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2024-04-20 09:19:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001278162 7413 bp mRNA linear PRI 14-MAY-2013
DEFINITION Homo sapiens homeodomain interacting protein kinase 3 (HIPK3),
transcript variant 2, mRNA.
ACCESSION NM_001278162
VERSION NM_001278162.1 GI:498917229
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7413)
AUTHORS Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
Honda,M. and Tokunaga,K.
TITLE An approach based on a genome-wide association study reveals
candidate loci for narcolepsy
JOURNAL Hum. Genet. 128 (4), 433-441 (2010)
PUBMED 20677014
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 7413)
AUTHORS Xu,Y., Li,F., Zhang,B., Zhang,K., Zhang,F., Huang,X., Sun,N.,
Ren,Y., Sui,M. and Liu,P.
TITLE MicroRNAs and target site screening reveals a pre-microRNA-30e
variant associated with schizophrenia
JOURNAL Schizophr. Res. 119 (1-3), 219-227 (2010)
PUBMED 20347265
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
REFERENCE 3 (bases 1 to 7413)
AUTHORS Lan,H.C., Li,H.J., Lin,G., Lai,P.Y. and Chung,B.C.
TITLE Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through
homeodomain-interacting protein kinase 3-mediated Jun N-terminal
kinase and c-Jun phosphorylation
JOURNAL Mol. Cell. Biol. 27 (6), 2027-2036 (2007)
PUBMED 17210646
REMARK GeneRIF: This finding has linked three common factors, HIPK3, JNK,
and c-Jun, to the cAMP signaling pathway leading to increased
steroidogenic gene expression
REFERENCE 4 (bases 1 to 7413)
AUTHORS Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
Lander,E.S. and Sakaki,Y.
TITLE Human chromosome 11 DNA sequence and analysis including novel gene
identification
JOURNAL Nature 440 (7083), 497-500 (2006)
PUBMED 16554811
REFERENCE 5 (bases 1 to 7413)
AUTHORS Venables,J.P., Bourgeois,C.F., Dalgliesh,C., Kister,L., Stevenin,J.
and Elliott,D.J.
TITLE Up-regulation of the ubiquitous alternative splicing factor
Tra2beta causes inclusion of a germ cell-specific exon
JOURNAL Hum. Mol. Genet. 14 (16), 2289-2303 (2005)
PUBMED 16000324
REFERENCE 6 (bases 1 to 7413)
AUTHORS Scaffidi,C., Volkland,J., Blomberg,I., Hoffmann,I., Krammer,P.H.
and Peter,M.E.
TITLE Phosphorylation of FADD/ MORT1 at serine 194 and association with a
70-kDa cell cycle-regulated protein kinase
JOURNAL J. Immunol. 164 (3), 1236-1242 (2000)
PUBMED 10640736
REFERENCE 7 (bases 1 to 7413)
AUTHORS Nupponen,N.N. and Visakorpi,T.
TITLE Assignment of the protein kinase homolog of YAK1 (HIPK3) to human
chromosome band 11p13 by in situ hybridization
JOURNAL Cytogenet. Cell Genet. 87 (1-2), 102-103 (1999)
PUBMED 10640824
REFERENCE 8 (bases 1 to 7413)
AUTHORS Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
TITLE Homeodomain-interacting protein kinases, a novel family of
co-repressors for homeodomain transcription factors
JOURNAL J. Biol. Chem. 273 (40), 25875-25879 (1998)
PUBMED 9748262
REFERENCE 9 (bases 1 to 7413)
AUTHORS Moilanen,A.M., Karvonen,U., Poukka,H., Janne,O.A. and Palvimo,J.J.
TITLE Activation of androgen receptor function by a novel nuclear protein
kinase
JOURNAL Mol. Biol. Cell 9 (9), 2527-2543 (1998)
PUBMED 9725910
REFERENCE 10 (bases 1 to 7413)
AUTHORS Begley,D.A., Berkenpas,M.B., Sampson,K.E. and Abraham,I.
TITLE Identification and sequence of human PKY, a putative kinase with
increased expression in multidrug-resistant cells, with homology to
yeast protein kinase Yak1
JOURNAL Gene 200 (1-2), 35-43 (1997)
PUBMED 9373137
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK293009.1, AK315277.1, AL122015.17 and BX117467.1.
