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2024-04-25 03:13:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001272044 5497 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1
(RPS6KB1), transcript variant 4, mRNA.
ACCESSION NM_001272044
VERSION NM_001272044.1 GI:440546398
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5497)
AUTHORS Yoshida,S., Matsumoto,K., Arao,T., Taniguchi,H., Goto,I.,
Hanafusa,T., Nishio,K. and Yamada,Y.
TITLE Gene amplification of ribosomal protein S6 kinase-1 and -2 in
gastric cancer
JOURNAL Anticancer Res. 33 (2), 469-475 (2013)
PUBMED 23393338
REMARK GeneRIF: No amplification of S6K1 was detected in gastric cancer
tissues
REFERENCE 2 (bases 1 to 5497)
AUTHORS Ben-Hur,V., Denichenko,P., Siegfried,Z., Maimon,A., Krainer,A.,
Davidson,B. and Karni,R.
TITLE S6K1 alternative splicing modulates its oncogenic activity and
regulates mTORC1
JOURNAL Cell Rep 3 (1), 103-115 (2013)
PUBMED 23273915
REFERENCE 3 (bases 1 to 5497)
AUTHORS Zhao,X.F., Zhao,M.Y., Chai,L., Kukuruga,D., Tan,M. and Stass,S.A.
TITLE Amplified RPS6KB1 and CDC2 genes are potential biomarkers for
aggressive HIV+/EBV+ diffuse large B-cell lymphomas
JOURNAL Int J Clin Exp Pathol 6 (2), 148-154 (2013)
PUBMED 23330000
REMARK GeneRIF: HIV+/EBV+ aggressive diffuse large B-cell lymphoma could
be potentially treated by targeting RPS6KB1 and CDC2 genes.
REFERENCE 4 (bases 1 to 5497)
AUTHORS Rosner,M. and Hengstschlager,M.
TITLE Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms
p85 and p31, is regulated by TSC2/mTOR
JOURNAL Oncogene 30 (44), 4509-4522 (2011)
PUBMED 21602892
REFERENCE 5 (bases 1 to 5497)
AUTHORS Fenton,T.R. and Gout,I.T.
TITLE Functions and regulation of the 70kDa ribosomal S6 kinases
JOURNAL Int. J. Biochem. Cell Biol. 43 (1), 47-59 (2011)
PUBMED 20932932
REMARK GeneRIF: Dysregulation of S6 kinases contributes to the
pathogenesis of human diseases.
Review article
REFERENCE 6 (bases 1 to 5497)
AUTHORS Karni,R., de Stanchina,E., Lowe,S.W., Sinha,R., Mu,D. and
Krainer,A.R.
TITLE The gene encoding the splicing factor SF2/ASF is a proto-oncogene
JOURNAL Nat. Struct. Mol. Biol. 14 (3), 185-193 (2007)
PUBMED 17310252
REFERENCE 7 (bases 1 to 5497)
AUTHORS Couch,F.J., Wang,X.Y., Wu,G.J., Qian,J., Jenkins,R.B. and
James,C.D.
TITLE Localization of PS6K to chromosomal region 17q23 and determination
of its amplification in breast cancer
JOURNAL Cancer Res. 59 (7), 1408-1411 (1999)
PUBMED 10197603
REFERENCE 8 (bases 1 to 5497)
AUTHORS Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
Wettenhall,R.E., Kozma,S.C. and Thomas,G.
TITLE Dual requirement for a newly identified phosphorylation site in
p70s6k
JOURNAL Mol. Cell. Biol. 17 (9), 5648-5655 (1997)
PUBMED 9271440
REFERENCE 9 (bases 1 to 5497)
AUTHORS Proud,C.G.
TITLE p70 S6 kinase: an enigma with variations
JOURNAL Trends Biochem. Sci. 21 (5), 181-185 (1996)
PUBMED 8871403
REMARK Review article
REFERENCE 10 (bases 1 to 5497)
AUTHORS Grove,J.R., Banerjee,P., Balasubramanyam,A., Coffer,P.J.,
Price,D.J., Avruch,J. and Woodgett,J.R.
