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2024-04-25 15:41:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001278547 5854 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript
variant JNK1-b2, mRNA.
ACCESSION NM_001278547 NM_139047
VERSION NM_001278547.1 GI:513788278
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5854)
AUTHORS Park,M.K., You,H.J., Lee,H.J., Kang,J.H., Oh,S.H., Kim,S.Y. and
Lee,C.H.
TITLE Transglutaminase-2 induces N-cadherin expression in
TGF-beta1-induced epithelial mesenchymal transition via
c-Jun-N-terminal kinase activation by protein phosphatase 2A
down-regulation
JOURNAL Eur. J. Cancer 49 (7), 1692-1705 (2013)
PUBMED 23290789
REMARK GeneRIF: Results suggest that Tgase-2/PP2A/JNK might be a novel
axis that affects N-cadherin switching in the
epithelial-mesenchymal-transition (EMT) of A549 lung cancer cells.
REFERENCE 2 (bases 1 to 5854)
AUTHORS Takahashi,R., Hirata,Y., Sakitani,K., Nakata,W., Kinoshita,H.,
Hayakawa,Y., Nakagawa,H., Sakamoto,K., Hikiba,Y., Ijichi,H.,
Moses,H.L., Maeda,S. and Koike,K.
TITLE Therapeutic effect of c-Jun N-terminal kinase inhibition on
pancreatic cancer
JOURNAL Cancer Sci. 104 (3), 337-344 (2013)
PUBMED 23237571
REMARK GeneRIF: activation of JNK promotes development of pancreatic
cancer
REFERENCE 3 (bases 1 to 5854)
AUTHORS An,J., Liu,H., Magyar,C.E., Guo,Y., Veena,M.S., Srivatsan,E.S.,
Huang,J. and Rettig,M.B.
TITLE Hyperactivated JNK is a therapeutic target in pVHL-deficient renal
cell carcinoma
JOURNAL Cancer Res. 73 (4), 1374-1385 (2013)
PUBMED 23393199
REMARK GeneRIF: Data indicate that von Hippel-Lindau (VHL)-deficient clear
cell renal cell carcinomas (RCC) are dependent upon
c-Jun-NH(2)-kinase (JNK) activity for in vitro and in vivo growth.
REFERENCE 4 (bases 1 to 5854)
AUTHORS Li,M., Qiu,L., Lin,T., He,D., Hua,Y., Yuan,X., Liu,X. and Wei,G.
TITLE c-Jun N-terminal kinase is upregulated in patients with hypospadias
JOURNAL Urology 81 (1), 178-183 (2013)
PUBMED 23273084
REMARK GeneRIF: We observed that the JNK1 gene and the phosphorylated
expression of JNK1 and JNK2 were upregulated in the skin of
patients with hypospadias compared with that in the normal prepuce
in the levels of mRNA and protein, respectively.
REFERENCE 5 (bases 1 to 5854)
AUTHORS Kanaji,N., Nelson,A., Wang,X., Sato,T., Nakanishi,M., Gunji,Y.,
Basma,H., Michalski,J., Farid,M., Rennard,S.I. and Liu,X.
TITLE Differential roles of JNK, ERK1/2, and p38 mitogen-activated
protein kinases on endothelial cell tissue repair functions in
response to tumor necrosis factor-alpha
JOURNAL J. Vasc. Res. 50 (2), 145-156 (2013)
PUBMED 23258237
REMARK GeneRIF: TNF-alpha stimulates tissue repair functions of HPAECs.
This may be mediated, at least in part, positively via JNK &
ERK1/2. This may play a role in endothelial cell-mediated tissue
repair, especially in an inflammatory milieu where TNF-alpha is
present.
REFERENCE 6 (bases 1 to 5854)
AUTHORS Kharbanda,S., Saleem,A., Shafman,T., Emoto,Y., Taneja,N., Rubin,E.,
Weichselbaum,R., Woodgett,J., Avruch,J., Kyriakis,J. et al.