Transcript Variant: This variant (2) differs in the 5' UTR and
lacks an in-frame exon in the central region, compared to variant
1. The resulting isoform (2) lacks an internal segment, compared to
isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK293009.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2232 AK293009.1 2-2233
2233-3947 AK315277.1 1954-3668
3948-4478 AK293009.1 3949-4479
4479-7097 AL122015.17 31791-34409 c
7098-7413 BX117467.1 1-316 c
FEATURES Location/Qualifiers
source 1..7413
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p13"
gene 1..7413
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="homeodomain interacting protein kinase 3"
/db_xref="GeneID:10114"
/db_xref="HGNC:4915"
/db_xref="MIM:604424"
exon 1..360
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 55
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:184677608"
variation 76
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:368785191"
variation 92
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:144280785"
variation 109
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:112387125"
variation 295
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:113852308"
variation 309
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:78088675"
misc_feature 354..356
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="upstream in-frame stop codon"
exon 361..1459
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
CDS 363..3947
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 2;
homeodomain-interacting protein kinase 3; ANPK; FIST;
homolog of protein kinase YAK1; fas-interacting
serine/threonine-protein kinase; androgen
receptor-interacting nuclear protein kinase"
/codon_start=1
/product="homeodomain-interacting protein kinase 3 isoform
2"
/protein_id="NP_001265091.1"
/db_xref="GI:498917230"
/db_xref="GeneID:10114"
/db_xref="HGNC:4915"
/db_xref="MIM:604424"
/translation="
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
"
misc_feature 951..1937
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:215690"
misc_feature 951..>1625
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:245201"
misc_feature order(969..983,993..995,1032..1034,1038..1040,1137..1139,
1185..1196,1203..1205,1209..1211,1326..1328,1332..1334,
1338..1343,1347..1349,1392..1394,1401..1403,1443..1454)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(969..983,993..995,1032..1034,1038..1040,1137..1139,
1185..1196,1203..1205,1326..1328,1332..1334,1338..1343,
1347..1349,1392..1394)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(981..983,1203..1205,1209..1211,1326..1328,
1332..1334,1338..1340,1401..1403,1443..1454)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(1389..1409,1443..1454)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 2685..2972
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Interaction with FAS (By similarity)"
misc_feature 2862..3332
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Required for localization to nuclear speckles (By
similarity)"
misc_feature 2895..3053
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: SUMO interaction motifs (SIM), required for
nuclear localization and kinase activity (By similarity)"
misc_feature 2907..2939
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Interaction with UBL1 (Probable)"
variation 366
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144688161"
variation 424
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372642188"
variation 479
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374944934"
variation 481
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200300898"
variation 483
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371285073"
variation 486
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148530680"
variation 493
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145481182"
variation 540
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147614894"
variation 562
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144644881"
variation 592
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144410310"
variation 604
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151214053"
variation 618
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140400527"
variation 671
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150292649"
variation 691
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144907072"
variation 694
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375017758"
variation 700
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187022690"
variation 733
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368850984"
variation 755
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140900571"
variation 787
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34193811"
variation 794
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144714786"
variation 869
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138597548"
variation 870
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374084636"
variation 871
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34698015"
variation 905
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369151270"
variation 915
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148715569"
variation 932
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201202256"
variation 933
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35689361"
variation 953
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372051248"
variation 961
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:141595291"
variation 982
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376339186"
variation 995
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55650492"
