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2024-03-29 16:27:15, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001272043            4332 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1
            (RPS6KB1), transcript variant 3, mRNA.
ACCESSION   NM_001272043
VERSION     NM_001272043.1  GI:440546396
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4332)
  AUTHORS   Yoshida,S., Matsumoto,K., Arao,T., Taniguchi,H., Goto,I.,
            Hanafusa,T., Nishio,K. and Yamada,Y.
  TITLE     Gene amplification of ribosomal protein S6 kinase-1 and -2 in
            gastric cancer
  JOURNAL   Anticancer Res. 33 (2), 469-475 (2013)
   PUBMED   23393338
  REMARK    GeneRIF: No amplification of S6K1 was detected in gastric cancer
            tissues
REFERENCE   2  (bases 1 to 4332)
  AUTHORS   Ben-Hur,V., Denichenko,P., Siegfried,Z., Maimon,A., Krainer,A.,
            Davidson,B. and Karni,R.
  TITLE     S6K1 alternative splicing modulates its oncogenic activity and
            regulates mTORC1
  JOURNAL   Cell Rep 3 (1), 103-115 (2013)
   PUBMED   23273915
REFERENCE   3  (bases 1 to 4332)
  AUTHORS   Zhao,X.F., Zhao,M.Y., Chai,L., Kukuruga,D., Tan,M. and Stass,S.A.
  TITLE     Amplified RPS6KB1 and CDC2 genes are potential biomarkers for
            aggressive HIV+/EBV+ diffuse large B-cell lymphomas
  JOURNAL   Int J Clin Exp Pathol 6 (2), 148-154 (2013)
   PUBMED   23330000
  REMARK    GeneRIF: HIV+/EBV+ aggressive diffuse large B-cell lymphoma could
            be potentially treated by targeting RPS6KB1 and CDC2 genes.
REFERENCE   4  (bases 1 to 4332)
  AUTHORS   Rosner,M. and Hengstschlager,M.
  TITLE     Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms
            p85 and p31, is regulated by TSC2/mTOR
  JOURNAL   Oncogene 30 (44), 4509-4522 (2011)
   PUBMED   21602892
REFERENCE   5  (bases 1 to 4332)
  AUTHORS   Fenton,T.R. and Gout,I.T.
  TITLE     Functions and regulation of the 70kDa ribosomal S6 kinases
  JOURNAL   Int. J. Biochem. Cell Biol. 43 (1), 47-59 (2011)
   PUBMED   20932932
  REMARK    GeneRIF: Dysregulation of S6 kinases contributes to the
            pathogenesis of human diseases.
            Review article
REFERENCE   6  (bases 1 to 4332)
  AUTHORS   Karni,R., de Stanchina,E., Lowe,S.W., Sinha,R., Mu,D. and
            Krainer,A.R.
  TITLE     The gene encoding the splicing factor SF2/ASF is a proto-oncogene
  JOURNAL   Nat. Struct. Mol. Biol. 14 (3), 185-193 (2007)
   PUBMED   17310252
REFERENCE   7  (bases 1 to 4332)
  AUTHORS   Couch,F.J., Wang,X.Y., Wu,G.J., Qian,J., Jenkins,R.B. and
            James,C.D.
  TITLE     Localization of PS6K to chromosomal region 17q23 and determination
            of its amplification in breast cancer
  JOURNAL   Cancer Res. 59 (7), 1408-1411 (1999)
   PUBMED   10197603
REFERENCE   8  (bases 1 to 4332)
  AUTHORS   Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
            Wettenhall,R.E., Kozma,S.C. and Thomas,G.
  TITLE     Dual requirement for a newly identified phosphorylation site in
            p70s6k
  JOURNAL   Mol. Cell. Biol. 17 (9), 5648-5655 (1997)
   PUBMED   9271440
REFERENCE   9  (bases 1 to 4332)
  AUTHORS   Proud,C.G.
  TITLE     p70 S6 kinase: an enigma with variations
  JOURNAL   Trends Biochem. Sci. 21 (5), 181-185 (1996)
   PUBMED   8871403
  REMARK    Review article
REFERENCE   10 (bases 1 to 4332)
  AUTHORS   Grove,J.R., Banerjee,P., Balasubramanyam,A., Coffer,P.J.,
            Price,D.J., Avruch,J. and Woodgett,J.R.
  TITLE     Cloning and expression of two human p70 S6 kinase polypeptides
            differing only at their amino termini
  JOURNAL   Mol. Cell. Biol. 11 (11), 5541-5550 (1991)
   PUBMED   1922062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP359158.1, BC053365.1,
            AC004686.2 and CA444907.1.
