2024-04-26 12:17:02, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001276717 2558 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), transcript variant 4, mRNA. ACCESSION NM_001276717 VERSION NM_001276717.1 GI:456367258 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2558) AUTHORS Liu,T., Li,Y., Gu,H., Zhu,G., Li,J., Cao,L. and Li,F. TITLE p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2) JOURNAL J. Biol. Chem. 288 (5), 3359-3369 (2013) PUBMED 23132866 REMARK GeneRIF: PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. REFERENCE 2 (bases 1 to 2558) AUTHORS Shepelev,M.V. and Korobko,I.V. TITLE Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV JOURNAL Biochemistry Mosc. 77 (1), 26-32 (2012) PUBMED 22339630 REFERENCE 3 (bases 1 to 2558) AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K., Gibbs,R.A. and Butte,N.F. TITLE Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population JOURNAL PLoS ONE 7 (12), E51954 (2012) PUBMED 23251661 REFERENCE 4 (bases 1 to 2558) AUTHORS McCarty,S.K., Saji,M., Zhang,X., Jarjoura,D., Fusco,A., Vasko,V.V. and Ringel,M.D. TITLE Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion JOURNAL Endocr. Relat. Cancer 17 (4), 989-999 (2010) PUBMED 20817787 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2558) AUTHORS Wells,C.M. and Jones,G.E. TITLE The emerging importance of group II PAKs JOURNAL Biochem. J. 425 (3), 465-473 (2010) PUBMED 20070256 REMARK Review article Publication Status: Online-Only REFERENCE 6 (bases 1 to 2558) AUTHORS Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A. TITLE p21 activated kinase 5 activates Raf-1 and targets it to mitochondria JOURNAL J. Cell. Biochem. 105 (1), 167-175 (2008) PUBMED 18465753 REMARK GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at mitochondria REFERENCE 7 (bases 1 to 2558) AUTHORS Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P., Schneider,M.C. and Lu,M.L. TITLE Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase JOURNAL J. Biol. Chem. 280 (5), 3323-3330 (2005) PUBMED 15550393 REMARK GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6 suggests that PAK6 plays a role in the cellular response to stress-related signals. REFERENCE 8 (bases 1 to 2558) AUTHORS Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and Bokoch,G.M. TITLE Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling JOURNAL J. Biol. Chem. 279 (3), 1922-1931 (2004) PUBMED 14573606 REFERENCE 9 (bases 1 to 2558) AUTHORS Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and Balk,S.P. TITLE AR and ER interaction with a p21-activated kinase (PAK6) JOURNAL Mol. Endocrinol. 16 (1), 85-99 (2002) PUBMED 11773441 REFERENCE 10 (bases 1 to 2558) AUTHORS Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z. TITLE Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6 JOURNAL J. Biol. Chem. 276 (18), 15345-15353 (2001) PUBMED 11278661 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191028.1 and BC035596.1. Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Transcript Variant: This variant (4) differs in the 5' UTR and the 3' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025085, ERS025091 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-6 DA191028.1 176-181 7-2558 BC035596.1 1-2552 FEATURES Location/Qualifiers source 1..2558 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14" gene 1..2558 /gene="PAK6" /gene_synonym="PAK5" /note="p21 protein (Cdc42/Rac)-activated kinase 6" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" exon 1..112 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 60 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:11636097" misc_feature 76..78 /gene="PAK6" /gene_synonym="PAK5" /note="upstream in-frame stop codon" exon 113..321 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 114 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201707008" CDS 118..2163 /gene="PAK6" /gene_synonym="PAK5" /EC_number="2.7.11.1" /note="isoform 1 is encoded by transcript variant 4; p21(CDKN1A)-activated kinase 6; serine/threonine-protein kinase PAK 6" /codon_start=1 /product="serine/threonine-protein kinase PAK 6 isoform 1" /protein_id="NP_001263646.1" /db_xref="GI:456367259" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" /translation="
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
" misc_feature 145..282 /gene="PAK6" /gene_synonym="PAK5" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; Region: CRIB_PAK_like; cd01093" /db_xref="CDD:29038" misc_feature order(151..153,160..162,169..171,175..177,184..186, 235..237,247..249) /gene="PAK6" /gene_synonym="PAK5" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:29038" misc_feature 193..1335 /gene="PAK6" /gene_synonym="PAK5" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9NQU5.1); Region: Linker" misc_feature 1270..2160 /gene="PAK6" /gene_synonym="PAK5" /note="Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 6; Region: STKc_PAK6; cd06659" /db_xref="CDD:132990" misc_feature 1351..2091 /gene="PAK6" /gene_synonym="PAK5" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(1354..1368,1378..1380,1417..1419,1423..1425, 1450..1452,1510..1512,1558..1572,1576..1581,1588..1590, 1693..1695,1699..1710,1714..1716,1744..1749,1756..1758, 1795..1809,1813..1815,1894..1896,1921..1929) /gene="PAK6" /gene_synonym="PAK5" /note="active site" /db_xref="CDD:132990" misc_feature order(1354..1368,1378..1380,1417..1419,1423..1425, 1510..1512,1558..1572,1576..1581,1588..1590,1705..1710, 1714..1716,1744..1749) /gene="PAK6" /gene_synonym="PAK5" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature order(1363..1368,1450..1452,1693..1695,1699..1707, 1756..1758,1795..1809,1813..1815,1894..1896,1921..1929) /gene="PAK6" /gene_synonym="PAK5" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature 1744..1815 /gene="PAK6" /gene_synonym="PAK5" /note="activation loop (A-loop); other site" /db_xref="CDD:132990" variation 125 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201346085" variation 143 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61733786" variation 147 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:139649727" variation 158 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11544039" variation 159 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145212795" variation 165 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371968905" variation 186 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202083311" variation 195 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376250193" variation 196 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149132419" variation 229 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372639063" variation 230 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:142256590" variation 259 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369235955" variation 267 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:199695379" variation 272 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146905959" variation 274 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371738802" variation 277 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147960311" variation 299 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:376432897" variation 