TITLE Cloning and expression of two human p70 S6 kinase polypeptides
differing only at their amino termini
JOURNAL Mol. Cell. Biol. 11 (11), 5541-5550 (1991)
PUBMED 1922062
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP359158.1, AK297147.1,
AC004686.2 and CA444907.1.
Summary: This gene encodes a member of the ribosomal S6 kinase
family of serine/threonine kinases. The encoded protein responds to
mTOR (mammalian target of rapamycin) signaling to promote protein
synthesis, cell growth, and cell proliferation. Activity of this
gene has been associated with human cancer. Alternatively spliced
transcript variants have been observed. The use of alternative
translation start sites results in isoforms with longer or shorter
N-termini which may differ in their subcellular localizations.
There are two pseudogenes for this gene on chromosome 17. [provided
by RefSeq, Jan 2013].
Transcript Variant: This variant (4) contains an alternate exon in
the 5' region, and initiates translation at the third in-frame
start codon, compared to variant 1. The encoded isoform (d) has a
shorter N-terminus, compared to isoform a.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK297147.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-219 BP359158.1 1-219
220-2239 AK297147.1 27-2046
2240-5047 AC004686.2 5281-8088 c
5048-5497 CA444907.1 1-450 c
FEATURES Location/Qualifiers
source 1..5497
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q23.1"
gene 1..5497
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="ribosomal protein S6 kinase, 70kDa, polypeptide 1"
/db_xref="GeneID:6198"
/db_xref="HGNC:10436"
/db_xref="MIM:608938"
exon 1..280
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 134
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:373348379"
variation 164
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:139530428"
variation 168
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:201606773"
variation 248
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142855919"
variation 250
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:376390460"
variation 253
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:200955904"
variation 256
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369943341"
variation 274
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:56376112"
exon 281..409
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
misc_feature 302..304
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="upstream in-frame stop codon"
exon 410..459
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
CDS 428..1846
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/EC_number="2.7.11.1"
/note="isoform d is encoded by transcript variant 4;
serine/threonine kinase 14 alpha; ribosomal protein S6
kinase beta-1; ribosomal protein S6 kinase I; p70 S6
kinase, alpha; serine/threonine-protein kinase 14A"
/codon_start=1
/product="ribosomal protein S6 kinase beta-1 isoform d"
/protein_id="NP_001258973.1"
/db_xref="GI:440546399"
/db_xref="GeneID:6198"
/db_xref="HGNC:10436"
/db_xref="MIM:608938"
/translation="
MDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
"
misc_feature 539..1324
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature 548..1516
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, 70 kDa ribosomal protein S6 kinase; Region:
STKc_p70S6K; cd05584"
/db_xref="CDD:173675"
misc_feature order(557..571,581..583,629..631,635..637,734..736,
782..787,791..793,803..805,809..811,920..922,926..928,
932..937,941..943,971..976,983..985,1025..1042,1121..1123,
1139..1141,1148..1150)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="active site"
/db_xref="CDD:173675"
misc_feature order(557..571,581..583,629..631,635..637,734..736,
785..793,803..805,920..922,926..928,932..937,941..943,
971..976)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173675"
misc_feature order(569..571,803..805,809..811,920..922,926..928,
932..934,983..985,1025..1042,1121..1123,1139..1141,
1148..1150)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173675"
misc_feature 971..1042
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173675"
misc_feature 1448..1450
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="turn motif phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:173675"
misc_feature 1490..1507
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173675"
exon 460..580
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 461
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200282847"
variation 467
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369352640"
variation 523
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:201788760"
exon 581..649
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 615
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:377332462"
variation 619
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:56010534"
exon 650..797
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 700
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:373972797"
variation 702
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183590386"
variation 764
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:367762054"
exon 798..855
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 811
