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2024-04-20 22:02:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001274 3517 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 3,
mRNA.
ACCESSION NM_001274
VERSION NM_001274.5 GI:349501059
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3517)
AUTHORS Cheng,Y.C., Lin,T.Y. and Shieh,S.Y.
TITLE Candidate tumor suppressor BTG3 maintains genomic stability by
promoting Lys63-linked ubiquitination and activation of the
checkpoint kinase CHK1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (15), 5993-5998 (2013)
PUBMED 23533280
REMARK GeneRIF: BTG3-dependent CHK1 ubiquitination contributes to its
chromatin localization and activation and a defect in this
regulation may increase genome instability and promote
tumorigenesis
REFERENCE 2 (bases 1 to 3517)
AUTHORS Wang,W.J., Wu,S.P., Liu,J.B., Shi,Y.S., Huang,X., Zhang,Q.B. and
Yao,K.T.
TITLE MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem
cell-like population of nasopharyngeal carcinoma cells
JOURNAL Cancer Res. 73 (3), 1219-1231 (2013)
PUBMED 23269272
REMARK GeneRIF: MYC regulation of CHK1 and CHK2 promotes radioresistance
in a stem cell-like population of nasopharyngeal carcinoma cells.
REFERENCE 3 (bases 1 to 3517)
AUTHORS Huh,J. and Piwnica-Worms,H.
TITLE CRL4(CDT2) targets CHK1 for PCNA-independent destruction
JOURNAL Mol. Cell. Biol. 33 (2), 213-226 (2013)
PUBMED 23109433
REMARK GeneRIF: CRL4 is a major regulator of CHK1 stability. CRL4CDT2
targets CHK1 for ubiquitination in the nucleoplasm, and for
PCNA-independent degradation. CHK1 is required for G2 arrest in
CDT2-depleted cells.
REFERENCE 4 (bases 1 to 3517)
AUTHORS Okita,N., Yoshimura,M., Watanabe,K., Minato,S., Kudo,Y., Higami,Y.
and Tanuma,S.
TITLE CHK1 cleavage in programmed cell death is intricately regulated by
both caspase and non-caspase family proteases
JOURNAL Biochim. Biophys. Acta 1830 (1), 2204-2213 (2013)
PUBMED 23085068
REMARK GeneRIF: CASP and non-CASP family proteases intricately regulate
cleavage for up-regulation of CHK1 kinase activity during PCD.
REFERENCE 5 (bases 1 to 3517)
AUTHORS Kumar,G., Breen,E.J. and Ranganathan,S.
TITLE Identification of ovarian cancer associated genes using an
integrated approach in a Boolean framework
JOURNAL BMC Syst Biol 7, 12 (2013)
PUBMED 23383610
REMARK GeneRIF: IRAK1, CHEK1 and BUB1 may play an important role in
ovarian cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3517)
AUTHORS Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
TITLE The physical association and phosphorylation of Cdc25C protein
phosphatase by Prk
JOURNAL Oncogene 18 (44), 6029-6036 (1999)
PUBMED 10557092
REFERENCE 7 (bases 1 to 3517)
AUTHORS Giaccia,A.J. and Kastan,M.B.
TITLE The complexity of p53 modulation: emerging patterns from divergent
signals
JOURNAL Genes Dev. 12 (19), 2973-2983 (1998)
PUBMED 9765199
REMARK Review article
REFERENCE 8 (bases 1 to 3517)
AUTHORS Flaggs,G., Plug,A.W., Dunks,K.M., Mundt,K.E., Ford,J.C.,
Quiggle,M.R., Taylor,E.M., Westphal,C.H., Ashley,T., Hoekstra,M.F.
and Carr,A.M.
TITLE Atm-dependent interactions of a mammalian chk1 homolog with meiotic
chromosomes
JOURNAL Curr. Biol. 7 (12), 977-986 (1997)
PUBMED 9382850
REFERENCE 9 (bases 1 to 3517)
AUTHORS Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
Piwnica-Worms,H.
