2024-04-27 08:10:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001276718 4228 bp mRNA linear PRI 22-JUN-2013 DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), transcript variant 5, mRNA. ACCESSION NM_001276718 VERSION NM_001276718.1 GI:456367260 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4228) AUTHORS Liu,T., Li,Y., Gu,H., Zhu,G., Li,J., Cao,L. and Li,F. TITLE p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2) JOURNAL J. Biol. Chem. 288 (5), 3359-3369 (2013) PUBMED 23132866 REMARK GeneRIF: PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. REFERENCE 2 (bases 1 to 4228) AUTHORS Shepelev,M.V. and Korobko,I.V. TITLE Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV JOURNAL Biochemistry Mosc. 77 (1), 26-32 (2012) PUBMED 22339630 REFERENCE 3 (bases 1 to 4228) AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K., Gibbs,R.A. and Butte,N.F. TITLE Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population JOURNAL PLoS ONE 7 (12), E51954 (2012) PUBMED 23251661 REFERENCE 4 (bases 1 to 4228) AUTHORS McCarty,S.K., Saji,M., Zhang,X., Jarjoura,D., Fusco,A., Vasko,V.V. and Ringel,M.D. TITLE Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion JOURNAL Endocr. Relat. Cancer 17 (4), 989-999 (2010) PUBMED 20817787 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 4228) AUTHORS Wells,C.M. and Jones,G.E. TITLE The emerging importance of group II PAKs JOURNAL Biochem. J. 425 (3), 465-473 (2010) PUBMED 20070256 REMARK Review article Publication Status: Online-Only REFERENCE 6 (bases 1 to 4228) AUTHORS Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A. TITLE p21 activated kinase 5 activates Raf-1 and targets it to mitochondria JOURNAL J. Cell. Biochem. 105 (1), 167-175 (2008) PUBMED 18465753 REMARK GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at mitochondria REFERENCE 7 (bases 1 to 4228) AUTHORS Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P., Schneider,M.C. and Lu,M.L. TITLE Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase JOURNAL J. Biol. Chem. 280 (5), 3323-3330 (2005) PUBMED 15550393 REMARK GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6 suggests that PAK6 plays a role in the cellular response to stress-related signals. REFERENCE 8 (bases 1 to 4228) AUTHORS Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and Bokoch,G.M. TITLE Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling JOURNAL J. Biol. Chem. 279 (3), 1922-1931 (2004) PUBMED 14573606 REFERENCE 9 (bases 1 to 4228) AUTHORS Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and Balk,S.P. TITLE AR and ER interaction with a p21-activated kinase (PAK6) JOURNAL Mol. Endocrinol. 16 (1), 85-99 (2002) PUBMED 11773441 REFERENCE 10 (bases 1 to 4228) AUTHORS Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z. TITLE Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6 JOURNAL J. Biol. Chem. 276 (18), 15345-15353 (2001) PUBMED 11278661 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK131522.1, AC020658.6, BC035596.1 and AK026592.1. Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131522.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025082, ERS025088 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-534 AK131522.1 1-534 535-535 AC020658.6 78000-78000 536-1089 AK131522.1 536-1089 1090-2054 BC035596.1 289-1253 2055-3518 AK131522.1 2055-3518 3519-3796 AK131522.1 3529-3806 3797-4228 AK026592.1 1-432 FEATURES Location/Qualifiers source 1..4228 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14" gene 1..4228 /gene="PAK6" /gene_synonym="PAK5" /note="p21 protein (Cdc42/Rac)-activated kinase 6" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" exon 1..712 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 57 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:373502421" variation 240 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:145904463" variation 357 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147797741" variation 481 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:187026068" variation 535 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:900056" variation 638 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:191466590" exon 713..795 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 738 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:184060506" variation 781 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:4924439" exon 796..907 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 855 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:11636097" misc_feature 871..873 /gene="PAK6" /gene_synonym="PAK5" /note="upstream in-frame stop codon" exon 908..1116 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 909 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201707008" CDS 913..2823 /gene="PAK6" /gene_synonym="PAK5" /EC_number="2.7.11.1" /note="isoform 2 is encoded by transcript variant 5; p21(CDKN1A)-activated kinase 6; serine/threonine-protein kinase PAK 6" /codon_start=1 /product="serine/threonine-protein kinase PAK 6 isoform 2" /protein_id="NP_001263647.1" /db_xref="GI:456367261" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" /translation="
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
" misc_feature 940..1077 /gene="PAK6" /gene_synonym="PAK5" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; Region: CRIB_PAK_like; cd01093" /db_xref="CDD:29038" misc_feature order(946..948,955..957,964..966,970..972,979..981, 1030..1032,1042..1044) /gene="PAK6" /gene_synonym="PAK5" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:29038" misc_feature 2065..2820 /gene="PAK6" /gene_synonym="PAK5" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:214163" misc_feature 2146..2751 /gene="PAK6" /gene_synonym="PAK5" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(2149..2163,2173..2175,2212..2214,2218..2220, 2305..2307,2353..2364,2374..2376,2380..2382,2488..2490, 2494..2496,2500..2505,2509..2511,2542..2544,2551..2553, 2599..2610) /gene="PAK6" /gene_synonym="PAK5" /note="active site" /db_xref="CDD:173623" misc_feature order(2149..2163,2173..2175,2212..2214,2218..2220, 2305..2307,2353..2364,2374..2376,2488..2490,2494..2496, 2500..2505,2509..2511,2542..2544) /gene="PAK6" /gene_synonym="PAK5" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(2161..2163,2374..2376,2380..2382,2488..2490, 2494..2496,2500..2502,2551..2553,2599..2610) /gene="PAK6" /gene_synonym="PAK5" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(2539..2559,2599..2610) /gene="PAK6" /gene_synonym="PAK5" /note="activation