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149835132"
variation 833
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371239209"
exon 856..956
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 901
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:368534737"
variation 920..921
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="c"
/db_xref="dbSNP:34994293"
exon 957..1047
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 973
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:372457945"
variation 1000
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:376961948"
exon 1048..1138
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1096
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201582805"
variation 1103
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370044721"
variation 1110
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:147955400"
exon 1139..1246
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1183
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:184521347"
variation 1198
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:373846364"
variation 1200
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200443093"
exon 1247..1309
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1249
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:370608471"
variation 1250
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:373201580"
variation 1276
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:141890234"
exon 1310..1387
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1384
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:367688464"
exon 1388..1495
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
exon 1496..1608
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1601
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:201316437"
variation 1604
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:146927684"
exon 1609..5484
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1609
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:369106764"
variation 1718
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:137873345"
variation 1730
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201664077"
STS 1761..1935
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="D17S1554"
/db_xref="UniSTS:61668"
variation 1763
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149039467"
variation 1771
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:143055403"
variation 1777
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:148223136"
variation 1813
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:373473920"
variation 1819
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306904"
variation 1883
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:369442815"
variation 1921..1922
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="aa"
/db_xref="dbSNP:76853887"
variation 1921
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:200620649"
variation 1922..1923
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:67846207"
variation 1922
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:25548"
variation 1950
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:144814059"
variation 1972
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:180515"
variation 2004
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:193186563"
variation 2020..2021
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="aa"
/db_xref="dbSNP:71685029"
variation 2021
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051424"
variation 2043
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:112530345"
STS 2072..2421
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="D17S1994"
/db_xref="UniSTS:6637"
STS 2197..2567
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="MARC_10535-10536:1000147856:1"
/db_xref="UniSTS:267161"
variation 2354
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:200194783"
variation 2419
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11549046"
polyA_signal 2493..2498
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
polyA_site 2519
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
variation 2531
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="g"
/db_xref="dbSNP:67046002"
variation 2550..2551
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="g"
/db_xref="dbSNP:35627972"
variation 2606
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:201868081"
variation 2625
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:372223764"
variation 3649
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:2158458"
variation 3691
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:148571848"
variation 3719
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:35485878"
variation 3728
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:62081839"
variation 3729
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:75120475"
variation 3864
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183346732"
variation 3896..3897
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:34975148"
variation 3985
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:144391145"
variation 4369
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:375536815"
variation 4415