            
            Summary: This gene encodes a member of the ribosomal S6 kinase
            family of serine/threonine kinases. The encoded protein responds to
            mTOR (mammalian target of rapamycin) signaling to promote protein
            synthesis, cell growth, and cell proliferation. Activity of this
            gene has been associated with human cancer. Alternatively spliced
            transcript variants have been observed. The use of alternative
            translation start sites results in isoforms with longer or shorter
            N-termini which may differ in their subcellular localizations.
            There are two pseudogenes for this gene on chromosome 17. [provided
            by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (3) differs in the 3' UTR and uses
            an alternate splice site in the 3' coding region, which results in
            a frameshift, compared to variant 1. This variant can initiate
            translation from two alternate in-frame AUG start codons. The
            isoform represented in this RefSeq (c) is derived from the first
            AUG start codon. It has a distinct C-terminus, and is shorter than
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BP359158.1         1-99
            100-2081            BC053365.1         2-1983
            2082-3882           AC004686.2         5281-7081           c
            3883-4332           CA444907.1         1-450               c
FEATURES             Location/Qualifiers
     source          1..4332
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..4332
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="ribosomal protein S6 kinase, 70kDa, polypeptide 1"
                     /db_xref="GeneID:6198"
                     /db_xref="HGNC:10436"
                     /db_xref="MIM:608938"
     exon            1..280
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    86..88
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="upstream in-frame stop codon"
     variation       134
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373348379"
     CDS             140..1495
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /EC_number="2.7.11.1"
                     /note="isoform c is encoded by transcript variant 3;
                     serine/threonine kinase 14 alpha; ribosomal protein S6
                     kinase beta-1; ribosomal protein S6 kinase I; p70 S6
                     kinase, alpha; serine/threonine-protein kinase 14A"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase beta-1 isoform c"
                     /protein_id="NP_001258972.1"
                     /db_xref="GI:440546397"
                     /db_xref="GeneID:6198"
                     /db_xref="HGNC:10436"
                     /db_xref="MIM:608938"
                     /translation="
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSTAMC
"
     misc_feature    209..211
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="Region: Alternative start codon"
     misc_feature    221..235
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P23443.2);
                     Region: TOS motif"
     misc_feature    410..1195
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:214567"
     misc_feature    419..1387
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, 70 kDa ribosomal protein S6 kinase; Region:
                     STKc_p70S6K; cd05584"
                     /db_xref="CDD:173675"
     misc_feature    order(428..442,452..454,500..502,506..508,605..607,
                     653..658,662..664,674..676,680..682,791..793,797..799,
                     803..808,812..814,842..847,854..856,896..913,992..994,
                     1010..1012,1019..1021)
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="active site"
                     /db_xref="CDD:173675"
     misc_feature    order(428..442,452..454,500..502,506..508,605..607,
                     656..664,674..676,791..793,797..799,803..808,812..814,
                     842..847)
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173675"
     misc_feature    order(440..442,674..676,680..682,791..793,797..799,
                     803..805,854..856,896..913,992..994,1010..1012,1019..1021)
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173675"
     misc_feature    842..913
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173675"
     misc_feature    893..895
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PDPK1; propagated from
                     UniProtKB/Swiss-Prot (P23443.2); phosphorylation site"
     misc_feature    1049..1051
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P23443.2); acetylation site"
     misc_feature    1319..1321
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:173675"
     misc_feature    1319..1321
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P23443.2); phosphorylation site"
     misc_feature    1361..1378
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:173675"
     misc_feature    1460..1462
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P23443.2); phosphorylation site"
     misc_feature    1469..1471
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P23443.2); phosphorylation site"
     misc_feature    1478..1480
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P23443.2); phosphorylation site"
     variation       164
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139530428"
     variation       168
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201606773"
     variation       248
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142855919"
     variation       250
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376390460"
     variation       253
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200955904"
     variation       256
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369943341"
     variation       274
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56376112"
     exon            281..330
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     exon            331..451
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       332
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200282847"
     variation       338
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369352640"
     variation       394
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201788760"
     exon            452..520
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       486
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377332462"
     variation       490
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56010534"
     exon            521..668
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       571