loop (A-loop); other site" /db_xref="CDD:173623" variation 920 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201346085" variation 938 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61733786" variation 942 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:139649727" variation 953 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11544039" variation 954 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145212795" variation 960 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371968905" variation 981 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202083311" variation 990 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376250193" variation 991 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149132419" variation 1024 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372639063" variation 1025 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:142256590" variation 1054 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369235955" variation 1062 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:199695379" variation 1067 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146905959" variation 1069 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371738802" variation 1072 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147960311" variation 1094 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:376432897" variation 1113 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372069647" exon 1117..1770 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1138 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:2412504" variation 1161 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:2016902" variation 1173 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:138470960" variation 1219 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36081263" variation 1233 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:150318570" variation 1234 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:137969148" variation 1237 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375852612" variation 1241 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149461942" variation 1267 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370496102" variation 1284 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200035365" variation 1285 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:202073596" variation 1308 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:375526083" variation 1313 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:373050572" variation 1329 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:376277766" variation 1336 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201017672" variation 1344 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34608644" variation 1356 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369750707" variation 1357 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373280531" variation 1362 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:138761742" variation 1364 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35593179" variation 1375 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370397655" variation 1377 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141846316" variation 1389 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373870185" variation 1390 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146254732" variation 1391 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:67578703" variation 1440 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377362218" variation 1454 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:191280501" variation 1462 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56349744" variation 1471 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:376068775" variation 1475 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:368829109" variation 1479 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138937506" variation 1481 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149315160" variation 1484 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61732685" variation 1497 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371505679" variation 1499 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200417617" variation 1500 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371452582" variation 1505 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144246288" variation 1507 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55741128" variation 1526 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:55920845" variation 1532 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141487285" variation 1534 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:35501648" variation 1541 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34869667" variation 1542 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:368535824" variation 1544 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147727470" variation 1546 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371550083" variation 1548 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370838549" variation 1556 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:3743135" variation 1576 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:181253186" variation 1590 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:185330250" variation 1608 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376968689" variation 1617 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:148386599" variation 1623 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375014773" variation 1636 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367656601" variation 1657 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371445081" variation 1671 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:374286048" variation 1684 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:143324236" variation 1686 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201350352" variation 1697 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61739745" variation 1755 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202230516" variation 1767 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:373963726" exon 1771..2268 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1780..1784 