TITLE Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
binding by phosphorylation of Cdc25C on serine-216
JOURNAL Science 277 (5331), 1501-1505 (1997)
PUBMED 9278512
REFERENCE 10 (bases 1 to 3517)
AUTHORS Sanchez,Y., Wong,C., Thoma,R.S., Richman,R., Wu,Z.,
Piwnica-Worms,H. and Elledge,S.J.
TITLE Conservation of the Chk1 checkpoint pathway in mammals: linkage of
DNA damage to Cdk regulation through Cdc25
JOURNAL Science 277 (5331), 1497-1501 (1997)
PUBMED 9278511
REMARK GeneRIF: Biochemical studies suggest the functional interactions of
this protein with cell cycle regulators. Cdc25A, Cdc25B, and Cdc25C
can be phosphoryalted by this protein.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP203333.1, BC017575.1,
CA441277.1, BC004202.2, BG191840.1, BM455102.1, BX506561.1,
BX114781.1, AI750792.1 and AA224205.1.
On Oct 4, 2011 this sequence version replaced gi:166295191.
Summary: The protein encoded by this gene belongs to the Ser/Thr
protein kinase family. It is required for checkpoint mediated cell
cycle arrest in response to DNA damage or the presence of
unreplicated DNA. This protein acts to integrate signals from ATM
and ATR, two cell cycle proteins involved in DNA damage responses,
that also associate with chromatin in meiotic prophase I.
Phosphorylation of CDC25A protein phosphatase by this protein is
required for cells to delay cell cycle progression in response to
double-strand DNA breaks. Several alternatively spliced transcript
variants have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (3) contains an alternate 5'
non-coding exon compared to variant 1. Variant 1-3 encode the same
isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC017575.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-123 BP203333.1 16-138
124-1650 BC017575.1 42-1568
1651-1651 CA441277.1 463-463 c
1652-1698 BC004202.2 1471-1517
1699-2085 BG191840.1 126-512
2086-2344 BM455102.1 369-627
2345-2616 BX506561.1 253-524
2617-3093 BX114781.1 281-757
3094-3486 AI750792.1 9-401 c
3487-3517 AA224205.1 1-31 c
FEATURES Location/Qualifiers
source 1..3517
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.2"
gene 1..3517
/gene="CHEK1"
/gene_synonym="CHK1"
/note="checkpoint kinase 1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
exon 1..220
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 28
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3731394"
variation 111
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201882373"
variation 149
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731395"
misc_feature 202..204
/gene="CHEK1"
/gene_synonym="CHK1"
/note="upstream in-frame stop codon"
variation 207
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12574644"
exon 221..305
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 223
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371037025"
CDS 241..1671
/gene="CHEK1"
/gene_synonym="CHK1"
/EC_number="2.7.11.1"
/note="isoform 1 is encoded by transcript variant 3;
Checkpoint, S. pombe, homolog of, 1;
serine/threonine-protein kinase Chk1; CHK1 checkpoint
homolog; checkpoint kinase-1; cell cycle checkpoint
kinase; Chk1-S"
/codon_start=1
/product="serine/threonine-protein kinase Chk1 isoform 1"
/protein_id="NP_001265.2"
/db_xref="GI:166295192"
/db_xref="CCDS:CCDS8459.1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
/translation="
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
"
misc_feature 241..1035
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14757.2);
Region: Interaction with CLSPN (By similarity)"
misc_feature 265..1032
/gene="CHEK1"
/gene_synonym="CHK1"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 283..1026
/gene="CHEK1"
/gene_synonym="CHK1"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(283..297,307..309,346..348,352..354,442..444,
490..501,511..513,517..519,628..630,634..636,640..645,
649..651,682..684,691..693,745..756)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(283..297,307..309,346..348,352..354,442..444,
490..501,511..513,628..630,634..636,640..645,649..651,
682..684)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(295..297,511..513,517..519,628..630,634..636,
640..642,691..693,745..756)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(679..699,745..756)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1096..1098
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1126..1128
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1141..1143
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1189..1191
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (O14757.2); phosphorylation site"
misc_feature 1273..1275
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (O14757.2); phosphorylation site"
misc_feature 1411..1668
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14757.2);
Region: Autoinhibitory region"
variation 250
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201459198"
variation 274
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200520758"
variation 279
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144523921"
exon 306..529
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 356
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367942205"
variation 399
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372546907"
variation 402
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112291840"
variation 441
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148040708"
variation 445
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375481689"
variation 452
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141665265"
variation 480
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371045906"
exon 530..594
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 594
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375305289"
exon 595..664
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 603
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368957964"
variation 616
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112275638"
variation 627
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114850047"
variation 655
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371765740"
exon 665..853
