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2024-03-29 00:03:20, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001276697            2271 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA.
ACCESSION   NM_001276697
VERSION     NM_001276697.1  GI:454544714
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Marcel,V., Tran,P.L., Sagne,C., Martel-Planche,G., Vaslin,L.,
            Teulade-Fichou,M.P., Hall,J., Mergny,J.L., Hainaut,P. and Van
            Dyck,E.
  TITLE     G-quadruplex structures in TP53 intron 3: role in alternative
            splicing and in production of p53 mRNA isoforms
  JOURNAL   Carcinogenesis 32 (3), 271-278 (2011)
   PUBMED   21112961
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Marcel,V., Perrier,S., Aoubala,M., Ageorges,S., Groves,M.J.,
            Diot,A., Fernandes,K., Tauro,S. and Bourdon,J.C.
  TITLE     Delta160p53 is a novel N-terminal p53 isoform encoded by
            Delta133p53 transcript
  JOURNAL   FEBS Lett. 584 (21), 4463-4468 (2010)
   PUBMED   20937277
  REMARK    GeneRIF: Delta133p53 transcript generates two different p53
            isoforms, Delta133p53 and Delta160p53
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Anczukow,O., Ware,M.D., Buisson,M., Zetoune,A.B.,
            Stoppa-Lyonnet,D., Sinilnikova,O.M. and Mazoyer,S.
  TITLE     Does the nonsense-mediated mRNA decay mechanism prevent the
            synthesis of truncated BRCA1, CHK2, and p53 proteins?
  JOURNAL   Hum. Mutat. 29 (1), 65-73 (2008)
   PUBMED   17694537
  REMARK    GeneRIF: the p53 protein encoded by the 770delT allele is as
            abundant as the wild-type protein, as removal of the C-terminal p53
            domain leads to a stabilized mutant protein, whose abundance is
            markedly increased when NMD is inhibited.
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Bourdon,J.C.
  TITLE     p53 Family isoforms
  JOURNAL   Curr Pharm Biotechnol 8 (6), 332-336 (2007)
   PUBMED   18289041
  REMARK    Review article
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Candeias,M.M., Powell,D.J., Roubalova,E., Apcher,S., Bourougaa,K.,
            Vojtesek,B., Bruzzoni-Giovanelli,H. and Fahraeus,R.
  TITLE     Expression of p53 and p53/47 are controlled by alternative
            mechanisms of messenger RNA translation initiation
  JOURNAL   Oncogene 25 (52), 6936-6947 (2006)
   PUBMED   16983332
  REMARK    GeneRIF: harbouring alternative translation initiation sites, the
            p53 mRNA gives rise to different levels of the p53 isoforms which
            help to orchestrate the cell biological outcome of p53 activation
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   Lamb,P. and Crawford,L.
  TITLE     Characterization of the human p53 gene
  JOURNAL   Mol. Cell. Biol. 6 (5), 1379-1385 (1986)
   PUBMED   2946935
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Isobe,M., Emanuel,B.S., Givol,D., Oren,M. and Croce,C.M.
  TITLE     Localization of gene for human p53 tumour antigen to band 17p13
  JOURNAL   Nature 320 (6057), 84-85 (1986)
   PUBMED   3456488
REFERENCE   8  (bases 1 to 2271)
  AUTHORS   Benchimol,S., Lamb,P., Crawford,L.V., Sheer,D., Shows,T.B.,
            Bruns,G.A. and Peacock,J.
  TITLE     Transformation associated p53 protein is encoded by a gene on human
            chromosome 17
  JOURNAL   Somat. Cell Mol. Genet. 11 (5), 505-510 (1985)
   PUBMED   2994241
REFERENCE   9  (bases 1 to 2271)
  AUTHORS   Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E.
  TITLE     Molecular cloning and in vitro expression of a cDNA clone for human
            cellular tumor antigen p53
  JOURNAL   Mol. Cell. Biol. 5 (7), 1601-1610 (1985)
   PUBMED   3894933
REFERENCE   10 (bases 1 to 2271)
  AUTHORS   Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M.
  TITLE     Human p53 cellular tumor antigen: cDNA sequence and expression in
            COS cells
  JOURNAL   EMBO J. 4 (5), 1251-1255 (1985)
   PUBMED   4006916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087388.9, DQ186650.1 and
            AK223026.1.