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tcttt" /db_xref="dbSNP:144811359" variation 1784 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:75694545" variation 1787 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:150100570" variation 1790 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371298913" variation 1791 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138523206" variation 1794 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141886873" variation 1821 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:146266050" variation 1844 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:374205024" variation 1845 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149513654" variation 1851 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371922217" variation 1854 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200815331" variation 1870 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200107644" variation 1884 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367831338" variation 1912 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:143993282" variation 1922 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:3743137" variation 1936 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371395174" variation 1945 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371593698" variation 1958 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201684963" variation 1969 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369825628" variation 2015 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:142340502" variation 2021 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202233605" variation 2024 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377762904" variation 2027 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67864419" variation 2039 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55806501" variation 2048 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:139850733" variation 2074 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145336671" variation 2090 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147750062" variation 2120 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:5021809" variation 2166 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149826022" variation 2185 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:145812191" variation 2186 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145647822" variation 2203 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369042481" variation 2205 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35119729" variation 2248..2249 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:35003343" variation 2264 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="a" /db_xref="dbSNP:68158967" variation 2265 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:1006606" exon 2269..2402 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2281 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:201655600" variation 2300 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201153660" variation 2301 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:144657412" variation 2335 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34445577" STS 2361..3352 /gene="PAK6" /gene_synonym="PAK5" /standard_name="D1S3693" /db_xref="UniSTS:474271" variation 2364 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200429138" variation 2386 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:140245743" variation 2398 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372547442" exon 2403..2529 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2406 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:146088177" variation 2412 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145203209" variation 2413 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377397005" variation 2521 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:148062077" exon 2530..2655 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2534 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373086987" variation 2565 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:199802493" variation 2567 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:113493588" variation 2574 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201198106" variation 2575 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141761526" variation 2595 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:35644942" exon 2656..4216 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2664 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201093320" variation 2680 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369819404" variation 2687 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147232997" variation 2697 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:186069684" variation 2727 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:374185464" variation 2785 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201637258" variation 2798 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:377614111" variation 2838..2839 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:373523942" variation 2863 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370753710" variation 2919 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67409239" variation 2969 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:34376657" variation 3175 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:34276379" variation 3213 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:2242120" variation 3252 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:192345226" variation 3262 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36068492" variation 3281 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34042288" variation 3351 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:2242119" variation 3438 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:189289921" variation 3441 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144984113" variation 3478..3479 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:371193727" variation 3479..3488 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:113864236" variation 3479..3486 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:376406581" variation 3500..3507 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72058737" variation 