318 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372069647" exon 322..975 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 343 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:2412504" variation 366 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:2016902" variation 378 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:138470960" variation 424 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36081263" variation 438 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:150318570" variation 439 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:137969148" variation 442 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375852612" variation 446 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149461942" variation 472 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370496102" variation 489 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200035365" variation 490 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:202073596" variation 513 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:375526083" variation 518 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:373050572" variation 534 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:376277766" variation 541 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201017672" variation 549 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34608644" variation 561 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369750707" variation 562 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373280531" variation 567 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:138761742" variation 569 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35593179" variation 580 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370397655" variation 582 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141846316" variation 594 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373870185" variation 595 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146254732" variation 596 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:67578703" variation 645 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377362218" variation 659 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:191280501" variation 667 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56349744" variation 676 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:376068775" variation 680 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:368829109" variation 684 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138937506" variation 686 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149315160" variation 689 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61732685" variation 702 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371505679" variation 704 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200417617" variation 705 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371452582" variation 710 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144246288" variation 712 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55741128" variation 731 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:55920845" variation 737 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141487285" variation 739 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:35501648" variation 746 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34869667" variation 747 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:368535824" variation 749 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147727470" variation 751 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371550083" variation 753 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370838549" variation 761 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:3743135" variation 781 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:181253186" variation 795 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:185330250" variation 813 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376968689" variation 822 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:148386599" variation 828 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375014773" variation 841 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367656601" variation 862 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371445081" variation 876 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:374286048" variation 889 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:143324236" variation 891 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201350352" variation 902 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61739745" variation 960 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202230516" variation 972 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:373963726" exon 976..1473 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 985..989 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tcttt" /db_xref="dbSNP:144811359" variation 989 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:75694545" variation 992 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:150100570" variation 995 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371298913" variation 996 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138523206" variation 999 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141886873" variation 1026 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:146266050" variation 1049 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:374205024" variation 1050 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149513654" variation 1056 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371922217" variation 1059 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200815331" variation 1075 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200107644" variation 1089 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367831338" variation 1117 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:143993282" variation 1127 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:3743137" variation 1141 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371395174" variation 1150 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371593698" variation 1163 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201684963" variation 1174 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369825628" variation 1220 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:142340502" variation 1226 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202233605" variation 1229 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377762904" variation 1232 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67864419" variation 1244 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55806501" variation 1253 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:139850733" variation 1279 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145336671" variation 1295 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147750062" variation 1325 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:5021809" variation 1371 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149826022" variation 