TITLE Ionizing radiation stimulates a Grb2-mediated association of the
stress-activated protein kinase with phosphatidylinositol 3-kinase
JOURNAL J. Biol. Chem. 270 (32), 18871-18874 (1995)
PUBMED 7642542
REFERENCE 7 (bases 1 to 5854)
AUTHORS van Dam,H., Wilhelm,D., Herr,I., Steffen,A., Herrlich,P. and
Angel,P.
TITLE ATF-2 is preferentially activated by stress-activated protein
kinases to mediate c-jun induction in response to genotoxic agents
JOURNAL EMBO J. 14 (8), 1798-1811 (1995)
PUBMED 7737130
REFERENCE 8 (bases 1 to 5854)
AUTHORS Livingstone,C., Patel,G. and Jones,N.
TITLE ATF-2 contains a phosphorylation-dependent transcriptional
activation domain
JOURNAL EMBO J. 14 (8), 1785-1797 (1995)
PUBMED 7737129
REFERENCE 9 (bases 1 to 5854)
AUTHORS Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
Ulevitch,R.J. and Davis,R.J.
TITLE Independent human MAP-kinase signal transduction pathways defined
by MEK and MKK isoforms
JOURNAL Science 267 (5198), 682-685 (1995)
PUBMED 7839144
REMARK Erratum:[Science 1995 Jul 7;269(5220):17]
REFERENCE 10 (bases 1 to 5854)
AUTHORS Seth,A., Alvarez,E., Gupta,S. and Davis,R.J.
TITLE A phosphorylation site located in the NH2-terminal domain of c-Myc
increases transactivation of gene expression
JOURNAL J. Biol. Chem. 266 (35), 23521-23524 (1991)
PUBMED 1748630
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA159335.1, AK292523.1,
AC016397.6 and AA808177.1.
On Jun 20, 2013 this sequence version replaced gi:20986520.
Summary: The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is activated by various
cell stimuli, and targets specific transcription factors, and thus
mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor
alpha (TNF-alpha) is found to be required for TNF-alpha induced
apoptosis. This kinase is also involved in UV radiation induced
apoptosis, which is thought to be related to cytochrom c-mediated
cell death pathway. Studies of the mouse counterpart of this gene
suggested that this kinase play a key role in T cell proliferation,
apoptosis and differentiation. Five alternatively spliced
transcript variants encoding distinct isoforms have been reported.
[provided by RefSeq, Jun 2013].
Transcript Variant: This variant (JNK1-b2) encodes the longer of
the two JNK1 beta isoforms (JNK1 beta2). The JNK1-b2 variant
differs from the JNK1-a2 variant in the use of an alternate
internal coding exon of the same length. Thus, JNK1 beta2 isoform
is the same length as JNK1 alpha2 isoform, with a few aa difference
in an internal protein segment.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC130570.1, U35005.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-104 DA159335.1 1-104
105-1733 AK292523.1 1-1629
1734-5475 AC016397.6 83055-86796
5476-5854 AA808177.1 1-379 c
FEATURES Location/Qualifiers
source 1..5854
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q11.22"
gene 1..5854
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="mitogen-activated protein kinase 8"
/db_xref="GeneID:5599"
/db_xref="HGNC:6881"
/db_xref="MIM:601158"
exon 1..183
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 184..354
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
misc_feature 218..220
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="upstream in-frame stop codon"
CDS 233..1516
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/EC_number="2.7.11.24"
/note="JNK1 beta2 is encoded by transcript variant
JNK1-b2; JUN N-terminal kinase; c-Jun N-terminal kinase 1;
mitogen-activated protein kinase 8 isoform JNK1 alpha1;
mitogen-activated protein kinase 8 isoform JNK1 beta2; MAP
kinase 8; stress-activated protein kinase 1;
stress-activated protein kinase 1c"
/codon_start=1
/product="mitogen-activated protein kinase 8 JNK1 beta2"
/protein_id="NP_001265476.1"
/db_xref="GI:513788279"
/db_xref="CCDS:CCDS7223.1"
/db_xref="GeneID:5599"
/db_xref="HGNC:6881"
/db_xref="MIM:601158"
/translation="
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
"
misc_feature 257..1312
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="Catalytic domain of the Serine/Threonine Kinase,
