GGRNA | NM_001278314.1

LOCUS       NM_001278314            2961 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens inscuteable homolog (Drosophila) (INSC), transcript
            variant 4, mRNA.
ACCESSION   NM_001278314
VERSION     NM_001278314.1  GI:507417928
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Mapelli,M. and Gonzalez,C.
  TITLE     On the inscrutable role of Inscuteable: structural basis and
            functional implications for the competitive binding of NuMA and
            Inscuteable to LGN
  JOURNAL   Open Biol 2 (8), 120102 (2012)
   PUBMED   22977735
  REMARK    GeneRIF: Studies indicate that the Inscuteable (Insc)and NuMA are
            mutually exclusive interactors of LGN.
            Review article
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (48), 19210-19215 (2011)
   PUBMED   22074847
  REMARK    GeneRIF: mInsc-LGN interaction is vital for stabilization of LGN
            and for intracellular localization of mInsc.
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Vural,A., Oner,S., An,N., Simon,V., Ma,D., Blumer,J.B. and
            Lanier,S.M.
  TITLE     Distribution of activator of G-protein signaling 3 within the
            aggresomal pathway: role of specific residues in the
            tetratricopeptide repeat domain and differential regulation by the
            AGS3 binding partners Gi(alpha) and mammalian inscuteable
  JOURNAL   Mol. Cell. Biol. 30 (6), 1528-1540 (2010)
   PUBMED   20065032
  REMARK    GeneRIF: These data present AGS3, G-proteins, and mInsc as
            candidate proteins involved in regulating cellular stress
            associated with protein-processing pathologies.
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Two forms of human Inscuteable-related protein that links Par3 to
            the Pins homologues LGN and AGS3
  JOURNAL   Biochem. Biophys. Res. Commun. 341 (4), 1001-1006 (2006)
   PUBMED   16458856
  REMARK    GeneRIF: cloning of two distinct cDNAs from Insc gene, which is
            differentially expressed from alternative first exons;Insc proteins
            bind to the Pins homologues LGN and AGS3, and also to Par3 and
            Par3beta
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human Inscuteable gene in
            silico
  JOURNAL   Int. J. Mol. Med. 11 (1), 111-116 (2003)
   PUBMED   12469229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127700.1, DY654442.1, AC090744.5 and AB236158.1.
            
            Summary: In Drosophila, neuroblasts divide asymmetrically into
            another neuroblast at the apical side and a smaller ganglion mother
            cell on the basal side. Cell polarization is precisely regulated by
            2 apically localized multiprotein signaling complexes that are
            tethered by Inscuteable, which regulates their apical localization
            (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. The
            resulting isoform (c) is shorter at the N-terminus and has an
            additional internal segment, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB231746.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               BC127700.1         1-615
            616-652             DY654442.1         397-433             c
            653-757             AC090744.5         78460-78564         c
            758-2961            AB236158.1         691-2894
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..2961
                     /gene="INSC"
                     /note="inscuteable homolog (Drosophila)"
                     /db_xref="GeneID:387755"
                     /db_xref="HGNC:33116"
                     /db_xref="MIM:610668"
     exon            1..129
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     CDS             74..1777
                     /gene="INSC"
                     /note="isoform c is encoded by transcript variant 4;
                     protein inscuteable homolog"
                     /codon_start=1
                     /product="protein inscuteable homolog isoform c"
                     /protein_id="NP_001265243.1"
                     /db_xref="GI:507417929"
                     /db_xref="GeneID:387755"
                     /db_xref="HGNC:33116"
                     /db_xref="MIM:610668"
                     /translation="

MMALPGGRHLDSVTLPGQRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQVESHSVTRLECSGAISAQCNLRLLGSSDSPASASQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV