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:111430839"
variation 4485
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11555598"
variation 4613
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369479523"
variation 4703
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:34061743"
variation 4723
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:34454406"
variation 4773
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:188457115"
variation 4903
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:139023905"
variation 4985
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:146705278"
variation 5042
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:139176752"
STS 5147..5387
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="RH69849"
/db_xref="UniSTS:15737"
variation 5194
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:192688444"
variation 5287
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:144027445"
variation 5385
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:373703630"
variation 5393
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183658577"
polyA_signal 5457..5462
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
variation 5473
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:187967995"
polyA_site 5484
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
ORIGIN
gtttggcttcacggaaccctgtacgcatgctcctacgctgaactttaggagccagtctaaggcctaggcgcagacgcactgagcctaagcagccggtgatggcggcagcggctgtggtggctgcggcgggtccgggcccatgaggcgacgaaggaggcgggacggcttttacccagccccggacttccgagacagggaagctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctctgaggatgagctggaggagggggaagcgctcagctgttagaagtgacagctgaaaacttctgtcgggagtagcactgccgctgctgttacagccaccaggagttttatttcgggagcaagggggctctgctgcatcttccaatcttccaggggtcagttaaatgaaagcatggaccatgggggagttggaccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaacagagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaagggggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactgggaaaatatttgccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcatacaaaagcagaacggaatattctggaggaagtaaagcatcccttcatcgtggatttaatttatgcctttcagactggtggaaaactctacctcatccttgagtatctcagtggaggagaactatttatgcagttagaaagagagggaatatttatggaagacactgcctgcttttacttggcagaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaagccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgcaaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatggcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttgggagcattaatgtatgacatgctgactggagcacccccattcactggggagaatagaaagaaaacaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagccagagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtctgggagctggtcctggggacgctggagaagttcaagctcatccattctttagacacattaactgggaagaacttctggctcgaaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtaagtcagtttgattccaagtttacacgtcagacacctgtcgacagcccagatgactcaactctcagtgaaagtgccaatcaggtctttctgggttttacatatgtggctccatctgtacttgaaagtgtgaaagaaaagttttcctttgaaccaaaaatccgatcacctcgaagatttattggcagcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggtgcttcggccagcacagcaaatcctcagacacctgtggaatacccaatggaaacaagtggcatagagcagatggatgtgacaatgagtggggaagcatcggcaccacttccaatacgacagccgaactctgggccatacaaaaaacaagcttttcccatgatctccaaacggccagagcacctgcgtatgaatctatgacagagcaatgcttttaatgaatttaaggcaaaaaaggtggagagggagatgtgtgagcatcctgcaaggtgaaacgactcaaaatgacagtttcagagagtcaatgtcattacatagaacacttcagacacaggaaaaataaacgtggattttaaaaaatcaatcaatggtgcaaaaaaaaacttaaagcaaaatagtattgctgaactcttaggcacatcaattaattgattcctcgcgacatcttctcaaccttatcaaggattttcatgttgatgactcgaaactgacagtattaagggtaggatgttgcttctgaatcactgttgagttctgattgtgttgaagaagggttatcctttcattaggcaaagtacaaaattgcctataatacttgcaactaaggacaaattagcatgcaagcttggtcaaactttttccagcaaaatggaagcaaagacaaaagaaacttaccaattgatgttttacgtgcaaacaacctgaatcttttttttatataaatatatatttttcaaatagatttttgattcagctcattatgaaaaacatcccaaactttaaaatgcgaaattattggttggtgtgaagaaagccagacaacttctgtttcttctcttggtgaaataataaaatgcaaatgaatcattgttaaccacagctgtggctcgtttgagggattggggtggacctggggtttattttcagtaacccagctgcaatacctgtctgtaatatgagaaaaaaaaaatgaatctatttaatcatttctacttgcagtactgctatgtgctaagcttaactggaagccttggaatgggcataagttgtatgtcctacatttcatcattgtcccgggcctgcattgcactggaaaaaaaaatcgccacctgttcttacaccagtatttggttcaagacaccaaatgtcttcagcccatggctgaagaacaacagaagagagtcaggataaaaaatacatactgtggtcggcaaggtgagggagatagggatatccaggggaagagggtgttgctgtggcccactctctgtctaatctctttacagcaaattggtaagattttcagttttacttctttctactgtttctgctgtctaccttccttatatttttttcctcaacagttttaaaaagaaaaaaaggtctatttttttttctcctatacttgggctacattttttgattgtaaaaatatttgatggccttttgatgaatgtcttccacagtaaagaaaacttagtggcttaatttaggaaacatgttaacaggacactatgtttttgaaattgtaacaaaatctacataaatgatttacaggttaaaagaataaaaataaaggtaactttacctttcttaaatatttcctgccttaaagagagcatttccatgactttagctggtgaaagggtttaatatctgcagagctttataaaaatatatttcagtgcatactggtataatagatgatcatgcagttgcagttgagttgtatcaccttttttgtttgtcttttataatgtcttcagtctgagtgtgcaaagtcaatttgtaatattttgcaaccctaggatttttttaaatagatgctgcttgctatgttttcaaacctttttgagccataggatccaagccataaaattctttatgcatgttgaattcagtcagaaaagagcaaggctttgctttttgaaattgcaactcaaatgagatgggatgaaatcctatgacagtaagcaaaaacagaaccatgaaaaatgattggacatacaccttttcaattgtggcaataattgaaagaatcgataaaagttcatctttggacagaaagcctttaaaaaaaaaatcactccctcttccccctcctcccttattgcagcagcctactgagaactttgactgttgctggtaaattagaagctacaataataattaagggcagaaattatacttaaaaagtgcagatccttgttctttgacaatttgtgatgtctgaaaaaacagaacccgaaaagctatggtgatatgtacaggcattatttcagactgtaaatggcttgtgatactcttgatacttgttttcaaatatgtttactaactgtagtgttgactgcctgaccaaattccagtgaaacttatacaccaaaatattcttcctaggtcctatttgctagtaacatgagcactgtgattggctggctataaccaccccagttaaaccattttcataattagtagtgccagcaatagtggcaaacactgcaacttttctgcataaaaagcattaattgcacagctaccatccacacaaatacatagtttttctgacttcacatttattaagtgaaatttatttcccatgctgtggaaagtttattgagaacttgtttcataaatggatatccctactatgactgtgaaaacatgtcaagtgtcacattagtgtcacagacagaaagcacacacctatgcaatatggcttatctatatttatttgtaaaaatccaagcatagtttaaaatatgatgtcgatattactagtcttgagtttctaagagggttctttatgttataccaggtaagtgtataaaagagattaagtgcttttttttcatcacttgattattttctttaaaatcagctattacaggatatttttttattttatacatgctgttttttaattaaaatataatcactgaagtttactaatttgattttataaggtttgtagcattacagaataactaaactgggatttataaaccagctgtgattaacaatgtaaagtattaattattgaactttgaaccagatttttaggaaaattatgttctttttccccctttatggtcttaactaatttgaatccttcaagaaggatttttccatactattttttaagatagaagataatttgtgggcaggggtggaggatgcatgtatgatactccataaattcaacattctttactataggtaatgaatgattataaacaagatgcatcttagatagtattaatatactgagccttggattatatatttaatataggacctattttgaatattcagttaatcatatggttcctagcttacaagggctagatctaagattattcccatgagaaatgttgaatttatgaagaatagattttaaggctttgaaaatggttaatttctcaaaaacatcaatgtccaaacatctaccttttttcataggagtagacactagcaagctggacaaactatcacaaaagtatttgtcacacataacctgtggtctgttgctgattaatacagtactttttcttgtgtgattcttaacattatagcacaagtattatctcagtggattatccggaataacatctgaaagatgggttcatctatgtttgtgtttgctctttaaactattgtttctcctatcccaagttcgctttgcatctatcagtaaataaaattcttcagctgccttattaggagtgctatgagggtaacacctgttctgcttttcatcttgtatttagttgactgtattatttgatttcggattgaatgaatgtaaatagaaattaaatgcaaatttgaatgaacataaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6198 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:6198 -> Molecular function: GO:0004711 [ribosomal protein S6 kinase activity] evidence: IEA
GeneID:6198 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6198 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6198 -> Molecular function: GO:0042277 [peptide binding] evidence: IEA
GeneID:6198 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IMP
GeneID:6198 -> Biological process: GO:0003009 [skeletal muscle contraction] evidence: IEA
GeneID:6198 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6198 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6198 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6198 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
GeneID:6198 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:6198 -> Biological process: GO:0007584 [response to nutrient] evidence: IEA
GeneID:6198 -> Biological process: GO:0007616 [long-term memory] evidence: IEA
GeneID:6198 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:6198 -> Biological process: GO:0009408 [response to heat] evidence: IEA
GeneID:6198 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
GeneID:6198 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
GeneID:6198 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0014732 [skeletal muscle atrophy] evidence: IEA
GeneID:6198 -> Biological process: GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation] evidence: IEA
GeneID:6198 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
GeneID:6198 -> Biological process: GO:0016477 [cell migration] evidence: IEA
GeneID:6198 -> Biological process: GO:0031929 [TOR signaling cascade] evidence: IDA
GeneID:6198 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
GeneID:6198 -> Biological process: GO:0033574 [response to testosterone stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0033762 [response to glucagon stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IEA
GeneID:6198 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:6198 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:6198 -> Biological process: GO:0043201 [response to leucine] evidence: IEA
GeneID:6198 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IEA
GeneID:6198 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:6198 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IMP
GeneID:6198 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IMP
GeneID:6198 -> Biological process: GO:0045948 [positive regulation of translational initiation] evidence: IMP
GeneID:6198 -> Biological process: GO:0046324 [regulation of glucose import] evidence: IEA
GeneID:6198 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: IMP
GeneID:6198 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:6198 -> Biological process: GO:0048633 [positive regulation of skeletal muscle tissue growth] evidence: IEA
GeneID:6198 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IEA
GeneID:6198 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0071363 [cellular response to growth factor stimulus] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:6198 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IEA
GeneID:6198 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6198 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
GeneID:6198 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:6198 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
GeneID:6198 -> Cellular component: GO:0045202 [synapse] evidence: IEA
GeneID:6198 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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