
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: DPF 1"
misc_feature 1423..1431
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: DPF 2"
misc_feature 1555..1557
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1708..1710
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1711..1713
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1732..1734
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P98082.3); phosphorylation site"
misc_feature 1732..1734
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1732..1734
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1795..1797
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2341..2727
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Sufficient for interaction with GRB2 (By
similarity)"
misc_feature 2386..2412
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Required for interaction with CSK (By similarity)"
misc_feature 2476..2841
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Required for interaction with MYO6 (By
similarity)"
misc_feature 2518..2544
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Required for interaction with GRB2 and CSK (By
similarity)"
misc_feature 2656..2706
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98082.3);
Region: Sufficient for interaction with SH3KBP1 SH3 domain
(By similarity)"
exon 623..762
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 672
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050907"
exon 763..861
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 775..776
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2738230"
exon 862..993
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 973
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131363"
exon 994..1074
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 1075..1101
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 1102..1155
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 1156..1218
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 1219..1872
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 1367
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1802925"
STS 1409..1820
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/standard_name="DAB2"
/db_xref="UniSTS:505776"
exon 1873..2035
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 2036..2668
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 2432
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3733801"
exon 2669..2778
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 2779..2849
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
exon 2850..4601
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/inference="alignment:Splign:1.39.8"
variation 2876
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:9487"
variation 2959
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1802927"
STS 3025..3183
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/standard_name="G54013"
/db_xref="UniSTS:109395"
polyA_signal 3055..3060
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
polyA_site 3080
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
variation 3124
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:4578"
polyA_signal 3218..3223
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
polyA_site 3237
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
STS 3324..3600
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/standard_name="RH67769"
/db_xref="UniSTS:74049"
variation 3388
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1802926"
variation 3631
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200337444"
variation 3645..3646
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace=""
/replace="a"
/replace="aaa"
/db_xref="dbSNP:4018989"
STS 4208..4327
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/standard_name="RH103057"
/db_xref="UniSTS:97391"
variation 4227
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046033"
variation 4445
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2738240"
variation 4457
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2738241"
variation 4515
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2738242"
polyA_signal 4551..4556
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
polyA_signal 4577..4582
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
polyA_site 4601
/gene="DAB2"
/gene_synonym="DOC-2; DOC2"
ORIGIN
gtccttatttgcacccgccccccgcccgcgtcggtctggggcttttgacttctccccgaacacatttcccctcccgtcgctgggtccctgcgatcgcccccagctggtggggctcgcggagctcaggggagcggggtcctctgcgccgctgcagcgcgagttaataaacagttaagtttggaagactctgcagacacgttgagggggagttaccaagcccaggcagcaaaaacatcctggcacattcctggggagtcctcagctgccagcatctgattagaaccatatctctcgccgggagtggccgcgcggctccgaagctcccggccggcggctatttaagcgaggcccgccgcatccgctgcgctgtagcctggaggctccgggcgcggggaagtcatgctcgcttcacggaggcaatagctagccggtgtctgtgggaggttatgtttatttgagacttctccatcgggatcgcctggtgtcaccaagtgtccactggtactgaggtttgctgcctgccttcttgccatgtctaacgaagtagaaacaagtgcaaccaatggtcagcccgaccaacaggccgcaccaaaagcaccctcaaagaaggaaaaaaagaaaggccctgaaaagacagatgaatatctcttagcaaggttcaaaggcgatggtgtaaaatataaggccaagctgattggcattgatgatgtgccagatgcaagaggggataaaatgagccaagactctatgatgaaactaaagggaatggcggcagctggtcggtctcagggacaacacaaacaaaggatctgggtcaacatttccctttctgggataaaaataattgatgagaaaactggggtaatagagcatgaacatccagtaaataagatttctttcattgcccgtgatgtgacagacaaccgggcatttggttacgtgtgtggaggagaaggccagcatcagttttttgccataaaaaccgggcaacaggctgaaccattagttgttgatcttaaagacctttttcaagttatctataatgtaaagaaaaaggaagaagaaaagaaaaagatagaggaagccagcaaagcagttgagaatgggagtgaggccctaatgattctagatgaccaaactaacaaactgaaatcgggtgttgaccagatggatttgtttggggacatgtctacacctcctgacctaaatagtccaacagaaagcaaagatatcctgttagtggatctaaactctgaaatcgacaccaatcagaattctttaagagaaaatccattcttaacaaacggcatcacctcctgttctcttcctcgaccaacgcctcaggcatccttcttgcctgaaaatgccttttctgccaatctcaacttctttcccacccctaatcctgatcctttccgtgacgatcctttcacacagccagaccaatcgacaccttcttcgtttgattctctcaaatctccagatcagaagaaagagaattcgagtagctcgtctactccgctgagtaatgggcccctgaatggtgatgttgactactttggtcagcaatttgaccagatctctaaccggactggcaaacaggaagctcaggcaggcccatggcccttttcaagttcgcaaacccagccagcagtgagaactcaaaatggggtatctgaaagagaacagaacggcttctctgtcaaatcctccccgaacccttttgtgggaagccctcccaaaggactgtccatacagaatggcgtaaagcaggacttggaaagctctgtccagtcctcaccacatgactccatagccattatcccacctccacaaagtaccaaaccaggaagaggcagaaggactgctaagtcttcagccaatgacttgcttgcatcagacatctttgctcctcccgtctcagaaccttcaggccaggcgtcacccacaggacaacctacagccctgcagcccaaccctctggatctcttcaaaacaagtgctcctgccccagtggggcccctggtgggtctaggtggtgtaactgtcacactccctcaggcaggaccatggaacacagcatctttggtcttcaatcagtccccttcaatggctccgggagccatgatgggtggtcaaccttcaggttttagtcagcccgtcatttttggtacaagtccagctgtttcaggttggaaccagccttcaccctttgcagcctcaactccccctccagtgcctgttgtctggggcccttctgcatctgtggcacccaatgcttggtcaacaacaagccctttggggaatccttttcagagcaatatttttccagctcctgctgtgtccactcagcccccatccatgcactcctctctcctggtcactcctcctcagccacctcccagagctggccctcccaaggacatctccagtgatgccttcactgccttagacccacttggggataaagagatcaaggatgtgaaagaaatgtttaaggatttccaactgcggcagccacctgctgtgcccgcgcggaagggagagcagacttcttctgggactttgagtgcctttgccagttatttcaacagcaaggttggcattcctcaggagaatgcagaccatgatgactttgatgctaatcaactattgaacaagatcaatgaaccaccaaagccagctcccagacaagtttccctgccagttaccaaatctactgacaatgcatttgagaaccctttctttaaagattcttttggttcatcacaagcctctgtggcttcttctcaacctgtatcttctgagatgtatagggatccatttggaaatccttttgcctaaattctgaacttggtctgcagaccatccagaggaataaaaaggttggccttagtagtcaaaaacaaagctgatagccagacacgttctgatttctgcccttgttccagctttgacgtattatctgttgccttatttctcattgcctcttctacttgtaaaatgcttttcactttctgtctaggttaaagctaaactgaatctatggctttaaataaattaagatcctaaactctctagcttaagtgtaaatgaagtacagtagtttccctactgaaccctgcctcttgtgtccctggaaccttctagaacacctgccttctaccctctggttgggagatgcagccaccacatcccttcatatcatactgttttgaataaattttcaaatccttattgttcagagttgtttgggggttctgtttcagagcataaaacctaaaggttatagtagaacaaggcaccttcttaaaagaaatcttgcttcagaccatcagttacagagaatttctaaagtaaaattgaagcaactacaacttctccttagacactttggaatctaaccacttaaggacctttttaaagagatagcttctcttctttctgaagatcaatttctcccaaggccaagattgtccttttctcccatttcttgctagctattgcaaatgagggaagaacattattcatctctcctccccttttttttctgattcttttttcagtcagttttgctcctgggttcaagtagtattaccaccctttcacaagcaacagactctcacagggcaaaaaaaaaaaaaaatctaatgattcacagacagatctggagcctctcttcattctcagtaattgctagtcccaagaactagaattgcaaatgggcacaacctatatccttcctgtggaagaggaggccactctcttgagctgaagttccagaagagcagttaatgttcaagagaaattgaactcaactcagcaacaaaggactctattttgaagagcaacatatcacaaagctaaatgtgattgtgccaaacacattaggtgcttatttggggtcatgctaggcctttatcaagtaactggaaaacttttcttgcagccacaatctcaatgtcgttagtaggaagataagaggggagaaaaagctgtagaacaaatgtttggggttaccattgaaaatctaatgtctgcaatatttttctcctcacaacttggaaacgttcccagttcattttcagtcctgttgtgagcacagttctgaagggtttattattgtcaaaataagttttgttttgttttgtttatgttgggtttttaatgttgtctcttgacccttaatgctcaggttcttgtgggagttaatcagccacatccaatgttaccttgagggggaagaagagggtgatgctcagaagctaaacaagacaggggccacatgaccctctattgattagccccaagtagaaagtcctgtggttttatgtttaatggtaatagttgatcatatatggcataattttctatcagcttcctactcagtcactataaacacagacttgaaatagtactttaaatgtccaaatacctaaatgtgctaaactggaggtaactatttctaggtagttgaatttttgaaagtcatgatcagccacacaactgttttgtacatacttattttctcatgcacttttctgtatgcaaataaagctataaatttactcatttcaataaactggagtggcagaatatcaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1601 -> Molecular function: GO:0005178 [integrin binding] evidence: IEA
