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2024-03-28 18:48:35, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001278464            4654 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens dynamin 1-like (DNM1L), transcript variant 5, mRNA.
ACCESSION   NM_001278464
VERSION     NM_001278464.1  GI:510937024
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4654)
  AUTHORS   Duboff,B., Feany,M. and Gotz,J.
  TITLE     Why size matters - balancing mitochondrial dynamics in Alzheimer's
            disease
  JOURNAL   Trends Neurosci. 36 (6), 325-335 (2013)
   PUBMED   23582339
REFERENCE   2  (bases 1 to 4654)
  AUTHORS   Guo,C., Hildick,K.L., Luo,J., Dearden,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes
            cell death following ischaemia
  JOURNAL   EMBO J. 32 (11), 1514-1528 (2013)
   PUBMED   23524851
REFERENCE   3  (bases 1 to 4654)
  AUTHORS   Ryu,S.W., Yoon,J., Yim,N., Choi,K. and Choi,C.
  TITLE     Downregulation of OPA3 is responsible for transforming growth
            factor-beta-induced mitochondrial elongation and F-actin
            rearrangement in retinal pigment epithelial ARPE-19 cells
  JOURNAL   PLoS ONE 8 (5), E63495 (2013)
   PUBMED   23658835
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4654)
  AUTHORS   Frohlich,C., Grabiger,S., Schwefel,D., Faelber,K., Rosenbaum,E.,
            Mears,J., Rocks,O. and Daumke,O.
  TITLE     Structural insights into oligomerization and mitochondrial
            remodelling of dynamin 1-like protein
  JOURNAL   EMBO J. 32 (9), 1280-1292 (2013)
   PUBMED   23584531
  REMARK    GeneRIF: An oligomerization mode for DNM1L which differs from that
            of dynamin and might be adapted to the remodelling of mitochondria.
REFERENCE   5  (bases 1 to 4654)
  AUTHORS   Li,D., Zhao,Z., Huang,Y., Lu,Z., Yao,M., Hao,Y., Zhai,C. and
            Wang,Y.
  TITLE     PsVPS1, a dynamin-related protein, is involved in cyst germination
            and soybean infection of Phytophthora sojae
  JOURNAL   PLoS ONE 8 (3), E58623 (2013)
   PUBMED   23516518
REFERENCE   6  (bases 1 to 4654)
  AUTHORS   Waterham,H.R., Koster,J., van Roermund,C.W., Mooyer,P.A.,
            Wanders,R.J. and Leonard,J.V.
  TITLE     A lethal defect of mitochondrial and peroxisomal fission
  JOURNAL   N. Engl. J. Med. 356 (17), 1736-1741 (2007)
   PUBMED   17460227
REFERENCE   7  (bases 1 to 4654)
  AUTHORS   Hong,Y.R., Chen,C.H., Cheng,D.S., Howng,S.L. and Chow,C.C.
  TITLE     Human dynamin-like protein interacts with the glycogen synthase
            kinase 3beta
  JOURNAL   Biochem. Biophys. Res. Commun. 249 (3), 697-703 (1998)
   PUBMED   9731200
REFERENCE   8  (bases 1 to 4654)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J. Cell. Sci. 111 (PT 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   9  (bases 1 to 4654)
  AUTHORS   Kamimoto,T., Nagai,Y., Onogi,H., Muro,Y., Wakabayashi,T. and
            Hagiwara,M.
  TITLE     Dymple, a novel dynamin-like high molecular weight GTPase lacking a
            proline-rich carboxyl-terminal domain in mammalian cells
  JOURNAL   J. Biol. Chem. 273 (2), 1044-1051 (1998)
   PUBMED   9422767
REFERENCE   10 (bases 1 to 4654)
  AUTHORS   Shin,H.W., Shinotsuka,C., Torii,S., Murakami,K. and Nakayama,K.
  TITLE     Identification and subcellular localization of a novel mammalian
            dynamin-related protein homologous to yeast Vps1p and Dnm1p
  JOURNAL   J. Biochem. 122 (3), 525-530 (1997)
   PUBMED   9348079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302565.1, AK299926.1 and
            AC087588.10.
            
            Summary: This gene encodes a member of the dynamin superfamily of
            GTPases. The encoded protein mediates mitochondrial and peroxisomal
            division, and is involved in developmentally regulated apoptosis
            and programmed necrosis. Dysfunction of this gene is implicated in
            several neurological disorders, including Alzheimer's disease.
