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2024-03-29 13:55:42, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001278313            2856 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens inscuteable homolog (Drosophila) (INSC), transcript
            variant 3, mRNA.
ACCESSION   NM_001278313
VERSION     NM_001278313.1  GI:507417926
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Mapelli,M. and Gonzalez,C.
  TITLE     On the inscrutable role of Inscuteable: structural basis and
            functional implications for the competitive binding of NuMA and
            Inscuteable to LGN
  JOURNAL   Open Biol 2 (8), 120102 (2012)
   PUBMED   22977735
  REMARK    GeneRIF: Studies indicate that the Inscuteable (Insc)and NuMA are
            mutually exclusive interactors of LGN.
            Review article
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (48), 19210-19215 (2011)
   PUBMED   22074847
  REMARK    GeneRIF: mInsc-LGN interaction is vital for stabilization of LGN
            and for intracellular localization of mInsc.
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Vural,A., Oner,S., An,N., Simon,V., Ma,D., Blumer,J.B. and
            Lanier,S.M.
  TITLE     Distribution of activator of G-protein signaling 3 within the
            aggresomal pathway: role of specific residues in the
            tetratricopeptide repeat domain and differential regulation by the
            AGS3 binding partners Gi(alpha) and mammalian inscuteable
  JOURNAL   Mol. Cell. Biol. 30 (6), 1528-1540 (2010)
   PUBMED   20065032
  REMARK    GeneRIF: These data present AGS3, G-proteins, and mInsc as
            candidate proteins involved in regulating cellular stress
            associated with protein-processing pathologies.
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Two forms of human Inscuteable-related protein that links Par3 to
            the Pins homologues LGN and AGS3
  JOURNAL   Biochem. Biophys. Res. Commun. 341 (4), 1001-1006 (2006)
   PUBMED   16458856
  REMARK    GeneRIF: cloning of two distinct cDNAs from Insc gene, which is
            differentially expressed from alternative first exons;Insc proteins
            bind to the Pins homologues LGN and AGS3, and also to Par3 and
            Par3beta
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human Inscuteable gene in
            silico
  JOURNAL   Int. J. Mol. Med. 11 (1), 111-116 (2003)
   PUBMED   12469229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127700.1, AB236158.1, DY654442.1 and AB231745.1.
            
            Summary: In Drosophila, neuroblasts divide asymmetrically into
            another neuroblast at the apical side and a smaller ganglion mother
            cell on the basal side. Cell polarization is precisely regulated by
            2 apically localized multiprotein signaling complexes that are
            tethered by Inscuteable, which regulates their apical localization
            (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (3) lacks an exon at the 5' end
            but has an alternate segment, which results in a downstream start
            codon, compared to variant 1. The resulting isoform (b) has a
            shorter N-terminus, compared to isoform a. Variants 2 and 3 encode
            the same isoform b.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB231745.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               BC127700.1         1-608
            609-615             AB236158.1         647-653
            616-1037            DY654442.1         12-433              c
            1038-1708           AB231745.1         1032-1702
            1709-2856           AB236158.1         1747-2894
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..2856
                     /gene="INSC"
                     /note="inscuteable homolog (Drosophila)"
                     /db_xref="GeneID:387755"
                     /db_xref="HGNC:33116"
                     /db_xref="MIM:610668"
     exon            1..129
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     CDS             74..1672
                     /gene="INSC"
                     /note="isoform b is encoded by transcript variant 3;
                     protein inscuteable homolog"
                     /codon_start=1
                     /product="protein inscuteable homolog isoform b"
                     /protein_id="NP_001265242.1"
                     /db_xref="GI:507417927"