3502..3509 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:71898851" variation 3508..3509 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72216147" variation 3509..3510 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:67649145" variation 3511..3518 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:58716292" variation 3518..3519 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="ac" /replace="acacacacac" /replace="cacacac" /db_xref="dbSNP:67205800" variation 3519..3520 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:72212801" variation 3566 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:75122003" variation 3590 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371075338" variation 3665 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:183657807" variation 3677 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:111385535" variation 3748 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:187963215" variation 3780 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:55738516" variation 3798 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:116029092" STS 3907..4187 /gene="PAK6" /gene_synonym="PAK5" /standard_name="WI-21468" /db_xref="UniSTS:26519" STS 3948..4099 /gene="PAK6" /gene_synonym="PAK5" /standard_name="RH15701" /db_xref="UniSTS:82077" variation 3968 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11635121" variation 3969 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:75108621" variation 4012 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138256759" polyA_signal 4194..4199 /gene="PAK6" /gene_synonym="PAK5" polyA_site 4216 /gene="PAK6" /gene_synonym="PAK5" ORIGIN
aaacgagcaggtcgatgcctgaggatttaatggagaaatcccaaagtgagccggggcgcgcggtggaggaggggcgcgccgcagccggggccgctgggccctgatgggcgggagcggggtggagcggcctcgcctgccaggcagccctgggcgcggggctcggcggccacactctggagacagccacggtccaggcaggtgggggagggcgctgctcccgtcctgatgtgccaggagccgccagcagccatccaggtgactaagccggcccactagcactgagtcaccgcccgcctcgagctgttcttgcttctcctttgcatctgattattttgggagctggaaacttggagctgcacctgagtcccgccccttctagctctcccctccctaccttgggctccaggaagatgggacttgctgtgagtctgctgccaccccctaaagatatggaagacgctgtgggggccagaagtgcccggggggctgtggcagcaggcagagtgcaatagcagatatggtggtcaggctgcctgtgtgtgtcctctggaggtgttgggacagaagggcagtcttgtccgagctgactggagtcctcccgggctggctctgaactcatctcccacggggatgtttcggtaaaggagtggcttctggggtcggagtggcatttggagagcgaggctggattggcttaggctggcctgggcagggagtgccgcttcctgggctagagacaagcaccagcctgcagtggagaacgcaggaccccgctgcccagaaggagcagccacggcctgcggaggactggcccagcaaggtcccaggtcttccctctcctcagcgcctaagagagaggcccagtgcgggtgaggagtcgcgaggaagaggcggaaggcgccggaaggcaccatgttccgcaagaaaaagaagaaacgccctgagatctcagcgccacagaacttccagcaccgtgtccacacctccttcgaccccaaagaaggcaagtttgtgggcctccccccacaatggcagaacatcctggacacactgcggcgccccaagcccgtggtggacccttcgcgaatcacacgggtgcagctccagcccatgaagacagtggtgcggggcagcgcgatgcctgtggatggctacatctcggggctgctcaacgacatccagaagttgtcagtcatcagctccaacaccctgcgtggccgcagccccaccagccggcggcgggcacagtccctggggctgctgggggatgagcactgggccaccgacccagacatgtacctccagagcccccagtctgagcgcactgacccccacggcctctacctcagctgcaacgggggcacaccagcaggccacaagcagatgccgtggcccgagccacagagcccacgggtcctgcccaatgggctggctgcaaaggcacagtccctgggccccgccgagtttcagggtgcctcgcagcgctgtctgcagctgggtgcctgcctgcagagctccccaccaggagcctcgccccccacgggcaccaataggcatggaatgaaggctgccaagcatggctctgaggaggcccggccacagtcctgcctggtgggctcagccacaggcaggccaggtggggaaggcagccctagccctaagacccgggagagcagcctgaagcgcaggctattccgaagcatgttcctgtccactgctgccacagcccctccaagcagcagcaagccaggccctccaccacagagcaagcccaactcctctttccgaccgccgcagaaagacaaccccccaagcctggtggccaaggcccagtccttgccctcggaccagccggtggggaccttcagccctctgaccacttcggataccagcagcccccagaagtccctccgcacagccccggccacaggccagcttccaggccggtcttccccagcgggatccccccgcacctggcacgcccagatcagcaccagcaacctgtacctgccccaggaccccacggttgccaagggtgccctggctggtgaggacacaggtgttgtgacacatgagcagttcaaggctgcgctcaggatggtggtggaccagggtgacccccggctgctgctggacagctacgtgaagattggcgagggctccaccggcatcgtctgcttggcccgggagaagcactcgggccgccaggtggccgtcaagatgatggacctcaggaagcagcagcgcagggagctgctcttcaacgaggtggtgatcatgcgggactaccagcacttcaacgtggtggagatgtacaagagctacctggtgggcgaggagctgtgggtgctcatggagttcctgcagggaggagccctcacagacatcgtctcccaagtcaggctgaatgaggagcagattgccactgtgtgtgaggctgtgctgcaggccctggcctacctgcatgctcagggtgtcatccaccgggacatcaagagtgactccatcctgctgaccctcgatggcagggtgaagctctcggacttcggattctgtgctcagatcagcaaagacgtccctaagaggaagtccctggtgggaaccccctactggatggctcctgaagtgatctccaggtctttgtatgccactgaggtctccccagtgctgcgagacttcctggagcggatgctggtgcgggacccccaagagagagccacagcccaggagctcctagaccaccccttcctgctgcagacagggctacctgagtgcctggtgcccctgatccagctctaccgaaagcagacctccacctgctgagcccaccccaagtatgcctgccacctacgcccacaggcagggcacactgggcagccagcctgccggcaggacttgcctgcctcctcctctcagtattctctccaaagattgaaatgtgaagccccagccccaccctctgcccttcagcctactgggccaggccggacctgccccctcagtgtctctccctcccgagtccccagatggagacccctttctacaggatgaccccttgatatttgcacagggatatttctaagaaacgcagaggccagcgttcctggcctctgcagccaacacagtagaaaaggctgctgtggttttttaaaggcagttgtccactagtgtcctaggccactgcagagggcagactgctggtctccacagatacctgctgttctcagctccagcttcaaacctcgagtctcgagagggccacggggtggtttttatgaccggaatcccgcttcctccctcacgtctgatgtcctgaaggtgcagtcccacctgtacagcccctccccgcccagaactgtgaatggcctgctccaggccatggctgggggcagggagtgaggggacaatttctgagtgaaagagaaagaatggggtcggtggtgaaggtgctctcactttacagaatggagagaacatcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaggggaggaaagccaccttgacagcccaggtccctccaggtcacccacagccagtttcaggaaggctgcccctctctcccactaagttctggcctgaagggacctgctttcttggcctggcttccacctctccactcctgtgtctacctggccagtggagtggtccatgctaagtctaacactcctgggagctcaggaggcttctgagcttctcctgtactgtgcatcgtgagggccagagacaggaatgtaaggattggcaactgtgttacctttcaagtttatctcaataaccaggtcatcagggacccattgttctcttcagaaccctatctgggagagaaggcgaaccacctccgggtttccatcatgtcaaggtcacaggcatccatgtgtgcaaaccatctgccccagctgcctccacagactgctgtctccttgtcctcctcggccctgccccacttcagggctgctgtgagatggaattccaggaaagaacttcaggtgtctggaccctttctatctagataatatttttagattcttctgctccctagtgacctacctgggggcaaagaaattgcaaggacttttttttaagggtcagagttttcaaaacaaaagcatcttccctagaaatttttgtgaattgtttgcacttgtgcctgttttaaattaaattgagtgttcaaagccaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:56924 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:56924 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:56924 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS GeneID:56924 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:56924 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS GeneID:56924 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:56924 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
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