c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850"
/db_xref="CDD:173746"
misc_feature 308..1195
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature order(326..346,350..352,389..391,395..397,446..448,
488..490,554..574,578..583,683..685,689..691,695..700,
704..706,734..739,746..748,779..781,785..796,800..802,
911..913)
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="active site"
/db_xref="CDD:173746"
misc_feature order(326..346,350..352,389..391,395..397,488..490,
554..574,704..706,734..736)
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173746"
misc_feature order(446..448,578..580,683..685,689..691,746..748,
779..781,785..796,800..802,911..913)
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173746"
misc_feature order(566..568,584..586,611..613,620..622,707..721,
1199..1204,1208..1210,1217..1219)
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="KIM docking site [polypeptide binding]; other site"
/db_xref="CDD:173746"
misc_feature order(734..766,779..802)
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173746"
misc_feature 779..787
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P45983.2);
Region: TXY"
misc_feature 779..781
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAP2K7; propagated from
UniProtKB/Swiss-Prot (P45983.2); phosphorylation site"
misc_feature 785..787
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by MAP2K4; propagated from
UniProtKB/Swiss-Prot (P45983.2); phosphorylation site"
exon 355..484
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 485..543
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 544..682
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 683..848
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 849..920
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 921..1103
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 1104..1228
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
STS 1162..1266
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="MARC_12374-12375:997362452:1"
/db_xref="UniSTS:267421"
STS 1168..1269
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="MARC_13424-13425:1002294866:1"
/db_xref="UniSTS:267492"
exon 1229..1292
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 1293..1370
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
exon 1371..5847
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/inference="alignment:Splign:1.39.8"
STS 1385..1521
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="STS-L26318"
/db_xref="UniSTS:6223"
STS 1404..1527
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="D10S2185"
/db_xref="UniSTS:27764"
STS 2107..2194
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="RH69616"
/db_xref="UniSTS:47949"
STS 2183..2320
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="STS-T94087"
/db_xref="UniSTS:42388"
polyA_signal 2343..2348
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
polyA_site 2370
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
STS 2605..2818
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="HSC1IF052"
/db_xref="UniSTS:25988"
STS 2670..2875
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="A004M36"
/db_xref="UniSTS:62067"
polyA_site 2914
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
STS 5654..5773
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
/standard_name="D10S1856"
/db_xref="UniSTS:81152"
polyA_signal 5812..5817
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
polyA_site 5847
/gene="MAPK8"
/gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
PRKM8; SAPK1; SAPK1c"
ORIGIN