variation 996
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369914142"
variation 1016
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:376935843"
variation 1028
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374098516"
variation 1103
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150819399"
variation 1164
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376939727"
variation 1165
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139279668"
variation 1174
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200282854"
variation 1238
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200073641"
variation 1281
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368956023"
variation 1365
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142299107"
variation 1366
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143910249"
variation 1413
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147258823"
variation 1434
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:199856578"
variation 1436
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201805414"
variation 1456
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140836901"
exon 1460..1583
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1553
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370526633"
variation 1562
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144371900"
exon 1584..1703
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1589
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:377260169"
variation 1647
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144565971"
variation 1675
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:370787117"
variation 1690
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148475804"
exon 1704..1790
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1782
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:266472"
exon 1791..1975
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1803
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373644583"
variation 1813
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368066220"
variation 1861
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11032229"
variation 1873
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201753105"
variation 1890
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200260579"
variation 1891
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201133345"
variation 1918
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371957082"
variation 1938
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188152932"
exon 1976..2135
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
STS 2065..2234
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="MARC_16007-16008:1017070197:5"
/db_xref="UniSTS:267932"
variation 2118
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140757794"
exon 2136..2259
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2139
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143169582"
exon 2260..2381
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2294
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146687175"
variation 2300
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140297828"
variation 2301
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:112993351"
variation 2311
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113037552"
variation 2321
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306723"
variation 2334
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77834200"
variation 2379
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374207916"
exon 2382..2506
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2383
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367997325"
variation 2395
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372518927"
variation 2428
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:199603859"
variation 2436
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:181305871"
exon 2507..2668
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2541
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189153633"
variation 2548
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55807239"
variation 2554
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:138907505"
variation 2581
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:547809"
variation 2599
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:149006860"
variation 2624
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="g"
/db_xref="dbSNP:5790928"
variation 2630
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77998863"
variation 2662
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:143841994"
exon 2669..2965
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2681
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111773781"
variation 2692
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143804053"
variation 2701
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:147249051"
variation 2706
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373565743"
variation 2744
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139123780"
variation 2774
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141483565"
variation 2778
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:150770633"
variation 2809
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370501263"
variation 2833
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:187124851"
variation 2860
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139168123"
variation 2879
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149933512"
variation 2896
