GGRNA Home | Help | Advanced search

2024-03-28 23:14:45, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001306               1318 bp    mRNA    linear   PRI 14-APR-2013
DEFINITION  Homo sapiens claudin 3 (CLDN3), mRNA.
ACCESSION   NM_001306
VERSION     NM_001306.3  GI:171541813
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Shang,X., Lin,X., Manorek,G. and Howell,S.B.
  TITLE     Claudin-3 and claudin-4 regulate sensitivity to cisplatin by
            controlling expression of the copper and cisplatin influx
            transporter CTR1
  JOURNAL   Mol. Pharmacol. 83 (1), 85-94 (2013)
   PUBMED   23053666
  REMARK    GeneRIF: Claudin-3(CLDN3) and claudin-4 (CLDN4) affect sensitivity
            of the ovarian cancer cells to the cytotoxic effect of cisplatin by
            regulating expression of the Cu transporter CTR1.
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Shang,X., Lin,X., Alvarez,E., Manorek,G. and Howell,S.B.
  TITLE     Tight junction proteins claudin-3 and claudin-4 control tumor
            growth and metastases
  JOURNAL   Neoplasia 14 (10), 974-985 (2012)
   PUBMED   23097631
  REMARK    GeneRIF: High CLDN3 expression is associated with tumor growth and
            metastases.
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Okugawa,T., Oshima,T., Chen,X., Hori,K., Tomita,T., Fukui,H.,
            Watari,J., Matsumoto,T. and Miwa,H.
  TITLE     Down-regulation of claudin-3 is associated with proliferative
            potential in early gastric cancers
  JOURNAL   Dig. Dis. Sci. 57 (6), 1562-1567 (2012)
   PUBMED   22290341
  REMARK    GeneRIF: Dow-regulation of Claudin-3 is associated with the
            progression of early gastric adenocarcinomas.
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Veshnyakova,A., Piontek,J., Protze,J., Waziri,N., Heise,I. and
            Krause,G.
  TITLE     Mechanism of Clostridium perfringens enterotoxin interaction with
            claudin-3/-4 protein suggests structural modifications of the toxin
            to target specific claudins
  JOURNAL   J. Biol. Chem. 287 (3), 1698-1708 (2012)
   PUBMED   22128179
  REMARK    GeneRIF: Mechanism of Clostridium perfringens enterotoxin
            interaction with claudin-3/-4 protein suggests structural
            modifications of the toxin to target specific claudins
REFERENCE   5  (bases 1 to 1318)
  AUTHORS   Sun,C., Yi,T., Song,X., Li,S., Qi,X., Chen,X., Lin,H., He,X.,
            Li,Z., Wei,Y. and Zhao,X.
  TITLE     Efficient inhibition of ovarian cancer by short hairpin RNA
            targeting claudin-3
  JOURNAL   Oncol. Rep. 26 (1), 193-200 (2011)
   PUBMED   21519794
  REMARK    GeneRIF: CLDN3 may have a role in ovarian cancer, and its
            inhibition by short hairpin RNA could be a treatment strategy.
REFERENCE   6  (bases 1 to 1318)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J. Cell Biol. 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   7  (bases 1 to 1318)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J. Cell Biol. 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 1318)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   9  (bases 1 to 1318)
  AUTHORS   Peacock,R.E., Keen,T.J. and Inglehearn,C.F.
  TITLE     Analysis of a human gene homologous to rat ventral prostate.1
            protein
  JOURNAL   Genomics 46 (3), 443-449 (1997)
   PUBMED   9441748
REFERENCE   10 (bases 1 to 1318)
  AUTHORS   Katahira,J., Sugiyama,H., Inoue,N., Horiguchi,Y., Matsuda,M. and
            Sugimoto,N.