                     /db_xref="GeneID:387755"
                     /db_xref="HGNC:33116"
                     /db_xref="MIM:610668"
                     /translation="
MMALPGGRHLDSVTLPGQRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV
"
     exon            130..475
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            476..528
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            529..652
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            653..766
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            767..892
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            893..1064
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1065..1243
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1244..1310
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1311..1466
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1467..1543
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
     exon            1544..2840
                     /gene="INSC"
                     /inference="alignment:Splign:1.39.8"
ORIGIN      
gttgtgccatcctgccctctattttcagggtcacgaccgctgcaagcaggctttgctgcagattgggatcaacatgatggcactgcctggaggtcgccacctggactccgtcaccctgccgggtcagcggctacacctgatgcaggtggactcagtccagcgctggatggaagatctgaagctcatgaccgagtgcgagtgcatgtgtgtcctgcaggccaagcccatcagcctggaagaggatgcacagggtgacctcatcctggcaggtggccctggccctggagaccccctgcagctgctgctcaaacggggttgggtcattagcacagagctgcgcaggatcgggcagaagctggcccaggaccgctgggcacgggtgcacagcatgagcgtgcgtctgacctgccatgcccgctccatggtcagcgagtacagtgctgtcagcaggaactccttgaaggaaatgggcgagattgagaagctgctaatggagaaatgctcggagctctcggcagtcacagagaggtgccttcaggttgagaatgagcatgtcctgaagtcaatgaaggcctgcgtgagtgagaccctgagcatgctgggccagcactttggtcagctgctggagctggccctgacacgggaggttcaggcactggtgagaaaaattgatgcctcagacaatatctacaccacagagtccaccacagggaacctgttcagcctgacccaggagggggctcccttgtgccgcatcatagccaaggagggtggggtcgtagcactcttcaaggtttgccggcaggacagtttccggtgcttgtacccccaggcgctccgcacgctggcctccatctgctgcgtggaagagggtgtccaccagctggagaaggtggatggcgttctgtgcttggccgacatcctgaccgacaacagccactcagaggccacacgggctgaggctgcggctgtggtggcccaggtcacctccccacacctgcccgtcacccagcacctcagtagcttcctggagagcatggaggagatcgtgacagccctcgtcaaactgtgccaagaggcctcatcaggggaagtcttcctactggcctctgcggcccttgccaacatcacgttctttgacacaatggcctgcgagatgctcctgcagttgaatgccatccgtgttctcctggaagcctgcagtgacaagcagagagtggacacgccttacactcgggaccagattgtgaccatcttggcaaacatgtctgtcctagaacagtgtgcctctgacatcattcaggaaaatggggtccagcttatcatgggcatgctgtctgaaaaaccaaggtctgggactcctgctgaagtggcagcctgtgagcgagtccagcagaaagctgcagtgaccctggctcgtctcagccgagacccagatgtggcacgggaggccgtgcggctcagctgcatgtcccgtctcatcgagctctgcagatccccatcagagaggaacagcagtgacgccgtgcttgtggcctgcctggctgctctgcgtagattggctggggtctgccctgaaggcctccaggactctgactttcagcagttggtccagcctcggctggtggactccttcttactctgcagcaacatggaggagagttttgtgtagtgagtgtgggcgaagaaatacatttggctgttctcacaccccctctgactatgcaccagtgaacacatctgagtacataccagctctcctcatcttcttatttatacttaacttatttttgtgtgaaataaatggaggacaaaatcttagagcaacatcatcaaacagtctttggtccttgagaatcttctttgtgttttattttttgatttctgtagcttttcagttgcagatgttgaaattcgtaatgacaaatatgacaaattgtcatgggtgattccacttcatcttattttttctactctcactatacaatcttgcctcattttttaaaactttggaaccagaggatttcaactgcctagcaagttttttttttaagttggatttgctcttcccaaaaatctaaaatgaatttaataattgggtagaatatattggaaagaagtttctttttctttaataaatggaatcatataaaatgtatcccggattttcttattaaattgtattttaaactaggttcttgcttcccaggtttcattccccaaaaacttttccaaccattaaaagtacacacagaattgtcttgttttcataggtgtataaataggttaagttctgagtgacttagtgagaaaccaaagtgactttcaaaaatacacccaaaggcaccagaaaccctgcttcctttggcttctttgcttttgtgtaacctcctgttcacctcctggtgaatagaatcctcagatgaggcttattgaatgattgattcctcctcaaaagtatacttgaaagcagtggtgtgctgaagccagctcatgcccactcacaagggacaactgtgagaatttcttcctaactctgcactcagtgaccttgcgttggtagccatgagctacttcatgagccctcatgttgaaattggccatagtgggagtatttacaccacagaaattcacagatgctataaagcacagctttcgctttttttttttttagagagagctggtttaccaatttcactgcttgaaagtatcacaaaaatctggggatccttttgaaaatataaatgccatcatattgtgatataatttatacaatataatataattgtgtaaaatcatgattataataatgtttcaataaacatttcttaaattcccaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:387755 -> Biological process: GO:0000132 [establishment of mitotic spindle orientation] evidence: IEA
            GeneID:387755 -> Biological process: GO:0007399 [nervous system development] evidence: IEA
            GeneID:387755 -> Biological process: GO:0060487 [lung epithelial cell differentiation] evidence: IEA
            GeneID:387755 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:387755 -> Cellular component: GO:0045177 [apical part of cell] evidence: IEA

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