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144093715"
variation 2964
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373619155"
exon 2966..3106
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2975
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201916597"
variation 3060
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368393624"
variation 3061
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372352323"
variation 3062
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:139983826"
variation 3097
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:143130710"
variation 3101
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147557040"
exon 3107..3342
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3110
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140277514"
variation 3115
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371101353"
variation 3154
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371278906"
variation 3158
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189975516"
variation 3169
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142589533"
variation 3173
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200853149"
variation 3178
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369147055"
variation 3210
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371973544"
variation 3216
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375435479"
variation 3227
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370104100"
variation 3228
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200063110"
variation 3236
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151298583"
variation 3247
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:140531306"
variation 3268
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201934152"
variation 3279
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373543551"
variation 3291
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368948226"
variation 3321
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200039689"
variation 3336
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201982369"
exon 3343..3470
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3348
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150461240"
variation 3449
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138517447"
exon 3471..7402
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3471
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374715839"
variation 3472
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148327404"
STS 3526..4059
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="HIPK3__6530"
/db_xref="UniSTS:463980"
variation 3527
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146323020"
variation 3530
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139085464"
variation 3569
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200186370"
variation 3579
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:141714879"
variation 3592
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200223965"
variation 3594
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199898293"
variation 3598..3599
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="c"
/db_xref="dbSNP:34253010"
variation 3610
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149374485"
variation 3633
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373637582"
variation 3651
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:186297123"
variation 3678
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368061213"
variation 3680
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144710455"
variation 3684
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371485212"
variation 3750
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148114408"
variation 3783..3785
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="cac"
/db_xref="dbSNP:141782878"
variation 3805..3806
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="a"
/db_xref="dbSNP:34629163"
variation 3821
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:141503633"
variation 3839
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201569128"
variation 3855
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146004527"
variation 3867
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:139964400"
variation 3875
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141882893"
variation 3885
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200574738"
variation 3899
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:369816213"
variation 3901
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373299730"
variation 3918
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:146182417"
variation 3919
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76323203"
variation 3949
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139062945"
variation 3962
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190940410"
variation 3978
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:150884070"
variation 4113
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183354813"
variation 4135
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140114380"
variation 4145
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187999224"
variation 4179
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115163947"
variation 4237
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144080192"
variation 4490
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147337267"
variation 4546
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192087334"
variation 4586
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:183081083"