  TITLE     Clostridium perfringens enterotoxin utilizes two structurally
            related membrane proteins as functional receptors in vivo
  JOURNAL   J. Biol. Chem. 272 (42), 26652-26658 (1997)
   PUBMED   9334247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM764277.1 and BC016056.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 1, 2008 this sequence version replaced gi:21536298.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. The protein encoded by this intronless
            gene, a member of the claudin family, is an integral membrane
            protein and a component of tight junction strands. It is also a
            low-affinity receptor for Clostridium perfringens enterotoxin, and
            shares aa sequence similarity with a putative apoptosis-related
            protein found in rat. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BM764277.1         1-24
            25-1318             BC016056.1         1-1294
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1318
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="claudin 3"
                     /db_xref="GeneID:1365"
                     /db_xref="HGNC:2045"
                     /db_xref="HPRD:04219"
                     /db_xref="MIM:602910"
     exon            1..1274
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="alignment:Splign:1.39.8"
     variation       166
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7084"
     CDS             222..884
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="Clostridium perfringens enterotoxin receptor 2;
                     CPE-receptor 2; ventral prostate.1-like protein; CPE-R 2;
                     ventral prostate.1 protein homolog"
                     /codon_start=1
                     /product="claudin-3"
                     /protein_id="NP_001297.1"
                     /db_xref="GI:4502875"
                     /db_xref="CCDS:CCDS5559.1"
                     /db_xref="GeneID:1365"
                     /db_xref="HGNC:2045"
                     /db_xref="HPRD:04219"
                     /db_xref="MIM:602910"
                     /translation="
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
"
     misc_feature    228..722
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    246..308
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15551.1);
                     transmembrane region"
     misc_feature    462..524
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15551.1);
                     transmembrane region"
     misc_feature    567..629
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15551.1);
                     transmembrane region"
     misc_feature    699..761
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15551.1);
                     transmembrane region"
     misc_feature    795..797
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03382"
     misc_feature    861..863
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    876..881
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15551.1);
                     Region: Interactions with TJP1, TJP2 and TJP3 (By
                     similarity)"
     misc_feature    876..878
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     STS             222..884
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /standard_name="Cldn3"
                     /db_xref="UniSTS:465377"
     STS             338..652
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /standard_name="D7S3297"
                     /db_xref="UniSTS:254196"
     variation       555
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:9133"
     STS             644..1269
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /standard_name="CLDN3_194"
                     /db_xref="UniSTS:277103"
     STS             1111..1248
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /standard_name="RH93920"
                     /db_xref="UniSTS:84235"
     variation       1129
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1129965"
ORIGIN      
agcccagtcgccgccgcccgcccacaaagccacaggcaggtgcaggcgcagccgcggcgagagcgtatggagccgagccgttagcgcgcgccgtcggtgagtcagtccgtccgtccgtccgtccgtcggggcgccgcagctcccgccaggcccagcggccccggcccctcgtctccccgcacccggagccacccggtggagcgggccttgccgcggcagccatgtccatgggcctggagatcacgggcaccgcgctggccgtgctgggctggctgggcaccatcgtgtgctgcgcgttgcccatgtggcgcgtgtcggccttcatcggcagcaacatcatcacgtcgcagaacatctgggagggcctgtggatgaactgcgtggtgcagagcaccggccagatgcagtgcaaggtgtacgactcgctgctggcactgccacaggaccttcaggcggcccgcgccctcatcgtggtggccatcctgctggccgccttcgggctgctagtggcgctggtgggcgcccagtgcaccaactgcgtgcaggacgacacggccaaggccaagatcaccatcgtggcaggcgtgctgttccttctcgccgccctgctcaccctcgtgccggtgtcctggtcggccaacaccattatccgggacttctacaaccccgtggtgcccgaggcgcagaagcgcgagatgggcgcgggcctgtacgtgggctgggcggccgcggcgctgcagctgctggggggcgcgctgctctgctgctcgtgtcccccacgcgagaagaagtacacggccaccaaggtcgtctactccgcgccgcgctccaccggcccgggagccagcctgggcacaggctacgaccgcaaggactacgtctaagggacagacgcagggagaccccaccaccaccaccaccaccaacaccaccaccaccaccgcgagctggagcgcgcaccaggccatccagcgtgcagccttgcctcggaggccagcccacccccagaagccaggaagcccccgcgctggactggggcagcttccccagcagccacggctttgcgggccgggcagtcgacttcggggcccagggaccaacctgcatggactgtgaaacctcacccttctggagcacggggcctgggtgaccgccaatacttgaccaccccgtcgagccccatcgggccgctgcccccatgctcgcgctgggcagggaccggcagccctggaaggggcacttgatatttttcaataaaagcctttcgttttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1365 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS
            GeneID:1365 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:1365 -> Molecular function: GO:0042802 [identical protein binding] evidence: IEA
            GeneID:1365 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEP
            GeneID:1365 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: IEA
            GeneID:1365 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:1365 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
            GeneID:1365 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.