            
            Summary: This gene encodes a tumor suppressor protein containing
            transcriptional activation, DNA binding, and oligomerization
            domains. The encoded protein responds to diverse cellular stresses
            to regulate expression of target genes, thereby inducing cell cycle
            arrest, apoptosis, senescence, DNA repair, or changes in
            metabolism. Mutations in this gene are associated with a variety of
            human cancers, including hereditary cancers such as Li-Fraumeni
            syndrome. Alternative splicing of this gene and the use of
            alternate promoters result in multiple transcript variants and
            isoforms. Additional isoforms have also been shown to result from
            the use of alternate translation initiation codons (PMIDs:
            12032546, 20937277). [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (5) uses an alternate promoter and
            lacks multiple 5' exons, compared to variant 1. This variant can
            initiate translation from two in-frame AUG start codons. The
            isoform represented in this variant (j, also known as
            delta160p53alpha) results from translation initiation at the
            downstream start codon. It has a shorter N-terminus, compared to
            isoform a. This variant is supported by data in PMID:16131611.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ186650.1, BM467806.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:20937277)
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC087388.9         79617-79783
            168-1100            DQ186650.1         164-1096
            1101-2252           AK223026.1         514-1665
            2253-2271           DQ186650.1         2257-2275
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2271
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="tumor protein p53"
                     /db_xref="GeneID:7157"
                     /db_xref="HGNC:11998"
                     /db_xref="MIM:191170"
     exon            1..441
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       67..68
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:17880765"
     misc_feature    135..137
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="upstream in-frame stop codon"
     variation       141
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35850753"
     variation       167
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2909430"
     variation       191
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2856920"
     STS             243..558
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:178567"
                     /db_xref="UniSTS:155019"
     STS             243..486
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:363689"
                     /db_xref="UniSTS:156784"
     STS             243..353
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:177724"
                     /db_xref="UniSTS:154952"
     misc_feature    279..281
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="alternative start codon; delta133p53alpha"
     variation       341
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72661116"
     CDS             360..1064
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="isoform j is encoded by transcript variant 5;
                     cellular tumor antigen p53; phosphoprotein p53;
                     transformation-related protein 53; p53 tumor suppressor;
                     antigen NY-CO-13"
                     /codon_start=1
                     /product="cellular tumor antigen p53 isoform j"
                     /protein_id="NP_001263626.1"
                     /db_xref="GI:454544715"
                     /db_xref="GeneID:7157"
                     /db_xref="HGNC:11998"
                     /db_xref="MIM:191170"
                     /translation="
MAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
"
     misc_feature    <360..746
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="P53 DNA-binding domain; Region: P53; cd08367"
                     /db_xref="CDD:176262"
     misc_feature    order(408..410,417..419,594..596,606..608)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:176262"
     misc_feature    order(411..419,423..425)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="dimerization site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176262"
     misc_feature    order(597..599,603..605,624..626,699..701,705..713,
                     720..722)
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     misc_feature    837..959
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="P53 tetramerisation motif; Region: P53_tetramer;
                     pfam07710"
                     /db_xref="CDD:149007"
     STS             360..434
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="PMC340938P3"
                     /db_xref="UniSTS:273171"
     variation       432
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661117"
     exon            442..554
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       521
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1800372"
     variation       531
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35163653"
     variation       548
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72661118"
     exon            555..664
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     STS             635..833
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="PMC310707P2"
                     /db_xref="UniSTS:272633"
     STS             639..713
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="GDB:190076"
                     /db_xref="UniSTS:155620"
     exon            665..801
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       669
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661119"
     variation       785
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72661120"
     exon            802..875
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       875
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11575996"
     exon            876..982
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       897
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17882252"
     variation       961
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35993958"
     variation       978
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17881470"
     exon            983..2271
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /inference="alignment:Splign:1.39.8"
     variation       1101
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1042526"
     STS             1134..1250
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="D17S1678"
                     /db_xref="UniSTS:82485"
     variation       1169
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35919705"
     variation       1378
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34486624"
     variation       1392
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17881366"
     variation       1555
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:916131"
     variation       1578
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:916132"
     STS             1591..1737
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="D17S1506E"
                     /db_xref="UniSTS:151711"
     variation       1598..1599
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1811095"
     variation       1634
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:17886358"
     variation       1677
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17879353"
     variation       1698..1699
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1794291"
     variation       1698
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042535"
     variation       1818
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199729221"
     variation       1890
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17884306"
     variation       1919
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17884586"
     variation       1950
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35659787"
     variation       2120..2121
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1794292"
     STS             2126..2202
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /standard_name="WI-20715"
                     /db_xref="UniSTS:59997"
     polyA_signal    2235..2240
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
     variation       2239
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78378222"
     polyA_site      2252
                     /gene="TP53"
                     /gene_synonym="BCC7; LFS1; P53; TRP53"
                     /note="The 3'most polyA site has not been determined."