1390 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:145812191" variation 1391 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145647822" variation 1408 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369042481" variation 1410 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35119729" variation 1453..1454 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:35003343" variation 1469 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="a" /db_xref="dbSNP:68158967" variation 1470 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:1006606" exon 1474..1607 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1486 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:201655600" variation 1505 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201153660" variation 1506 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:144657412" variation 1540 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34445577" variation 1569 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200429138" variation 1591 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:140245743" variation 1603 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372547442" exon 1608..1734 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1611 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:146088177" variation 1617 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145203209" variation 1618 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377397005" variation 1726 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:148062077" exon 1735..1860 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1739 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373086987" variation 1770 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:199802493" variation 1772 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:113493588" variation 1779 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201198106" variation 1780 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141761526" variation 1800 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:35644942" exon 1861..1995 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1881 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149385124" variation 1898 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147489955" variation 1939 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:74468066" variation 1950 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:139943572" variation 1953 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201804704" variation 1958 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:143844489" variation 1959 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:375706027" variation 1980 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56111625" variation 1990 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371992889" exon 1996..2174 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2004 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201093320" variation 2020 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369819404" variation 2027 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147232997" variation 2037 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:186069684" variation 2067 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:374185464" variation 2125 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201637258" variation 2138 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:377614111" exon 2175..2546 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" STS 2237..2517 /gene="PAK6" /gene_synonym="PAK5" /standard_name="WI-21468" /db_xref="UniSTS:26519" STS 2278..2429 /gene="PAK6" /gene_synonym="PAK5" /standard_name="RH15701" /db_xref="UniSTS:82077" variation 2298 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11635121" variation 2299 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:75108621" variation 2342 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138256759" polyA_signal 2524..2529 /gene="PAK6" /gene_synonym="PAK5" polyA_site 2546 /gene="PAK6" /gene_synonym="PAK5" ORIGIN
gcctgcggaggactggcccagcaaggtcccaggtcttccctctcctcagcgcctaagagagaggcccagtgcgggtgaggagtcgcgaggaagaggcggaaggcgccggaaggcaccatgttccgcaagaaaaagaagaaacgccctgagatctcagcgccacagaacttccagcaccgtgtccacacctccttcgaccccaaagaaggcaagtttgtgggcctccccccacaatggcagaacatcctggacacactgcggcgccccaagcccgtggtggacccttcgcgaatcacacgggtgcagctccagcccatgaagacagtggtgcggggcagcgcgatgcctgtggatggctacatctcggggctgctcaacgacatccagaagttgtcagtcatcagctccaacaccctgcgtggccgcagccccaccagccggcggcgggcacagtccctggggctgctgggggatgagcactgggccaccgacccagacatgtacctccagagcccccagtctgagcgcactgacccccacggcctctacctcagctgcaacgggggcacaccagcaggccacaagcagatgccgtggcccgagccacagagcccacgggtcctgcccaatgggctggctgcaaaggcacagtccctgggccccgccgagtttcagggtgcctcgcagcgctgtctgcagctgggtgcctgcctgcagagctccccaccaggagcctcgccccccacgggcaccaataggcatggaatgaaggctgccaagcatggctctgaggaggcccggccacagtcctgcctggtgggctcagccacaggcaggccaggtggggaaggcagccctagccctaagacccgggagagcagcctgaagcgcaggctattccgaagcatgttcctgtccactgctgccacagcccctccaagcagcagcaagccaggccctccaccacagagcaagcccaactcctctttccgaccgccgcagaaagacaaccccccaagcctggtggccaaggcccagtccttgccctcggaccagccggtggggaccttcagccctctgaccacttcggataccagcagcccccagaagtccctccgcacagccccggccacaggccagcttccaggccggtcttccccagcgggatccccccgcacctggcacgcccagatcagcaccagcaacctgtacctgccccaggaccccacggttgccaagggtgccctggctggtgaggacacaggtgttgtgacacatgagcagttcaaggctgcgctcaggatggtggtggaccagggtgacccccggctgctgctggacagctacgtgaagattggcgagggctccaccggcatcgtctgcttggcccgggagaagcactcgggccgccaggtggccgtcaagatgatggacctcaggaagcagcagcgcagggagctgctcttcaacgaggtggtgatcatgcgggactaccagcacttcaacgtggtggagatgtacaagagctacctggtgggcgaggagctgtgggtgctcatggagttcctgcagggaggagccctcacagacatcgtctcccaagtcaggctgaatgaggagcagattgccactgtgtgtgaggctgtgctgcaggccctggcctacctgcatgctcagggtgtcatccaccgggacatcaagagtgactccatcctgctgaccctcgatggcagggtgaagctctcggacttcggattctgtgctcagatcagcaaagacgtccctaagaggaagtccctggtgggaaccccctactggatggctcctgaagtgatctccaggtctttgtatgccactgaggtggatatctggtctctgggcatcatggtgattgagatggtagatggggagccaccgtacttcagtgactccccagtgcaagccatgaagaggctccgggacagccccccacccaagctgaaaaactctcacaaggtctccccagtgctgcgagacttcctggagcggatgctggtgcgggacccccaagagagagccacagcccaggagctcctagaccaccccttcctgctgcagacagggctacctgagtgcctggtgcccctgatccagctctaccgaaagcagacctccacctgctgagcccaccccaaaaccctatctgggagagaaggcgaaccacctccgggtttccatcatgtcaaggtcacaggcatccatgtgtgcaaaccatctgccccagctgcctccacagactgctgtctccttgtcctcctcggccctgccccacttcagggctgctgtgagatggaattccaggaaagaacttcaggtgtctggaccctttctatctagataatatttttagattcttctgctccctagtgacctacctgggggcaaagaaattgcaaggacttttttttaagggtcagagttttcaaaacaaaagcatcttccctagaaatttttgtgaattgtttgcacttgtgcctgttttaaattaaattgagtgttcaaagccaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:56924 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:56924 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:56924 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS GeneID:56924 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:56924 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS GeneID:56924 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:56924 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
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