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 672
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113468080"
variation 706
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140276570"
variation 707
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731410"
variation 718
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369248914"
variation 738
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373714183"
variation 764
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75583143"
variation 825
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200960815"
variation 846
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190137928"
variation 847
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376741119"
exon 854..958
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 888
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377704459"
variation 908
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:35817404"
variation 918
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370350660"
exon 959..1054
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 991
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201395400"
variation 1000
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553952"
variation 1012
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201385540"
exon 1055..1163
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1080
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:111852956"
variation 1117
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147323405"
variation 1152
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:182542971"
exon 1164..1341
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1174
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34097480"
variation 1185
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371546941"
variation 1218
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2847422"
variation 1240
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139936669"
variation 1272
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375729370"
variation 1276
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199535573"
variation 1282
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374866866"
variation 1294
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149667923"
variation 1314
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111415405"
variation 1323
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239581"
exon 1342..1473
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1347
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375980825"
variation 1350
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77764256"
variation 1377
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369650833"
variation 1392
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192063586"
variation 1410
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372751798"
variation 1428
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374032447"
variation 1448
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115991933"
variation 1449
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149857578"
variation 1457
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145794689"
exon 1474..1575
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1480
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148568641"
variation 1500
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141332865"
variation 1502
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370268372"
exon 1576..3498
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1636
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146590504"
variation 1651
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:506504"
variation 1674
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373998065"
variation 1693
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375887872"
variation 1732
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:9282658"
variation 1766
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148807246"
variation 1807
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373169887"
variation 1838
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184393295"
variation 1997
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142447277"
variation 2043..2044
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:141464656"
variation 2044..2045
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:113628894"
variation 2044
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199723723"
variation 2045..2046
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:72531173"
variation 2046..2047
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:3731480"
variation 2047..2048
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:35167388"
variation 2047
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201914580"
polyA_signal 2075..2080
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2094
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:190098261"
polyA_site 2096
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2117
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181773130"
variation 2195
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184932784"
variation 2414
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113311223"
variation 2453
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189829306"
variation 2509
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151312608"
variation 2592
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140546391"
variation 2616
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144047942"
variation 2617
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:567889"
variation 2619
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368655022"
variation 2675
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="t"
/db_xref="dbSNP:34215005"
variation 2688
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146445217"
variation 2783
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370171293"
variation 2791
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140816182"
variation 3152
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623058"
variation 3166