ORIGIN      
tgaggccaggagatggaggctgcagtgagctgtgatcacaccactgtgctccagcctgagtgacagagcaagaccctatctcaaaaaaaaaaaaaaaaaagaaaagctcctgaggtgtagacgccaactctctctagctcgctagtgggttgcaggaggtgcttacgcatgtttgtttctttgctgccgtcttccagttgctttatctgttcacttgtgccctgactttcaactctgtctccttcctcttcctacagtactcccctgccctcaacaagatgttttgccaactggccaagacctgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatggccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgagcgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaatttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctatgagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagttcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactccagtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggagagaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgcccccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaagaaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatgttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggggggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccataaaaaactcatgttcaagacagaagggcctgactcagactgacattctccacttcttgttccccactgacagcctcccacccccatctctccctcccctgccattttgggttttgggtctttgaacccttgcttgcaataggtgtgcgtcagaagcacccaggacttccatttgctttgtcccggggctccactgaacaagttggcctgcactggtgttttgttgtggggaggaggatggggagtaggacataccagcttagattttaaggtttttactgtgagggatgtttgggagatgtaagaaatgttcttgcagttaagggttagtttacaatcagccacattctaggtaggggcccacttcaccgtactaaccagggaagctgtccctcactgttgaattttctctaacttcaaggcccatatctgtgaaatgctggcatttgcacctacctcacagagtgcattgtgagggttaatgaaataatgtacatctggccttgaaaccaccttttattacatggggtctagaacttgacccccttgagggtgcttgttccctctccctgttggtcggtgggttggtagtttctacagttgggcagctggttaggtagagggagttgtcaagtctctgctggcccagccaaaccctgtctgacaacctcttggtgaaccttagtacctaaaaggaaatctcaccccatcccacaccctggaggatttcatctcttgtatatgatgatctggatccaccaagacttgttttatgctcagggtcaatttcttttttcttttttttttttttttttctttttctttgagactgggtctcgctttgttgcccaggctggagtggagtggcgtgatcttggcttactgcagcctttgcctccccggctcgagcagtcctgcctcagcctccggagtagctgggaccacaggttcatgccaccatggccagccaacttttgcatgttttgtagagatggggtctcacagtgttgcccaggctggtctcaaactcctgggctcaggcgatccacctgtctcagcctcccagagtgctgggattacaattgtgagccaccacgtccagctggaagggtcaacatcttttacattctgcaagcacatctgcattttcaccccacccttcccctccttctccctttttatatcccatttttatatcgatctcttattttacaataaaactttgctgccacctgtgtgtctgaggggtg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7157 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:7157 -> Molecular function: GO:0001085 [RNA polymerase II transcription factor binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0002039 [p53 binding] evidence: IBA
            GeneID:7157 -> Molecular function: GO:0003677 [DNA binding] evidence: IMP
            GeneID:7157 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0003684 [damaged DNA binding] evidence: IBA
            GeneID:7157 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0005507 [copper ion binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0008270 [zinc ion binding] evidence: TAS
            GeneID:7157 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0030971 [receptor tyrosine kinase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0035033 [histone deacetylase regulator activity] evidence: IEA
            GeneID:7157 -> Molecular function: GO:0035035 [histone acetyltransferase binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:7157 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0051087 [chaperone binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0051721 [protein phosphatase 2A binding] evidence: IPI
            GeneID:7157 -> Molecular function: GO:0097371 [MDM2/MDM4 family protein binding] evidence: IEA
            GeneID:7157 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IBA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7157 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:7157 -> Biological process: GO:0000733 [DNA strand renaturation] evidence: IDA
            GeneID:7157 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:7157 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA
            GeneID:7157 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002309 [T cell proliferation involved in immune response] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002326 [B cell lineage commitment] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002360 [T cell lineage commitment] evidence: IEA
            GeneID:7157 -> Biological process: GO:0002931 [response to ischemia] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006284 [base-excision repair] evidence: TAS
            GeneID:7157 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: IMP
            GeneID:7157 -> Biological process: GO:0006302 [double-strand break repair] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006461 [protein complex assembly] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
            GeneID:7157 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
            GeneID:7157 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:7157 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0006983 [ER overload response] evidence: IDA
            GeneID:7157 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IDA
            GeneID:7157 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: IEP
            GeneID:7157 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007369 [gastrulation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007406 [negative regulation of neuroblast proliferation] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007417 [central nervous system development] evidence: IEA
            GeneID:7157 -> Biological process: GO:0007569 [cell aging] evidence: IMP