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373972797"
     variation       573
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183590386"
     variation       635
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367762054"
     exon            669..726
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       682
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149835132"
     variation       704
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371239209"
     exon            727..827
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       772
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368534737"
     variation       791..792
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34994293"
     exon            828..918
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       844
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372457945"
     variation       871
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376961948"
     exon            919..1009
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       967
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201582805"
     variation       974
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370044721"
     variation       981
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147955400"
     exon            1010..1117
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       1054
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:184521347"
     variation       1069
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373846364"
     variation       1071
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200443093"
     exon            1118..1180
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       1120
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370608471"
     variation       1121
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373201580"
     variation       1147
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141890234"
     exon            1181..1258
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       1255
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367688464"
     exon            1259..1366
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     exon            1367..1479
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       1472
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201316437"
     variation       1475
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146927684"
     exon            1480..4319
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:1.39.8"
     variation       2484
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2158458"
     variation       2526
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148571848"
     variation       2554
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35485878"
     variation       2563
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:62081839"
     variation       2564
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:75120475"
     variation       2699
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183346732"
     variation       2731..2732
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34975148"
     variation       2820
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144391145"
     variation       3204
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375536815"
     variation       3250
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111430839"
     variation       3320
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11555598"
     variation       3448
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369479523"
     variation       3538
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34061743"
     variation       3558
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34454406"
     variation       3608
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188457115"
     variation       3738
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:139023905"
     variation       3820
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146705278"
     variation       3877
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139176752"
     STS             3982..4222
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /standard_name="RH69849"
                     /db_xref="UniSTS:15737"
     variation       4029
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192688444"
     variation       4122
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144027445"
     variation       4220
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373703630"
     variation       4228
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183658577"
     polyA_signal    4292..4297
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
     variation       4308
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187967995"
     polyA_site      4319
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
ORIGIN      
gtttggcttcacggaaccctgtacgcatgctcctacgctgaactttaggagccagtctaaggcctaggcgcagacgcactgagcctaagcagccggtgatggcggcagcggctgtggtggctgcggcgggtccgggcccatgaggcgacgaaggaggcgggacggcttttacccagccccggacttccgagacagggaagctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctctgaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttggaccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaacagagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaagggggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactgggaaaatatttgccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcatacaaaagcagaacggaatattctggaggaagtaaagcatcccttcatcgtggatttaatttatgcctttcagactggtggaaaactctacctcatccttgagtatctcagtggaggagaactatttatgcagttagaaagagagggaatatttatggaagacactgcctgcttttacttggcagaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaagccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgcaaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatggcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttgggagcattaatgtatgacatgctgactggagcacccccattcactggggagaatagaaagaaaacaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagccagagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtctgggagctggtcctggggacgctggagaagttcaagctcatccattctttagacacattaactgggaagaacttctggctcgaaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtaagtcagtttgattccaagtttacacgtcagacacctgtcgacagcccagatgactcaactctcagtgaaagtgccaatcaggtctttctgggttttacatatgtggctccatctgtacttgaaagtgtgaaagaaaagttttcctttgaaccaaaaatccgatcacctcgaagatttattggcagcccacgaacacctgtcagtactgctatgtgctaagcttaactggaagccttggaatgggcataagttgtatgtcctacatttcatcattgtcccgggcctgcattgcactggaaaaaaaaatcgccacctgttcttacaccagtatttggttcaagacaccaaatgtcttcagcccatggctgaagaacaacagaagagagtcaggataaaaaatacatactgtggtcggcaaggtgagggagatagggatatccaggggaagagggtgttgctgtggcccactctctgtctaatctctttacagcaaattggtaagattttcagttttacttctttctactgtttctgctgtctaccttccttatatttttttcctcaacagttttaaaaagaaaaaaaggtctatttttttttctcctatacttgggctacattttttgattgtaaaaatatttgatggccttttgatgaatgtcttccacagtaaagaaaacttagtggcttaatttaggaaacatgttaacaggacactatgtttttgaaattgtaacaaaatctacataaatgatttacaggttaaaagaataaaaataaaggtaactttacctttcttaaatatttcctgccttaaagagagcatttccatgactttagctggtgaaagggtttaatatctgcagagctttataaaaatatatttcagtgcatactggtataatagatgatcatgcagttgcagttgagttgtatcaccttttttgtttgtcttttataatgtcttcagtctgagtgtgcaaagtcaatttgtaatattttgcaaccctaggatttttttaaatagatgctgcttgctatgttttcaaacctttttgagccataggatccaagccataaaattctttatgcatgttgaattcagtcagaaaagagcaaggctttgctttttgaaattgcaactcaaatgagatgggatgaaatcctatgacagtaagcaaaaacagaaccatgaaaaatgattggacatacaccttttcaattgtggcaataattgaaagaatcgataaaagttcatctttggacagaaagcctttaaaaaaaaaatcactccctcttccccctcctcccttattgcagcagcctactgagaactttgactgttgctggtaaattagaagctacaataataattaagggcagaaattatacttaaaaagtgcagatccttgttctttgacaatttgtgatgtctgaaaaaacagaacccgaaaagctatggtgatatgtacaggcattatttcagactgtaaatggcttgtgatactcttgatacttgttttcaaatatgtttactaactgtagtgttgactgcctgaccaaattccagtgaaacttatacaccaaaatattcttcctaggtcctatttgctagtaacatgagcactgtgattggctggctataaccaccccagttaaaccattttcataattagtagtgccagcaatagtggcaaacactgcaacttttctgcataaaaagcattaattgcacagctaccatccacacaaatacatagtttttctgacttcacatttattaagtgaaatttatttcccatgctgtggaaagtttattgagaacttgtttcataaatggatatccctactatgactgtgaaaacatgtcaagtgtcacattagtgtcacagacagaaagcacacacctatgcaatatggcttatctatatttatttgtaaaaatccaagcatagtttaaaatatgatgtcgatattactagtcttgagtttctaagagggttctttatgttataccaggtaagtgtataaaagagattaagtgcttttttttcatcacttgattattttctttaaaatcagctattacaggatatttttttattttatacatgctgttttttaattaaaatataatcactgaagtttactaatttgattttataaggtttgtagcattacagaataactaaactgggatttataaaccagctgtgattaacaatgtaaagtattaattattgaactttgaaccagatttttaggaaaattatgttctttttccccctttatggtcttaactaatttgaatccttcaagaaggatttttccatactattttttaagatagaagataatttgtgggcaggggtggaggatgcatgtatgatactccataaattcaacattctttactataggtaatgaatgattataaacaagatgcatcttagatagtattaatatactgagccttggattatatatttaatataggacctattttgaatattcagttaatcatatggttcctagcttacaagggctagatctaagattattcccatgagaaatgttgaatttatgaagaatagattttaaggctttgaaaatggttaatttctcaaaaacatcaatgtccaaacatctaccttttttcataggagtagacactagcaagctggacaaactatcacaaaagtatttgtcacacataacctgtggtctgttgctgattaatacagtactttttcttgtgtgattcttaacattatagcacaagtattatctcagtggattatccggaataacatctgaaagatgggttcatctatgtttgtgtttgctctttaaactattgtttctcctatcccaagttcgctttgcatctatcagtaaataaaattcttcagctgccttattaggagtgctatgagggtaacacctgttctgcttttcatcttgtatttagttgactgtattatttgatttcggattgaatgaatgtaaatagaaattaaatgcaaatttgaatgaacataaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6198 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
            GeneID:6198 -> Molecular function: GO:0004711 [ribosomal protein S6 kinase activity] evidence: IEA
            GeneID:6198 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6198 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:6198 -> Molecular function: GO:0042277 [peptide binding] evidence: IEA
            GeneID:6198 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IMP
            GeneID:6198 -> Biological process: GO:0003009 [skeletal muscle contraction] evidence: IEA
            GeneID:6198 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:6198 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:6198 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:6198 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
            GeneID:6198 -> Biological process: GO:0007568 [aging] evidence: IEA
            GeneID:6198 -> Biological process: GO:0007584 [response to nutrient] evidence: IEA
            GeneID:6198 -> Biological process: GO:0007616 [long-term memory] evidence: IEA
            GeneID:6198 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:6198 -> Biological process: GO:0009408 [response to heat] evidence: IEA
            GeneID:6198 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
            GeneID:6198 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA
            GeneID:6198 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
            GeneID:6198 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
            GeneID:6198 -> Biological process: GO:0014732 [skeletal muscle atrophy] evidence: IEA
            GeneID:6198 -> Biological process: GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation] evidence: IEA
            GeneID:6198 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
            GeneID:6198 -> Biological process: GO:0016477 [cell migration] evidence: IEA
            GeneID:6198 -> Biological process: GO:0031929 [TOR signaling cascade] evidence: IDA
            GeneID:6198 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
            GeneID:6198 -> Biological process: GO:0033574 [response to testosterone stimulus] evidence: IEA
            GeneID:6198 -> Biological process: GO:0033762 [response to glucagon stimulus] evidence: IEA
            GeneID:6198 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IEA
            GeneID:6198 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:6198 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
            GeneID:6198 -> Biological process: GO:0043201 [response to leucine] evidence: IEA
            GeneID:6198 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IEA
            GeneID:6198 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
            GeneID:6198 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IMP
            GeneID:6198 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IMP
            GeneID:6198 -> Biological process: GO:0045948 [positive regulation of translational initiation] evidence: IMP
            GeneID:6198 -> Biological process: GO:0046324 [regulation of glucose import] evidence: IEA
            GeneID:6198 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: IMP
            GeneID:6198 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:6198 -> Biological process: GO:0048633 [positive regulation of skeletal muscle tissue growth] evidence: IEA
            GeneID:6198 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IEA
            GeneID:6198 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: IEA
            GeneID:6198 -> Biological process: GO:0071363 [cellular response to growth factor stimulus] evidence: IDA
            GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:6198 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:6198 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:6198 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0045202 [synapse] evidence: IEA
            GeneID:6198 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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