2024-03-29 13:44:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001276453 3951 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens karyopherin (importin) beta 1 (KPNB1), transcript variant 2, mRNA. ACCESSION NM_001276453 VERSION NM_001276453.1 GI:449784878 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3951) AUTHORS Desmond,C.R., Atwal,R.S., Xia,J. and Truant,R. TITLE Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein JOURNAL J. Biol. Chem. 287 (47), 39626-39633 (2012) PUBMED 23012356 REMARK GeneRIF: Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein. REFERENCE 2 (bases 1 to 3951) AUTHORS Zhen,Y., Sorensen,V., Skjerpen,C.S., Haugsten,E.M., Jin,Y., Walchli,S., Olsnes,S. and Wiedlocha,A. TITLE Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1 JOURNAL Traffic 13 (5), 650-664 (2012) PUBMED 22321063 REMARK GeneRIF: LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes REFERENCE 3 (bases 1 to 3951) AUTHORS Depping,R., Schindler,S.G., Jacobi,C., Kirschner,K.M. and Scholz,H. TITLE Nuclear transport of Wilms' tumour protein Wt1 involves importins alpha and beta JOURNAL Cell. Physiol. Biochem. 29 (1-2), 223-232 (2012) PUBMED 22415091 REMARK GeneRIF: Nuclear translocation of Wilms' tumour protein involves importins alpha and beta, and a nuclear localisation signal in the third zinc finger REFERENCE 4 (bases 1 to 3951) AUTHORS Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalban J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA and de Bakker PI. CONSRTM Bayer Pharma MS Genetics Working Group; Steering Committees of Studies Evaluating IFNbeta-1b and a CCR1-Antagonist; ANZgene Consortium; GeneMSA; International Multiple Sclerosis Genetics Consortium TITLE Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci JOURNAL Ann. Neurol. 70 (6), 897-912 (2011) PUBMED 22190364 REFERENCE 5 (bases 1 to 3951) AUTHORS van der Watt,P.J., Ngarande,E. and Leaner,V.D. TITLE Overexpression of Kpnbeta1 and Kpnalpha2 importin proteins in cancer derives from deregulated E2F activity JOURNAL PLoS ONE 6 (11), E27723 (2011) PUBMED 22125623 REMARK GeneRIF: Findings suggest that the deregulated activity of E2F in cancer cells causes increased activation of the Kpnbeta1 and Kpnalpha2 promoters, leading to elevated levels of these proteins, and ultimately impacting the cancer phenotype. REFERENCE 6 (bases 1 to 3951) AUTHORS O'Neill,R.E., Jaskunas,R., Blobel,G., Palese,P. and Moroianu,J. TITLE Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import JOURNAL J. Biol. Chem. 270 (39), 22701-22704 (1995) PUBMED 7559393 REFERENCE 7 (bases 1 to 3951) AUTHORS Chi,N.C., Adam,E.J. and Adam,S.A. TITLE Sequence and characterization of cytoplasmic nuclear protein import factor p97 JOURNAL J. Cell Biol. 130 (2), 265-274 (1995) PUBMED 7615630 REFERENCE 8 (bases 1 to 3951) AUTHORS Gorlich,D., Kostka,S., Kraft,R., Dingwall,C., Laskey,R.A., Hartmann,E. and Prehn,S. TITLE Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope JOURNAL Curr. Biol. 5 (4), 383-392 (1995) PUBMED 7627554 REFERENCE 9 (bases 1 to 3951) AUTHORS Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L., Bukrinskaya,A.G., Haggerty,S. and Stevenson,M. TITLE Active nuclear import of human immunodeficiency virus type 1 preintegration complexes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (14), 6580-6584 (1992) PUBMED 1631159 REFERENCE 10 (bases 1 to 3951) AUTHORS Mukaigawa,J. and Nayak,D.P. TITLE Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2 JOURNAL J. Virol. 65 (1), 245-253 (1991) PUBMED 1985200 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301463.1, BC036703.2, BQ009884.1, AC015674.12 and AI076614.1. Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. Transcript Variant: This variant (2) has an alternate exon in place of the first two exons compared to variant 1, which causes translation to begin at a downstream AUG compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-666 AK301463.1 1-666 667-2998 BC036703.2 892-3223 2999-3417 BQ009884.1 1-419 c 3418-3597 AC015674.12 113700-113879 c 3598-3951 AI076614.1 1-354 c FEATURES Location/Qualifiers source 1..3951 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q21.32" gene 1..3951 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="karyopherin (importin) beta 1" /db_xref="GeneID:3837" /db_xref="HGNC:6400" /db_xref="MIM:602738" exon 1..181 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 47 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="g" /replace="t" /db_xref="dbSNP:150206498" variation 112 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:188571646" misc_feature 158..160 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="upstream in-frame stop codon" exon 182..364 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 271 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:367812711" variation 277 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:372728539" variation 290 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:61750353" variation 293 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:199885874" variation 298 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:371998597" variation 329 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:200458673" variation 364 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:372937397" exon 365..565 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 373 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:1136612" variation 385 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:201367880" variation 491 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:74482416" variation 493 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:192361570" variation 499 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:145422566" variation 510 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:147688413" CDS 518..2713 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="isoform 2 is encoded by transcript variant 2; importin 1; nuclear factor p97; importin 90; importin beta-1 subunit; importin subunit beta-1; PTAC97; importin-90; karyopherin subunit beta-1; pore targeting complex 97 kDa subunit" /codon_start=1 /product="importin subunit beta-1 isoform 2" /protein_id="NP_001263382.1" /db_xref="GI:449784879" /db_xref="GeneID:3837" /db_xref="HGNC:6400" /db_xref="MIM:602738" /translation="
MKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
" misc_feature 1175..1513 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020" /db_xref="CDD:28904" misc_feature 1220..1387 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="HEAT-like repeat; Region: HEAT_EZ; pfam13513" /db_xref="CDD:205691" misc_feature order(1232..1234,1244..1246,1256..1258,1349..1351, 1361..1363,1370..1372,1382..1384,1487..1489,1496..1498, 1505..1510) /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="protein binding surface [polypeptide binding]; other site" /db_xref="CDD:28904" misc_feature 1352..1513 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /note="HEAT-like repeat; Region: HEAT_EZ; pfam13513" /db_xref="CDD:205691" variation 529 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:200123721" variation 533 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:149173509" variation 544 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:200692809" variation 559 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:199518298" exon 566..718 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 580 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:370600841" variation 601 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:143335705" variation 658 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:375360850" variation 667 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:1136613" exon 719..778 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" exon 779..868 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 830 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:140578762" exon 869..979 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 874 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:145900699" variation 959..960 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="c" /db_xref="dbSNP:35203825" exon 980..1081 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 997 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:137864253" variation 1036 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:142374321" variation 1039 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:145950162" exon 1082..1306 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1093 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:369246693" variation 1096 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:369957359" variation 1123 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:138445847" variation 1129 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:373998655" variation 1130..1131 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="g" /db_xref="dbSNP:35984944" variation 1136 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:149283729" variation 1223 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:199957614" exon 1307..1498 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1378 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:373504765" variation 1387 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:377575686" variation 1426 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:11540824" variation 1445 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:373649777" variation 1459 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:373754285" exon 1499..1629 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1533 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:11540826" variation 1536 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:186736441" variation 1541 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:202234934" exon 1630..1777 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1630 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:11540825" variation 1714 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:1136614" variation 1732 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:111692950" variation 1750 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:200182905" variation 1771 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:371931503" exon 1778..1849 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1787..1788 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="c" /db_xref="dbSNP:34904500" variation 1801 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:372705173" exon 1850..1994 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 1852 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:148458554" variation 1882 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:180862063" variation 1887 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:369233805" variation 1927 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:145279930" exon 1995..2077 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 2041 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:150687408" variation 2065 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:149068819" exon 2078..2185 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 2082 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="g" /replace="t" /db_xref="dbSNP:78999663" variation 