"
     exon            130..475
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            476..528
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            529..652
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            653..757
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            758..871
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            872..997
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            998..1169
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1170..1348
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1349..1415
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1416..1571
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1572..1648
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1649..2945
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
ORIGIN

gttgtgccatcctgccctctattttcagggtcacgaccgctgcaagcaggctttgctgcagattgggatcaacatgatggcactgcctggaggtcgccacctggactccgtcaccctgccgggtcagcggctacacctgatgcaggtggactcagtccagcgctggatggaagatctgaagctcatgaccgagtgcgagtgcatgtgtgtcctgcaggccaagcccatcagcctggaagaggatgcacagggtgacctcatcctggcaggtggccctggccctggagaccccctgcagctgctgctcaaacggggttgggtcattagcacagagctgcgcaggatcgggcagaagctggcccaggaccgctgggcacgggtgcacagcatgagcgtgcgtctgacctgccatgcccgctccatggtcagcgagtacagtgctgtcagcaggaactccttgaaggaaatgggcgagattgagaagctgctaatggagaaatgctcggagctctcggcagtcacagagaggtgccttcaggttgagaatgagcatgtcctgaagtcaatgaaggcctgcgtgagtgagaccctgagcatgctgggccagcactttggtcagctgctggagctggccctgacacgggaggttcaggtggagtctcactctgtcaccaggctggagtgcagtggtgcaatctcggctcaatgcaacctccgcctcctgggttcaagtgattcccctgcctcagcctcccaggcactggtgagaaaaattgatgcctcagacaatatctacaccacagagtccaccacagggaacctgttcagcctgacccaggagggggctcccttgtgccgcatcatagccaaggagggtggggtcgtagcactcttcaaggtttgccggcaggacagtttccggtgcttgtacccccaggcgctccgcacgctggcctccatctgctgcgtggaagagggtgtccaccagctggagaaggtggatggcgttctgtgcttggccgacatcctgaccgacaacagccactcagaggccacacgggctgaggctgcggctgtggtggcccaggtcacctccccacacctgcccgtcacccagcacctcagtagcttcctggagagcatggaggagatcgtgacagccctcgtcaaactgtgccaagaggcctcatcaggggaagtcttcctactggcctctgcggcccttgccaacatcacgttctttgacacaatggcctgcgagatgctcctgcagttgaatgccatccgtgttctcctggaagcctgcagtgacaagcagagagtggacacgccttacactcgggaccagattgtgaccatcttggcaaacatgtctgtcctagaacagtgtgcctctgacatcattcaggaaaatggggtccagcttatcatgggcatgctgtctgaaaaaccaaggtctgggactcctgctgaagtggcagcctgtgagcgagtccagcagaaagctgcagtgaccctggctcgtctcagccgagacccagatgtggcacgggaggccgtgcggctcagctgcatgtcccgtctcatcgagctctgcagatccccatcagagaggaacagcagtgacgccgtgcttgtggcctgcctggctgctctgcgtagattggctggggtctgccctgaaggcctccaggactctgactttcagcagttggtccagcctcggctggtggactccttcttactctgcagcaacatggaggagagttttgtgtagtgagtgtgggcgaagaaatacatttggctgttctcacaccccctctgactatgcaccagtgaacacatctgagtacataccagctctcctcatcttcttatttatacttaacttatttttgtgtgaaataaatggaggacaaaatcttagagcaacatcatcaaacagtctttggtccttgagaatcttctttgtgttttattttttgatttctgtagcttttcagttgcagatgttgaaattcgtaatgacaaatatgacaaattgtcatgggtgattccacttcatcttattttttctactctcactatacaatcttgcctcattttttaaaactttggaaccagaggatttcaactgcctagcaagttttttttttaagttggatttgctcttcccaaaaatctaaaatgaatttaataattgggtagaatatattggaaagaagtttctttttctttaataaatggaatcatataaaatgtatcccggattttcttattaaattgtattttaaactaggttcttgcttcccaggtttcattccccaaaaacttttccaaccattaaaagtacacacagaattgtcttgttttcataggtgtataaataggttaagttctgagtgacttagtgagaaaccaaagtgactttcaaaaatacacccaaaggcaccagaaaccctgcttcctttggcttctttgcttttgtgtaacctcctgttcacctcctggtgaatagaatcctcagatgaggcttattgaatgattgattcctcctcaaaagtatacttgaaagcagtggtgtgctgaagccagctcatgcccactcacaagggacaactgtgagaatttcttcctaactctgcactcagtgaccttgcgttggtagccatgagctacttcatgagccctcatgttgaaattggccatagtgggagtatttacaccacagaaattcacagatgctataaagcacagctttcgctttttttttttttagagagagctggtttaccaatttcactgcttgaaagtatcacaaaaatctggggatccttttgaaaatataaatgccatcatattgtgatataatttatacaatataatataattgtgtaaaatcatgattataataatgtttcaataaacatttcttaaattcccaaaaaaaaaaaaaaaaaa

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