variation 4917
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202123118"
variation 4928
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4755571"
variation 5047
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187860214"
variation 5079..5080
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:200851825"
variation 5079
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370250777"
variation 5080..5081
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:11429812"
variation 5151
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375339434"
variation 5158
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375418698"
variation 5217
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032233"
variation 5223
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368071186"
variation 5234
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032234"
variation 5235
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032235"
variation 5390
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373082522"
variation 5573
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:192913092"
variation 5712
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184157642"
variation 5769
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:79556626"
STS 5960..6029
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="D11S2229E"
/db_xref="UniSTS:25085"
variation 6160
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140296161"
variation 6177..6178
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:35464888"
variation 6225
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:189429278"
variation 6314
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191474583"
variation 6383
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:16924206"
variation 6449
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:78602081"
variation 6519
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73489287"
variation 6717
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5021318"
variation 6777
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142600026"
STS 7006..7180
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="RH98961"
/db_xref="UniSTS:91554"
variation 7027
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184628276"
variation 7042
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:10600"
variation 7180
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:189463875"
variation 7189
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146479622"
variation 7200..7201
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="g"
/db_xref="dbSNP:35645257"
variation 7316
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369088368"
variation 7364
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:141043933"
variation 7388
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181421671"
ORIGIN
ttcattaaggggaacaaacaaacgcgcaggcacgcagcttgagcaccccagccgatggccgcgtcccgggctttgtggccccgtccccagcgtcgcggagcagcgggtttgcagggtgtcaactctggggacgtgcgtgcgtgtgtgtgattgttggggaggagaaatgtgatccgcggctccgcgtccccagcggcggcgggaggaaggcgtggcggccgcgcggcggggctgttgccggcttctctcgttacggtggctgccgcccgcttcccttcgccgcactgggagaactggcggaaagactttggatgaaaatgtctgtttctctgtcgggagggagacggctgttgtaaaatggtatggcctcacaagtcttggtctacccaccatatgtttatcaaactcagtcaagtgccttttgtagtgtgaagaaactcaaagtagagccaagcagttgtgtattccaggaaagaaactatccacggacctatgtgaatggtagaaactttggaaattctcatcctcccactaagggtagtgcttttcagacaaagataccatttaatagacctcgaggacacaacttttcattgcagacaagtgctgttgttttgaaaaacactgcaggtgctacaaaggtcatagcagctcaggcacagcaagctcacgtgcaggcacctcagattggggcgtggcgaaacagattgcatttcctagaaggcccccagcgatgtggattgaagcgcaagagtgaggagttggataatcatagcagcgcaatgcagattgtcgatgaattgtccatacttcctgcaatgttgcaaaccaacatgggaaatccagtgacagttgtgacagctaccacaggatcaaaacagaattgtaccactggagaaggtgactatcagttagtacagcatgaagtcttatgctccatgaaaaatacttacgaagtccttgattttcttggtcgaggcacgtttggccaggtagttaaatgctggaaaagagggacaaatgaaattgtagcaatcaaaattttgaagaatcatccttcttatgcccgtcaaggtcaaatagaagtgagcatattagcaaggctcagtactgaaaatgctgatgaatataactttgtacgagcttatgaatgctttcagcaccgtaaccatacttgtttagtctttgagatgctggaacaaaacttgtatgactttctgaaacaaaataaatttagtcccctgccactaaaagtgattcggcccattcttcaacaagtggccactgcactgaaaaaattgaaaagtcttggtttaattcatgctgatctcaagccagagaatattatgttggtggatcctgttcggcagccttacagggttaaagtaatagactttgggtcggccagtcatgtatcaaagactgtttgttcaacatatctacaatctcggtactacagagctccagagattatattggggttgccattttgtgaagccatagacatgtggtcattgggatgtgtgattgcagaattatttcttggatggccgctctacccaggagccttggagtatgatcagattcgatacatttctcagactcaaggtttgccaggagaacagttgttaaatgtgggtactaaatccacaagatttttttgcaaagaaacagatatgtctcattctggttggagattaaagacattggaagagcatgaggcagagacaggaatgaagtctaaagaagccagaaaatacattttcaacagtctggatgatgtagcgcatgtgaacacagtgatggatttggaaggaagtgatcttttggctgagaaagctgatagaagagaatttgttagtctgttgaagaaaatgttgctgattgatgcagatttaagaattactccagctgagaccctgaaccatccttttgttaatatgaaacatcttctagatttccctcatagcaaccatgtaaagtcctgttttcatattatggatatttgtaagtcccacctaaattcatgtgacacaaataatcacaacaaaacttcacttttaagaccagttgcttcaagcagtactgctacactgactgcaaattttactaaaatcggaacattaagaagtcaggcattgaccacatctgctcattcagttgtgcaccatggaatacctctgcaggcaggaactgctcagtttggttgtggtgatgcttttcagcagacattgattatctgtcccccagctattcaaggtattcctgcaacacatggtaaacccaccagttattcaataagggtagataatacagttccacttgtaactcaggccccagctgtgcagccactacagatccgaccaggagttctttctcagacgtggtctggtagaacacagcagatgctggtgcctgcctggcaacaggtgacacccctggctcctgctactactacactaacttctgagagtgtggctggttcacacaggcttggagactgggggaagatgatttcatgcagcaatcattataactcagtgatgccgcagcctcttctgaccaatcagataactttatctgcccctcagccagttagtgtggggattgcacatgttgtctggcctcagcctgccactaccaagaaaaataaacagtgccagaacaggagtaattcattacagaataccaatatcccacattcagcatttatttctccaaagataattaatgggaaagatgtcgaggaagtaagttgtatagaaacacaggacaatcagaactcagaaggagaggcaagaaattgctgtgaaacatctatcagacaggactctgattcatcagtttcagacaaacagcggcaaaccatcattattgccgactccccgagtcctgcagtgagtgtcatcactatcagcagtgacactgatgaggaagagacttcccagagacattcactcagagaatgtaaaggtagtctagattgtgaagcttgccagagcactttgaatattgatcggatgtgttcattaagtagtcctgatagtactctgagtaccagctcctcagggcagtccagcccatccccctgcaagagaccgaatagtatgtcagatgaagagcaagaaagtagttgtgatacggtggatggctctccgacatctgactcttccgggcatgacagtccatttgcagagagcacttttgtggaggacactcatgaaaacacagaattggtatcctctgctgacacagaaaccaagccagctgtctgttctgttgtggtgccaccagtggaactagaaaatggcttaaatgccgatgagcatatggcaaacacagattctatatgccagccattaataaaaggacgatctgcccctggaagattaaaccagccttctgcagtgggtactcgtcagcaaaaattgacatcagcattccagcagcagcatttgaacttcagtcaggttcagcactttggatctgggcatcaagagtggaatggaaactttgggcacagaagacagcaagcttatattcctactagtgttaccagtaatccattcactctttctcatggaagtcccaatcacacagcagtgcatgcccacctggctggaaatacacacctcggaggacagcctactctacttccatacccatcatcagccaccctcagtagtgctgcaccagtggcccacctgttagcctctccgtgtacctcaagacctatgttacagcatccaacttataatatctcccatcccagtggcatagttcaccaagtcccagtgggcttaaatccccgtctgttaccatccccaaccattcatcagactcagtacaaaccaatcttcccaccacattcttacattgcagcatcacctgcatatactggatttccactgagtccaacaaaactcagccagtatccatatatgtgaaaaacagtatattggggaagctcaatgatacaaacatttgattaaaaataaaaacatggtatttaatattagccatggcacaagaaaattatttttgaatcatgtagacttgggtgcaatttaaacaactttgagctttaaaaactcacttttgatgtgttttgcacatttggtataacttgtctttggtcatgttatcttcttatgtagtaactctagacaggtgacttatgggagcagaagtccagttttgctcctgctattttttataaattgccttctaactagtgcaagacacgtctacatttgggaagccattctgtgtacagacttagagcaacagatgcacatatgtcagaattacagcatacaagtgaattgtattatccgtgtcttagtgtataaatgttgggtcacttacctaagaaattgagctattgttctttacatttgcatgtgtcttttgcatgggcaaaatgttgcctagactttgctcttaaatgttgttctaataatctcagctgcattgtaaaccgttcctacacatagtgccttaaatatttgaggttgttaatgttattacctatatataaatgttgaggactgcagcacttaaaattcagacctactatttagtttccttttgatagcgtaatgttcatttttgtttttgtgtggtatgatttcaggtagtagctgtttttttccttattaagagggcagcatgtttgctatagctgaattctgctgtctgatttttcagaatgatctagcttcaagaaaagcaagcagttagtagtgcttaagaaaaattgattcagtatctaatggatagttgataactgtcacagcacagcattttatatactgttaagtgaaactgcaatacaatctaagtttattttgagagtgtttgctgtataattggacttaataaaatgtttagaggtacagtaggcatgactttgggtagataataaaatgcaaaatgctcattgattcatgatgtggttttatcttagcttgggcaaaccatgcagtatttaataaatagtagcagaacttttactattgaagcttgaaaagatgtgagttctttgtgtgcaatttttgatttatgcatgtgagagggttttttttttttttaagtatttttacattgcagtacttgttttgcttgttggtgatgtttgcttatttaatacattccgtcagggacagaaattacatgcttttttttctttctaggaagtgtgttgagttccccccttccccgacatttttttcttttttgggtggtggtgatggtagtggttatgtctgtttaaatgaagttgcttttacagcaccaaagacttaatcatccatttcctatataaaggtagctactttttgcatagacctcaagtatattgtagtgtaaaggtggaatttaaggaaaggtattaaattgaggctgtgttttagcttacaggcaagtaataaattgtatcatttatcttgaatgtatcatagataagctgctatataacgattgccacttcagatagctgtgaaattaggtgattaactagttgttatttagccttctaatttctgtataagtctaattacatgaatagaaattggggttttgattttttactttgcttttctgtttggagtgtcattgtaactactgtattgtaaatggtggaaaataattgcatttgttactttggggtgtgttatttgcatcagtattttatctctattaatgtttgtgctcatcactgcatattaaaaaaacttggatgtatcagtgtaacttaattttttattttcatactggcattgtagacacttgagaaagctgtatcttgcaggcttgacttaacttttttccttaaaaatctggaatataatcttacagcatttactggaataaacagtacaaagcattggagtgtaaaactctagatgttttggatttacagcgtttctttgataaatgaattgtataccactagtacagctctagtacagcgttcacaataagctaataatggataagttttcttcactccattaacacaagcagtgttttatttaataatcatcaatgaaataaatgtgcctgaaattgattttaaaaattacagtattagatcataaagtaaaaaccagcagtacatttttagtcacactgaaaatgaaggacttaattttccccacaagtttcagtgtttttagtaattaattctatgcattttatacaaatagaaatatatatatataaaaaattaaatgtttaaaaaggagtagcctaagattaatttaaaagattatttacagatgacacatttatggggtcactatttaagtaaatttgctgccctccacagccttctaattttatttatatgttccagcagattattaggatctgcttacttcttaggaaagaatcaatgctggcaacacattgtttcagaaacaccaagtgcaaaggattgattgtatcacaacaggtacaaaactgacagagttttctttttgtttagggccatgtttactaccctgaaatgttgtattttttgtctttaatttccaagacttaaagcagtcttgttaaattgacataaatggtaaacttcaacattttcataatacagtattaatgtttgataaaggtatatcccagttaactacactgctctttaattgcaatcatgggcattttaatgtattttaaaataaatttcaaaattctgctaaattcttaatttagcatattgacaaagtaatctggatttataccttttaaaaaccattttgaccagttttcttcggttttaatgctttcttaaataaaacactgcatgatttccaagttgcatatttgcatactattttaatttgcaaaatgttttttaaatcaaatatcctgatatttagttgttttttttttcctccagcgtgtttaattaaatatgttactgtattagcaaaacattttcatttttaaaatctgctaattttaaacttggactgtgttaagtaaaagttaaatcatacactgcaaggtgtaggaagatttgttttaatgaatccaatgatacagatttgattactaagtttgaactgttaattgtttaacaattttagacttgtggctttctttctttggtttatttgtttttgcttttactcctatgctacactagtttgccatgtagcaattgcactgtgcaatattacaataaggactgggaaaattttatggatgtaatgtctattacggtttgcgatagtatttctctctagttctcagtgatttaaatgtgaccaagccttctgtactttgtcacaaaaagcgggttttccaggtgactattttggtgagtgtcaaaataagaatttatggtgtattactgtcgattcactttgaattaaaatatatatattgcagcaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10114 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:10114 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:10114 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: ISS
GeneID:10114 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS
GeneID:10114 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:10114 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:10114 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10114 -> Biological process: GO:0009299 [mRNA transcription] evidence: IDA
GeneID:10114 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: ISS
GeneID:10114 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: ISS
GeneID:10114 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:10114 -> Biological process: GO:0043508 [negative regulation of JUN kinase activity] evidence: ISS
GeneID:10114 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10114 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:10114 -> Cellular component: GO:0016605 [PML body] evidence: IEA
by
@meso_cacase at
DBCLS
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