2108 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:56696965" variation 2111 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:368599936" variation 2116 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:72628350" variation 2152 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:371651425" exon 2186..2329 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 2215 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:75547905" variation 2254 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:145340584" variation 2291 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="c" /db_xref="dbSNP:147677268" exon 2330..2435 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 2368 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:139770498" variation 2381..2382 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="g" /db_xref="dbSNP:34896194" variation 2399 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:200435017" exon 2436..2550 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" STS 2484..2612 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /standard_name="STS-H47054" /db_xref="UniSTS:79462" variation 2503 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:61750354" variation 2511 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:375622550" variation 2520 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:11540827" exon 2551..2712 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" variation 2572 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:149798768" variation 2578 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:200805705" variation 2671 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:373865263" exon 2713..3947 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /inference="alignment:Splign:1.39.8" STS 2718..3470 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /standard_name="KPNB1_2429" /db_xref="UniSTS:280815" variation 2768 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:78625504" variation 2881 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:375423595" variation 2887 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:186102346" variation 2930 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:190866202" variation 2931 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:370124590" variation 2941 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:140734776" variation 3032 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:8065792" variation 3034 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="g" /replace="t" /db_xref="dbSNP:373034343" variation 3056 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:8065920" variation 3094 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:373333049" variation 3174 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="c" /db_xref="dbSNP:183449696" STS 3184..3304 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /standard_name="RH68781" /db_xref="UniSTS:84862" variation 3242 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="t" /db_xref="dbSNP:376451451" variation 3280 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:143757780" variation 3292 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:8070379" variation 3299 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:59388318" variation 3372 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:8070516" variation 3376 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:8070520" variation 3389 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="c" /db_xref="dbSNP:1136638" variation 3468..3469 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="t" /db_xref="dbSNP:371366125" variation 3481..3487 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="ggttttg" /db_xref="dbSNP:370386449" variation 3481..3482 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="gg" /db_xref="dbSNP:147437271" variation 3527 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:111736320" variation 3597 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:12938318" variation 3601..3602 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="ggc" /db_xref="dbSNP:368942806" variation 3604 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="g" /db_xref="dbSNP:111909537" variation 3677 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:377604528" variation 3679 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:187761848" variation 3684 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:370365372" variation 3689 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:142967465" STS 3734..3893 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /standard_name="SHGC-2553" /db_xref="UniSTS:84945" variation 3757 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:191906951" variation 3778 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="g" /replace="t" /db_xref="dbSNP:79382496" variation 3785 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="c" /replace="t" /db_xref="dbSNP:3200046" variation 3791 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="g" /db_xref="dbSNP:182928451" STS 3855..3937 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /standard_name="D11S4360" /db_xref="UniSTS:154700" variation 3902 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="" /replace="a" /db_xref="dbSNP:76100192" polyA_signal 3904..3909 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" variation 3904 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" /replace="a" /replace="t" /db_xref="dbSNP:377171949" polyA_site 3947 /gene="KPNB1" /gene_synonym="IMB1; Impnb; IPO1; IPOB; NTF97" ORIGIN