            Mutations in this gene are associated with the autosomal dominant
            disorder, encephalopathy, lethal, due to defective mitochondrial
            and peroxisomal fission (EMPF). Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (5) contains an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (5) is longer, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard
                                                (PMID:17460227)
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AK302565.1         1-87
            88-2786             AK299926.1         1-2699
            2787-4654           AC087588.10        138112-139979       c
FEATURES             Location/Qualifiers
     source          1..4654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..4654
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:10059"
                     /db_xref="HGNC:2973"
                     /db_xref="MIM:603850"
     exon            1..266
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     CDS             165..2414
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /EC_number="3.6.5.5"
                     /note="isoform 5 is encoded by transcript variant 5;
                     Dnm1p/Vps1p-like protein; dynamin family member
                     proline-rich carboxyl-terminal domain less; dynamin-like
                     protein 4; dynamin-like protein IV; dynamin-related
                     protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 5"
                     /protein_id="NP_001265393.1"
                     /db_xref="GI:510937025"
                     /db_xref="GeneID:10059"
                     /db_xref="HGNC:2973"
                     /db_xref="MIM:603850"
                     /translation="
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
"
     misc_feature    231..1109
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    246..854
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Dynamin family; Region: Dynamin_N; pfam00350"
                     /db_xref="CDD:215874"
     misc_feature    258..281
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(261..263,267..284,321..326,339..341,639..641,
                     849..851,855..860,936..950,957..959)
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(264..269,651..653,690..692,765..767,771..773,
                     777..788,792..797,858..860,864..875,945..953)
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    339..341
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    351..359
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    465..>1706
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Predicted GTPases (dynamin-related) [General
                     function prediction only]; Region: COG0699"
                     /db_xref="CDD:223771"
     misc_feature    639..650
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(645..650,738..743)
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    846..857
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    879..1757
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:216255"
     misc_feature    936..944
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1233..1670
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00429.2);
                     Region: Middle domain"
     misc_feature    1545..2258
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00429.2);
                     Region: Interaction with GSK3B"
     misc_feature    1707..1910
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O00429.2);
                     Region: B domain"
     misc_feature    1845..1847
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O00429.2); phosphorylation site"
     misc_feature    2022..2024
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O00429.2); phosphorylation site"
     misc_feature    2049..2051
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK1; propagated from
                     UniProtKB/Swiss-Prot (O00429.2); phosphorylation site"
     misc_feature    2112..2114
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CAMK1 and PKA; propagated from
                     UniProtKB/Swiss-Prot (O00429.2); phosphorylation site"
     misc_feature    2124..2393
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:202159"
     misc_feature    2133..2135
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="S-nitrosocysteine; propagated from
                     UniProtKB/Swiss-Prot (O00429.2); nitrosylation site"
     exon            267..414
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            415..453
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            454..500
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            501..572
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            573..659
