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2024-03-29 10:42:20, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001276312            1915 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD
            domain) (NOL3), transcript variant 1, mRNA.
ACCESSION   NM_001276312
VERSION     NM_001276312.1  GI:443928955
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   McKimpson,W.M., Weinberger,J., Czerski,L., Zheng,M., Crow,M.T.,
            Pessin,J.E., Chua,S.C. Jr. and Kitsis,R.N.
  TITLE     The apoptosis inhibitor ARC alleviates the ER stress response to
            promote beta-cell survival
  JOURNAL   Diabetes 62 (1), 183-193 (2013)
   PUBMED   22933109
  REMARK    GeneRIF: ARC is a previously unrecognized inhibitor of apoptosis in
            beta-cells and that its protective effects are mediated through
            suppression of the ER stress response pathway.
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Russell,J.F., Steckley,J.L., Coppola,G., Hahn,A.F., Howard,M.A.,
            Kornberg,Z., Huang,A., Mirsattari,S.M., Merriman,B., Klein,E.,
            Choi,M., Lee,H.Y., Kirk,A., Nelson-Williams,C., Gibson,G.,
            Baraban,S.C., Lifton,R.P., Geschwind,D.H., Fu,Y.H. and Ptacek,L.J.
  TITLE     Familial cortical myoclonus with a mutation in NOL3
  JOURNAL   Ann. Neurol. 72 (2), 175-183 (2012)
   PUBMED   22926851
  REMARK    GeneRIF: This study utilized unbiased, genome-wide approaches to
            identify a NOL3 mutation that likely causes Familial cortical
            myoclonus.
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Ao,J.E., Kuang,L.H., Zhou,Y., Zhao,R. and Yang,C.M.
  TITLE     Hypoxia-inducible factor 1 regulated ARC expression mediated
            hypoxia induced inactivation of the intrinsic death pathway in p53
            deficient human colon cancer cells
  JOURNAL   Biochem. Biophys. Res. Commun. 420 (4), 913-917 (2012)
   PUBMED   22475487
  REMARK    GeneRIF: HIF-1alpha directly bound to hypoxia-responsive element
            located at -419 to -414 of ARC gene, which is essential for
            HIF-1-induced expression.
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Zaiman,A.L., Damico,R., Thoms-Chesley,A., Files,D.C., Kesari,P.,
            Johnston,L., Swaim,M., Mozammel,S., Myers,A.C., Halushka,M.,
            El-Haddad,H., Shimoda,L.A., Peng,C.F., Hassoun,P.M., Champion,H.C.,
            Kitsis,R.N. and Crow,M.T.
  TITLE     A critical role for the protein apoptosis repressor with caspase
            recruitment domain in hypoxia-induced pulmonary hypertension
  JOURNAL   Circulation 124 (23), 2533-2542 (2011)
   PUBMED   22082675
  REMARK    GeneRIF: ARC, previously unlinked to pulmonary hypertension, is a
            critical determinant of vascular remodeling in this syndrome.
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Jo,D.G., Jun,J.I., Chang,J.W., Hong,Y.M., Song,S., Cho,D.H.,
            Shim,S.M., Lee,H.J., Cho,C., Kim,D.H. and Jung,Y.K.
  TITLE     Calcium binding of ARC mediates regulation of caspase 8 and cell
            death
  JOURNAL   Mol. Cell. Biol. 24 (22), 9763-9770 (2004)
   PUBMED   15509781
  REMARK    GeneRIF: calcium binding mediates regulation of caspase 8 and cell
            death by ARC
REFERENCE   6  (bases 1 to 1915)
  AUTHORS   Nam,Y.J., Mani,K., Ashton,A.W., Peng,C.F., Krishnamurthy,B.,
            Hayakawa,Y., Lee,P., Korsmeyer,S.J. and Kitsis,R.N.
  TITLE     Inhibition of both the extrinsic and intrinsic death pathways
            through nonhomotypic death-fold interactions
  JOURNAL   Mol. Cell 15 (6), 901-912 (2004)
   PUBMED   15383280
  REMARK    GeneRIF: ARC is recruited to the Fas DISC. By interacting with Fas
            and FADD through CARD-DD and CARD-DED interactions, ARC prevents
            DISC assembly and procaspase-8 activation.
            GeneRIF: The CARD of ARC binds the Bax C-terminus, preventing Bax
            activation and activation of the intrinsic mitochondrial pathway
            GeneRIF: ARC holds multiple death pathways in check by
            non-homotypic death-fold interactions. Loss of ARC disinhibits
            these, leading to accelerated DISC assembly and Bax activation and
            may be an apoptotic trigger in heart failure and
            ischemia-reperfusion.