atttaaggggtccggagaaaatgaagctaagtccgctagagactggtcctttgtataaaaatgtgggatggattggttgaaacagcctagatgccagttaagtttctctttggtgtccatctcctgttgggggatggggtcagagggaaggattggatgatgcttgacatctttgagaaagcccactttccttgtggaactgtccagagtgctggcaaatccaggaaacagtcaggttgccagagttgcagctggtctacaaatcaagaactctttgacatctaaagatccagatatcaaggcacaatatcagcagaggtggcttgctattgatgctaatgctcgacgagaagtcaagaactatgttttgcagacattgggtacagaaacttaccggcctagttctgcctcacagtgtgtggctggtattgcttgtgcagagatcccagtaaaccagtggccagaactcattcctcagctggtggccaatgtcacaaaccccaacagcacagagcacatgaaggagtcgacattggaagccatcggttatatttgccaagatatagacccagagcagctacaagataaatccaatgagattctgactgccataatccaggggatgaggaaagaagagcctagtaataatgtgaagctagctgctacgaatgcactcctgaactcattggagttcaccaaagcaaactttgataaagagtctgaaaggcactttattatgcaggtggtctgtgaagccacacagtgtccagatacgagggtacgagtggctgctttacagaatctggtgaagataatgtccttatattatcagtacatggagacatatatgggtcctgctctttttgcaatcacaatcgaagcaatgaaaagtgacattgatgaggtggctttacaagggatagaattctggtccaatgtctgtgatgaggaaatggatttggccattgaagcttcagaggcagcagaacaaggacggccccctgagcacaccagcaagttttatgcgaagggagcactacagtatctggttccaatcctcacacagacactaactaaacaggacgaaaatgatgatgacgatgactggaacccctgcaaagcagcaggggtgtgcctcatgcttctggccacctgctgtgaagatgacattgtcccacatgtcctccccttcattaaagaacacatcaagaacccagattggcggtaccgggatgcagcagtgatggcttttggttgtatcttggaaggaccagagcccagtcagctcaaaccactagttatacaggctatgcccaccctaatagaattaatgaaagaccccagtgtagttgttcgagatacagctgcatggactgtaggcagaatttgtgagctgcttcctgaagctgccatcaatgatgtctacttggctcccctgctacagtgtctgattgagggtctcagtgctgaacccagagtggcttcaaatgtgtgctgggctttctccagtctggctgaagctgcttatgaagctgcagacgttgctgatgatcaggaagaaccagctacttactgcttatcttcttcatttgaactcatagttcagaagctcctagagactacagacagacctgatggacaccagaacaacctgaggagttctgcatatgaatctctgatggaaattgtgaaaaacagtgccaaggattgttatcctgctgtccagaaaacgactttggtcatcatggaacgactgcaacaggttcttcagatggagtcacatatccagagcacatccgatagaatccagttcaatgaccttcagtctttactctgtgcaactcttcagaatgttcttcggaaagtgcaacatcaagatgctttgcagatctctgatgtggttatggcctccctgttaaggatgttccaaagcacagctgggtctgggggagtacaagaggatgccctgatggcagttagcacactggtggaagtgttgggtggtgaattcctcaagtacatggaggcctttaaacccttcctgggcattggattaaaaaattatgctgaataccaggtttgtttggcagctgtgggcttagtgggagacttgtgccgtgccctgcaatccaacatcatacctttctgtgacgaggtgatgcagctgcttctggaaaatttggggaatgagaacgtccacaggtctgtgaagccgcagattctgtcagtgtttggtgatattgcccttgctattggaggagagtttaaaaaatacttagaggttgtattgaatactcttcagcaggcctcccaagcccaggtggacaagtcagactatgacatggtggattatctgaatgagctaagggaaagctgcttggaagcctatactggaatcgtccagggattaaagggggatcaggagaacgtacacccggatgtgatgctggtacaacccagagtagaatttattctgtctttcattgaccacattgctggagatgaggatcacacagatggagtagtagcttgtgctgctggactaataggggacttatgtacagcatttgggaaggatgtactgaaattagtagaagctaggccaatgatccatgaattgttaactgaagggcggagatcgaagactaacaaagcaaaaacccttgctacatgggcaacaaaagaactgaggaaactgaagaaccaagcttgatctgttaccattgggatgataacctgaggacccccactggaaatctcccatcttttgaaaaacctggaagtgaggagtgtgcacggatgctgaatgtttgggaatgagaggatgagtgagtgaggcttgaaaacacaccacattgaaaatcctgccacagcagcagccgcagccgccaacagcagcgctgttagtgagctaagtaagcactgacttcgtagaaaaccataacatcggccatcttggaaaagagaaaaacaatggagttacttatttaaaaaaaaagaaagaaagttatctcttcccaggagaggctagaagtagcttttctgtcttttggccagtgccgagtggaatgcctggtttgggggaggaggagggactgggttcagctgtggtgctttgttgtaaaaggcagcctggcctttgctactgaggagaaagatggagcctgggtctcaagcccaccttcgctgtacctttgccacatggtactgtatgcttgccagctagaaggagggtcagggattttttacagtctgagaatgagtgtgtgtgagtgaggcggtatccacattctcaacttcaagtcattgcagtttctttttcccagaaaacaaggggttagatgttgcatttcataaaactaaccgaagttctgtctactgatgcagcacaagagatgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaacacacacacagaggaaagacgctctttaggttttgttttgttttttttttttggttttgttttttgttttttttactctagggaaaacactgacgaatggtcagagctcctatcctgatcttttcatcaaggcgcctttcctaataatatggttcaactgtgaatgtagaagtgggggggaggggggagaaaaagaaaactctggcgttagaggatatagaaaaatataagtacaattgttacaaataacgcagacttcaaaaacaaaaaaatcacaacccaaacaaaccaaaatttaaatgatcagaattggcagcacaaagaaaacgccctctcctgacttgtattgtggcagtctgaacgcccccagaaaattgtgccaaagagtttagaaaaataaatatacaataaaagtaaacacatacacacaaaacagcaaacttcaggtaactattttggattgcaaacaggataaattaaatgttcaaacaatctgataaaataaccatttggaaactgaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:3837 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:3837 -> Molecular function: GO:0008139 [nuclear localization sequence binding] evidence: TAS GeneID:3837 -> Molecular function: GO:0008270 [zinc ion binding] evidence: TAS GeneID:3837 -> Molecular function: GO:0008536 [Ran GTPase binding] evidence: IEA GeneID:3837 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IEA GeneID:3837 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI GeneID:3837 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: TAS GeneID:3837 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: TAS GeneID:3837 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IDA GeneID:3837 -> Biological process: GO:0006607 [NLS-bearing substrate import into nucleus] evidence: TAS GeneID:3837 -> Biological process: GO:0006610 [ribosomal protein import into nucleus] evidence: IDA GeneID:3837 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:3837 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:3837 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:3837 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS GeneID:3837 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS GeneID:3837 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:3837 -> Biological process: GO:0075733 [intracellular transport of viral material] evidence: TAS GeneID:3837 -> Cellular component: GO:0005643 [nuclear pore] evidence: TAS GeneID:3837 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:3837 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:3837 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:3837 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
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