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            660..822
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            823..943
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            944..1075
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1076..1282
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1283..1403
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1404..1559
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1560..1649
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1650..1742
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1743..1799
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1800..1877
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1878..1910
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            1911..2087
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            2088..2197
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            2198..2357
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     exon            2358..4654
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /inference="alignment:Splign:1.39.8"
     STS             2467..2591
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="RH15679"
                     /db_xref="UniSTS:46217"
     STS             2733..3382
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="DNM1L_7961"
                     /db_xref="UniSTS:467656"
     STS             2937..3065
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="G43506"
                     /db_xref="UniSTS:94963"
     STS             2958..3058
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="G59502"
                     /db_xref="UniSTS:136666"
     STS             3458..3562
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             3459..3668
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="RH80030"
                     /db_xref="UniSTS:87680"
     STS             3544..3631
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             4142..4249
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
                     /standard_name="SGC30841"
                     /db_xref="UniSTS:38655"
     polyA_signal    4526..4531
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
     polyA_site      4551
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV"
ORIGIN      
agcgcatggcctgccgggagggggcaggtagccggcgggcccggtccaatgggtgccggcttccgaggagagggcggaggagaggaggaaggaggcgaactgtgggccccggccccattcattgccgtggccggcgggcactggggccccgtgttttcagagtcatggaggcgctaattcctgtcataaacaagctccaggacgtcttcaacacggtgggcgccgacatcatccagctgcctcaaatcgtcgtagtgggaacgcagagcagcggaaagagctcagtgctagaaagcctggtggggagggacctgcttcccagaggtactggaattgtcacccggagacctctcattctgcaactggtccatgtttcacaagaagataaacggaaaacaacaggagaagaaaatgaccctgctacatggaaaaactcaagacacctttctaaaggggtggaagcagaagaatggggtaaatttcttcacaccaaaaataagctttacacggattttgatgaaattcgacaagaaattgaaaatgaaacagaaagaatttcaggaaataataagggagtaagccctgaaccaattcatcttaagattttttcacccaacgttgtcaatttgacacttgtggatttgccaggaatgaccaaggtgcctgtaggtgatcaacctaaggatattgagcttcaaatcagagagctcattcttcggttcatcagtaatcctaattccattatcctcgctgtcactgctgctaatacagatatggcaacatcagaggcacttaaaatttcaagagaggtagatccagatggtcgcagaaccctagctgtaatcactaaacttgatctcatggatgcgggtactgatgccatggatgtattgatgggaagggttattccagtcaaacttggaataattggagtagttaacaggagccagctagatattaacaacaagaagagtgtaactgattcaatccgtgatgagtatgcttttcttcaaaagaaatatccatctctggccaatagaaatggaacaaagtatcttgctaggactctaaacaggttactgatgcatcacatcagagattgtttaccagagttgaaaacaagaataaatgttctagctgctcagtatcagtctcttctaaatagctacggtgaacccgtggatgataaaagtgctactttactccaacttattaccaaatttgccacagaatattgtaacactattgaaggaactgcaaaatatattgaaacttcggagctatgcggtggtgctagaatttgttatattttccatgagacttttgggcgaaccttagaatctgttgatccacttggtggccttaacactattgacattttgactgccattagaaatgctactggtcctcgtcctgctttatttgtgcctgaggtttcatttgagttactggtgaagcggcaaatcaaacgtctagaagagcccagcctccgctgtgtggaactggttcatgaggaaatgcaaaggatcattcagcactgtagcaattacagtacacaggaattgttacgatttcctaaacttcatgatgccatagttgaagtggtgacttgtcttcttcgtaaaaggttgcctgttacaaatgaaatggtccataacttagtggcaattgaactggcttatatcaacacaaaacatccagactttgctgatgcttgtgggctaatgaacaataatatagaggaacaaaggagaaacaggctagccagagaattaccttcagctgtatcacgagacaagtcttctaaagttccaagtgctttggcacctgcctcccaggagccctcccccgctgcttctgctgaggctgatggcaagttaattcaggacagcagaagagaaactaaaaatgttgcatctggaggtggtggggttggagatggtgttcaagaaccaaccacaggcaactggagaggaatgctgaaaacttcaaaagctgaagagttattagcagaagaaaaatcaaaacccattccaattatgccagccagtccacaaaaaggtcatgccgtgaacctgctagatgtgccagttcctgttgcacgaaaactatctgctcgggaacagcgagattgtgaggttattgaacgactcattaaatcatattttctcattgtcagaaagaatattcaagacagtgtgccaaaggcagtaatgcattttttggttaatcatgtgaaagacactcttcagagtgagctagtaggccagctgtataaatcatccttattggatgatcttctgacagaatctgaggacatggcacagcgcaggaaagaagcagctgatatgctaaaggcattacaaggagccagtcaaattattgctgaaatccgggagactcatctttggtgaagagaactatgtaatactgagactttgttgactcaaaacttgctagttactgcctacctgagtagaatcttatttatgaactcctgtgtattgcaatggtatgaatctgctcatgtggagactggctataaactgaaaagtgtattccaaattgcagaacacatcacacatttaatccaaataataaatggctgtttctaaagtttcccagtatatataaaatacatcaagtctgtcttgtgacagtttcatctgaacttaacttaaaaacaactgttaatgttctagttgtgcaaagcagtttgcctgtggataagatgacctgtgtaataatctttgttagtagtcttaaagctgctgccatagtcctccaagaagaaagcaccaagacaacatttcatatgactataatgcatgtactatataagctgatctggctttgaaagatgtgagttggcaagttcctcacatagagtcattgtattccacctgtccttcaatttagttttttctgagcttctttgcagcctttgatgtgtttttaagaaagctgaatgcacaagaggatctgtgacactgacatggctgtggtgtgcatactgtgtagttacatagcccttccaattctgggtccatttgcactagcaaattaaaatatgctttgattcatacttaaacctgaaagcaggaatgcctacattaattcctacattaaaaacagccatctacccttgattatctagaaagacttggtaatgatggtcagttccttttagatttcagaaaatcaaatgatgacctaaatttcccttaatttgcaaatacagtagtaattaaggtacatctctaaagtggagcacttacaccaggctctaagattcactttgaggtggaacttaaaaccagtgtactgtatgtatgcattggtaatagctacttttgcttcatagcttcataccaacaaaatatatttattagaatagtatgaaagtactggaggagctgaaagaaaaacacccaaggctgggcgtggtggcacacgcctgtaatcccagcactttgggaggccgaggcaggtggatcacctgaggttgggagttggagaccagcttgaccaacatggagaaaccccgtctctactaaaaatacaaaattggccgggcgtggtggcgcatgcctgtaatcccagctactcgggagggtgaggcaggagaattgcttgaccctgggaggtggaggttgtggtgagctaagatcgtgccattgcactccagccttggcaacaagagcgaaactccgtctcaaaaaaaaaaaataaaacaacacccagatagatacacatactccttcagacttacagacctaagctgcatttatggggtagtgatgaggtttagaacatatacatattttgttaaaattccccagatgattcttggtatgaacgactatattataaattttaagatgtacttagaaatccttaagacatctagccccgtctctaatagacaacacatttatattgcagatattacttttttttcagtttatgaccaggtatttatgaaggactattggcagggaaaatatgaatatgttaactttagcttatggcatcaatttactaaggaacaacaggctcaccaactgatgtcaaacataaaaacccccacatcagtctgatacgatatggtactactttgaatctgttactagtaccatcttgacagaggatacatgctcccaaaacgtttgttaccacacttaaaaatcactgccatcattaagcatcagtttcaaaattatagccattcatgatttactttttccagatgactatcattattctagtcctttgaatttgtaaggggaaaaaaaacaaaaacaaaaacttacgatgcacttttctccagcacatcagatttcaaattgaaaattaaagacatgctatggtaatgcacttgctagtactacacactttgtacaacaaaaaacagaggcaagaaacaacggaaagagaaaagccttcctttgttggcccttaaactgagtcaagatctgaaatgtagagatgatctctgacgatacctgtatgttcttattgtgtaaataaaattgctggtatgaaatgacactaaagtttgtcaaaaaatgaattcttaacttttctcccagagaaagggagacaaaaggagctttttaatacctaatctactttggaacataaccgtatagag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10059 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
            GeneID:10059 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10059 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
            GeneID:10059 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
            GeneID:10059 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:10059 -> Biological process: GO:0000266 [mitochondrial fission] evidence: IMP
            GeneID:10059 -> Biological process: GO:0003374 [dynamin polymerization involved in mitochondrial fission] evidence: IDA
            GeneID:10059 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:10059 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
            GeneID:10059 -> Biological process: GO:0010821 [regulation of mitochondrion organization] evidence: IMP
            GeneID:10059 -> Biological process: GO:0016559 [peroxisome fission] evidence: IDA
            GeneID:10059 -> Biological process: GO:0016559 [peroxisome fission] evidence: IMP
            GeneID:10059 -> Biological process: GO:0043653 [mitochondrial fragmentation involved in apoptotic process] evidence: IMP
            GeneID:10059 -> Biological process: GO:0050714 [positive regulation of protein secretion] evidence: IDA
            GeneID:10059 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IDA
            GeneID:10059 -> Biological process: GO:0070584 [mitochondrion morphogenesis] evidence: IMP
            GeneID:10059 -> Biological process: GO:0090141 [positive regulation of mitochondrial fission] evidence: TAS
            GeneID:10059 -> Biological process: GO:0090149 [membrane fission involved in mitochondrial fission] evidence: IDA
            GeneID:10059 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IMP
            GeneID:10059 -> Biological process: GO:1900063 [regulation of peroxisome organization] evidence: IMP
            GeneID:10059 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP
            GeneID:10059 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS
            GeneID:10059 -> Cellular component: GO:0005777 [peroxisome] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:10059 -> Cellular component: GO:0005874 [microtubule] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA
            GeneID:10059 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
            GeneID:10059 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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