gacgtgcgcgggcgtgcgcggtgacggcccgcgtctctgttactcagccgagcggccgaggccggacgacgcggcttggattgcggagccgcgagcagcgctgggtaacggccgcggcgaccaccccggacggcccctgtccccgctggcgggcttccctgtcgccgttcgctgcgctgccggcttcttggtgaatttttggatgaagccattaaattaattgcttgccatcatgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattcacagtcctgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagtatgcgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccgaccatttcagaatcagactcatgccaagcgggcctacagagagctagttcttatgaaatgtgttaatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaatttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcagatggagctagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaagcaccttcattctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaatctgattgcactttgaagattcttgacttcggtctggccaggactgcaggaacgagttttatgatgacgccttatgtagtgactcgctactacagagcacccgaggtcatccttggcatgggctacaaggaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaaggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacagcttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttacgttgaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtccttttcccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaaatgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccaacacccgtacatcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatccctgacaagcagttagatgaaagggaacacacaatagaagagtggaaagaattgatatataaggaagttatggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggtgcagcagtgatcaatggctctcagcatccatcatcatcgtcgtctgtcaatgatgtgtcttcaatgtcaacagatccgactttggcctctgatacagacagcagtctagaagcagcagctgggcctctgggctgctgtagatgactacttgggccatcggggggtgggagggatggggagtcggttagtcattgatagaactactttgaaaacaattcagtggtcttatttttgggtgatttttcaaaaaatgtagaattcattttgtagtaaagtagtttattttttttaatttcaagtgatgtaatttaaaacctaagttgtgtttcaaaacagcaacaaaactgtattgtattttttttgctgtaattaactgtataatgtaaacctaattattttatcatggtttaaattttttgcatatttgctttatcttatgctgctgatttttttaactgaatttgtaagattttgtttatcaaagcaactattatgtggtgacttgcctatatcatgaattatttaagatttttatagttttttttaattagaatttatttcagatgttttgttcatgatactatccttcagggttatgtgcttatcaatgaaataaccccagaggagtgagggaaaataacttgtagccagttatattcaggaataactactgtaaatgatgaacgtgttaggagacctccaatatttgctacttgccaatcctaatttagttacaagaattggtaggcaatcctacttaattttggcaaaagccccgtcatctaaatggcagaataactcagagcatgtctttgaagatgctgggcgtctaccaccaccttatgtccccaccctacccaacaaaaataagtaaaaagaatatggtgtattctacaaatttgtggcatgctcaaagtttatgatcacataaaggcaagaggatacttcatgaataatacatttcaatgcaaataaacagatggttcacttctactagctatgagcctgtttttgtatacactgagttaatctactcaggctgtaggtcccagcaatgttctagagtctggtctttccctttcctgcagcttcgggtccttggacctttcctgtttcctattacttggagtgtctgtcagttgagcaccagttgttctggtgtttcatttgattctacttgtagcataatcatttatacgagctattgggaggttccaaaccctacctagatttgtgtaggtgatgtatcaaatgagcaatataccgttcatctgaaaatagtagcacacagccatatataggatatcattttctaaggactgtttcttcacattgagcagagcaggcataaatggtggttatttagtctaagtcttttatttttttatacctgattttcaacataacacgcaatgtggatgtcgagtagtgttaagaatggtgctgctcctgacaagtgtatgttaactgtttacattttctatctgtagaattatttctctattactgaacttttcctaagtaaaatgtctttgaagtctcgttatttctgaaatacgttgtctgtaatagacccaggcaccttttaaattatctctggaacaagagggatttcatgtaatgaactaggaaatgcatactcacataagcaacaaggttctaggcagaaagccccttggaatttgtgaccaacaggagcaagaacaggtgcggctcaacatgcaatgtctgaaaatttgcttggcattttattcatatatttagtgcaaaattatttttgagtgagatattttacatcactgttaatgtgcaatatttaagattaaaatacattagcttttttatatactttgaagtagcaagtttgttttcgatggcttagagtcatgatttccagcttcccagcctttttatcagtcccttttctaatacaacaaggtgcattaatttgattaggcaaattagagttctaagacacttcttgaattgtagacagaaaatattggattcacaatttcagcagaaatttgagaatgagtgtgtttatattaatttcacaattagctgtattttctgtagcatagattatgtcactgttgcactttcacagcagacatgctttcagaaggttctcatattttatgtttgattgctgataagccatctctattgatacagattttggttaagtaaggaaaaccaggtgtgtgtctgtatcatttattgtaaatgccagctgccacttgccaaccatcatgttcagttcaattcaaagaaaacaaactctcattacttagtgtaaactaaaatacttaacaaattatatcctaaaaacaaggtctctttgttaaatgttgcatgccctaggttttaaattactacatccaaatacagttttcgtcttaaatttgttaagctaaatatatgttggttctttttattttggaatcctttaagcatcttaaacattttttttttgaagagaagttacaaataacatttctatcaggtagtacttgtatgaaaccacctttcttattctataattttgatttttcaattttatatacttaatatactcactgtcttactatcagaaagttattttgaccaagatttttattatcttcatagattcagaaagagatgctaattctgtaccaatgtcttcctggttactattctcttccctctaatatatactggccatttgtaaaaccattgtgttgttgggatcacttagttatactatacgcagatagagcatctcaactctgtcatagtgtttgctgaacagttttcagtgtcatgcacctttggctgctaattgttcctgacgtgcactcttccgagttggtaaaggcacagtgtgttcatgccagacttctaagagaaacaccagcctcttaaatcagaagcctacacacaacccccttaacaatccaaagaagcttgatggtgtgcaaagaagcatcctgccagccttgtcattgttctgttctatgctaatcctgctgtgttgtctaaaagatggagggaagaggacatcagtgtctgatagtgaaatcatcagcaggaaagtgaagctctttccttggttacagataagacttggtttacactattggccagtatctgctaaacatatgaagacttaactattcagtgttgcctaggcattcgcctgcacaacattttgaggttagaacatagaatattttcagaaatactgttgtagtttgtgagtgttgttcattagttacacattagctatagagtggatgcatgaagccccatgacaccagtaaacttctcttaccagtaggtaaaccaaacaccattctgtcattagcagccctcttaaatgttgcctctccgtatcctgttgcatttttgtgtgcattgtgtttctactgatctctcttaggtttttacggaatcaaaggaaactaatttttccttaatagcaagaaagatgaagaggtaaagggcattgaagcagaaatgtatagtttggggtacgattagaaaactcgtaaggaaaacagaagtcctaatttcaaactgactgctcttcgttaagtgctcttaaggagagtctagtaacagtaacactttctggccatttctagtttagattctcttcgttactgaaacttttgagaaatattacctgtggattaattttgcacaatgttctattctcataatgacttacaaattaaactaggtttttattgaactacctcacactaattttctatgctttcccaagtaagctgttgccctgttagatctttactgagtgaattataaatgtgtgttaaatactttctagccaatgttgacacaataccagtaagtatgtaaagtatataccttacatcagtaagagacacgtgtaaaatctttgactgtatgtcttgcaaaattgtgctcgttgacattattactgtttttgtaagtagaaacctgctcgtgatatcggtccatttacattttacaaaaggagtaaatcttagtaaaaattttacgaagaaataaattacttttgtaggcccaatatttggtatatttttgagaagctgttaatcttttagctgaataatgaagttagactgaattacgtgtctccctggactgtgacatctattttctcattacagtttatcctggtcagcagggtgtcacacctggaaacctgagtatgatagctgacatttgcttttctccctctgcgatgtcattcctcctccattcctctccttccctgtgttccgttccctctcctttcctctagacaaaacaaaatggggcactttttagggaatgctgagatcattattgtggtttttcatcattcatgccctagtcattaaacatgcaccactggaatgtaaacaatgttatctagtatgtcaattggttataatattttaaataaaaaagaaaaaagtggtatgaaaattatgaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5599 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5599 -> Molecular function: GO:0004705 [JUN kinase activity] evidence: IDA
GeneID:5599 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5599 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5599 -> Molecular function: GO:0035033 [histone deacetylase regulator activity] evidence: IMP
GeneID:5599 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IPI
GeneID:5599 -> Biological process: GO:0001503 [ossification] evidence: IEA
GeneID:5599 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5599 -> Biological process: GO:0006950 [response to stress] evidence: TAS
GeneID:5599 -> Biological process: GO:0007254 [JNK cascade] evidence: IDA
GeneID:5599 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
GeneID:5599 -> Biological process: GO:0007258 [JUN phosphorylation] evidence: IDA
GeneID:5599 -> Biological process: GO:0009411 [response to UV] evidence: IDA
GeneID:5599 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
GeneID:5599 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:5599 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:5599 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IMP
GeneID:5599 -> Biological process: GO:0031063 [regulation of histone deacetylation] evidence: IMP
GeneID:5599 -> Biological process: GO:0032091 [negative regulation of protein binding] evidence: IDA
GeneID:5599 -> Biological process: GO:0032880 [regulation of protein localization] evidence: IDA
GeneID:5599 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS
GeneID:5599 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:5599 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5599 -> Biological process: GO:0046686 [response to cadmium ion] evidence: IEA
GeneID:5599 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:5599 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:5599 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:5599 -> Biological process: GO:0090045 [positive regulation of deacetylase activity] evidence: IMP
GeneID:5599 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
GeneID:5599 -> Biological process: GO:2000017 [positive regulation of determination of dorsal identity] evidence: IEA
GeneID:5599 -> Biological process: GO:2001235 [positive regulation of apoptotic signaling pathway] evidence: IEA
GeneID:5599 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5599 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5599 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:5599 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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