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370678835"
variation 3230
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11220176"
STS 3255..3361
/gene="CHEK1"
/gene_synonym="CHK1"
/standard_name="A006U05"
/db_xref="UniSTS:17547"
STS 3269..3392
/gene="CHEK1"
/gene_synonym="CHK1"
/standard_name="RH36540"
/db_xref="UniSTS:25497"
variation 3361
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138368921"
variation 3421
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:180885007"
polyA_signal 3469..3474
/gene="CHEK1"
/gene_synonym="CHK1"
polyA_site 3498
/gene="CHEK1"
/gene_synonym="CHK1"
ORIGIN
cgctgccgcaggcgttttctgccccataccgctccctatatcctcttcctctcttccccagacccccacctctccctcctccttccccagtcgttcgccggaaagcatttgtctcccacctcttcataacaacaattaatttcctctggggcctgaggagggcagaatttcaaccttcggtgtgcttgggagtggcgattgtgatttacacgacaaaatgccgaggtgctcggtggagtcatggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctatggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgtagatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaaatgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaatatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacataggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttatctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaaagggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgtgagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaagagaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgcaatgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgactggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagctctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaaaaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttcaggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttctctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaaccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaagggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttacttggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattctttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttgggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggagaaacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgacttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaagggaagctgattgatattgtgagcagccagaagatttggcttcctgccacatgatcggaccatcggctctggggaatcctggtgaatatagtgctgctatgttgacattattcttcctagagaagattatcctgtcctgcaaactgcaaatagtagttcctgaagtgttcacttccctgtttatccaaacatcttccaatttattttgtttgttcggcatacaaataatacctatatcttaattgtaagcaaaactttggggaaaggatgaatagaattcatttgattatttcttcatgtgtgtttagtatctgaatttgaaactcatctggtggaaaccaagtttcaggggacatgagttttccagcttttatacacacgtatctcatttttatcaaaacattttgtttaattcaaaaagtacatattccatgttgatttaattctaagatgaaccaataaagacataattcttgtgacttttggacagtagatttatcagtctgtgaagcgaagccagcttcaaaacatatccccaagatttgtacttatattttcaaaagggcctggccagttatataaacctgtttttgaattataatgattaattaaaattgcaagtaggtgttttttccagtgtagttagtaaaatacttgtattttacagtgttgcataaactctagtgcttaactaactttactctaaaaattactgttgaacatcttaaatatttttctatattttctactttcatagccatattttaaccttttcaacttactggtgaccaagcttttaggtgataaagaataaaagagggaagggaagagtaaggaagctataagaaaaatagatctgattctttgttcctttacctgttagacttacaaaaagtttgtttttctaataaaatttgtatcaactttggggcatattaggttgaggccttggctcctgcctgtagtcccagctacttaggaggctgagagaggaggatcgcgtgaacctggaagtttgaggctgtagtgagctatgattgcaccagtgcactccagcttggatgacagagtaagaccctacctctaataaaaatttttaaaattgtaaaacattataaaattaatcagttattttaatctgaagccaagaacatgtagaatgttatgattagagtttatcacatattaatgtatactggcaaattgtgttactggagtatacccataggaggaataaattcaaacctgttttatttatttgaacctatttacggtatgcttaagaattgaatcagtataaattctcaaatatgggagaaattttgttcttgagaattatctgagtcattaatatttttcaaaaacagctctcactgacttgaacctcttctgtaagctctaaccttttacctgctttacatttccacttgaatgtctagtaggcatctcttgaccaaaaacagcttttgattcctgttctccaacctgttcctctcctagttttctccatctcagaaatgttacttcctctgcaaagtctttccctgacttatctaaaataataacctcctctgtttgctgtgggaatttgtatagaatggtgggaaaatttcaagtttcatatttggattagctctgacatttatttatctgaacactggtaattgcctcagtaaagacactgataataagtaccttttagagttattttaatctttaatgctttaatgtgtaggaagagtatagtgtcctgttttgcacagaaaggcattctgtaaataataagttgccttaattttcctgtaatgttcattatattgttgtgggaaggtatttactcctattattaaaaataaaaatgtgtaaaatttactacctgaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1111 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:1111 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1111 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1111 -> Molecular function: GO:0035402 [histone kinase activity (H3-T11 specific)] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:1111 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:1111 -> Biological process: GO:0006281 [DNA repair] evidence: IMP
GeneID:1111 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:1111 -> Biological process: GO:0006975 [DNA damage induced protein phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0010569 [regulation of double-strand break repair via homologous recombination] evidence: IDA
GeneID:1111 -> Biological process: GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] evidence: ISS
GeneID:1111 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0033261 [regulation of S phase] evidence: IEA
GeneID:1111 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
GeneID:1111 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IDA
GeneID:1111 -> Biological process: GO:0046602 [regulation of mitotic centrosome separation] evidence: IDA
GeneID:1111 -> Biological process: GO:0048096 [chromatin-mediated maintenance of transcription] evidence: ISS
GeneID:1111 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:1111 -> Biological process: GO:0071313 [cellular response to caffeine] evidence: IEA
GeneID:1111 -> Biological process: GO:0090399 [replicative senescence] evidence: NAS
GeneID:1111 -> Biological process: GO:2000615 [regulation of histone H3-K9 acetylation] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
GeneID:1111 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000794 [condensed nuclear chromosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1111 -> Cellular component: GO:0005657 [replication fork] evidence: IEA
GeneID:1111 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001265 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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