2024-04-24 01:47:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001278595 3105 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens minichromosome maintenance complex component 7 (MCM7), transcript variant 3, mRNA. ACCESSION NM_001278595 VERSION NM_001278595.1 GI:518830596 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3105) AUTHORS Fristrup,N., Birkenkamp-Demtroder,K., Reinert,T., Sanchez-Carbayo,M., Segersten,U., Malmstrom,P.U., Palou,J., Alvarez-Mugica,M., Pan,C.C., Ulhoi,B.P., Borre,M., Orntoft,T.F. and Dyrskjot,L. TITLE Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer JOURNAL Am. J. Pathol. 182 (2), 339-349 (2013) PUBMED 23201130 REMARK GeneRIF: the expression of cyclin D1, MCM7, TRIM29, and UBE2C was found to be significantly associated with progression to muscle-invasive bladder cancer. REFERENCE 2 (bases 1 to 3105) AUTHORS Zhou,Y.M., Zhang,X.F., Cao,L., Li,B., Sui,C.J., Li,Y.M. and Yin,Z.F. TITLE MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma JOURNAL Liver Int. 32 (10), 1505-1509 (2012) PUBMED 22784096 REMARK GeneRIF: MCM7 expression may be a useful predictor of prognosis in patients with hepatocellular carcinoma after resection. REFERENCE 3 (bases 1 to 3105) AUTHORS Liu,Y.Z., Jiang,Y.Y., Hao,J.J., Lu,S.S., Zhang,T.T., Shang,L., Cao,J., Song,X., Wang,B.S., Cai,Y., Zhan,Q.M. and Wang,M.R. TITLE Prognostic significance of MCM7 expression in the bronchial brushings of patients with non-small cell lung cancer (NSCLC) JOURNAL Lung Cancer 77 (1), 176-182 (2012) PUBMED 22456526 REMARK GeneRIF: MCM7 and Ki67 in tumor tissues may be potential markers of a poor prognosis for non-small cell lung cancer patients REFERENCE 4 (bases 1 to 3105) AUTHORS Marnerides,A., Vassilakopoulos,T.P., Boltetsou,E., Levidou,G., Angelopoulou,M.K., Thymara,I., Kyrtsonis,M.C., Pappi,V., Tsopra,O., Panayiotidis,P., Pangalis,G.A., Beris,P., Patsouris,E. and Korkolopoulou,P. TITLE Immunohistochemical expression and prognostic significance of CCND3, MCM2 and MCM7 in Hodgkin lymhoma JOURNAL Anticancer Res. 31 (10), 3585-3594 (2011) PUBMED 21965782 REMARK GeneRIF: Lymph node sections from 138 HL patients were immunohistochemically stained for cyclin D3 (CCND3), MCM2 and MCM7 aiming to investigate clinical outcome. REFERENCE 5 (bases 1 to 3105) AUTHORS Toyokawa,G., Masuda,K., Daigo,Y., Cho,H.S., Yoshimatsu,M., Takawa,M., Hayami,S., Maejima,K., Chino,M., Field,H.I., Neal,D.E., Tsuchiya,E., Ponder,B.A., Maehara,Y., Nakamura,Y. and Hamamoto,R. TITLE Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer JOURNAL Mol. Cancer 10, 65 (2011) PUBMED 21619671 REMARK GeneRIF: elevated expression of MCM7 to be associated with poor prognosis for patients with non-small cell lung cancer Publication Status: Online-Only REFERENCE 6 (bases 1 to 3105) AUTHORS Suzuki,S., Adachi,A., Hiraiwa,A., Ohashi,M., Ishibashi,M. and Kiyono,T. TITLE Cloning and characterization of human MCM7 promoter JOURNAL Gene 216 (1), 85-91 (1998) PUBMED 9714754 REFERENCE 7 (bases 1 to 3105) AUTHORS Fujita,M., Kiyono,T., Hayashi,Y. and Ishibashi,M. TITLE hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase JOURNAL J. Biol. Chem. 271 (8), 4349-4354 (1996) PUBMED 8626784 REFERENCE 8 (bases 1 to 3105) AUTHORS Musahl,C., Schulte,D., Burkhart,R. and Knippers,R. TITLE A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins JOURNAL Eur. J. Biochem. 230 (3), 1096-1101 (1995) PUBMED 7601140 REFERENCE 9 (bases 1 to 3105) AUTHORS Nakatsuru,S., Sudo,K. and Nakamura,Y. TITLE Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication JOURNAL Cytogenet. Cell Genet. 68 (3-4), 226-230 (1995) PUBMED 7842741 REFERENCE 10 (bases 1 to 3105) AUTHORS Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R. TITLE The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins JOURNAL Nucleic Acids Res. 21 (23), 5289-5293 (1993) PUBMED 8265339 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA538092.1, DA397394.1, AK226175.1 and D86748.1. Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK226175.