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2024-03-28 18:52:29, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001278709            2644 bp    mRNA    linear   PRI 11-JUL-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 2 (PSMD2), transcript variant 3, mRNA.
ACCESSION   NM_001278709
VERSION     NM_001278709.1  GI:523425735
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Matsuyama Y, Suzuki M, Arima C, Huang QM, Tomida S, Takeuchi T,
            Sugiyama R, Itoh Y, Yatabe Y, Goto H and Takahashi T.
  TITLE     Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic
            target in association with various clinicopathologic features in
            lung adenocarcinomas
  JOURNAL   Mol. Carcinog. 50 (4), 301-309 (2011)
   PUBMED   21465578
  REMARK    GeneRIF: Results suggest that PSMD2 may be a good molecular target
            candidate.
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanche H,
            Schreiber S and Nebel A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat. Res. 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL and Ye J.
  TITLE     Regulated endoplasmic reticulum-associated degradation of a
            polytopic protein: p97 recruits proteasomes to Insig-1 before
            extraction from membranes
  JOURNAL   J. Biol. Chem. 284 (50), 34889-34900 (2009)
   PUBMED   19815544
  REMARK    GeneRIF: These data suggest that p97 recruits proteasomes to
            polytopic ER proteins, such as Insig-1, even before they are
            extracted from membranes.
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Smith L, Qutob O, Watson MB, Beavis AW, Potts D, Welham KJ,
            Garimella V, Lind MJ, Drew PJ and Cawkwell L.
  TITLE     Proteomic identification of putative biomarkers of radiotherapy
            resistance: a possible role for the 26S proteasome?
  JOURNAL   Neoplasia 11 (11), 1194-1207 (2009)
   PUBMED   19881955
  REMARK    GeneRIF: the 26S proteasome may provide a general predictive
            biomarker for radiotherapy outcome.
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Djakovic SN, Schwarz LA, Barylko B, DeMartino GN and Patrick GN.
  TITLE     Regulation of the proteasome by neuronal activity and
            calcium/calmodulin-dependent protein kinase II
  JOURNAL   J. Biol. Chem. 284 (39), 26655-26665 (2009)
   PUBMED   19638347
  REMARK    GeneRIF: Data show that data provide a novel mechanism whereby
            CaMKII may regulate the proteasome in neurons to facilitate
            remodeling of synaptic connections through protein degradation.
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Seeger M, Ferrell K, Frank R and Dubiel W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Tsurumi C, Shimizu Y, Saeki M, Kato S, Demartino GN, Slaughter CA,
            Fujimuro M, Yokosawa H, Yamasaki M, Hendil KB, Toh-e A, Tanahashi N
            and Tanaka K.
  TITLE     cDNA cloning and functional analysis of the p97 subunit of the 26S
            proteasome, a polypeptide identical to the type-1
            tumor-necrosis-factor-receptor-associated protein-2/55.11
  JOURNAL   Eur. J. Biochem. 239 (3), 912-921 (1996)
   PUBMED   8774743
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Coux O, Tanaka K and Goldberg AL.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu. Rev. Biochem. 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Song HY and Donner DB.
  TITLE     Association of a RING finger protein with the cytoplasmic domain of
            the human type-2 tumour necrosis factor receptor
  JOURNAL   Biochem. J. 309 (PT 3), 825-829 (1995)
   PUBMED   7639698
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Boldin MP, Mett IL and Wallach D.
  TITLE     A protein related to a proteasomal subunit binds to the
            intracellular domain of the p55 TNF receptor upstream to its 'death
            domain'
  JOURNAL   FEBS Lett. 367 (1), 39-44 (1995)
   PUBMED   7601280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302177.1, AK301759.1,
            BC002997.1 and AI026024.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the non-ATPase subunits of the 19S regulator lid. In addition to
            participation in proteasome function, this subunit may also
            participate in the TNF signalling pathway since it interacts with
            the tumor necrosis factor type 1 receptor. A pseudogene has been
            identified on chromosome 1. Alternative splicing results in
            multiple transcript variants of this gene. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and the
            5' coding region and initiates translation at an alternate start
            codon, compared to variant 1. It encodes isoform 3, which has a
            shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302177.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               AK302177.1         1-675
            676-745             AK301759.1         689-758
            746-2488            AK302177.1         746-2488
            2489-2624           BC002997.1         2774-2909
            2625-2644           AI026024.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..2644
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 2"
                     /db_xref="GeneID:5708"
                     /db_xref="HGNC:9559"
                     /db_xref="MIM:606223"
     exon            1..105
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            106..227
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    179..181
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="upstream in-frame stop codon"
     CDS             215..2464
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     TNFR-associated protein 2; 55.11 protein; 26S proteasome
                     non-ATPase regulatory subunit 2; protein 55.11; tumor
                     necrosis factor type 1 receptor-associated protein 2"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 2
                     isoform 3"
                     /protein_id="NP_001265638.1"
                     /db_xref="GI:523425736"
                     /db_xref="GeneID:5708"
                     /db_xref="HGNC:9559"
                     /db_xref="MIM:606223"