REFERENCE   7  (bases 1 to 1915)
  AUTHORS   Ekhterae,D., Platoshyn,O., Zhang,S., Remillard,C.V. and Yuan,J.X.
  TITLE     Apoptosis repressor with caspase domain inhibits cardiomyocyte
            apoptosis by reducing K+ currents
  JOURNAL   Am. J. Physiol., Cell Physiol. 284 (6), C1405-C1410 (2003)
   PUBMED   12734105
  REMARK    GeneRIF: These results suggest that the antiapoptotic effect of
            apoptotic repressor with caspase recruitment domain is, in part,
            due to inhibition of voltage-gated potassium channels in
            cardiomyocytes.
REFERENCE   8  (bases 1 to 1915)
  AUTHORS   Li,P.F., Li,J., Muller,E.C., Otto,A., Dietz,R. and von Harsdorf,R.
  TITLE     Phosphorylation by protein kinase CK2: a signaling switch for the
            caspase-inhibiting protein ARC
  JOURNAL   Mol. Cell 10 (2), 247-258 (2002)
   PUBMED   12191471
REFERENCE   9  (bases 1 to 1915)
  AUTHORS   Stoss,O., Schwaiger,F.W., Cooper,T.A. and Stamm,S.
  TITLE     Alternative splicing determines the intracellular localization of
            the novel nuclear protein Nop30 and its interaction with the
            splicing factor SRp30c
  JOURNAL   J. Biol. Chem. 274 (16), 10951-10962 (1999)
   PUBMED   10196175
REFERENCE   10 (bases 1 to 1915)
  AUTHORS   Koseki,T., Inohara,N., Chen,S. and Nunez,G.
  TITLE     ARC, an inhibitor of apoptosis expressed in skeletal muscle and
            heart that interacts selectively with caspases
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (9), 5156-5160 (1998)
   PUBMED   9560245
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB959673.1, AK294145.1,
            AC074143.5 and AF064599.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes an anti-apoptotic protein that has been
            shown to down-regulate the enzyme activities of caspase 2, caspase
            8 and tumor protein p53. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform. Variants 1, 2, 4, and 5
            encode the same protein (isoform MYP).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294145.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025088 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CB959673.1         28-65
            39-1423             AK294145.1         4-1388
            1424-1424           AC074143.5         143910-143910
            1425-1635           AK294145.1         1390-1600
            1636-1915           AF064599.1         1102-1381
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1915
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /note="nucleolar protein 3 (apoptosis repressor with CARD
                     domain)"
                     /db_xref="GeneID:8996"
                     /db_xref="HGNC:7869"
                     /db_xref="MIM:605235"
     exon            1..78
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     exon            79..384
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     variation       346
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146699716"
     variation       376
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62057951"
     exon            385..569
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    389..391
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /note="upstream in-frame stop codon"
     variation       481
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113475662"
     variation       553
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2233455"
     exon            570..872
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     CDS             578..1204
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /note="isoform MYP is encoded by transcript variant 1;
                     nucleolar protein of 30 kDa; muscle-enriched cytoplasmic
                     protein"
                     /codon_start=1
                     /product="nucleolar protein 3 isoform MYP"
                     /protein_id="NP_001263241.1"
                     /db_xref="GI:443928956"
                     /db_xref="CCDS:CCDS42176.1"
                     /db_xref="GeneID:8996"
                     /db_xref="HGNC:7869"
                     /db_xref="MIM:605235"
                     /translation="
MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS
"
     misc_feature    590..853
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /note="Caspase recruitment domain; Region: CARD;
                     smart00114"
                     /db_xref="CDD:128424"
     variation       601
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369557885"
     variation       614
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2233457"
     variation       652
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199980306"
     variation       686
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202111825"
     variation       743
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375270565"
     variation       762
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201067296"
     variation       797
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375650340"
     variation       821
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369265508"
     variation       827
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201367451"
     exon            873..1196
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     variation       908
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2233458"
     variation       919
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200144674"
     variation       937
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371108668"
     variation       948
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375028825"