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025098 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-76 DA538092.1 1-76 77-570 DA397394.1 58-551 571-2331 AK226175.1 1-1761 2332-3032 D86748.1 1697-2397 3033-3105 AK226175.1 2463-2535 FEATURES Location/Qualifiers source 1..3105 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7q21.3-q22.1" gene 1..3105 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /note="minichromosome maintenance complex component 7" /db_xref="GeneID:4176" /db_xref="HGNC:6950" /db_xref="MIM:600592" exon 1..677 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" misc_feature 572 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /note="transcription initiation site as determined in PMID:9714754; the 5'-most transcription initiation site has not been determined." exon 678..757 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 758..922 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 923..1303 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" STS 939..1150 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /standard_name="WI-19563" /db_xref="UniSTS:67073" misc_feature 1103..1105 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /note="upstream in-frame stop codon" CDS 1250..2881 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /EC_number="3.6.4.12" /note="isoform 2 is encoded by transcript variant 3; minichromosome maintenance deficient 7; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; CDC47 homolog" /codon_start=1 /product="DNA replication licensing factor MCM7 isoform 2" /protein_id="NP_001265524.1" /db_xref="GI:518830597" /db_xref="GeneID:4176" /db_xref="HGNC:6950" /db_xref="MIM:600592" /translation="
MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
" exon 1304..1441 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 1442..1591 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" STS 1482..1633 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /standard_name="RH65692" /db_xref="UniSTS:23889" exon 1592..1706 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" STS 1599..1752 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /standard_name="RH47672" /db_xref="UniSTS:21589" exon 1707..1838 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 1839..1922 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" STS 1917..2057 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /standard_name="D7S2929" /db_xref="UniSTS:33096" exon 1923..2316 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 2317..2400 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 2401..2569 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" exon 2570..2679 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" STS 2679..2830 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /standard_name="RH78474" /db_xref="UniSTS:37137" exon 2680..3085 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" /inference="alignment:Splign:1.39.8" polyA_signal 3010..3015 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" polyA_site 3033 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" polyA_signal 3058..3063 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" polyA_site 3085 /gene="MCM7" /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146" ORIGIN
agtcccgtcagcttccggtagaagagctcggccacatcccggccgccactgtccccgcggactggcgggtggaaggactcagtgaaggatcctgcgacacaggctggccctgggcgcccctcccgcccggcccctccgccccttcccagccccaagggtctaggatacagtctttgtagatgagcgggtcccccttggaggacagaatgaagaattgggaaatcatggccgttctggagagtagacaagaagacggcgaaagtcgggcctgccccgccctgcggccccggaacaaaagaacgcgtgtgcgctggccctttaagagcgattctcctccgcccgcgccagctcggaccgcgggaaacccggcgcctgcactaccccgcccggagattcccttccgacgcccgcaccgcctccccgtcactcattctaggcccgcacggtgattggcttgcggctagcgggaggtgaagaaggccgccttgtccgattggcccgcacgcagtggcgccggtcacgtggggggcgacgtttcgcgccaatttcggttggccggccacagtccaccgcgcggagattctcagcttccccaggagcaagacctctgagcccgccaagcgcggccgcacggccctcggcagcgatggcactgaaggactacgcgctagagaaggaaaaggttaagaagttcttacaagagttctaccaggatgatgaactcgggaagaagcagttcaagtatgggaaccagttggttcggctggctcatcgggaacaggtggctctgtatgtggacctggacgacgtagccgaggatgaccccgagttggtggactcaatttgtgagaatgccaggcgctacgcgaagctctttgctgatgccgtacaagagctgctgcctcagtacaaggagagggaagtggtaaataaagatgtcctggacgtttacattgagcatcggctaatgatggagcagcggagtcgggaccctgggatggtccgaagcccccagaaccagtaccctgctgaactcatgcgcagattgtgagtggtctctgtcgggaaagatgtagggattggttctccaggatcttgtttgtgactgttttctccccttagtgagctgtattttcaaggccctagcagcaacaagcctcgtgtgatccgggaagtgcgggctgactctgtggggaagttggtaactgtgcgtggaatcgtcactcgtgtctctgaagtcaaacccaagatggtggtggccacttacacttgtgaccagtgtggggcagagacctaccagccgatccagtctcccactttcatgcctctgatcatgtgcccaagccaggagtgccaaaccaaccgctcaggagggcggctgtatctgcagacacggggctccagattcatcaaattccaggagatgaagatgcaagaacatagtgatcaggtgcctgtgggaaatatccctcgtagtatcacggtgctggtagaaggagagaacacaaggattgcccagcctggagaccacgtcagcgtcactggtattttcttgccaatcctgcgcactgggttccgacaggtggtacagggtttactctcagaaacctacctggaagcccatcggattgtgaagatgaacaagagtgaggatgatgagtctggggctggagagctcaccagggaggagctgaggcaaattgcagaggaggatttctacgaaaagctggcagcttcaatcgccccagaaatatacgggcatgaagatgtgaagaaggcactgctgctcctgctagtcgggggtgtggaccagtctcctcgaggcatgaaaatccggggcaacatcaacatctgtctgatgggggatcctggtgtggccaagtctcagctcctgtcatacattgatcgactggcgcctcgcagccagtacacaacaggccggggctcctcaggagtggggcttacggcagctgtgctgagagactccgtgagtggagaactgaccttagagggtggggccctggtgctggctgaccagggtgtgtgctgcattgatgagttcgacaagatggctgaggccgaccgcacagccatccacgaggtcatggagcagcagaccatctccattgccaaggccggcattctcaccacactcaatgcccgctgctccatcctggctgccgccaaccctgcctacgggcgctacaaccctcgccgcagcctggagcagaacatacagctacctgctgcactgctctcccggtttgacctcctctggctgattcaggaccggcccgaccgagacaatgacctacggttggcccagcacatcacctatgtgcaccagcacagccggcagcccccctcccagtttgaacctctggacatgaagctcatgaggcgttacatagccatgtgccgcgagaagcagcccatggtgccagagtctctggctgactacatcacagcagcatacgtggagatgaggcgagaggcttgggctagtaaggatgccacctatacttctgcccggaccctgctggctatcctgcgcctttccactgctctggcacgtctgagaatggtggatgtggtggagaaagaagatgtgaatgaagccatcaggctaatggagatgtcaaaggactctcttctaggagacaaggggcagacagctaggactcagagaccagcagatgtgatatttgccaccgtccgtgaactggtctcagggggccgaagtgtccggttctctgaggcagagcagcgctgtgtatctcgtggcttcacacccgcccagttccaggcggctctggatgaatatgaggagctcaatgtctggcaggtcaatgcttcccggacacggatcacttttgtctgattccagcctgcttgcaaccctggggtcctcttgttccctgctggcctgccccttgggaaggggcagtgatgcctttgaggggaaggaggagcccctctttctcccatgctgcacttactccttttgctaataaaagtgtttgtagattgtcatcttctagcctgggcctgacttccattaaaacagggttttgtgcgttttttaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4176 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS GeneID:4176 -> Molecular function: GO:0003697 [single-stranded DNA binding] evidence: IEA GeneID:4176 -> Molecular function: GO:0004003 [ATP-dependent DNA helicase activity] evidence: IDA GeneID:4176 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4176 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:4176 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:4176 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:4176 -> Biological process: GO:0006260 [DNA replication] evidence: TAS GeneID:4176 -> Biological process: GO:0006268 [DNA unwinding involved in DNA replication] evidence: IEA GeneID:4176 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IEA GeneID:4176 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS GeneID:4176 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP GeneID:4176 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA GeneID:4176 -> Biological process: GO:0042325 [regulation of phosphorylation] evidence: IMP GeneID:4176 -> Biological process: GO:0042493 [response to drug] evidence: IEA GeneID:4176 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA GeneID:4176 -> Cellular component: GO:0000785 [chromatin] evidence: TAS GeneID:4176 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:4176 -> Cellular component: GO:0005829 [cytosol] evidence: IEA GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IDA GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IMP
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