            GeneID:7157 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0008104 [protein localization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0008156 [negative regulation of DNA replication] evidence: IEA
            GeneID:7157 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: ISS
            GeneID:7157 -> Biological process: GO:0008340 [determination of adult lifespan] evidence: ISS
            GeneID:7157 -> Biological process: GO:0009303 [rRNA transcription] evidence: IEA
            GeneID:7157 -> Biological process: GO:0009651 [response to salt stress] evidence: IEA
            GeneID:7157 -> Biological process: GO:0010165 [response to X-ray] evidence: IBA
            GeneID:7157 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:7157 -> Biological process: GO:0030154 [cell differentiation] evidence: TAS
            GeneID:7157 -> Biological process: GO:0030308 [negative regulation of cell growth] evidence: IMP
            GeneID:7157 -> Biological process: GO:0030330 [DNA damage response, signal transduction by p53 class mediator] evidence: IDA
            GeneID:7157 -> Biological process: GO:0030330 [DNA damage response, signal transduction by p53 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
            GeneID:7157 -> Biological process: GO:0031065 [positive regulation of histone deacetylation] evidence: IBA
            GeneID:7157 -> Biological process: GO:0031497 [chromatin assembly] evidence: IDA
            GeneID:7157 -> Biological process: GO:0031571 [mitotic G1 DNA damage checkpoint] evidence: IMP
            GeneID:7157 -> Biological process: GO:0032461 [positive regulation of protein oligomerization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: IEA
            GeneID:7157 -> Biological process: GO:0034103 [regulation of tissue remodeling] evidence: IEA
            GeneID:7157 -> Biological process: GO:0034613 [cellular protein localization] evidence: IDA
            GeneID:7157 -> Biological process: GO:0034644 [cellular response to UV] evidence: IBA
            GeneID:7157 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:7157 -> Biological process: GO:0035690 [cellular response to drug] evidence: IEP
            GeneID:7157 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IDA
            GeneID:7157 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IDA
            GeneID:7157 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IBA
            GeneID:7157 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:7157 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7157 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IGI
            GeneID:7157 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:7157 -> Biological process: GO:0046677 [response to antibiotic] evidence: IEP
            GeneID:7157 -> Biological process: GO:0046902 [regulation of mitochondrial membrane permeability] evidence: TAS
            GeneID:7157 -> Biological process: GO:0048147 [negative regulation of fibroblast proliferation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: ISS
            GeneID:7157 -> Biological process: GO:0051097 [negative regulation of helicase activity] evidence: TAS
            GeneID:7157 -> Biological process: GO:0051262 [protein tetramerization] evidence: TAS
            GeneID:7157 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:0070245 [positive regulation of thymocyte apoptotic process] evidence: ISS
            GeneID:7157 -> Biological process: GO:0071158 [positive regulation of cell cycle arrest] evidence: IMP
            GeneID:7157 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IEP
            GeneID:7157 -> Biological process: GO:0071479 [cellular response to ionizing radiation] evidence: IMP
            GeneID:7157 -> Biological process: GO:0071850 [mitotic cell cycle arrest] evidence: IEA
            GeneID:7157 -> Biological process: GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] evidence: IMP
            GeneID:7157 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IDA
            GeneID:7157 -> Biological process: GO:0090343 [positive regulation of cell aging] evidence: IEA
            GeneID:7157 -> Biological process: GO:0090399 [replicative senescence] evidence: IMP
            GeneID:7157 -> Biological process: GO:0090403 [oxidative stress-induced premature senescence] evidence: IMP
            GeneID:7157 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:7157 -> Biological process: GO:0097252 [oligodendrocyte apoptotic process] evidence: IDA
            GeneID:7157 -> Biological process: GO:1901525 [negative regulation of macromitophagy] evidence: IEA
            GeneID:7157 -> Biological process: GO:2000378 [negative regulation of reactive oxygen species metabolic process] evidence: IEA
            GeneID:7157 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IMP
            GeneID:7157 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP
            GeneID:7157 -> Cellular component: GO:0000785 [chromatin] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:7157 -> Cellular component: GO:0005657 [replication fork] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0005669 [transcription factor TFIID complex] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: IEA
            GeneID:7157 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
            GeneID:7157 -> Cellular component: GO:0005829 [cytosol] evidence: IBA
            GeneID:7157 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016604 [nuclear body] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0016605 [PML body] evidence: IDA
            GeneID:7157 -> Cellular component: GO:0043234 [protein complex] evidence: IDA

by @meso_cacase at DBCLS
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