     variation       985
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2233459"
     variation       1083
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377659624"
     variation       1104
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375346192"
     variation       1130
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367640749"
     variation       1152
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371908750"
     variation       1155
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201221648"
     variation       1163
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201587168"
     STS             1168..1287
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /standard_name="RH47869"
                     /db_xref="UniSTS:40524"
     variation       1174
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368688530"
     variation       1192
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188696118"
     exon            1197..1887
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /inference="alignment:Splign:1.39.8"
     variation       1215
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377629448"
     variation       1233
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199600705"
     variation       1240
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201000974"
     STS             1254..1330
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /standard_name="RH41857"
                     /db_xref="UniSTS:52321"
     variation       1254
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2233460"
     variation       1331
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34549032"
     variation       1433
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369479649"
     variation       1468
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75280012"
     variation       1502
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8057598"
     variation       1596
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374851015"
     variation       1657
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548450"
     variation       1700
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369065916"
     variation       1751..1753
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace=""
                     /replace="att"
                     /db_xref="dbSNP:375713230"
     variation       1752..1753
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:368811483"
     variation       1753
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111417515"
     variation       1835
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372985188"
     variation       1857
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149556040"
     polyA_site      1888
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYP; NOP; NOP30"
ORIGIN      
gccgcagctgctgcacccacccccaccctgcccggccctttctgcaccgtcatctcctgccccgccgaggcttgacccgtgctgtccccctctcccttcctttgcccaccgattggagggacactctggaaaactcagttgaagaaagcggagagtctgcgtgtacacagtgcaatgatgtcagttaatgcactagtgagggcatgtgttgttcacggtacacagaagaaggaaccaccagcccttgggacacttaggcattggtgtagacaagggaacatttgagtcctggacgatggataggtccacggagcggagggaggagaaaaggattccagtcttagcgatcagcatcagcaaaggctccgaggtgccagaggcataagagtagatgccagtcctgggaaaggcaggggaggagaggagagccacggctgacgcttggggacagaaggaggagcctgaggaggagacaggacagagcgtctggagaggcaggaggacaccgagttccccgtgttggcctccaggtcctgtgcttgcggagccgtccggcggctgggatcgagccccgacaatgggcaacgcgcaggagcggccgtcagagactatcgaccgcgagcggaaacgcctggtcgagacgctgcaggcggactcgggactgctgttggacgcgctgctggcgcggggcgtgctcaccgggccagagtacgaggcattggatgcactgcctgatgccgagcgcagggtgcgccgcctactgctgctggtgcagggcaagggcgaggccgcctgccaggagctgctacgctgtgcccagcgtaccgcgggcgcgccggaccccgcttgggactggcagcacgtgggtccgggctaccgggaccgcagctatgaccctccatgcccaggccactggacgccggaggcacccggctcggggaccacatgccccgggttgcccagagcttcagaccctgacgaggccgggggccctgagggctccgaggcggtgcaatccgggaccccggaggagccagagccagagctggaagctgaggcctctaaagaggctgaaccggagccggagccagagccagagctggaacccgaggctgaagcagaaccagagccggaactggagccagaaccggacccagagcccgagcccgacttcgaggaaagggacgagtccgaagattcctgaaggccagagctctgacaggcggtgccccgcccatgctggataggacctgggatgctgctggagctgaatcggatgccaccaaggctcggtccagcccagtaccgctggaagtgaataaactccggagggtcggacgggacctgggctctctccacgattctggctgtttgcccaggaacttagggtgggtacctctgagtcccagggacctgggcaggcccaagcccaccacgagcatcatccagtcctcagccctaatctgcccttaggagtccaggctgcaccctggagatcccaaacctagccccctagtgggacaaggacctgaccctcctgcccgcatacacaacccatttcccctggtgagccacttggcagcatatgtaggtaccagctcaaccccacgcaagttcctgagctgaacatggagcaaggggagggtgacttctctccacatagggagggcttagagctcacagccttgggaagtgagactagaagaggggagcagaaagggaccttgagtagacaaaggccacacacatcattgtcattactgttttaattgtctggcttctctctggactgggagctcagtgaggattctgaccagtgacttacacaaaaggcgctctatacatattataatatattcgcttactaaatgaataaggactttccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8996 -> Molecular function: GO:0003723 [RNA binding] evidence: TAS
            GeneID:8996 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8996 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:8996 -> Biological process: GO:0006397 [mRNA processing] evidence: IEA
            GeneID:8996 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:8996 -> Biological process: GO:0008380 [RNA splicing] evidence: IEA
            GeneID:8996 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:8996 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
            GeneID:8996 -> Cellular component: GO:0005739 [mitochondrion] evidence: ISS
            GeneID:8996 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:8996 -> Cellular component: GO:0016528 [sarcoplasm] evidence: IEA

by @meso_cacase at DBCLS
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