                     /translation="
MSMSGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL
"
     exon            228..441
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            442..600
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            601..745
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            746..806
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            807..953
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            954..1060
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1061..1188
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1189..1276
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1277..1439
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1440..1541
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     STS             1477..1604
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /standard_name="RH70376"
                     /db_xref="UniSTS:73065"
     exon            1542..1687
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1688..1771
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1772..1940
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            1941..2035
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            2036..2162
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     exon            2163..2281
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     STS             2184..2404
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /standard_name="T03659"
                     /db_xref="UniSTS:14455"
     exon            2282..2628
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:1.39.8"
     STS             2391..2549
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /standard_name="RH65279"
                     /db_xref="UniSTS:84197"
     STS             2400..2582
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /standard_name="G62053"
                     /db_xref="UniSTS:139161"
     polyA_signal    2604..2609
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
     polyA_site      2628
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
ORIGIN      
aaaatatctacagaagagctgaaaggaaggtcagcttctcagaagacactgtttctgtcatgtgtattggactttggggtttcattagcatggtctacttttaaccgttttgctgctgacatcatctccgttttggccatgaccatgagtggggagcgtgagtgcctcaagtatcggctagtgggctcccaggaggaattggcatcatggggtcatgagtatgtcaggagaagtggctaaggagtggcaggagctggatgacgcagagaaggtccagcgggagcctctgctcactctggtgaaggaaatcgtcccctataacatggcccacaatgcagagcatgaggcttgcgacctgcttatggaaattgagcaggtggacatgctggagaaggacattgatgaaaatgcatatgcaaaggtctgcctttatctcaccagttgtgtgaattacgtgcctgagcctgagaactcagccctactgcgttgtgccctgggtgtgttccgaaagtttagccgcttccctgaagctctgagattggcattgatgctcaatgacatggagttggtagaagacatcttcacctcctgcaaggatgtggtagtacagaaacagatggcattcatgctaggccggcatggggtgttcctggagctgagtgaagatgtcgaggagtatgaggacctgacagagatcatgtccaatgtacagctcaacagcaacttcttggccttagctcgggagctggacatcatggagcccaaggtgcctgatgacatctacaaaacccacctagagaacaacaggtttgggggcagtggctctcaggtggactctgcccgcatgaacctggcctcctcttttgtgaatggctttgtgaatgcagcttttggccaagacaagctgctaacagatgatggcaacaaatggctttacaagaacaaggaccacggaatgttgagtgcagctgcatctcttgggatgattctgctgtgggatgtggatggtggcctcacccagattgacaagtacctgtactcctctgaggactacattaagtcaggagctcttcttgcctgtggcatagtgaactctggggtccggaatgagtgtgaccctgctctggcactgctctcagactatgttctccacaacagcaacaccatgagacttggttccatctttgggctaggcttggcttatgctggctcaaatcgtgaagatgtcctaacactgctgctgcctgtgatgggagattcaaagtccagcatggaggtggcaggtgtcacagctttagcctgtggaatgatagcagtagggtcctgcaatggagatgtaacttccactatccttcagaccatcatggagaagtcagagactgagctcaaggatacttatgctcgttggcttcctcttggactgggtctcaaccacctggggaagggtgaggccatcgaggcaatcctggctgcactggaggttgtgtcagagccattccgcagttttgccaacacactggtggatgtgtgtgcatatgcaggctctgggaatgtgctgaaggtgcagcagctgctccacatttgtagcgaacactttgactccaaagagaaggaggaagacaaagacaagaaggaaaagaaagacaaggacaagaaggaagcccctgctgacatgggagcacatcagggagtggctgttctggggattgcccttattgctatgggggaggagattggtgcagagatggcattacgaacctttggccacttgctgagatatggggagcctacactccggagggctgtacctttagcactggccctcatctctgtttcaaatccacgactcaacatcctggataccctaagcaaattctctcatgatgctgatccagaagtttcctataactccatttttgccatgggcatggtgggcagtggtaccaataatgcccgtctggctgcaatgctgcgccagttagctcaatatcatgccaaggacccaaacaacctcttcatggtgcgcttggcacagggcctgacacatttagggaagggcacccttaccctctgcccctaccacagcgaccggcagcttatgagccaggtggccgtggctggactgctcactgtgcttgtctctttcctggatgttcgaaacattattctaggcaaatcacactatgtattgtatgggctggtggctgccatgcagccccgaatgctggttacgtttgatgaggagctgcggccattgccagtgtctgtccgtgtgggccaggcagtggatgtggtgggccaggctggcaagccgaagactatcacagggttccagacgcatacaaccccagtgttgttggcccacggggaacgggcagaattggccactgaggagtttcttcctgttacccccattctggaaggttttgttatccttcggaagaaccccaattatgatctctaagtgaccaccaggggctctgaactgcagctgatgttatcagcaggccatgcatcctgctgccaagggtggacacggctgcagacttctgggggaattgtcgcctcctgctcttttgttactgagtgagataaggttgttcaataaagacttttatccccaaggtcaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5708 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5708 -> Molecular function: GO:0030234 [enzyme regulator activity] evidence: IEA
            GeneID:5708 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5708 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5708 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5708 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5708 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5708 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5708 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5708 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0042176 [regulation of protein catabolic process] evidence: IEA
            GeneID:5708 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5708 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5708 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5708 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5708 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5708 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5708 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5708 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5708 -> Cellular component: GO:0005838 [proteasome regulatory particle] evidence: TAS
            GeneID:5708 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS

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