GeneID:1601 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1601 -> Molecular function: GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] evidence: IEA
GeneID:1601 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IPI
GeneID:1601 -> Molecular function: GO:0035612 [AP-2 adaptor complex binding] evidence: IEA
GeneID:1601 -> Molecular function: GO:0035615 [clathrin adaptor activity] evidence: IMP
GeneID:1601 -> Molecular function: GO:0038024 [cargo receptor activity] evidence: IMP
GeneID:1601 -> Molecular function: GO:0046332 [SMAD binding] evidence: IDA
GeneID:1601 -> Biological process: GO:0000904 [cell morphogenesis involved in differentiation] evidence: IEA
GeneID:1601 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:1601 -> Biological process: GO:0001921 [positive regulation of receptor recycling] evidence: IEA
GeneID:1601 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP
GeneID:1601 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: IMP
GeneID:1601 -> Biological process: GO:0006907 [pinocytosis] evidence: IEA
GeneID:1601 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:1601 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: IEA
GeneID:1601 -> Biological process: GO:0007492 [endoderm development] evidence: IEA
GeneID:1601 -> Biological process: GO:0007588 [excretion] evidence: IEA
GeneID:1601 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:1601 -> Biological process: GO:0010718 [positive regulation of epithelial to mesenchymal transition] evidence: IDA
GeneID:1601 -> Biological process: GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] evidence: IDA
GeneID:1601 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:1601 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:1601 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
GeneID:1601 -> Biological process: GO:0030099 [myeloid cell differentiation] evidence: IEA
GeneID:1601 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IEA
GeneID:1601 -> Biological process: GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] evidence: IDA
GeneID:1601 -> Biological process: GO:0032091 [negative regulation of protein binding] evidence: IMP
GeneID:1601 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: IMP
GeneID:1601 -> Biological process: GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] evidence: IEA
GeneID:1601 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:1601 -> Biological process: GO:0045807 [positive regulation of endocytosis] evidence: IMP
GeneID:1601 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
GeneID:1601 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
GeneID:1601 -> Biological process: GO:0048268 [clathrin coat assembly] evidence: IEA
GeneID:1601 -> Biological process: GO:0060391 [positive regulation of SMAD protein import into nucleus] evidence: IDA
GeneID:1601 -> Biological process: GO:0060766 [negative regulation of androgen receptor signaling pathway] evidence: IMP
GeneID:1601 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IEA
GeneID:1601 -> Biological process: GO:0090090 [negative regulation of canonical Wnt receptor signaling pathway] evidence: IMP
GeneID:1601 -> Biological process: GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] evidence: IEA
GeneID:1601 -> Biological process: GO:2000096 [positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway] evidence: IMP
GeneID:1601 -> Biological process: GO:2000370 [positive regulation of clathrin-mediated endocytosis] evidence: IMP
GeneID:1601 -> Biological process: GO:2000643 [positive regulation of early endosome to late endosome transport] evidence: IMP
GeneID:1601 -> Biological process: GO:2001046 [positive regulation of integrin-mediated signaling pathway] evidence: IEA
GeneID:1601 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:1601 -> Cellular component: GO:0005765 [lysosomal membrane] evidence: TAS
GeneID:1601 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:1601 -> Cellular component: GO:0005905 [coated pit] evidence: IDA
GeneID:1601 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:1601 -> Cellular component: GO:0030132 [clathrin coat of coated pit] evidence: IEA
GeneID:1601 -> Cellular component: GO:0030665 [clathrin-coated vesicle membrane] evidence: IEA
GeneID:1601 -> Cellular component: GO:0070022 [transforming growth factor beta receptor homodimeric complex] evidence: IDA
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@meso_cacase at
DBCLS
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